• Comparison of morphinan alkaloids during different stages of growth in the medicinal plant opium poppy [papaver somniferum L. (bvsalud.org)
  • This research has been carried out to investigate accumulation process of morphinan alkaloids in opium poppy plant during different stages of growth . (bvsalud.org)
  • The present invention generally relates to improved processes for the synthesis of quaternary N-alkyl salts of morphinan alkaloids such as naltrexone methobromide. (justia.com)
  • N-methyl quaternary derivatives of morphinan alkaloids such as naltrexone ((5α)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one sometimes referred to as N-cyclopropylmethyl-noroxymorphone) and naloxone ((5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one sometimes referred to as N-allyl-noroxymorphone) have useful pharmacological properties as potent antagonists of the mu receptor. (justia.com)
  • generally describe the preparation of quaternary derivatives of certain morphinan alkaloids by quaternizing a tertiary N-substituted morphinan alkaloid with a methylating agent such as methyl bromide, methyl iodide or dimethyl sulfate. (justia.com)
  • While this process constitutes significant progress in the synthesis of naltrexone methobromide and other quaternary morphinan alkaloids, a need remains for yet further improvement. (justia.com)
  • Bifunctional protein involved in the biosynthesis of morphinan-type benzylisoquinoline alkaloids. (uniprot.org)
  • Selective reduction of morphinan alkaloids. (mpg.de)
  • Morphinan is the prototype chemical structure of a large chemical class of psychoactive drugs, consisting of opiate analgesics, cough suppressants, and dissociative hallucinogens, among others. (wikipedia.org)
  • Morphinans are a class of psychoactive drugs consisting of opiate analgesics , cough suppressants, and dissociative hallucinogens , among others. (psychonautwiki.org)
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  • Synthetic analgesics - Aralkyl substitution on nitrogen of morphinan. (wikipedia.org)
  • Of the major naturally occurring opiates of the morphinan type-morphine, codeine and thebaine-thebaine has no therapeutic properties (it causes seizures in mammals), but it provides a low-cost feedstock for the industrial production of at least four semi-synthetic opiate agonists, including hydrocodone, hydromorphone, oxycodone and oxymorphone, and the opioid antagonist naloxone. (wikipedia.org)
  • Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. (nih.gov)
  • Active morphinan derivatives often act upon the NMDA receptor , the μ-opioid receptor and the σ1 and σ2 sigma receptors. (psychonautwiki.org)
  • Ro4-1539 (furethylnorlevorphanol) is an opioid analgesic drug from the morphinan series that was discovered by the pharmaceutical company Hoffmann-La Roche in the 1950s. (wikipedia.org)
  • Morphinan derivatives as opioid selective antagonists. (nih.gov)
  • A method of producing promorphinan, morphinan, nal-opioid, and nor-opioid alkaloid products through the increased conversion of a promorphinan alkaloid to a morphinan alkaloid. (sumobrain.com)
  • Morphinan is the base chemical structures of a subgroup of opioids. (statemaster.com)
  • UGT2B7 seems to be a major human isoform responsible for the glucuronidation of opioids of the morphinan and oripavine class and is capable of catalyzing the glucuronidation of both the 3- and 6-hydroxyl moieties on these molecules. (aspetjournals.org)
  • Seedlings of various ages (0-14 days old) were analyzed for their dopamine, thebaine, morphinan alkaloid immunoreactivity, and benzophenanthridine alkaloid levels. (semanticscholar.org)
  • A particularly complex gene cluster contains many critical enzymes in the metabolic pathway that generates the alkaloid drugs noscapine and morphinan. (semanticscholar.org)
  • Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. (pacb.com)
  • An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives. (justia.com)
  • The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. (sumobrain.com)
  • Modelling of other important κ-OR-selective ligands, including the morphinan-derived antagonists norbinaltorphimine and 5'-guanidinonaltrindole, and the diterpene agonist salvinorin A analogue RB-64, reveals both common and distinct features for binding these diverse chemotypes. (nih.gov)
  • morphinan antagonists like. (dsaj.org)
  • Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. (pacb.com)
  • Paralog analysis identified P450 and oxidoreductase genes that combined to form the STORR gene fusion essential for morphinan biosynthesis in opium poppy. (pacb.com)
  • Here we describe the 2.8 Å crystal structure of the mouse µ-OR in complex with an irreversible morphinan antagonist. (nih.gov)
  • We have identified enantiomeric analogues of traditional (−)-morphinans as having TLR9 antagonist properties on reporter cell lines. (jimmunol.org)
  • A synthetic morphinan analgesic with narcotic antagonist action. (nih.gov)
  • Morphinan has a phenanthrene core structure with the A ring remaining aromatic and the B and C rings being saturated, and an additional nitrogen-containing, six-membered, saturated ring, the D ring, being attached to carbons 9 and 13 of the core, and with the nitrogen being at position 17 of the composite. (wikipedia.org)
  • Morphinan has the phenanthrene backbone. (pearltrees.com)
  • This compound belongs to the class of organic compounds known as morphinans. (drugbank.ca)
  • Low dose morphine-like agents - known as morphinans - have been used "off label" for individuals. (healthcanal.com)
  • Chemical derivatives[edit] Immediate derivatives of morphinan include: More distant of derivatives include: As well as the following: Levomethorphan. (pearltrees.com)
  • The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. (freepatentsonline.com)
  • The present invention is directed to processes for the synthesis of morphinans. (patentsencyclopedia.com)
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  • In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched. (freepatentsonline.com)
  • The morphinans are a large chemical class and compounds within it have differing pharmacological effects. (psychonautwiki.org)
  • The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. (patentsencyclopedia.com)
  • Disclosed is a novel method for the introduction of a 7-methyl group into the morphinan nucleus to thereby provide precursors for the preparation of therapeutically useful 7-methyl-4,5α-epoxy morphinan and morphinan-6-one compounds. (google.co.uk)
  • The team looked at dextromethorphan because it is one of a few morphinan drugs similar in structure to morphine, but without the addictive properties. (healthcanal.com)
  • This invention relates to methods of treating agitation comprising administering a morphinan compound or a pharmaceutically acceptable salt thereof. (patents.com)
  • The physiological behavior of morphinans (naturally occurring and semi-synthetic derivatives) is thought to be associated with the aromatic A ring, the nitrogen-containing D ring and the "bridge" between these two rings formed by carbons 9, 10 and 11 of the core, with the D ring "above" the core (levorotatory). (wikipedia.org)
  • Small groups are usually found on morphinan derivatives at carbons 3 and 6. (wikipedia.org)
  • Morphinans are made up of the morphinan molecule with altering functional groups attached on the numbered carbons. (psychonautwiki.org)
  • The well known narcotic analgesic morphine has the basic ring system: ##STR1## When the oxygen bridge is present and the double bond in the lower ring is removed by saturation, the ring system is referred to as a 4,5α-epoxy morphinan. (google.co.uk)
  • Compared to the buried binding pocket observed in most G-protein-coupled receptors published so far, the morphinan ligand binds deeply within a large solvent-exposed pocket. (nih.gov)
  • Morphinan is comprised of a 1-benzylisoquinoline backbone with two additional ring closures. (psychonautwiki.org)
  • 1. A method for the introduction of a methyl group into the 7-position of the morphinan nucleus which method comprises reacting, in an inert solvent under an inert atmosphere, thebaine with lithium dimethyl cuprate for a time sufficient to form 3,6-dimethoxy-7β,17-dimethyl-4-hydroxy-5,6,8,14-tetrahydromorphinane. (google.co.uk)
  • A narcotic analgesic morphinan used as a sedative in veterinary practice. (drugbank.ca)
  • The identification of a morphinan-based novel small-molecule structure with TLR9 antagonism is a significant step in expanding therapeutic strategies in the field of sterile inflammatory injury. (jimmunol.org)
  • Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. (pearltrees.com)
  • In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst. (patentsencyclopedia.com)
  • 1. A one-pot process for the preparation of a morphinan comprising a saturated ketone ring moiety, the process comprising contacting a morphinan comprising an allyl alcohol ring moiety with an allyl-transition metal catalyst under acidic conditions such that the allyl alcohol ring moiety is catalytically isomerized to the saturated ketone ring moiety. (patentsencyclopedia.com)
  • When the oxygen bridge is not present, the ring system is referred to as the morphinan system, which has the basic structural formula: ##STR2## in which the numbering of carbon atoms and ring designations are as indicated. (google.co.uk)
  • The following are the current most viewed articles on Wikipedia within Wikipedia's Morphinans category. (thefullwiki.org)