• We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
  • Protein tyrosine kinase inhibitors inhibit both proliferation and chemotaxis of vascular smooth muscle cells. (researchmap.jp)
  • Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation : The isoform that may mediate G1/S inhibition. (researchmap.jp)
  • Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
  • These drugs, called GGTIs, inhibit proliferation of various human cancer cells and inhibit tumor growth in animal model systems. (uclahealth.org)
  • The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
  • GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)
  • text "QUATERNARY STRUCTURE -- ASSOCIATION OF TWO IDENTICAL CHAINS (HIV PROTEASE)" The HIV protease is a protein involved in the proliferation of the virus which causes AIDS. (wustl.edu)
  • Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)
  • They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators. (bvsalud.org)
  • Their experiments demonstrated that treating mice with a small molecule inhibitor that specifically target the hepatic gap junction protein connexion 32 (Cx32) provides significant protection against liver damage and death resulting from subsequent or simultaneous challenge with known hepatotoxic drugs such as acetaminophen. (genengnews.com)
  • The companies agreed to co-develop BMS-795311, BMS'preclinical small-molecule inhibitor of the Cholesteryl Ester Transfer Protein(CETP). (drugdiscoverynews.com)
  • Here, we confirmed that rutin can effectively inhibit biofilm formation in S. xylosus, of which the inhibition mechanism involves its ability to interact with imidazole glycerol phosphate dehydratase (IGPD), a key enzyme in the process of biofilm formation. (figshare.com)
  • Protein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells. (researchmap.jp)
  • After inhibition of sirtuin 1 (Sirt1) by EX27, RSV failed to inhibit p53 acetylation and expression. (hindawi.com)
  • Moreover, the absence of inhibition by GABA uptake inhibitors shows that gamma-hydroxybutyrate transport is a separate entity from GABA transport. (erowid.org)
  • Among the many protease inhibitors in plasma, tissue factor pathway inhibitor (TFPI) and antithrombin are the ones that are most specifically involved in inhibition of coagulation factors. (medscape.com)
  • The presence of protein Z, a vitamin K-dependent plasma protein, increases its inhibition of factor Xa over 1000-fold. (medscape.com)
  • Considering the destructive potential of the complement system, it is no surprise that nearly half of the system's proteins are involved in its inhibition. (lu.se)
  • The investigators moved on to think about evaluating the therapeutic potential of pharmacologically inhibiting Cx32, using 2-aminoethoxy-dipenyl-borate (2APB), a compound previously shown to transiently inhibit Cx32 gap junctions in vitro, and which they confirmed was specific to the Cx32 gap junction protein. (genengnews.com)
  • Moreover, we show that apabetalone inhibits SARS-CoV-2 infection in vitro to levels comparable to antiviral agents. (biorxiv.org)
  • Tamanoi and his researchers were the first to show that these nanoparticles can deliver anticancer drugs and inhibit tumor growth in vitro and in vivo. (uclahealth.org)
  • Anle138b is an oligomeric aggregation inhibitor that inhibits formation of pathological prion protein (PrP Sc ) and α-synuclein aggregates in vitro . (tocris.com)
  • Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
  • Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. (tocris.com)
  • The NLS within a proteins destined for nuclear localization includes a unipartite or even a bipartite simple amino acidity cluster such as for example KKKRK in SV40 huge tumor antigen (25) or RKR-Xn-RKRKR in T cell proteins tyrosine phosphatase (26) that is acknowledged by an importin-α/β heterodimer. (molecularcircuit.com)
  • Ibrutinib (Imbruvica) and acalabrutinib (Calquence) inhibit the function of a type of kinase called Bruton's tyrosine kinase (BTK). (cancercare.org)
  • Is classified as a tyrosine kinase inhibitor. (pharmacology2000.com)
  • Tyrosine kinase ingibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells. (researchmap.jp)
  • Entrectinib is a selective tyrosine kinase inhibitor designed to inhibit the kinase activity of the tropomyosin receptor kinase (TRK) A/B/C and ROS1 proteins. (medscape.com)
  • UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
  • Autocrine FGF-2 is responsible for the cell density-dependent susceptibility to apoptosis of HUVEC : a role of a calpain inhibitor-sensitive mechanism. (researchmap.jp)
  • ATF4 induces expression of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates PERK-induced apoptosis ( 16 ). (spandidos-publications.com)
  • The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
  • RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. (hindawi.com)
  • GSK2606414 is a novel, highly selective inhibitor of protein kinase R‑like endoplasmic reticulum kinase (PERK). (spandidos-publications.com)
  • Novel selective inhibitors of nuclear export (SINE) have achieved outstanding preclinical results and are currently in Phase I trials. (massgeneral.org)
  • Until now, it has not been possible to inhibit the ubiquitin-proteasome system in a target-selective manner. (businesswire.com)
  • Stablix possesses a first-in-category platform that can restore protein stability and function in a target-selective manner," said Carlo Rizzuto, Ph.D., partner at Versant and acting CEO of Stablix. (businesswire.com)
  • Second, a suite of biochemical and functional assays is used to monitor the ubiquitination and functional status of target proteins in cells. (businesswire.com)
  • My research revolves around ADP-ribosyltransferases, which cleave NAD+ to link ADP-ribose to their target proteins. (lu.se)
  • This flags these target proteins for specific activities in our cells. (lu.se)
  • A trypsin inhibitor assay reveals that Ara h 3 allergen protein has trypsin inhibitory activity. (usda.gov)
  • Several chemicals and proteins were used to test this assay. (bvsalud.org)
  • This whisker follicle microinjection assay will be useful when investigating protein functions and when developing drugs to treat hair loss and abnormal skin pigmentation. (bvsalud.org)
  • Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (K i = 109 nM). (tocris.com)
  • Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)
  • Activated protein C (APC) is a serine proteinase that regulates blood coagulation. (lu.se)
  • article{fa034414-84ff-4d16-a944-527a92f49369, abstract = {{Activated protein C (APC) is a serine proteinase that regulates blood coagulation. (lu.se)
  • A deficiency of antithrombin increases the risk of thrombosis, revealing its importance as a functional inhibitor of the blood coagulation proteases. (medscape.com)
  • With inherited diseases such as cystic fibrosis, mutations in the CFTR gene produce a protein that remains functional but is subject to excessive ubiquitination, leading to its rapid degradation via the proteasome. (businesswire.com)
  • The therapeutic value of augmenting protein stabilization has also been demonstrated with proteasome inhibitors. (businesswire.com)
  • In these studies, proteasome inhibitors were able to increase levels of deficient proteins across a range of targets and organ systems. (businesswire.com)
  • However, because proteasome inhibitors globally inhibit protein degradation in a non-specific manner, their use outside of oncology is limited by poor tolerability, highlighting the need for targeted approaches. (businesswire.com)
  • They identified inhibitors against the enterovirus capsid protein and protease. (europa.eu)
  • Another potentially important regulator of the coagulation system, the protein Z/protein Z-dependent protease inhibitor (ZPI) system, is also emerging. (medscape.com)
  • Unlike other coagulation protease inhibitors, TFPI has inhibitory sites for factor Xa and for the factor VIIa/tissue factor (TF) complex, and it cannot inhibit the factor VIIa/TF complex without being bound to factor Xa. (medscape.com)
  • Coagulation factors XIa and Xa are inhibited by ZPI, an Mr 72,000 serine protease inhibitor. (medscape.com)
  • Herein, we demonstrate apabetalone, the most clinical advanced BET inhibitor, downregulates expression of cell surface receptors involved in SARS-CoV-2 entry, including angiotensin-converting enzyme 2 (ACE2) and dipeptidyl-peptidase 4 (DPP4 or CD26) in SARS-CoV-2 permissive cells. (biorxiv.org)
  • The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
  • The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
  • Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
  • Inhibiting this protein resulted in the desired increased expression of the estrogen receptor. (unibas.ch)
  • Thus, PCI has been hypothesized to have a protective role: if acrosomal enzymes were released prematurely, or if the spermatozoa was degenerated within the male reproductive tract, the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. (wikipedia.org)
  • GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. (mdpi.com)
  • Using concentrations of 3 mu M, GF109203X and Go6983 inhibited EFS- and noradrenaline-induced contractions, with similar effect sizes as 500 and 300 nM, respectively. (uni-muenchen.de)
  • A-inhibited guanine nucleotide-exchange protein BIG1 and BIG2 are activators of ADP-ribosylation SNS-314 aspect GTPases which are needed for regulating vesicular visitors among intracellular organelles. (molecularcircuit.com)
  • Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)
  • Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational modifications of G-proteins. (oncotarget.com)
  • Tamanoi's laboratory has developed anti-cancer drugs against Ras proteins aimed at inhibiting their posttranslational modification and membrane association. (uclahealth.org)
  • McCormick SJ, Tunnicliff G. "Inhibitors of synaptosomal gamma-hydroxybutyrate transport" Pharmacology . (erowid.org)
  • In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)
  • In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
  • Furthermore, HIF-1 actively limits the mitochondrial consumption of pyruvate at two levels: (i) through the enzyme PDK (PDH-kinase), which in turn inhibits PDH activity preventing the conversion of pyruvate into acetyl CoA, and thereby limiting mitochondrial metabolism of pyruvate [ 6 ] and (ii) through the direct activation of LDH [ 7 , 8 ]. (hindawi.com)
  • The most effective inhibitor was harmaline (Ki = 94 +/- 21 micromol/l), a known competitive inhibitor of Na+ binding to certain transport proteins. (erowid.org)
  • The fact that XPO1 and other essential nucleo-cytoplasmatic transport proteins are over expressed in cancer, specifically in melanoma, offers the opportunity to treat cancer by modulating this transport system. (massgeneral.org)
  • Stablix's RESTORED platform generates heterobifunctional small molecules (RESTORACS) that recruit deubiquitinase enzymes to remove ubiquitin from targeted proteins and consequently stabilize or increase target protein levels and activity. (businesswire.com)
  • PARP enzymes are drug targets: Drugs that inhibit PARP activity are already in use today in treatment of certain forms of cancer. (lu.se)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • This process activates protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 and activating transcription factor (ATF) 6, and initiates unfolded protein response (UPR) signaling pathways ( 13 , 14 ). (spandidos-publications.com)
  • C4b-binding protein (C4BP) is the major soluble inhibitor of the classical and lectin pathways whereas factor H (FH) inhibits the alternative route. (lu.se)
  • This gene provides instructions for making a protein called plasminogen activator inhibitor 1 (PAI-1). (medlineplus.gov)
  • The SERPINE1 gene mutations that cause complete PAI-1 deficiency result in the production of a PAI-1 protein that is nonfunctional or that is unstable and quickly broken down. (medlineplus.gov)
  • Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. (medlineplus.gov)
  • The ank gene that the team found produces a protein that spans the membrane surrounding cells. (stanford.edu)
  • His group is the first to pinpoint the ank gene, identify the protein encoded by it and construct a model explaining how the ank protein may be involved in arthritis. (stanford.edu)
  • Protein tyrosines and protein kinase C are required for gene expression of monocyte chemoattractant protein-1 in human monocytes. (researchmap.jp)
  • What does this gene/protein do? (cancerindex.org)
  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
  • The neuraminidase (NA) gene encodes the other surface protein of the virus. (cdc.gov)
  • Co-founders Dr. Colecraft and Scott Kanner, Ph.D., developed an approach to selectively recruit deubiquitinases (DUBs) to proteins of interest. (businesswire.com)
  • Proteins phosphorylation near the NLS is normally reported to try out a major function in modulating NLS-dependent nuclear import and will facilitate NLS identification with the NLS-binding importin-α subunit (23 27 28 Proteins kinases including PKA regulate the subcellular localization of several protein. (molecularcircuit.com)
  • Phosphorylation of S312 within the dorsal proteins of by PKA elevated its affinity for importin-α and was associated with enhanced nuclear deposition (21). (molecularcircuit.com)
  • In addition, GSK2606414 treatment inhibited eIF2α phosphorylation and reduced CHOP and VEGF mRNA expression levels in RPE cells under TG‑induced ER stress. (spandidos-publications.com)
  • Protein stabilization can be thought of as the inverse of protein degradation. (businesswire.com)
  • instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. (nature.com)
  • Venetoclax (Venclexta) targets the B-cell lymphoma 2 (BCL-2) protein, leading to the death of CLL cells. (cancercare.org)
  • RSV has also been found to regulate other molecular targets such as AMP-activated protein kinase, nuclear factor erythroid 2-related factor 2, nuclear factor- (NF-) κ B, and endothelial nitric oxide synthase and has also been considered to have powerful antioxidant and anti-inflammatory properties. (hindawi.com)
  • This involves both farnesylation (catalyzed by protein farnesyltransferase) and geranylgeranylation (catalyzed by protein geranylgeranyltransferase-I). Small molecular inhibitors of protein geranylgeranyltransferase-I were identified from a library of compounds generated by phosphine catalysis of allenoate compounds. (uclahealth.org)
  • Absence of functional PAI-1 protein allows plasminogen activators to dissolve blood clots prematurely, resulting in the abnormal bleeding associated with this disorder. (medlineplus.gov)
  • It is hypothesized that PCAIs work as anticancer agents by disrupting polyisoprenylation-dependent functional interactions of the G-Proteins. (oncotarget.com)
  • Some microorganisms either produce a functional mimic of a complement regulatory protein or hijack host's regulatory proteins. (lu.se)
  • Each of these four structural classes has not been reported as FIH1 inhibitor, and therefore can be considered for further development by structure-activity relationship or denovo design methods. (nih.gov)
  • PCI has been demonstrated to inhibit the proteolytic activity of acrosin. (wikipedia.org)
  • At the protein level, it is demonstrated that peanut allergen Ara h 3 also has trypsin inhibitory activity. (usda.gov)
  • In ischemic heart tissue, senescence-associated β -galactosidase (SA- β -gal) activity and proteins (such as p16, p19, and p53) are significantly upregulated [ 6 ]. (hindawi.com)
  • PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
  • These inhibitors are potent cancer therapeutics but have also been profiled for activity in Mendelian diseases in multiple animal and patient studies. (businesswire.com)
  • The presence or absence of a factor VIII inhibitor can be determined through comparison of the difference in factor VIII activity between the incubation mixture and a control mixture. (medscape.com)
  • [ 10 ] Protein Z/ZPI's physiologic activity in the coagulation system is unclear. (medscape.com)
  • The enzymatic activity of NA is inhibited by one class of antiviral drugs that are FDA-approved for treatment of in uenza (i.e. (cdc.gov)
  • Most inhibitors act on complement convertases through increased dissociation of these enzymatic complexes (acceleration of decay) or through promoting enzymatic cleavage of activated complement factors C3b or C4b by a serine proteinase factor I (FI). (lu.se)
  • Initial in vivo studies demonstrated that mice deficient in Cx32, the primary gap junction protein in the liver, were far less susceptible than wild-type mice to actual liver damage and inflammation caused by treatment with the hepatotoxin thioacetamide (TAA). (genengnews.com)
  • They are also known to possess antinutritional elements, to inhibit trypsin digestion, and depress growth in animals. (usda.gov)
  • Proteins bigger than 45 kDa need a nuclear localization series (NLS) for entrance in to the nucleus (15). (molecularcircuit.com)
  • Nuclear importation of proteins is really a two-step procedure relating to the dimeric importin-α/β where the α-subunit straight binds the NLS theme and acts as an adaptor for importin-β. (molecularcircuit.com)
  • Several types of cellular stress, including hypoxia ( 8 ), infection ( 9 ), nutrient deprivation ( 10 ), oxidative stress ( 11 ) and dysfunctional calcium homeostasis ( 12 ), may induce accumulation of unfolded proteins in the ER lumen. (spandidos-publications.com)
  • We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
  • Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. (mdpi.com)
  • Complete plasminogen activator inhibitor 1 deficiency (complete PAI-1 deficiency) is a disorder that causes abnormal bleeding. (medlineplus.gov)
  • In a mouse model, protein Z deficiency does not cause thrombosis, but it does significantly increase the thrombotic tendency of mice who simultaneously express the factor V Leiden genotype, a known thrombotic risk factor. (medscape.com)
  • We want to understand enzymatic mechanisms and improve the fit of PARP inhibitors to their enzymatic pockets. (lu.se)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • In addition to the HA and NA, the RNA transcription and replication complex (PB2, PB1, PA, NP) also have species-speci c determinants that impact e cient replication in humans and other mammals, particularly polymerase basic protein 2 (PB2). (cdc.gov)
  • These findings implicate the potential role of PCAIs as anticancer agents through their direct interaction with monomeric G-proteins. (oncotarget.com)
  • Dr. Fuyu Tamanoi's research focuses on signal transduction involving the Ras-superfamily G-proteins, anti-cancer drugs and nanoparticle-based delivery of anticancer drugs. (uclahealth.org)
  • The researchers found the human version of the protein using the mouse ank protein as a guide. (stanford.edu)
  • Here, we examined the effects of the PKC inhibitors Go6983 and GF109203x on contractions of human prostate tissues. (uni-muenchen.de)
  • Conclusions: GF109203X and Go6983 inhibit neurogenic, alpha(1)-adrenergic, and thromboxane A(2)-induced smooth muscle contractions in the human prostate, suggesting a role of PKC for human prostate smooth muscle contraction. (uni-muenchen.de)
  • Studies were undertaken to determine whether extracellular signal regulated kinase (ERK) oscillations regulate a unique subset of genes in human keratinocytes and subsequently whether the p38 stress response inhibits ERK oscillations. (cdc.gov)
  • Bromate inhibited ERK oscillations in human keratinocytes and JB6 cells and induced an increase in phospho-p38 and a decrease in phospho-MED1 protein levels. (cdc.gov)
  • This structural feature is consistent with the secondary binding protein hypothesis, as charge-charge interactions would stabilize a protein-zona pellucida "tethering" complex. (wikipedia.org)
  • The interactions with the amino acid residues responsible for the stabilizations of the inhibitors in the active site are addressed in detail. (nih.gov)
  • They thus postulated that liver-specific gap junction inhibitors might act to protect the liver if they could be co-formulated with hepatotoxic drugs. (genengnews.com)
  • Successful inhibitors can subsequently be used as drugs to counter the disease. (wustl.edu)
  • We hope to create inhibitors also for their activities, with the aim of creating new anti-infective drugs. (lu.se)
  • The PAI-1 protein blocks (inhibits) the action of other proteins called plasminogen activators. (medlineplus.gov)
  • By inhibiting plasminogen activators, the PAI-1 protein helps ensure that clots remain intact until they are no longer needed to stop bleeding. (medlineplus.gov)
  • Flevaris P, Vaughan D. The Role of Plasminogen Activator Inhibitor Type-1 in Fibrosis. (medlineplus.gov)
  • Role of AMP-activated protein kinase in mechanism of MetF. (tocris.com)
  • Involvement of protein kinase C (PKC) has been commonly assumed, but available studies were limited to nonhuman prostate smooth muscle or cell cultures. (uni-muenchen.de)
  • Dorsomorphin dihydrochloride is also offered as part of the Tocriscreen 2.0 Max , Tocriscreen Kinase Inhibitor Library , Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library . (tocris.com)
  • They found that the compounds showing the most promising results were inhibitors of an essential cell cycle protein called polo-like kinase 1 (PLK1). (unibas.ch)
  • The National Institute for Health and Care Excellence (NICE) is approving entrectinib ( Rozlytrek , Roche) as a treatment option for ROS1-positive, advanced non-small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitors. (medscape.com)
  • Unless it is complexed to TF in the presence of heparin or cell surface glycosaminoglycans, factor VIIa resists being inhibited by antithrombin. (medscape.com)
  • The compound is an inhibitor of mammalian protein kinase and has been applied topically for the treatment of skin metastasis showing good local tolerability [5]. (who.int)
  • The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. (tocris.com)
  • Inhibiting the NLRP3 pathway has been suggested to be an effective strategy for protecting against IHD [ 7 ]. (hindawi.com)
  • Likewise, WIKI4 also effectively inhibits the Wnt/β-catenin pathway-dependent growth of DLD1 (by 67% in 10 days;1μM). (fishersci.com)
  • Gap junction protein inhibitor protects mice from death and liver damage after hepatotoxic drug challenge. (genengnews.com)
  • Metformin, a known inhibitor of mitochondrial OXPHOS, has been indicated to reduce NSCLC morbidity and mortality in clinical studies. (spandidos-publications.com)
  • Mechanistically, SEs recruited bromodomain containing 4 (BRD4) at the site of ZBTB16 , which then bound to RNA polymerase II-associated protein 2 (RPAP2) that transported RNA polymerase II (POL II) into the nucleus. (nature.com)
  • Under the secondary binding protein hypothesis, acrosin could serve a role in binding to molecules on the zona pellucida, tethering the spermatozoa to the egg. (wikipedia.org)
  • Further consistent with this structural hypothesis is the knowledge that suramin - a polysulfated drug (with substantial corresponding negative charge) has been found to inhibit sperm-zona pellucida binding. (wikipedia.org)
  • This study tested this hypothesis by determining the effect of the PCAIs on the levels of RAS and related monomeric G-proteins. (oncotarget.com)