• Both enzymes produce phosphatidylinositol 3,4,5-trisposphate in vivo and are regulated by both heterotrimeric G proteins and small GTPases from the Ras or Rho families. (elsevierpure.com)
  • Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases. (embl.de)
  • Thus, the dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein. (broadinstitute.org)
  • Rab proteins are low-molecular weight (20-25 kDa) monomeric GTPases that are central to the control and regulation of vesicle trafficking. (bvsalud.org)
  • Rab proteins are small monomeric GTPases/GTP-binding proteins, which form the largest branch of the Ras superfamily. (bvsalud.org)
  • they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. (umassmed.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins p21(ras)" by people in Profiles. (uchicago.edu)
  • Methods: We examined the concentration of CHI3L1 in the culture medium of splenocytes and bone marrow derived macrophages (BMDMs) from wild-type or Rab37 knockout mice, and macrophage or T cell lines expressing wild type, active GTP-bound or inactive GDP-bound Rab37. (ncku.edu.tw)
  • By using the MDeNM (Molecular Dynamics with excited Normal Modes) method, we were able to widely map the conformational surface of the C-terminus of Ran in the active GTP-bound form, which allows us to envisage how it can embrace RanBDs. (tau.ac.il)
  • Price TJ, Das V, Dussor G. Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain. (rush.edu)
  • Tracking the ATP-binding response in adenylate kinase in real time. (scilifelab.se)
  • Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3. (scilifelab.se)
  • Here, this specific problem is addressed by molecular studies of the human NMP kinase AK3, which uses GTP to phosphorylate AMP. (scilifelab.se)
  • The overall features with specific recognition of the correct substrate and nonproductive binding by the incorrect substrate bear a strong similarity to previous findings for the ATP specific NMP kinase adenylate kinase. (scilifelab.se)
  • Taken together, we are now able to provide the fundamental principles for GTP and ATP selectivity in the large NMP kinase family. (scilifelab.se)
  • Rab37 mediated CHI3L1 intracellular vesicle trafficking and exocytosis in a GTP-dependent manner, which is abolished in the splenocytes and BMDMs from Rab37 knockout mice and attenuated in macrophage or T cell lines expressing the inactive Rab37. (ncku.edu.tw)
  • ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the interaction of coat proteins with organelle membranes in the early secretory pathway. (ucdenver.edu)
  • Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (rush.edu)
  • These nonspecific interactions likely act to lower the available intracellular GTP and ATP concentrations and may have driven evolution of the Michaelis constants of NMP kinases accordingly. (scilifelab.se)
  • Multiplex fluorescence immunohistochemistry was performed to detect the protein level of Rab37 and CHI3L1, and localization of the tumor-infiltrating immune cells in allografts from mice or tumor specimens from cancer patients. (ncku.edu.tw)
  • Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. (wikipedia.org)
  • However, PI3Kβ is also regulated by direct interactions with receptor tyrosine kinases (RTKs) and their tyrosine phosphorylated substrates, and similar to the class II and III PI3Ks, it binds activated Rab5. (elsevierpure.com)
  • The unusually complex regulation of PI3Kβ by small and trimeric G proteins and RTKs leads to a rich landscape of signaling responses at the cellular and organismic levels. (elsevierpure.com)
  • Possible mechanisms for regulation of these G proteins and their effector molecules are considered. (elsevierpure.com)
  • A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization , gene expression and cell cycle progression. (online-medical-dictionary.org)
  • While the role of collective protein motions in substrate binding, product release, and regulation of enzymatic activity is generally understood, their roles in catalytic steps per se remain uncertain. (scilifelab.se)
  • The Rho family small G proteins RhoA and Rac1 also regulate secretion through remodeling of the actin cytoskeleton. (elsevierpure.com)
  • Results Here, we show that actomyosin contractility in the C elegans spermatheca is under control of RHO-1/RhoA, which, in turn, is regulated by the F-BAR and RhoGAP protein SPV-1. (tau.ac.il)
  • The tuberous sclerosis complex 1 and 2 (TSC1/2) proteins and their target, the small GTPase Rheb, constitute a key regulatory pathway upstream of mTOR. (illinois.edu)
  • It is a component of COAT PROTEIN COMPLEX I. This enzyme was formerly listed as EC 3.6.1.47. (ucdenver.edu)
  • extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. (umassmed.edu)
  • From the MRD data, the rotational correlation time of detergent-solubilized BR was determined to 35 ns at 300 K, con- sistent with a monomeric protein in complex with about 150 detergent molecules. (lu.se)
  • rab2 GTP-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "rab2 GTP-Binding Protein" by people in this website by year, and whether "rab2 GTP-Binding Protein" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "rab2 GTP-Binding Protein" by people in Profiles. (umassmed.edu)
  • Only two PI3Ks are directly regulated downstream from G protein-coupled receptors (GPCRs): the class I enzymes PI3Kβ and PI3Kγ. (elsevierpure.com)
  • The ~200 amino acid TBC/rab GTPase-activating protein (GAP) domain is well conserved across species and has been found in a wide range of different proteins from plant adhesion molecules to mammalian oncogenes. (embl.de)
  • It has been proposed that this cleft is the binding site for the GTPase. (embl.de)
  • Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family. (embl.de)
  • A yeast open reading frame sharing homology with the two known yeast Rab GTPase-activating proteins (GAPs), Gyp6p and Gyp7p, was found in a data base search. (embl.de)
  • Gyp1p also stimulated the GTPase activity of several other yeast Rab proteins including Ypt1p, Ypt7p, and Ypt51p but showed no GAP activity on Ypt6p and Ypt32p. (embl.de)
  • These processes are controlled entirely or in part by TGF-β and the small RHO GTPase RAC1 with both proteins acting as tumor promoters in late-stage cancers. (uni-luebeck.de)
  • The small Ras-related G proteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to stimulate pinocytosis when microinjected into Xenopus oocytes. (elsevierpure.com)
  • Small GTP-binding (G) proteins act as molecular switches to regulate a number of cellular processes, including vesicular transport. (elsevierpure.com)
  • Emerging evidence indicates that small G proteins regulate a number of steps in the secretion of pancreatic acinar cells. (elsevierpure.com)
  • Diverse small G proteins have been localized at discrete compartments along the secretory pathway and particularly on the secretory granule. (elsevierpure.com)
  • Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. (geneticsmr.com)
  • Here we describe the uncharacterized human member 9 of the solute carrier family 38 (SLC38A9) as a lysosomal membrane-resident protein competent in amino acid transport. (ox.ac.uk)
  • First kind of alternative: Maintaining the conserved moiety For the initial type of alternative a stoichiometric evaluation of most known and forecasted glycosomal enzymes [18]-[20] was performed to point what extra reactions in the glycosome can recover the bound-phosphate dropped via Rib-5-P (Desks S3 S4 Amount S1). (technuc.com)
  • AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP. (rush.edu)
  • Enzymes employ a wide range of protein motions to achieve efficient catalysis of chemical reactions. (scilifelab.se)
  • Therefore, enzymes that bind to either of them must develop robust mechanisms to selectively utilize one or the other. (scilifelab.se)
  • In the following, we refer to pump of halophilic archaebacteria, has become the these as the extracellular (EC) channel and the paradigm of membrane proteins in general and ion cytoplasmic (CP) channel. (lu.se)
  • Here, starting from the crystal structure of Ran in both GDP- and GTP-bound forms we show how rigid the C-terminal region in the inactive structure is during molecular dynamics (MD) simulations. (tau.ac.il)
  • Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
  • This activation leads to effector protein interactions, activation, and biological responses in the vasculature, including vasorelaxation. (johnshopkins.edu)
  • Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. (geneticsmr.com)
  • The finding that yeast Rab GAPs share homology with proteins in other species, such as Caenorhabditis elegans and human, suggests the existence of a conserved Rab GAP family. (embl.de)
  • In vascular smooth muscle cells derived from human dermal arterioles (micro-VSM), Rap1 selectively regulates expression of G protein-coupled α 2C -adrenoceptors (α 2C -ARs) through JNK-c-jun nuclear signaling. (johnshopkins.edu)
  • Whether the function of these G proteins is simply to ensure appropriate targeting or if they are involved as regulatory molecules is discussed. (elsevierpure.com)
  • ATP and GTP are exceptionally important molecules in biology with multiple, and often discrete, functions. (scilifelab.se)
  • While the locations and inferred H-bond connec- water molecules in a membrane protein, despite tivities of these internal water molecules are essen- being deeply buried and extensively H-bonded to tial, one would also like to quantify their mobility. (lu.se)
  • Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
  • Wang C, Timmons CL, Shao Q, Kinlock BL, Turner TM, Iwamoto A, Zhang H, Liu H, Liu B. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1. (ucdenver.edu)
  • Dynamic Connection between Enzymatic Catalysis and Collective Protein Motions. (scilifelab.se)
  • The results illustrate a linkage between enzymatic catalysis and collective protein motions, whereby the disparate time scales between the two processes are bridged by a cascade of intermediate-scale motion of catalytic residues modulating the free energy landscapes of the catalytic and conformational change processes. (scilifelab.se)
  • could be recognized: (i) including additional enzymatic reactions in the glycosome or (ii) adding a mechanism to transfer bound phosphates between cytosol and glycosome. (technuc.com)
  • Conclusions Our results demonstrate how transient membrane localization of a novel F-BAR domain, likely via specific binding to curved membranes, coupled to a RhoGAP domain, can provide feedback between a mechanical signal (membrane stretching) and actomyosin contractility. (tau.ac.il)
  • A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in transport from the cell membrane to early endosomes. (wakehealth.edu)
  • These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
  • and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)
  • It functions as a molecular switch cycling between the GDP-bound inactive and GTP-bound active state. (tau.ac.il)
  • First, it nucleates the activating conformational transition of the ATP binding domain and also affects the specificity in the distant AMP binding domain. (scilifelab.se)
  • Crystal structures of the GTP-bound active form complexed with Ran binding proteins (RanBP) show that the C-terminus undergoes a large conformational change, embracing Ran binding domains (RanBD). (tau.ac.il)
  • It consists of a globular (G) domain and a C-terminal region, which is bound to the G-domain in the inactive, GDP-bound states. (tau.ac.il)
  • Protein unc-13 homolog A". UniProt. (wikipedia.org)
  • RabX6 is an insect-specific Rab protein that has no close homolog in vertebrates. (bvsalud.org)