Monofunctional alkylating agents. Medical search. Frequent questions

Once it has entered the cell, phenanthriplatin is distributed in a similar manner to other platinum-based anticancer agents, residing primarily in the cell's nucleus. (wikipedia.org)
Therefore, elimination of the checkpoint increases the sensitivity of human tumor cell lines to anticancer agents. (hsp90-inhibitors.com)
Recently, certain cancer chemotherapy agents have been found to exert their anticancer activities by disrupting the dynamics of microtubule assembly, thus perturbing the formation and function of the mitotic spindle apparatus and arresting cells in mitosis. (hsp90-inhibitors.com)
Farnesyltransferase inhibitor as anticancer agent. (hsp90-inhibitors.com)

Pyrazines are a class of heterocyclic compounds with two nitrogen atoms in a six-membered ring, which have potential medicinal applications as antimicrobial, antiparasitic, and anti-inflammatory agents. (lookformedical.com)

The findings of this study provide evidence to support the hypothesis that DFMO may inhibit progression of DNA mutations caused by alkylating chemotherapy agents, such as TMZ. (oncotarget.com)

Surface-enhanced raman spectrometry of organophosphorus chemical agents. (cdc.gov)

Both classes of drugs alkylate DNA and have relatively unrestricted passage from blood into brain where infiltrative tumor cells reside. (oncotarget.com)

The current chemotherapy options include nitrosoureas (e.g., lomustine) and the imidazotetrazine-class monofunctional DNA alkylating agent, temozolomide (TMZ). (oncotarget.com)

Monofunctional alkylating agents are found in certain environmental pollutants as well as anticancer drugs, such as temozolomide. (nih.gov)
In terms of medication, says Levin, "The only drugs we've had are drugs that alkylate DNA, either bifunctional cross-functioning DNA agents like nitrosoureas, or monofunctional agents like temozolomide and procarbazine. (oncnursingnews.com)
BER is a major pathway that copes with DNA damage induced by several anticancer agents, including ionizing radiation and temozolomide. (nih.gov)
Compound 3 and related analogues exhibit single-digit micromolar activity against the purified APE1 enzyme and comparable activity in HeLa whole cell extract assays and potentiate the cytotoxicity of the alkylating agents methylmethane sulfonate and temozolomide. (nih.gov)

NIEHS grantees discovered that monofunctional alkylating agents can form cross-links between DNA and histone proteins, a toxic form of DNA damage. (nih.gov)

38. The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. (nih.gov)

This monofunctional alkylating agent TMZ provides a few main revised bases with Geonomics, N7-methylguanine, 3-methyladenine plus O6-methylguanine, ppos becoming remedied by the O6-methylguanine-DNA methyltransferase6(AGT). (immune-source.com)
By contrast, O-alkylated bases, such as O 6 -methylguanine can be repaired by the action of a single protein, O 6 -methylguanine-DNA methyltransferase (MGMT). (biologists.com)

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. (nih.gov)

Report on Carcinogens as either a known to be human carcinogen, or reasonably anticipated to be human carcinogen or there is convincing relevant information that the agent acts through mechanisms indicating it would likely cause cancer in humans. (nih.gov)

The primary objective of our studies was to characterize the genetic damage produced by each agent with regard to (1) mutagenic potency, and (2) the spectrum of specific-locus mutations induced in a lower eukaryotic organism. (cdc.gov)

Organisms are permanently exposed to endogenous and exogenous agents that damage DNA. (biologists.com)

The researchers studied the effect of monofunctional alkylating agents in free DNA and in nucleosome core particles, which serve as the protein-containing packaging material for DNA. (nih.gov)

There is sufficient evidence of carcinogenicity from studies in humans, which indicates a causal relationship between exposure to the agent, substance or mixture and human cancer. (nih.gov)

For example, there may be substances for which there is evidence of carcinogenicity in laboratory animals but there are compelling data indicating that the agent acts through mechanisms which do not operate in humans and would therefore not reasonably be anticipated to cause cancer in humans. (nih.gov)

Overexpression of APE1 and enhanced AP endonuclease activity have been linked to increased resistance of tumor cells to treatment with monofunctional alkylators, implicating inhibition of APE1 as a valid strategy for cancer therapy. (nih.gov)

The genotoxic action of contaminating agents affects human health directly, damaging the genetic material, which is considered to play an important role in oncogenesis [6,7]. (researchgate.net)

It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. (wikipedia.org)

Based on the specific revertibility of complementing and noncomplementing ad-3B mutations induced by other agents, this difference in the percentages of ad-3B mutations showing allelic complementation results from a difference between the spectrum of genetic alterations at the molecular level. (cdc.gov)