• Leukadherin-1, a CR3 agonist molecule, has been shown to suppress human innate inflammatory signals. (wikipedia.org)
  • The glycosylphosphatidylinositol-anchored receptor CD14 plays a major role in the inflammatory response of monocytes to lipopolysaccharide. (unideb.hu)
  • In an inflammatory state, the expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) is upregulated in endothelial cells. (fujita-hu.ac.jp)
  • IVIG is used in (i) low dose or ''substitution'' therapy in immunodeficient patients up to 300-500 mg/kg body weight every 3-4 weeks and [3] (ii) in high dose '' immunomodulatory '' therapy of autoimmune and inflammatory diseases employing 1-2 g/kg body weight in single injection or five daily doses of 400 mg/kg with additional maintenance dose at 4-6 week intervals [4, 5]. (academie-medecine.fr)
  • Augmentation of the platelet counts in the immune thrombocytopenic purpura (ITP) as first demonstrated by Imbach and co-workers, opened the way for the application of IVIG in other autoimmune and inflammatory diseases [1, 9]. (academie-medecine.fr)
  • Thus, blockade of activating FcγR inhibits binding of opsonized antigens, induction of effector functions and secretion of pro-inflammatory cytokines by macrophages, and degranulation of granulocytes. (academie-medecine.fr)
  • In conditions such as like ITP that is autoantibody-mediated, IVIG Fc fragmentmediated competitive blockade of activating FcγR might inhibit: binding of opsonized antigens, induction of effector functions and secretion of pro-inflammatory cytokines by macrophages, and degranulation of granulocytes [1, 12]. (academie-medecine.fr)
  • In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. (elifesciences.org)
  • Changes of leukocytes are regularly accompanied by an exercise-induced increase of inflammatory cytokines such as IL-6, IL-10, and IL-1ra [ 1 ]. (hindawi.com)
  • The antigen for MRP 8/14 has been found in inflammatory tissues only and shown to be absent from normal resident mononuclear phagocytes 13 . (ersjournals.com)
  • We further showed that this T cell network, in the context of acute injuries, helps facilitate recruitment of anti-inflammatory monocyte-derived macrophages to the CNS, and that these cells support tissue repair by through their local phagocytic and anti-inflammatory activity (8-11). (weizmann.ac.il)
  • Here, we showed that nasal inoculation of murine coronavirus (CoV) in the absence of direct lung infection primes the lung immune environment by recruiting activated monocytes (Ly6C+ inflammatory monocytes) and NK cells into the lungs. (jci.org)
  • Unlike infiltration of these cells into directly infected lungs, a process that requires type I IFN signaling, nasally induced infiltration of Ly6C+ inflammatory monocytes into the lungs is IFN-I independent. (jci.org)
  • Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
  • MC can be classified into inflammatory or anti-inflammatory subsets ( 1 ). (frontiersin.org)
  • It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer. (biolegend.com)
  • Remarkably, tissue-resident macrophages and inflammatory monocyte were identified as potential sources of TAMs. (biomedcentral.com)
  • Induced EndoMT in PAECs by inflammatory cytokines IL-1β, tumor necrosis factor α, and transforming growth factor β led to actin cytoskeleton reorganization and the development of a mesenchymal morphology. (surrey.ac.uk)
  • We purified the MAX.1/11 antigen by immunoaffinity chromatography using monoclonal antibody MAX.11. (uni-regensburg.de)
  • Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. (wikidata.org)
  • Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
  • The 1A8 antibody reacts with Ly-6G, a 21 - 25 kDa GPI-anchored protein, which together with the structurally related Ly-6C protein comprises the granulocyte receptor-1 antigen (Gr-1). (stemcell.com)
  • Flow (Intracellular): NOD2 Antibody (2D9) [NB100-524] - An intracellular stain was performed on THP-1 cells with NOD2 (2D9) antibody NB100-524AF488 (blue) and a matched isotype control NBP2-27287AF488 (orange). (novusbio.com)
  • Immunocytochemistry/ Immunofluorescence: NOD2 Antibody (2D9) [NB100-524] - NOD2 was detected in human monocytes using NOD2 antibody (2D9) [DyLight 488 (NB100-524G)]- with a concentration of 1:500 in PBS for 2 hours. (novusbio.com)
  • Western Blot: NOD2 Antibody (2D9) [NB100-524] - Whole cell protein from THP-1 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. (novusbio.com)
  • The following product was used in this experiment: CD279 (PD-1) Monoclonal Antibody (J43), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-9985-82, RRID AB_467023. (thermofisher.com)
  • Description: The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. (thermofisher.com)
  • Applications Tested: The J43 antibody has been tested by flow cytometric analysis of Con A-simulated mouse splenocytes and mouse PD-1 transfected cells. (thermofisher.com)
  • C57BL/6 mouse bone marrow cells were stained with anti-mouse CD11b PE and anti-mouse Ly-6G/Ly-6C (Gr-1) (clone RB6-8C5) Spark Violet™ 423 (left) or CD11b PE only (right). (biolegend.com)
  • Gr-1 is also transiently expressed on bone marrow cells in the monocyte lineage. (biolegend.com)
  • Monocytes in the bone marrow transiently express Gr-1 during development and the expression level is strongly correlated with granulocyte differentiation and maturation. (stemcell.com)
  • Mediator of monocyte chemotaxis and bone marrow homeostasis. (biolegend.com)
  • The receptor is progressively upregulated as bone marrow precursor cells mature into macrophages and thus may serve as a marker of differentiation. (wustl.edu)
  • MMR expression was therefore assessed after exposure of bone marrow macrophage precursor (BMMP) cells to these prostanoids. (wustl.edu)
  • Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes. (ox.ac.uk)
  • The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. (ox.ac.uk)
  • mDC, derived from peripheral blood monocytes cultured for 6 days in presence of interleukin (IL)-4 and granulocyte-macrophage colony stimulating factor (GM-CSF) and stimulated with lipopolysaccharide (LPS) for the last 24 h, were phenotyped for the expression of the co-stimulatory molecules B7.1 and B7.2. (torvergata.it)
  • Upregulation of Mac-1 in the presence of certain factors such as IL-2 may cause a prolongation of the life of the immune cell while the presence of TNF-α induces apoptosis and selective removal of the cell. (wikipedia.org)
  • Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. (elifesciences.org)
  • Using state-of-the-art fate-mapping models and genetic and pharmacological targeting approaches, the authors provide solid evidence that the absence of resident macrophages do not influence infarct size but instead alter the immune cell crosstalk in response to injury. (elifesciences.org)
  • Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
  • We discovered, against the common wisdom at that time, that immune cells are pivotal for CNS neuroprotection and repair, though their spontaneous recruitment to the CNS is insufficient (1, 2). (weizmann.ac.il)
  • We found that treatment with immune checkpoint blockade targeting the Programmed cell death protein 1 (PD-1) (20) or its ligand (PD-L1) (16), drives an immune response that leads to trafficking of leukocytes to the brain, and culminates in reversal of disease pathology, and cognitive improvement (16, 20). (weizmann.ac.il)
  • IL-1 is one of the most important immune modifying interleukins. (dadamo.com)
  • Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
  • A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate entities including systemic juvenile idiopathic arthritis (sJIA) and its counterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers and cancer immunotherapy. (nature.com)
  • Conversely, at the other boundary, immune hypersensitivity with gain of immune function in MHC class II-associated sJIA-AOSD and with chimeric antigen receptor (CAR) T cell therapy also triggers MAS. (nature.com)
  • Dysregulated production of IFNγ and other pivotal cytokines including IL-1, IL-6 and IL-18 can arise from either loss or gain of function in the immune response, with different implications for therapy and prognosis. (nature.com)
  • Type 1 leprosy reactions (T1LRs) occur mainly in patients with borderline leprosy and an unstable immune status. (bvsalud.org)
  • BACKGROUND: Type 1 leprosy reaction, also known as "reversal reaction", is related to cellular immune responses to Mycobacterium leprae antigens. (bvsalud.org)
  • immune destruction of insulin-pro- vestigate the relationship of VDR gene ducing beta cells by T-cell infiltration polymorphism to the risk of type 1 DM DNA isolation and PCR experiments of the pancreatic islets [1]. (who.int)
  • In contrast, unlike normal peripheral blood monocytes or alveolar macrophages, RA synovial tissue macrophages constitutively expressed MCP-1 mRNA and antigen. (northwestern.edu)
  • however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
  • The SARS-CoV-2 receptor ACE2 was extensively detected by IHC within turbinate epithelium, with decreased detection in lower respiratory tract epithelium and alveolar macrophages. (cdc.gov)
  • METHODS: Human peripheral blood mononuclear cells (PBMCs) were stimulated in vitro with HDI-albumin conjugates or control antigen, and changes in phenotype, gene and protein expression were characterized by flow cytometry, microarray, Western blot and ELISA. (cdc.gov)
  • Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. (elifesciences.org)
  • The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages. (ersjournals.com)
  • CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
  • Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
  • The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
  • Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
  • We investigated whether alterations in phenotype and function of DC may contribute to the pathogenesis of Type 1 diabetes (T1DM). (torvergata.it)
  • The distinct MAS phenotype that arises with hypercytokinaemia can be explained by activation of macrophages that are closely juxtaposed to sinusoids that permit direct phagocytic access to haematopoietic lineage cells. (nature.com)
  • Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
  • This myeloid differentiation antigen is a glycosylphosphatidylinositol (GPI)-linked protein expressed on granulocytes and macrophages. (biolegend.com)
  • Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. (wikidata.org)
  • The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. (jci.org)
  • These results indicate that prostaglandins accelerate MMR expression and hence the differentiation of macrophage precursor cells. (wustl.edu)
  • Results In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. (bmj.com)
  • In human mononuclear phagocytes, phagocytosis of Mycobacterium tuberculosis is mediated in part by human monocyte complement receptors including CR3. (wikipedia.org)
  • Chemokines that regulate monocyte/macrophage trafficking (MIF, MCP-1) and pattern-recognition receptors that bind chitin (chitinases) and oxidized low-density lipoprotein (CD68) were also increased following isocyanate -albumin exposure. (cdc.gov)
  • Moreover, there was a higher diversity of T-cell receptors on day-8 in the responder group, than on day-1, indicating that they had better regulated recovery from sepsis compared with the non-response patients. (biomedcentral.com)
  • T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. (thermofisher.com)
  • CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. (angioproteomie.com)
  • Within this inflammation, migration of neutrophils and macrophages into the damaged tissue several hours after exercise is observed. (hindawi.com)
  • Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease. (dadamo.com)
  • METHODS: To investigate effects of the IL-1 gene cluster polymorphisms on wasting and inflammation, we studied 189 ESRD patients (52+/- 12 years, 62% males) close to the start of renal replacement therapy. (dadamo.com)
  • CONCLUSION: The investigated IL-1 gene cluster polymorphisms were associated with nutritional status and inflammation in ESRD patients, but marked differences were found between the genders. (dadamo.com)
  • These results suggest that synovial production of MCP-1 may play an important role in the recruitment of mononuclear phagocytes during inflammation associated with RA and that synovial tissue macrophages are the dominant source of this cytokine. (northwestern.edu)
  • The term 'cytokine storm' entered the popular lexicon with previous influenza virus pandemics but has become even more mainstream because of the severe inflammation that can accompany SARS-CoV-2 infection 1 . (nature.com)
  • Two-color flow cytometric analysis of CD163 expression on human peripheral blood monocytes. (bdbiosciences.com)
  • In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
  • CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. (angioproteomie.com)
  • These cells are reported to express the CD163 antigen 7 , 8 . (ersjournals.com)
  • D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)
  • Both neutrophils and macrophages are involved in the release of cytokines such as IL-1, TNF- α , and IL-6 [ 3 , 8 ]. (hindawi.com)
  • GM-CSF was shown to induce both the expression of HLA-DR and the cytokines IL-1 and TNF alpha in a dose-dependent manner. (ox.ac.uk)
  • Northern blotting showed that mRNA levels of IL-1 and TNF alpha were transiently induced, similar to other cytokines. (ox.ac.uk)
  • The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. (uni-regensburg.de)
  • The NH2-terminal amino acid sequence was determined and turned out to be identical to the NH2-terminal sequence of the membrane-bound carboxypeptidase M. By precipitation with antibodies MAX.1 and MAX.11, membrane preparations of macrophages and placental microvilli were almost completely depleted of enzyme activity, indicating that the two antibodies indeed recognize carboxypeptidase M. Immunoreactivity of both antibodies correlates with the reported tissue distribution of enzyme activity. (uni-regensburg.de)
  • Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
  • Intravenous immunoglobulin (IVIG) is a therapeutic preparation of polyspecific antibodies isolated from pools of plasma obtained from several thousand healthy blood donors [1]. (academie-medecine.fr)
  • FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
  • The T-helper 1 responses are more specific, and the body develops antibodies to these allergens when the T-helper 1 system is activated. (ceufast.com)
  • Immunohistochemical analysis of synovial tissue showed that a significantly greater percentage of RA macrophages (50±8%) as compared to either OA macrophages (5±2) or normal macrophages (1±0.3) reacted with anti-MCP-1 antibodies. (northwestern.edu)
  • Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
  • Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2). (wikipedia.org)
  • For the most part, these two forms of IL-1 bind to the same cellular receptor. (dadamo.com)
  • The IL-1 receptor antagonist, IL-1Ra, is an agent which binds to the same receptor on the cell surface as IL-1, and thus prevents IL-1 from sending a signal to that cell. (dadamo.com)
  • Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). (biolegend.com)
  • Further, we uncovered several ligand-receptor pairs lining tumor cells and macrophages. (biomedcentral.com)
  • The macrophage mannose receptor (MMR) 1 facilitates the binding and internalization of microorganisms and glycoproteins with terminal mannose residues. (wustl.edu)
  • Thus, prostaglandins enhanced mannose receptor expression in adherent but not fully differentiated macrophage precursors. (wustl.edu)
  • ABSTRACT Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. (who.int)
  • In addition, carboxypeptidase M expression could be detected in HL-60, U937, and THP-1 myeloid cell lines. (uni-regensburg.de)
  • Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)
  • We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. (elifesciences.org)
  • Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. (msdmanuals.com)
  • Histiocytoses encompass a group of diverse proliferative disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
  • The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)
  • Macrophage-derived apolipoprotein (apo) E and multimers of a synthetic apo E-peptide display monokine-like functions by inhibiting mitogen- or antigen-driven lymphocyte proliferation. (jci.org)
  • Prostaglandins of the E series (PGE) are known inhibitors of monocyte and macrophage precursor proliferation, an effect often associated with cellular maturation. (wustl.edu)
  • CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)
  • General references The histiocytic disorders are clinically heterogeneous disorders that result from an abnormal proliferation of histiocytes that are either Dendritic cells (antigen-presenting cells) Monocyte-macrophages. (msdmanuals.com)
  • We typically use 1 × 10^6 cells in a 100-µl experimental sample (a test). (bdbiosciences.com)
  • Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. (bmj.com)
  • Methods We stimulated purified monocytes and whole peripheral blood mononuclear cells (PBMCs) from patients with GPA, patients with MPA or healthy controls with PR3 or MPO and visualised MGC and granuloma-like structure formation using light, confocal and electron microscopy, as well as measuring the cell cytokine production. (bmj.com)
  • We previously reported that miR-1914-5p in endothelial cells suppresses interleukin (IL)-1β-induced ICAM-1 expression and monocyte adhesion to endothelial cells. (fujita-hu.ac.jp)
  • Moreover, miR-1914-5p inhibition enhanced adhesion to endothelial cells with the upregulation of macrophage-1 antigen (Mac-1), a counter-ligand to ICAM-1. (fujita-hu.ac.jp)
  • LFA-1 also plays a role of cytotoxic killing by T cells. (medscape.com)
  • It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. (angioproteomie.com)
  • In the periphery, Gr-1 is found predominantly on neutrophils and is a useful marker for these cells. (stemcell.com)
  • A similar effect was observed when IFN was added to differentiated THP-1 cells. (jci.org)
  • Both circulating monocyte-derived macrophages, and helper T cells were shown to have crucial and beneficial roles. (weizmann.ac.il)
  • The protective T cells were found to have specificity for self-brain antigens, leading us to formulate the model of "Protective autoimmunity" (3-5). (weizmann.ac.il)
  • s, monocytes and dendritic cells. (dadamo.com)
  • However, IFN-gamma enhanced the cell surface expression of HLA-DR and the production of IL-1 and TNF alpha on monocyte-enriched cells stimulated by GM-CSF. (ox.ac.uk)
  • In six patients and six controls allogenic mixed leucocyte reaction (AMLR) was performed using mDC and cord blood-derived naive T cells at a DC/T naive ratio of 1 : 200. (torvergata.it)
  • Finally, IFN-γ has been shown to upregulate ICAM-1, but not E-Selectin or VCAM-1, expression on endothelial cells. (eaglebio.com)
  • Antigen binds to IgE (bound to tissue mast cells and blood basophils), trigger the release of mediators (histamine, chemotactic factors, etc.), and synthesize other mediators (prostaglandins, leukotrienes, platelet-activating factor, interleukins). (ceufast.com)
  • STAT3 ablation in tumor cells mitigates polarization of protumor macrophages and increases tumor-infiltrating T cells on PARP inhibition. (bmj.com)
  • Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. (thermofisher.com)
  • It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. (thermofisher.com)
  • When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. (thermofisher.com)
  • CD15 (Lewis x), also known as stage specific embryonic antigen-1 (SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. (exbio.cz)
  • Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. (exbio.cz)
  • Benharroch D, Dima E, Levy A, Ohana-Malka O, Ariad S, Prinsloo I, Mejirovsky E, Sacks M, Gopas J: Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease. (exbio.cz)
  • Although macrophage activation syndrome (MAS) is often termed autoinflammatory in both loss and gain of function phenotypes, adaptive lineage cells, especially T cells, are clearly important in both settings. (nature.com)
  • Gr-1 is a 21-25 kD protein also known as Ly-6G/Ly-6C. (biolegend.com)
  • Transmigration through the endothelial layer was also promoted with the upregulation of monocyte chemotactic protein-1 (MCP-1). (fujita-hu.ac.jp)
  • RESULTS: Human monocytes take up HDI-albumin conjugates and undergo marked changes in morphology and gene/protein expression in vitro. (cdc.gov)
  • The mature CD52 antigen is a very small protein (12 aminoacids) of 8-9 kDa. (beckman.com)
  • An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
  • We investigated the production of the chemotactic cytokine monocyte chemoattractant protein-1 (MCP-1) using sera, synovial fluid, synovial tissue, as well as macrophages and fibroblasts isolated from synovial tissues from 80 arthritic patients. (northwestern.edu)
  • This effect is further enhanced by addition of the programmed cell death protein-1 blockade. (bmj.com)
  • Li C, Wong P, Pan T, Xiao F, Yin S, Chang B, Kang SC, Ironside J, Sy MS: Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X). Biochem J. 2007 Sep 1;406(2):333-41. (exbio.cz)
  • Sia + IgG induced increased expression of CD80 and dendritic cell immunoreceptor (DCIR) on monocytes, whereas the expression of HLA-DR was decreased. (scirp.org)
  • The present study examined the effects of Sia + IgG on human peripheral blood mononuclear cell (PBMC)-derived monocyte and macrophage surface marker expression and cytokine/chemokine secretion. (scirp.org)
  • In contrast, continuous CSF1R inhibition led to depletion of both resident and recruited macrophage populations. (elifesciences.org)
  • These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction. (elifesciences.org)
  • Markedly increased populations of protumor macrophages are found in BRCA-deficient ovarian tumors that rendered resistance to PARPi in both murine models and patients. (bmj.com)
  • Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). (thermofisher.com)
  • PD-1 can bind two different but related ligands, PDL-1 and PDL-2. (thermofisher.com)
  • It is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. (dadamo.com)
  • Moreover, in vitro differentiated macrophages show the highest specific activity yet described in any tissue. (uni-regensburg.de)
  • in vitro complement-mediated cytotoxicity 2 , in vivo depletion 3-5,9 , immunoprecipitation 1 , immunohistochemical staining 6 (including paraffin-embedded sections 9,16,33-35 , acetone-fixed frozen sections 11 and zinc-fixed sections 15 ), and Western blotting 7 . (biolegend.com)
  • Our data extended prior observations of Sia + IgG on DC function and showed that Sia + IgG was able to differentially modulate multiple pathways in monocytes and macrophages. (scirp.org)
  • We identified the dynamic transcriptome and enriched pathways of differentially expressed genes between day-8 and day-1 through DVID enrichment analysis and Gene Set Enrichment Analysis. (biomedcentral.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease harboring significant microenvironment heterogeneity, especially for the macrophages. (biomedcentral.com)
  • The association between prognosis and islet macrophage count has been confirmed recently by others in an independent cohort of patients 5 but the stromal macrophage counts in that study were not associated with survival. (ersjournals.com)
  • We investigated the expression of PR3 binding partners on monocytes and tested the impact of their inhibition. (bmj.com)
  • Sia + IgG also increased the expression of cell surface markers associated with macrophage polarization (e.g. (scirp.org)
  • In this study, IL-1β decreased miR-1914-5p expression in a human monocyte cell line. (fujita-hu.ac.jp)
  • 1% expression of CD18). (medscape.com)
  • In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
  • The most significant (P-values 0.007-0.05) changes in microarray gene expression were noted in lysosomal genes, especially peptidases and proton pumps involved in antigen processing. (cdc.gov)
  • Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
  • In contrast, interferon-gamma (IFN-gamma), which induced major histocompatibility complex (MHC) class II expression, did not induce IL-1 or TNF alpha production. (ox.ac.uk)
  • By itself, GM-CSF did not induce surface class II expression on the human monocytic tumour cell line THP-1, whereas it synergized with IFN-gamma to induce surface expression. (ox.ac.uk)
  • CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. (biolegend.com)
  • PGE 1 and PGE 2 at 10 -9 -10 -8 M upregulated MMR surface expression and biosynthesis four- to sixfold in a dose-dependent manner. (wustl.edu)
  • BMMPs responsive to prostaglandins were characterized by plastic adherence, F4/80 antigen expression, and nonspecific esterase activity. (wustl.edu)
  • Further investigation of miR-1914-5p in monocytes could lead to the development of novel diagnostic markers and therapeutic strategies for atherosclerosis. (fujita-hu.ac.jp)
  • In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. (ersjournals.com)
  • Ly6C high MC expressed higher levels of macrophage (MΦ) markers, whereas, Ly6C low MC highly expressed lymphocyte markers in both mice. (frontiersin.org)
  • Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms. (jci.org)
  • The self-reactive immunoglobulins referred to as natural autoantibodies (NAbs) have been shown to exert homeostatic roles [1]. (academie-medecine.fr)
  • Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. (elifesciences.org)
  • The islet density of both M1 and M2 macrophages was markedly increased in extended compared with poor survival patients. (ersjournals.com)
  • MRP 8/14 is enhanced by interferon-γ and lipopolysaccharide 13 , 14 , a characteristic of M1 macrophages, and also has bacteriostatic properties 15 . (ersjournals.com)
  • The fluorescence histograms were derived from CD14 positive-gated events with the forward and side light-scatter characteristics of intact monocytes. (bdbiosciences.com)
  • Tumor-associated macrophages (TAMs) orchestrate PDAC malignancy, but their dynamics during disease progression remains poorly understood. (biomedcentral.com)
  • These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)
  • Pulse-chase experiments indicated that IFN reduced the accumulation of extracellular apo E and increased the degradation of intracellular apo E. The inhibitory effect of IFN on apo E production also was observed in human monocyte-derived macrophages. (jci.org)
  • The taxonomic positions of these bacteria have been determined with much greater scientific clarity by the recent application of molecular methods, which were critical for the identification of E. chaffeensis and essential for that of human granulocytic ehrlichia (HGE) ( 1 , 2 ). (cdc.gov)
  • matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
  • Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with a 5-year survival rate of less than 8% [ 1 ]. (biomedcentral.com)
  • This study demonstrated how the target lymphocyte itself can modulate macrophage apo E production. (jci.org)
  • Viral genome, antigen, or both were found in several tissues, along with a parasitic infection and a generalized lymphocytic depletion. (cdc.gov)
  • In addition, the synovial lining layer reacted with MCP-1 in both RA and OA synovial tissues. (northwestern.edu)
  • Therefore, modulating monocyte recruitment represents a potential therapeutic strategy. (fujita-hu.ac.jp)
  • However, whether monocyte miR-1914-5p affects monocyte recruitment is unclear. (fujita-hu.ac.jp)
  • [ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)