MacrophagesDerived from peripheral blood monocytesCD86APCsDendritic cellSpecialized antigen-presePeripheralPeptidesMoleculesCellsNeutrophilsInduceCytotoxicAllelesAntibodyInhibitoryProteinMacrophageTuberculosisPresentationAssaysNeutrophilViralProliferationGenesExpressionGeneAcceptorHeterodimerHumanFacilitateSpecific
Macrophages5
- The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
- CD86 exhibits constitutive expression on resting monocytes, macrophages and dendritic cells. (annexpublishers.co)
- Dendritic cells (DCs), activated macrophages, and activated B cells are all capable of presenting antigen peptides. (biomedcentral.com)
- PMNs are rapidly recruited to tissues upon injury or infection, where they likely encounter other cells, for instance local and/or recruited dendritic cells and monocytes/macrophages. (springeropen.com)
- however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
Derived from peripheral blood monocytes2
- mDC, derived from peripheral blood monocytes cultured for 6 days in presence of interleukin (IL)-4 and granulocyte-macrophage colony stimulating factor (GM-CSF) and stimulated with lipopolysaccharide (LPS) for the last 24 h, were phenotyped for the expression of the co-stimulatory molecules B7.1 and B7.2. (torvergata.it)
- Autologous mature dendritic cells derived from peripheral blood monocytes were pulsed with the HLA-A2-binding MUC1 peptides (M1.1 and M1.2). (aacrjournals.org)
CD866
- Furthermore, FP pretreatment significantly reduced O(3)-induced modification of CD11b, mCD14, CD64, CD16, HLA-DR, and CD86 on sputum monocytes in a dose-dependent manner. (nih.gov)
- We marked of B7-1(CD80) and B7-2(CD86) costimulatory molecules. (annexpublishers.co)
- The presence of CD80 and CD86 in NETs could influence the cell environment through the B7-1/B7-2:CD28/CTLA-4 pathway. (annexpublishers.co)
- B7 molecules (B7-1/CD80 and B7-2/CD86) are integral membrane glycoproteins that are expressed on the surface of APCs. (annexpublishers.co)
- Our data revealed that at early times (30 min), both Antigen Presenting Cells (APCs) showed induction of important costimulatory molecules (CD80, CD86). (springeropen.com)
- CD80(B7-1) and CD86(B7-2) co-stimulatory molecules have been reported to activate Th1/Th2 development pathways differentially. (keyopinionleaders.com)
APCs5
- Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
- Polymorphonuclear neutrophils (PMNs) activated in vitro may express molecules normally associated with antigen presenting cells (APCs). (annexpublishers.co)
- We aimed to clarify whether soluble CD40 ligand (sCD40L) activated B cells may be loaded with HBcAg18-27 peptide and served as antigen-producing cells (APCs) to induce HBV-specific cytolytic T lymphocytes (CTLs). (biomedcentral.com)
- Efficient antigen presentation by antigen presenting cells (APCs) is critical for inducing T-cell mediated immunity in vivo [ 1 , 2 ]. (biomedcentral.com)
- In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
Dendritic cell1
- 1. Basic immunology with an emphasis on dendritic cell, monocyte and T cell biology. (universityofgalway.ie)
Specialized antigen-prese1
- Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Peripheral2
- Human monocyte-derived dendritic cells (MoDCs) obtained from peripheral blood monocytes (PBMC) cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) can be activated in vitro by a variety of simple chemicals such as haptens and several metals. (keyopinionleaders.com)
- To analyze the interactions between M. tuberculosis and immune cells, human peripheral blood monocyte-derived immature DCs were infected with M. tuberculosis H37Rv wild type strain and flow cytometry was used to analyse cell surface expression markers. (biomedcentral.com)
Peptides4
- DCs populate almost all body surfaces and they do not kill the pathogens directly, they utilize and subsequently degrade antigens to peptides by their proteolytic activity. (wikipedia.org)
- In this work, we analyzed the binding affinities of mutated peptides of Omicron strain variants BA.1-BA.5 and the worldwide prevalent HLA alleles. (bvsalud.org)
- We showed that, for all five viral variants, mutations cause a significant reduction in the number of tightly binding peptides for HLA-B*07:02 and HLA-C*01:02 molecules. (bvsalud.org)
- Interestingly, mutations caused multidirectional effect on the binding affinities of the viral peptides and HLA-DRB1*03:01. (bvsalud.org)
Molecules5
- Upon infection many viruses, including Herpesviruses, target T cell function via specific interactions with TCR and HLA-I molecules. (frontiersin.org)
- In a study of lung adenocarcinoma [ 4 ] , EMT markers were associated with enhanced tumor infiltration of CD4 + Foxp3 + Tregs and upregulation of inhibitory immune checkpoint molecules such as programmed cell death (PD)-ligand (L) 1, PD-L2, TIM-3, B7-H3, and CTLA-4. (encyclopedia.pub)
- PMNs activated in vitro may express molecules normally associated with antigen presenting cells required for T cell activation. (annexpublishers.co)
- It is well known that Langerhans cells (LC), potent antigen-presenting dendritic cells in the epidermis, express several co-stimulatory molecules and that this expression is modulated by several cytokines. (keyopinionleaders.com)
- During this process, LC become mature DC with augmented expression of various co-stimulatory molecules and MHC class II antigens. (keyopinionleaders.com)
Cells18
- Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens. (wikipedia.org)
- DCs are also the only cell type which can activate naïve T cells and induce antigen-specific immune responses. (wikipedia.org)
- CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. (thermofisher.com)
- HLA-identical sibling stem cells are used for the treatment of patients suffering from various hematologic malignant and nonmalignant diseases. (ashpublications.org)
- Antigen-specific CD40L-activated B cells may efficiently endocytose and present antigens, such as protein, RNA, and cDNA, to prime primary T cells and boost robust memory T-cell responses [ 9 ]. (biomedcentral.com)
- However, little is known whether CD40L-activated B cells may present HBV antigen to T cells. (biomedcentral.com)
- The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
- In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
- Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
- Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
- One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)
- Specificity : The mouse monoclonal antibody 3D11 recognizes an extracellular epitope of HLA-F, a 42 kDa type I transbembrane protein expressed on B cells, NK cells, monocytes, and T cells, but mainly in the endoplasmic reticulum and Golgi apparatus, only a small amount on the cell surface, where, however, it can be expressed after cell activation. (abeomics.com)
- Delivery of OX40L to human monocytes using a recombinant replication-defective adenovirus led to greater expansion, up-regulation of perforin, enhanced cytolytic activity, and increased numbers of IFN-γ- and TNF-α-producing antiviral memory CD8 T cells in cultures of total T cells. (aai.org)
- bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
- Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
- Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
- Dendritic cells (DCs) can take up an array of different antigens, including microorganisms which they can process and present more effectively than any other antigen presenting cell. (biomedcentral.com)
- DCs comprise a family of antigen presenting cells that act like 'conductors' of the immune response in their capacity to orchestrate signals derived from the different parts of the immune system [ 2 ]. (biomedcentral.com)
Neutrophils1
- Comparing patients treated with anti-CTLA-4 to those treated with anti-PD-1, similar upregulation of IL6 and genes encoding chemokines for neutrophils and monocytes were found. (acir.org)
Induce2
- INTRODUCTION: In this study, we evaluated whether SARS-CoV-2 mRNA vaccines induce anti-human leukocyte antigen (HLA) antibodies and anti- ABO blood type antibodies (ABOAb) in kidney transplant recipients (KTRs). (bvsalud.org)
- CONCLUSIONS: The SARS-CoV-2 mRNA vaccine did not induce anti-HLA antibody or ABOAb production in KTRs. (bvsalud.org)
Cytotoxic2
- There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)
- the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). (thermofisher.com)
Alleles6
- CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. (transcriptionfactor.org)
- In this regard, global efforts are currently underway to study possible correlations between HLA alleles with the occurrence and severity of SARS-CoV-2 infection. (bvsalud.org)
- Specifically, this study examined the possible association between specific HLA alleles and susceptibility to SARS-CoV-2 in a population from the United Arab Emirates (UAE). (bvsalud.org)
- HLA alleles and supertypes were compared between hospitalized and non-hospitalized subjects. (bvsalud.org)
- Statistical significance was observed between certain HLA alleles and supertypes and the severity of the infection. (bvsalud.org)
- Specifically, alleles HLA-B*51:01 and HLA-A*26:01 showed a negative association (suggestive of protection), whilst genotypes HLA-A*03:01, HLA-DRB1*15:01, and supertype B44 showed a positive association (suggestive of predisposition) to COVID-19 severity. (bvsalud.org)
Antibody1
- Changes in anti-ABO blood type immunoglobulin IgM and IgG antibody titers, flow panel reactive antibody (PRA), de novo donor-specific anti-human leukocyte antigen antibodies (DSA), and kidney allograft function before and after vaccination were evaluated. (bvsalud.org)
Inhibitory1
- Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. (transcriptionfactor.org)
Protein2
- HLA-F, an MHC class I molecule, is a type I transmembrane protein (heavy chain), which forms heterodimers with beta-2 microglobulin (light chain) and binds to KIR3DS1, KIR3DS4, KIR3DL2, ILT2, ILT4, and TAP. (abeomics.com)
- PD-L1 (also known as CD274 or B7-homolog 1 [B7-H1]) is a transmembrane protein involved in the immune system suppression. (studylib.net)
Macrophage2
- We generated Monocyte-macrophage Lymphocytic Rosettes (MLRs) with OVA stimulation. (annexpublishers.co)
- matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
Tuberculosis3
- Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
- These data clearly demonstrate that M. tuberculosis induces activation and maturation of human monocyte-derived immature DC as well as induces T cell proliferation in vitro . (biomedcentral.com)
- Henderson et al reported that human monocyte derived DC phagocytose M. tuberculosis efficiently, suggesting a role for this important cell in the early response to TB infection. (biomedcentral.com)
Presentation1
- However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Assays1
- However, there was no DSA in single antigen flow-bead assays. (bvsalud.org)
Neutrophil2
- Other upregulated genes included acute-phase reactants induced by IL6 , such as IL11 , and genes encoding neutrophil- and monocyte-attracting chemokines. (acir.org)
- Among the 343 genes, the largest differences were found in IL6 and genes encoding for neutrophil and monocyte chemokines, while there was no significant difference for these genes between irEC and non-responding tumor tissue. (acir.org)
Viral2
- The class I and class II Human Leucocyte Antigens (HLA) are an integral part of the host adaptive immune system against viral infections. (bvsalud.org)
- The characterization of HLA allele frequency in the population can play an important role in determining whether HLA antigens contribute to viral susceptibility. (bvsalud.org)
Proliferation1
- exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
Genes2
- The synthesis of Lewis antigens depends on the interaction of the transferases produced by the Lewis and secretor genes. (keepnotes.com)
- Development of Lewis antigens o Depending on the genes inherited, Lea and Leb glycoproteins will be present in the saliva of ewborns, but Lewis glycolipids are not detectable in the plasma until about 10 days after birth. (keepnotes.com)
Expression1
- We did not find differences in the HLA-DR expression (P = 0.07). (torvergata.it)
Gene2
- Multiple transcript variants encoding different isoforms have been found for HLA-F gene. (abeomics.com)
- o Lewis antigens will start to appear shortly after birth, with Lea developing first when the Le gene is present. (keepnotes.com)
Acceptor1
- These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. (abeomics.com)
Heterodimer1
- which is expressed as a heterodimer with either of b1 (CD29) or b7. (bios-mep.info)
Human1
- Figure B. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse anti Human HLA DP DQ DR ( MCA477AMO ). (bio-rad-antibodies.com)
Facilitate1
- Whereas there is little evidence to indicate whether self-antigens in SLE are aberrant in sequence or structure, there is evidence that the aberrant handling of self-antigens could facilitate lupus pathogenesis. (biomedcentral.com)
Specific2
- There was also an increase in the number of CD8 + T eff specific to B16 melanoma antigens (p15 and TRP-2). (acir.org)
- The results support the potential use of HLA testing to differentiate between patients who require specific clinical management strategies. (bvsalud.org)