• Cerium oxide nanoparticle s attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension. (cdc.gov)
  • The aim of the present study was to investigate the protective effects of RSV against monocrotaline (MCT)-induced right ventricular (RV) hypertrophy in rats. (lacienciadelvino.com)
  • In this study, we examined the acute vasodilator effects of fasudil, a Rho-kinase inhibitor, in monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats. (elsevierpure.com)
  • In this study, we tested this hypothesis by examining the mechanoenergetic response of the atrophied LV to RV hypertrophy in rats treated with monocrotaline. (frontiersin.org)
  • Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. (nih.gov)
  • CRE-containing genes were upregulated in PH PASMCs, and total and phosphorylated CREB protein levels were elevated in PASMCs from rats with monocrotaline (MCT)-induced PH. (researchsquare.com)
  • A process design for supercritical extraction of the pyrrolizidine alkaloid monocrotaline from seed material has been developed. (uky.edu)
  • The team members in our laboratory also have expertise in various pre-clinical models of pulmonary hypertension (heart failure, hypoxia, monocrotaline, sugen/hypoxia) and use hemodynamic, molecular biology and histological methods along with cell cultures, isolated pulmonary arteries, isolated lungs and nuclear medicine. (icm-mhi.org)
  • Compared with wild-type mice, SM22-5-HTT(+) mice showed depressed hypoxic pulmonary vasoconstriction contrasting with greater severity of hypoxia- or monocrotaline-induced PH. (hal.science)
  • All animals underwent percutanous pulmonary artery catheterization to measure right heart hemodynamics prior to and 8 weeks after a right atrial injection of either monocrotaline pyrrole (MCTP, n=8) or placebo (CTL, n=8). (duke.edu)
  • Herein, we investigate whether CeO2 nanoparticle administration can diminish right ventricular (RV) hypertrophy following four weeks of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). (cdc.gov)
  • Doppler echocardiography demonstrated that CeO2 nanoparticle treatment attenuated monocrotaline-induced changes in pulmonary flow and RV wall thickness. (cdc.gov)
  • Therefore, in monocrotaline (MCT) rat model of PAH, the role of 5-LO has been investigated through the formulation of RF-22c-SLN. (unict.it)
  • The monocrotaline model of pulmonary hypertension in perspective. (nih.gov)
  • This study was designed to examine the effects of both nitric oxide and milrinone on pulmonary hemodynamics and right ventricular function using a newly established model of monocrotaline pyrrole-induced chronic pulmonary hypertension. (duke.edu)
  • This study demonstrates the well-known clinical effects of nitric oxide and milrinone in improving pulmonary hypertension, which were also associated with an increase in pulmonary blood flow, transpulmonary efficiency, and right ventricular hydraulic power in the setting of monocrotaline pyrrole-induced chronic pulmonary hypertension. (duke.edu)
  • This review summarizes information about the monocrotaline, showing such effects in these environments, both above and below ground, and their potential use in pest management programs. (bvsalud.org)
  • control, monocrotaline (MCT) only, MCT with treprostinil treatment (MCT/TRE), and treprostinil treatment only (TRE). (umsystem.edu)
  • Inflammatory mechanisms appear to play a significant role in some types of pulmonary hypertension (PH), including monocrotaline-induced PH in rats and pulmonary arterial hypertension of various origins in humans, such as connective tissue diseases (scleroderma, systemic lupus erythematosus, mixed connective disease), human immunodeficiency virus infection, or plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal (M) protein and skin changes (POEMS) syndrome. (ersjournals.com)
  • Immunoblotting was used to detect the IP and prostanoid EP4 receptor in lung tissue from patients with idiopathic pulmonary arterial hypertension, and immunohistochemistry was used to detect these receptors in lung sections from rats treated with monocrotaline (MCT28d). (nih.gov)
  • PAH was induced by a single intraperitoneal injection of monocrotaline (MCT) into Sprague-Dawley rats. (medscimonit.com)
  • 1997. Exogenous nitric oxide attenuates monocrotaline-induced pulmonary hypertension in rats. (nymc.edu)
  • This study was designed to examine the effects of both nitric oxide and milrinone on pulmonary hemodynamics and right ventricular function using a newly established model of monocrotaline pyrrole-induced chronic pulmonary hypertension. (duke.edu)
  • This study demonstrates the well-known clinical effects of nitric oxide and milrinone in improving pulmonary hypertension, which were also associated with an increase in pulmonary blood flow, transpulmonary efficiency, and right ventricular hydraulic power in the setting of monocrotaline pyrrole-induced chronic pulmonary hypertension. (duke.edu)
  • Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. (wikipedia.org)
  • Changes in angiotensin-converting enzyme activity in lungs damaged by the pyrrolizidine alkaloid monocrotaline. (nih.gov)
  • All animals underwent percutanous pulmonary artery catheterization to measure right heart hemodynamics prior to and 8 weeks after a right atrial injection of either monocrotaline pyrrole (MCTP, n=8) or placebo (CTL, n=8). (duke.edu)
  • The monocrotaline pyrrole (MCTP)-treated rat is a useful model for the study of certain chronic pulmonary vascular diseases. (tno.nl)
  • Cerium oxide nanoparticle s attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension. (cdc.gov)
  • Attenuate monocrotaline-induced PAH and RVH. (pulmonologyadvisor.com)
  • When the total activity per lung is calculated, however, there is no significant difference between control and monocrotaline-treated animals. (nih.gov)
  • 1999. Monocrotaline induces IL6 mRNA expression in rat lungs. (nymc.edu)
  • Monocrotaline (MCT) causes chronic pulmonary hypertension associated with pulmonary vascular thickening in rats. (elsevierpure.com)
  • Disruption of endothelial-cell caveolin-1/raft scaffolding during development of monocrotaline-induced pulmonary hypertension. (nymc.edu)
  • Methods: Pulmonary hypertension was induced by parenteral injection of monocrotaline (60 mg/kg) and creation of a left-to-right shunt aortocaval fistula in rats. (ncku.edu.tw)
  • El alcaloide causa hipertensión arterial pulmonar, hipertrofia del ventrículo derecho y alteraciones patológicas en la red vascular pulmonar. (bvsalud.org)
  • 2002. Effects of Monocrotaline on eNOS expression and sulfhydryl levels in rat lungs, Heart Disease:4:152-158. (nymc.edu)
  • 1. The PERK/eIF2α/ATF4/CHOP pathway plays a role in regulating monocrotaline-induced endoplasmic reticulum stress in rat liver. (nih.gov)
  • The effects of NTP42:KVA4 were evaluated in the monocrotaline (MCT) and pulmonary artery banding (PAB) models of PAH and RV dysfunction, respectively, and when compared with leading standard-of-care (SOC) PAH drugs. (frontiersin.org)
  • Loss-of-function and gain-of-function studies using gene knock-in or gene knock-out and the combinations of the proteomic technology and genome-wide ChIP-Seq were employed to determine the downstream targets of miR-182-3p/Myadm in response to monocrotaline (MCT)-induced PAH. (thno.org)