AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
I-kappa B KinaseNF-kappa BI-kappa B ProteinsProtein-Serine-Threonine KinasesTranscription Factor RelAEnzyme ActivationPhosphorylationSignal TransductionCell LineTumor Necrosis Factor-alphaAntibodies, MonoclonalAurora Kinase BEnzyme InhibitorsTranscription Factor RelBHeLa CellsCells, CulturedAurora KinasesProto-Oncogene Proteins c-relMitogen-Activated Protein KinasesMolecular Sequence DataDNA-Binding ProteinsPhosphatidylinositol 3-KinasesProtein KinasesMAP Kinase Signaling SystemProto-Oncogene ProteinsBase SequenceProtein Kinase InhibitorsNF-kappa B p50 SubunitOncogene Proteins v-relAmino Acid SequenceReceptors, Opioid, kappaCalcium-Calmodulin-Dependent Protein KinasesTosylphenylalanyl Chloromethyl KetoneProtein Kinase CImmunoglobulin kappa-ChainsCell NucleusTransfectionsrc-Family KinasesTumor Cells, CulturedProtein BindingJNK Mitogen-Activated Protein KinasesCDC2 Protein KinaseTranscription Factorsp38 Mitogen-Activated Protein KinasesProtein-Tyrosine KinasesCyclic AMP-Dependent Protein KinasesCasein Kinase IIKineticsRecombinant ProteinsGene Expression RegulationMitosisTranscription, GeneticRecombinant Fusion ProteinsBlotting, WesternMitogen-Activated Protein Kinase 1Antibody SpecificityPhosphorylase KinaseTranscriptional ActivationRNA, MessengerAurora Kinase ABinding SitesDNAEpitopesMitogen-Activated Protein Kinase KinasesTetradecanoylphorbol AcetateApoptosisLipopolysaccharidesp21-Activated KinaseseIF-2 KinaseIsoenzymesMitogen-Activated Protein Kinase 3MAP Kinase Kinase KinasesOrganophosphatesMutationSerineCyclin-Dependent KinasesPrecipitin TestsMultienzyme ComplexesReticuloendotheliosis Viruses, AvianCreatine KinaseOligodeoxyribonucleotidesRetroviridae Proteins, OncogenicLeupeptinsHybridomasT-LymphocytesCytoplasmChromosome Segregation3T3 CellsMice, Inbred BALB CPhosphoproteinsPromoter Regions, GeneticCell Line, TumorDNA PrimersElectrophoresis, Polyacrylamide GelCysteine EndopeptidasesCasein KinasesCell Cycle ProteinsNuclear ProteinsPyruvate KinaseFluorescent Antibody Technique
AntibodiesCloneReceptorIgG1Member of the protein-tyrosiMitogen-activaActivatesHuman IgG antibody LaboratoriesPhosphorylationInhibitorsProtein tyrosinGammopathyReactsTyrosine kinasesGeneTumorIMMUNOGLOBULINMouseMolecularSubunitEncodesPhosphorylatesNuclearThermo Fisher SciBruton'sProliferationActivationProteinsHeLaCytoplasmicInhibitsApoptosisELISAActivatorRegulationSignaling cascadeBindingChronicNucleusRepresentsActivityProductsCell
Antibodies6
  • For the last two decades, our understanding of immunology exploded with the advent of technologies that allowed high throughput screening and generation of large molecule biologics such as monoclonal antibodies (mAb) and small molecule compounds. (frontiersin.org)
  • We previously identified two types of rat CD28-specific monoclonal antibodies (mAbs): "conventional," TCR signaling-dependent costimulatory mAbs and "superagonistic" mAbs capable of inducing the full activation of primary resting T cells in the absence of TCR ligation both in vitro and in vivo. (ox.ac.uk)
  • If patients have recurrent infections and lymphopenia, lymphocyte phenotyping using flow cytometry and monoclonal antibodies to T, B, and natural killer (NK) cells is indicated to check for lymphocyte deficiency. (ferienwohnung-uelsen.de)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
  • Treatment includes plasma exchange as needed for hyperviscosity and systemic therapy with alkylating drugs, corticosteroids, nucleoside analogs, Bruton's tyrosine kinase (BTK) inhibitors, venetoclax , or monoclonal antibodies. (merckmanuals.com)
  • Patients have shown deposition of IgM in the involved tissue, and using anti-idiotype antibodies, IgM monoclonal antibodies were demonstrated to react with epidermal antigens. (medscape.com)
Clone2
  • Western Blot: Sphingosine Kinase 1/SPHK1 Antibody (1D6) [H00008877-M01] - SPHK1 monoclonal antibody (M01), clone 1D6. (novusbio.com)
  • Recombinant anti-mouse PD-L1 rat IgG2b kappa monoclonal antibody, which shares the same variable region sequences with the rat anti-mouse PD-L1 monoclonal antibody (clone number: 10F.9G2), was produced from mammalian cells and good for in vitro and in vivo studies. (ushelf.com)
Receptor14
  • Animal studies claim that kappa opioid receptor antagonists (KORAn) potentially could deal with a multitude of addictive and depressive disorder. (sciencepop.org)
  • Intro The kappa opioid receptor (KOR) and its endogenous ligand dynorphin are enriched in mind regions involved in stress response and potential medical energy for KOR antagonists (KORAn) offers been shown in major depression and substance abuse (Carroll and Carlezon 2013 JDTic is a potent and selective KORAn (Thomas 3 (50%) of the 6 subjects who received JDTic 1?mg. (sciencepop.org)
  • BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. (enzolifesciences.com)
  • IL-17 not only induces proinflammatory cytokines, but also directly enhances osteoclastogenesis by upregulating receptor activator nuclear kappa ligand (RANKL) on osteoblasts [ 5 ], contributing to bone erosion in RA. (hindawi.com)
  • As signal transducer and activator of transcription (STAT) 3 phosphorylation directly regulates retinoic acid receptor-related orphan receptor (ROR) γ t, which is the master molecule of Th17, the Janus kinase (JAK)2-STAT3 pathway initiated by IL-6 is essential in the Th17 development. (hindawi.com)
  • Murine anti-human CD3 monoclonal antibody OKT3 (muromonab-CD3) binds towards the T cell receptor CD3 complex and is an established T cell activator [50]. (pteninhibitor.com)
  • CD40 receptor stimulation also increases phosphoinositide 3-kinase (PI3K) activity. (pteninhibitor.com)
  • Description: The RM4-5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. (cytekbio.com)
  • Description: The APA5 monoclonal antibody reacts with the mouse CD140a molecule, the alpha chain of the platelet derived growth factor receptor (PDGF receptor). (cytekbio.com)
  • PDGFRa is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. (cytekbio.com)
  • Insulin-like development aspect 1 receptor (IGF-1 R) and Receptor of turned on protein kinase C 1 (RACK1) which scaffolds IGF-1R to β1 integrin had been also elevated indicating a changed phenotype. (healthweeks.com)
  • These cell-surface receptors are called receptor tyrosine kinases (RTKs). (lumenlearning.com)
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (abnova.com)
  • Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. (bioss.com.cn)
IgG11
  • ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. (abcam.com)
Member of the protein-tyrosi1
  • FYN is a member of the protein-tyrosine kinase oncogene family. (thermofisher.com)
Mitogen-activa1
  • TNF signaling controls immune cell activation via regulation of gene expression of chemokines, cytokines, and toxic molecules, including the reactive oxygen species, transcription factor nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). (xiahepublishing.com)
Activates8
  • This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. (origene.com)
  • Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
  • Upon phosphorylation, ERK enters the nucleus and activates a protein kinase that, in turn, regulates protein translation (Figure 1). (lumenlearning.com)
  • ERK is a MAP kinase that activates translation when it is phosphorylated. (lumenlearning.com)
  • Cyclic AMP activates PKA (protein kinase A), which in turn phosphorylates two enzymes. (lumenlearning.com)
  • The first enzyme promotes the degradation of glycogen by activating intermediate glycogen phosphorylase kinase (GPK) that in turn activates glycogen phosphorylase (GP) that catabolizes glycogen into glucose. (lumenlearning.com)
  • Activation of RTKs initiates a signaling pathway that includes a G-protein called RAS, which activates the MAP kinase pathway described earlier. (lumenlearning.com)
  • Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. (bioss.com.cn)
Human IgG antibody Laboratories2
  • Human IgG antibody Laboratories manufactures the monoclonal igm kappa paraproteins reagents distributed by Genprice. (diastrip.com)
  • Human IgG antibody Laboratories manufactures the lanthascreen™ eu kinase binding assay reagents distributed by Genprice. (diastrip.com)
Phosphorylation3
  • Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. (novusbio.com)
  • The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. (wikidata.org)
  • Focal Adhesion Kinase (FAK) and cofilin phosphorylation and RhoA Guanosine Triphosphatase (GTPase) activity Desmethyldoxepin HCl had been all improved in these spheroids in comparison to control acini. (healthweeks.com)
Inhibitors3
  • TNF α induziert die Poly-Ubiquitinierung der rezeptorinteragierenden Proteinkinase (RIP), und die ubiquitinierte RIP assoziiert mit NEMO (NF-κB Essential Modulator), um den IKKα- und IKKβ-Kinase-Komplex (Inhibitors of Nuclear Factor Kappa B) zu aktivieren. (antikoerper-online.de)
  • Although combination chemotherapy regimens, including the nucleoside analogue fludarabine, were once the most commonly used first-line therapy in CLL, non-chemotherapy regimens (eg, with Bruton tyrosine kinase [BTK] inhibitors) are currently preferred in most cases. (medscape.com)
  • These results highlight the interest of therapies targeting the PD-1/PD-L1 axis in activated lymphomas with PD-L1 expression, with possible synergies with tyrosine kinase inhibitors. (springer.com)
Protein tyrosin1
Gammopathy7
  • Waldenström macroglobulinemia is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance and smoldering Waldenström macroglobulinemia. (wikipedia.org)
  • After myeloma, macroglobulinemia is the 2nd most common malignant disorder associated with a monoclonal gammopathy. (merckmanuals.com)
  • Schnitzler syndrome is an autoinflammatory disease characterized by chronic, nonpruritic urticaria in association with monoclonal gammopathy. (medscape.com)
  • those with an immunoglobulin G (IgG) monoclonal gammopathy are considered to be a distinct group. (medscape.com)
  • Monoclonal gammopathy. (medscape.com)
  • 2 major and 2 minor criteria if the monoclonal gammopathy is IgM. (medscape.com)
  • 2 major and 3 minor criteria if the monoclonal gammopathy is IgG. (medscape.com)
Reacts2
  • Mouse monoclonal to CD8.COV8 reacts with the 32 kDa a chain of CD8. (buyresearchchemicalss.net)
  • 5C3 monoclonal antibody which reacts with human CD40 is reported to activate B cells in in vitro functional assays [51]. (pteninhibitor.com)
Tyrosine kinases2
  • Most growth factors bind to cell-surface receptors that are linked to tyrosine kinases. (lumenlearning.com)
  • CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. (stemcell.com)
Gene2
  • Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. (novusbio.com)
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. (bioss.com.cn)
Tumor3
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • The pre-clinical LMP1/CD40-expressing transgenic mouse model is characterized by B-cell specific CD40 signaling responsible for NF-κB continuous activation with a spleen monoclonal B-cell tumor after 1 year in 60% of cases. (springer.com)
  • Treatment of LMP1/CD40-expressing lymphomatous mice with an anti-PD-L1 monoclonal antibody induced tumor regression with decreased spleen content, activation and proliferation rate of B-cells as well as a marked increase in T-cell activation, as assessed by CD62L and CD44 expression. (springer.com)
IMMUNOGLOBULIN2
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
  • Excessive amounts of IgM M-proteins (monoclonal immunoglobulin protein, which may consist of both heavy and light chains or of only one type of chain) can also accumulate in other disorders, causing manifestations similar to macroglobulinemia. (merckmanuals.com)
Mouse5
  • Mouse monoclonal antibody to LCK. (sciencepop.org)
  • The blot was probed with Anti-Fyn Mouse Monoclonal Antibody (Product # MA1-12607, 1-3 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.4 µg/mL, 1:2500 dilution). (thermofisher.com)
  • PDLIM2 (also called Mystique or SLIM) is certainly Mouse monoclonal to ALDH1A1 a cytoskeletal and nuclear PDZ-LIM area protein that regulates the balance of many transcription elements including NFκB and sign transducer and activator of transcription proteins (STATs) in hemopoietic and epithelial cells [7-9]. (healthweeks.com)
  • ICC/IF analysis of PEBP1 in HeLa cells line, monoclonal anti-human PEBP1 antibody (1:100) stained with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green). (nkmaxbio.com)
  • Mouse monoclonal antibody raised against a partial recombinant STAT2. (abnova.com)
Molecular1
  • Less commonly, patients develop hyperviscosity due to the large amounts of high molecular weight monoclonal IgM proteins circulating in plasma, but most patients do not develop problems related to high IgM levels. (merckmanuals.com)
Subunit2
  • The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). (abcam.com)
  • The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (thermofisher.com)
Encodes1
  • It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. (thermofisher.com)
Phosphorylates1
  • Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. (wikidata.org)
Nuclear2
  • Furthermore, various other mechanisms have been HCV Protease supplier proposed by which CD40 leads to cytokine production, like protein kinase B (Akt) and nuclear factor (NF)-kappa B (NF-B) signaling pathways [55].2. (pteninhibitor.com)
  • PDLIM2 is a cytoskeletal and nuclear PDZ-LIM area protein that regulates the balance of Nuclear Aspect kappa-B (NFκB) and other transcription elements and is necessary for polarized cell migration. (healthweeks.com)
Thermo Fisher Sci2
  • The following product was used in this experiment: IL-17A Monoclonal Antibody (eBio17B7), APC, eBioscience™ from Thermo Fisher Scientific, catalog # 17-7177-81, RRID AB_763580. (thermofisher.com)
  • The following product was used in this experiment: Fyn Monoclonal Antibody (1S) from Thermo Fisher Scientific, catalog # AHO0482, RRID AB_2536311. (thermofisher.com)
Bruton's1
  • Ibrutinib , a blocker of Bruton's tyrosine kinase (BTK), has been shown to be successful in treating Schnitzler sybdrome, with or without an accompaying hematologic malignancy. (medscape.com)
Proliferation3
  • Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive proliferation and accumulation of mature yet functionally incompetent lymphocytes. (medscape.com)
  • Mainly, it controls three pathways through the TNFR1, inducing the proliferation of various kinases. (xiahepublishing.com)
  • Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
Activation4
  • The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, cytochrome c release NF-κB WNT/beta-catenin mTOR ERK MAPK Bcl-2 The protein Src tyrosine kinase is overexpressed in Waldenström macroglobulinemia cells compared with control B cells. (wikipedia.org)
  • MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. (gentaur.uk)
  • 14 , 15 MKK3 and MKK6 are both involved in the activation of p38 kinase. (xiahepublishing.com)
  • involved in NF-kappa-B activation. (bioss.com.cn)
Proteins2
HeLa1
  • Immunocytochemistry/ Immunofluorescence: NM23-H2/NME2 Antibody (1D3) [H00004831-M06] - Analysis of monoclonal antibody to NME2 on HeLa cell. (novusbio.com)
Cytoplasmic1
  • In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. (cytekbio.com)
Inhibits1
  • inhibits dimerization of the kinase domain and autophosphorylation. (bioss.com.cn)
Apoptosis1
  • Excitotoxic production of ROS elevates death-associated protein kinase (DAPK) activity, which provokes neuronal apoptosis in cerebral ischemia and seizure models 8 . (nature.com)
ELISA1
  • ELISA: Sphingosine Kinase 1/SPHK1 Antibody (1D6) [H00008877-M01] - Detection limit for recombinant GST tagged SPHK1 is approximately 1ng/ml as a capture antibody. (novusbio.com)
Activator1
  • Oxidative stress is an important activator of PKD1 in cellular models, but its capacity to activate this kinase in vivo is largely unknown. (nature.com)
Regulation1
  • Finally, the results of ROC curves, immunohistochemical staining, immune cell infiltration and kinase / miRNA / transcription factor regulation showed that KCNK2, KCNK4, KCNK5 and KCNK15 levels could be used as biomarkers for PTC diagnosis. (jcancer.org)
Signaling cascade1
  • May also activate the NF-kappa-B signaling cascade. (bioss.com.cn)
Binding1
  • The Lanthascreen™ Eu Kinase Binding Assay reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (diastrip.com)
Chronic2
  • Chronic lymphocytic leukemia (CLL) is the most common type of leukemia and the anti-CD20 monoclonal antibody, rituximab, represents the therapeutic gold standard for more than 2 decades in this pathology, when used in combination with chemotherapy. (bmj.com)
  • Chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL) is a monoclonal disorder characterized by a progressive accumulation of functionally incompetent lymphocytes (see the image below). (medscape.com)
Nucleus1
  • An example of a protein that regulates translation in the nucleus is the MAP kinase ERK. (lumenlearning.com)
Represents1
Activity3
  • In conclusion, this study provides an additional argument to consider that del(17p) is effective not only to control chemoresistance but also monoclonal antibody activity, based on higher rituximab turnover. (bmj.com)
  • Dimers of PDGFR consist of either homodimers of alpha/alpha, beta/beta, or heterodimers of alpha/beta and serve as a substrate for its kinase activity. (cytekbio.com)
  • Polarity could be restored by inhibition of either FAK or Rho kinase (ROCK) activity. (healthweeks.com)
Products1
  • Other Monoclonal products are available in stock. (diastrip.com)
Cell3
  • The Monoclonal Igm Kappa Paraproteins reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (diastrip.com)
  • This was associated with dysregulation of cues from the ECM which is indicated by increased cell-cell and cell-ECM signaling through β1-integrin focal adhesion kinase (FAK) and RhoA. (healthweeks.com)
  • Immunofluorescence of monoclonal antibody to STAT2 on A-431 cell. (abnova.com)