Monoclonal antibody was specific. Medical search. Frequent questions

We screened 332 antibodies in five immune cell populations in blood from cynomologus macaques ( Macaca fascicularis ), rhesus macaques ( Macaca mulatta ), African green monkeys ( Chlorocebus aethiops ) and olive/yellow baboons (P apio hamadryas anubis × Papio hamadryas cynocephalus ), thereby generating a comprehensive cross-reactivity catalog that includes cell type-specificity. (biorxiv.org)
An advantage and disadvantage of monoclonal antibodies reside in their specificity. (forbes.com)
Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. (biosensis.com)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Based on antigen-binding assay, Western blotting, and/or ELISA, the antibody reacts with the light chains on sheep IgG and with those common to other sheep immunoglobulins. (jacksonimmuno.com)
Monoclonal antibodies against a glycoprotein presumably involved in adhesion of aggregating Dictyostelium discoideum cells have been used for labeling of the antigen at the cell surface. (uni-regensburg.de)
Another antigen strongly reacting with the same monoclonal antibodies has an apparent molecular weight of 106 000 and is not detectable before slugs are formed. (uni-regensburg.de)
Monoclonal antibodies can have monovalent affinity, binding only to the same epitope (the part of an antigen that is recognized by the antibody). (wikipedia.org)
These abnormal antibodies or paraproteins were used to study the structure of antibodies, but it was not yet possible to produce identical antibodies specific to a given antigen. (wikipedia.org)
Much of the work behind production of monoclonal antibodies is rooted in the production of hybridomas, which involves identifying antigen-specific plasma/plasmablast cells that produce antibodies specific to an antigen of interest and fusing these cells with myeloma cells. (wikipedia.org)
The antibodies secreted by the different clones are then assayed for their ability to bind to the antigen (with a test such as ELISA or antigen microarray assay) or immuno-dot blot. (wikipedia.org)
Monoclonal antibodies target the CD20 antigen expressed on the surface of pre-B and mature B-lymphocytes. (medscape.com)
Figure-1: Immunohistochemistry staining of prostate (paraffin-embedded sections) with anti-human Prostate-specific antigen (A67-B/E3). (abeomics.com)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (abeomics.com)
Dr. Fox explains this process: "We receive the antigen from the person who wishes to develop a monoclonal antibody. (labmanager.com)
Supernatant [fluid] is taken from the hybridomas, and the investigator screens for the monoclonal antibody of interest that will recognize a specific antigen and is appropriate for their application. (labmanager.com)
Scientists have screened neutralizing antibodies utilizing the virus receptor-binding area (RBD) as an antigen, indicating that RBD accommodates a number of conformational neutralizing epitopes, that are the primary structural domains for inducing neutralizing antibodies and T-cell immune responses. (bd-academy.org)
Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members related to the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family and are encoded by 10 genes in the human. (ucc.ie)
Antigen-specific, IgE-mediated MC activation was inhibited by nanoparticles co-displaying antigen and Siglec-8 ligands in vitro . (dailymedicalnews.org)
Recognizes a human melanoma-specific antigen present in melanocytic cells and junctional nevi. (enzolifesciences.com)

As positive control a polyclonal anti-C1q antibody was used and as negative control an isotype matched monoclonal antibody (Ref.1). (origene.com)

Neutralizing monoclonal antibodies (MAbs), particularly those having cross-clade neutralizing activity, play a critical role in immunoprotection against various influenza A virus (IAV) infections, particularly those caused by the highly pathogenic avian influenza H5N1 virus and any future unpredictable virus strains. (justia.com)
Neutralizing antibodies can provide a first line of defense against influenza pathogens and passive immunization with neutralizing MAbs can provide immediate effects to prevent the spread of influenza infection and mortality. (justia.com)
Disclosed herein are neutralizing monoclonal antibodies (MAbs) specific for the surface hemagglutinin (HA) protein of the influenza H5N1 strain. (justia.com)
Passive transfusion of specific monoclonal antibodies (mAbs) protected animals from ANDV challenge in the lethal Syrian hamster disease model ( 9 - 11 ). (cdc.gov)
Therapeutic monoclonal antibodies (mAbs), for example, have emerged as a promising treatment strategy. (labmanager.com)
mAbs are used to target and bind tumor cells expressing cancer-specific antigens and induce cell death. (labmanager.com)
MDV-1-encoded unique Meq protein is the major oncoprotein and the availability of Meq-specific monoclonal antibodies (mAbs) is crucial for revealing MDV pathogenesis/oncogenesis. (pirbright.ac.uk)
Our data presented here, using synthesized polypeptide immunization combined with cross IFA staining on CRISPR/Cas9 gene-edited viruses, has provided a new efficient approach for future generation of specific mAbs against viral proteins. (pirbright.ac.uk)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
On the newest podcast with Drug Target Review ( Episode 6 - mAbs and SARS-CoV-2 with Dr. Carter Mitchell & Dr. Sharath Madasu, Kemp Proteins ), Carter Mitchell, Chief Scientific Officer and Sharath Madasu, Manager of Protein Characterization of Kemp Proteins , discussed the role of monoclonal antibodies (mAbs) against COVID-19 and how the pandemic has shaped their discovery and development. (moleculardevices.com)
Monoclonal antibodies (mAbs) act on viruses through viral neutralization. (moleculardevices.com)
A latest Frontiers in Immunology journal research by College of North Carolina at Chapel Hill and Vanderbilt College researchers has created an in vitro system to find out potential therapeutics focusing on sensitized effector cells based mostly on human, allergen-specific, Immunoglobulin E (IgE) monoclonal antibodies (mAbs). (dailymedicalnews.org)
A novel in vitro system was designed to imitate the effector part of peanut allergy, utilizing naturally occurring peanut-specific human IgE monoclonal antibodies (mAbs) for sensitization of a longtime effector cell line. (dailymedicalnews.org)
Two novel human peanut-specific IgE mAbs had been generated utilizing human hybridoma methods, which had been used to sensitize rat basophilic leukemia (RBL) SX-38 cells expressing the human IgE receptor (FcϵRI). (dailymedicalnews.org)
These peanut-specific human IgE mAbs may very well be crosslinked instantly with clinically related meals allergen peanut, which reproducibly elicits allergic effector cell activation and degranulation. (dailymedicalnews.org)

In 1975, Georges Köhler and César Milstein succeeded in making fusions of myeloma cell lines with B cells to create hybridomas that could produce antibodies, specific to known antigens and that were immortalized. (wikipedia.org)
Previously, target-specific monovalent VLRB antibodies were isolated from sea lamprey larvae after immunization with model antigens. (usgs.gov)
It has been suggested that the O-side chains of the lipopolysaccharide (LPS) of serotype 0:3 strains of Yersinia enterocolitica vary quantitatively and qualitatively depending on whether they are cultured at 37 degrees C or 25 degrees C. It is uncertain whether this affects the expression of the serotype-specific antigens that are probably carried on the LPS. (aai.org)
Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
Antibodies are proteins that fight infection by attaching to antigens. (cancer.net)
Through the allergy effector part, mast cells are activated because of crosslinking between allergenic antigens and allergen-specific immunoglobulin (Ig)E, which binds to the IgE receptor (FcϵRI) on MCs. (dailymedicalnews.org)

This antibody reacts to lysine-acetylated proteins. (sigmaaldrich.com)
Monoclonal antibodies are lab-made proteins that work like the natural antibodies of the immune system. (ohsu.edu)
Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
Monoclonals can be used directly to bind to surface proteins on cancer cells to kill or inhibit their growth," explains Dr. Moran. (labmanager.com)
Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
They are based on natural antibodies - which are proteins that the body produces to defend itself against disease - but are created in the lab and mass-produced in factories. (iavi.org)
Antibodies are proteins produced by our immune system and are one of the main ways the body defends itself against diseases. (iavi.org)
This is also considered a type of targeted therapy , which is a cancer treatment using medication that targets a cancer's specific genes, proteins, or the tissue environment that helps the tumor grow and survive. (cancer.net)
The immune system makes proteins called antibodies to help fight infections. (cancercouncil.com.au)
In non-Hodgkin lymphoma, different monoclonal antibodies may be used for different proteins. (cancercouncil.com.au)

This Ring1B antibody was raised against the recombinant full-length mouse protein. (fishersci.com)

By Western blot, this antibody recognizes a 116 kDa protein which corresponds to PARP and the 85 kDa apoptosis-induced cleavage product of prICE and CPP32 from rat thymus extract. (thermofisher.com)
These antibodies have been directed at the Spike protein on the virus's exterior. (forbes.com)
This is a favored target, as studies show that greater than ninety percent of naturally-occurring antibodies that neutralize SARS-CoV-2 are directed against the Spike protein. (forbes.com)
They stick to specific targets, such as protein on the outside of a cancer cell. (ohsu.edu)
This monoclonal antibody immunoprecipitated a 39K major protein from detergent-solubilized 125I-labeled Yersinia preparation. (aai.org)
Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. (sigmaaldrich.com)
The antibody detects endogenous Collagen II protein. (biocheminfo.org)
Through mRNA administration, vaccines prompt your cells to produce a harmless version of the spike protein, thereby stimulating your immune system to produce antibodies to fight off the potential threat. (moleculardevices.com)
In this PhD dissertation, we aimed to assess the binding efficacy and function of monoclonal antibodies targeting the GAS M protein. (lu.se)
In the second paper we discovered a novel form of antibody binding whereby a monoclonal binds the GAS M protein in a bivalent dual-Fab cis mode. (lu.se)
Even so this antibody bound to a region of the M protein associated with non-opsonic antibodies we found that this Ab could enhance phagocytosis suggesting that this novel binding form can circumvent the M protein's anti-phagocytic properties. (lu.se)

Affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. (biocheminfo.org)

The antibody showed good affinity (Kd=0.33 µM) and sensitivity ( IC50 =17.9 ng/mL in ELISA ) with negligible cross-reactivity with common mycotoxins . (bvsalud.org)

Choose a good quality enzyme-linked anti-mouse IgG1 antibody for detection). (enzolifesciences.com)

Monoclonal antibodies are made in a laboratory to boost the body's natural antibodies or act as antibodies themselves. (cancer.net)
Monoclonal antibodies are manufactured versions of these natural antibodies. (cancercouncil.com.au)

The following product was used in this experiment: PARP1 Monoclonal Antibody (C-2-10) from Thermo Fisher Scientific, catalog # MA3-950, RRID AB_325523. (thermofisher.com)
The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)

The 80 kilodalton glycoprotein typical of aggregation competent cells has been purified by affinity chromatography on a monoclonal antibody column. (uni-regensburg.de)
By the 1970s, lymphocytes producing a single antibody were known, in the form of multiple myeloma - a cancer affecting B-cells. (wikipedia.org)
324 In 1973, Jerrold Schwaber described the production of monoclonal antibodies using human-mouse hybrid cells. (wikipedia.org)
Some monoclonal antibody treatments are designed to block signals that cancer cells use to grow. (ohsu.edu)
Cells that secrete antibodies can be made immortal by fusing them with tumor cells and cloning the hybrids. (scientificamerican.com)
In an early study, they fused mouse myeloma and spleen cells from an immunized donor to produce cell lines that secreted anti-sheep red blood cell antibodies. (labmanager.com)
Once there is sufficient antibody titer in the serum, the spleen is removed to create hybridomas by fusing spleen cells with a cell line. (labmanager.com)
They] can work by recruiting immune elements, delivering toxins, producing CAR-T cells, or as bispecific antibodies that recruit T or NK cells to kill the cancer cells. (labmanager.com)
Tositumomab is used in the treatment of some B-cell non-Hodgkin lymphomas and is an example of a monoclonal antibody used to deliver toxins, as some of the antibody delivers a linked radioactive substance to the B-cells. (labmanager.com)
Four of these hybridomas, namely 2A9, 5A7, 7F9 and 8G11, were further confirmed to secrete specific antibodies against Meq as confirmed by the IFA staining of 293T cells overexpressing Meq. (pirbright.ac.uk)
Confocal microscopic analysis of cells stained with these antibodies confirmed the nuclear localization of Meq in MDV-infected CEF cells and MDV-transformed MSB-1 cells. (pirbright.ac.uk)
They work by binding to their specific targets - for example viruses, bacteria or cancerous cells - and making them harmless. (iavi.org)
Most monoclonal antibodies are produced in Chinese hamster ovary cells which are typically grown in large bioreactors for around 10 to 15 days. (iavi.org)
Non-specific immunotherapies, also called non-specific immunomodulating agents, help your immune system destroy cancer cells. (cancer.net)
Targeted therapy drugs attack specific features of cancer cells to stop the cancer growing or to reduce its size. (cancercouncil.com.au)
After initial infection, all herpesviruses remain latent within specific host cells and may subsequently. (msdmanuals.com)

Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)

A Yersinia enterocolitica serotype 0:3 lipopolysaccharide-specific monoclonal antibody reacts more strongly with bacteria cultured at room temperature than those cultured at 37 degrees C. (aai.org)

1) Monoclonal antibodies directed against amyloid that are approved by FDA for the treatment of AD based upon evidence of efficacy from a change in a surrogate endpoint (e.g., amyloid reduction) considered as reasonably likely to predict clinical benefit may be covered in a randomized controlled trial conducted under an investigational new drug (IND) application. (cms.gov)
2) Monoclonal antibodies directed against amyloid that are approved by FDA for the treatment of AD based upon evidence of efficacy from a direct measure of clinical benefit may be covered in CMS approved prospective comparative studies. (cms.gov)
For instance, although most Emergency Use Authorized antibodies work on the Alpha and the Delta Variants, they exhibit a lower efficacy in the Omicron Variant. (moleculardevices.com)
Five years from now, if a new type of variant comes out, we might be able to use a monoclonal antibody raised against the wild type PLUS one that came out in 2023 as a combination therapy to have more efficacy against that particular variant. (moleculardevices.com)

Furthermore, these vaccines are limited to one or just a few strains and don't produce highly potent neutralizing antibodies or cross-reactive immunity against divergent influenza viruses. (justia.com)
And several antibodies that can act against different strains of HIV are also in development. (iavi.org)

Two experimental antibody therapies against Ebola are being used to great effect as part of an emergency access programme in the Democratic Republic of the Congo. (iavi.org)
Ebola monoclonal antibodies may interfere with immune response of live vaccines. (medscape.com)
Background: Experience from the Zaire Ebolavirus epidemic in the eastern Democratic Republic of the Congo (2018-2020) demonstrates that early initiation of essential critical care and administration of Zaire Ebolavirus specific monoclonal antibodies may be associated with improved outcomes among patients with Ebola virus disease (EVD). (bvsalud.org)
Ebola-specific monoclonal antibodies, were available 2 weeks after onset of the outbreak. (bvsalud.org)
All eight patients who received Ebola-specific monoclonal antibodies survived. (bvsalud.org)
Trained clinical teams can provide WHO-recommended optimised supportive care, including safe administration of Ebola-specific monoclonal antibodies. (bvsalud.org)
Contribution: This article describes clinical realities associated with implementation of WHO-recommended standards of 'optimized supportive care' and administration of Ebola virus specific treatments. (bvsalud.org)

ABSTRACT To estimate the seroprevalence of HCV infection among HIV-infected haemophiliacs and to demonstrate the most prevalent HCV genotype, 47 HIV-infected haemophilia patients were screened for anti-HCV antibodies. (who.int)

Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one monoclonal antibody to two epitopes. (wikipedia.org)

Monoclonal antibodies are a critical tool for immunologists, with applications including immunomicroscopy and cytometry, and non-human primates are essential models for drug development. (biorxiv.org)
instead, researchers typically use anti-human antibodies that are found to be cross-reactive with non-human primates. (biorxiv.org)
Monoclonal antibodies have successfully been raised to human glycoproteins. (ucl.ac.uk)
The antibody has been tested by ELISA to ensure minimal cross-reaction with bovine, horse, human, mouse, rabbit and rat immunoglobulins, but it may cross-react with immunoglobulins from other species. (jacksonimmuno.com)
Human G1/S-specific cyclin-D1 has a predicted length of 295 residues and MW of 34 kDa. (biosensis.com)
Remedy and prevention of those viral illnesses name for the analysis and improvement of human neutralizing monoclonal antibodies (NMAbs). (bd-academy.org)
First, scientists extract the relevant antibodies from human blood. (iavi.org)
To determine whether PSGs are expressed in tumors, we characterized 16 novel monoclonal antibodies to human PSG1 and used 2 that do not cross-react with CEACAMs to study PSG expression in tumors and in the gastrointestinal (GI) tract using tissue arrays and immunohistochemistry. (ucc.ie)
Examine: Novel peanut-specific human IgE monoclonal antibodies allow screens for inhibitors of the effector part in meals allergy. (dailymedicalnews.org)
A number of in vitro fashions of the allergy effector part have been developed based mostly on purified human IgE antibodies. (dailymedicalnews.org)
These fashions revealed that anti-human IgE antibodies at all times crosslinked IgE-FcεRI complexes on the MC and induced degranulation. (dailymedicalnews.org)
Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. (cdc.gov)

There are also 2 checkpoint inhibitors that are used to treat tumors anywhere in the body if they have specific genetic changes. (cancer.net)
For instance, pembrolizumab (Keytruda) is approved to treat any tumors that have spread to distant parts of the body if they have a specific molecular change called microsatellite instability-high (MSI-H) or DNA mismatch repair deficiency (dMMR). (cancer.net)
Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies. (ucc.ie)

Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)

Nonetheless, giant quantities of a single antibody are required for effectiveness when delivered by systemic administration (usually intravenous infusion) precluding the possible dosing of antibody mixtures through this route. (bd-academy.org)

In another embodiment, the neutralizing antibody is a monoclonal antibody such as a mouse antibody, a humanized antibody, a chimeric antibody, or a fragment thereof. (justia.com)
The monoclonal antibody JL-1 recognizes the collagen-like region (CLR) of mouse C1q. (origene.com)
The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q. (origene.com)
Product Description google Mouse anti-G1/S-specific cyclin D1 Monoclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded. (biosensis.com)
Once they are considered a therapeutic lead, these mouse antibodies must be humanized (by genetic engineering) unless they are made in a humanized mouse, which allows more rapid progress to a potential drug stage," explains Dr. Thomas Moran, a professor of microbiology at the Icahn School of Medicine at Mount Sinai and the director of the Center for Therapeutic Antibody Development. (labmanager.com)
Monoclonal antibodies specific for class i and class ii molecules controlled by the mouse h-2 complex. (jax.org)

The large 2018 ANDV outbreak in the Austral Patagonian region at Epuyén village (Chubut Province, Argentina) reemphasized the probability of person-to-person transmission, highlighting the urgent need for specific therapies and vaccines ( 5 ). (cdc.gov)

It stabilizes lysosomal membranes and suppresses lymphocytes and antibody production. (medscape.com)

In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different antibody-secreting plasma cell lineages. (wikipedia.org)

The monoclonal antibodies I have developed and characterised immunologically have been used, in association with the in-vitro bioassay, to neutralise or extract FSH bioactivity from serum samples and standards. (ucl.ac.uk)

We studied this question with a serotype 0:3-specific monoclonal antibody, 2C1. (aai.org)

Other monoclonal antibody therapies are used as checkpoint inhibitors, boosting immune defenses by blocking immune system checkpoints. (ohsu.edu)

This advance exploits the invention that airway supply is a stronger manner of administering anti-influenza antibodies in comparison with systemic supply, making this a possible and cost-effective therapeutic method. (bd-academy.org)

This underpinned the concept of monoclonal antibodies and monoclonal drug conjugates. (wikipedia.org)
The guaranteed shelf life from date of receipt for antibodies and conjugates is listed on the product information sheet. (biotium.com)
Antibodies and other conjugates often are functional for significantly longer than the guaranteed shelf life. (biotium.com)
For lyophilized antibodies, we recommend reconstituting the antibody with glycerol and antimicrobial preservative like sodium azide for the longest shelf life (note that sodium azide is not compatible with HRP-conjugates). (biotium.com)

In 2020, the administration of monoclonal antibodies was authorized by several countries for treating moderate symptoms of COVID-19. (wikipedia.org)

Dual-modular immunosensor for bongkrekic acid detection using specific monoclonal antibody. (bvsalud.org)
In this work , a monoclonal antibody specific to BA was first generated and a dual-modular immunosensor for on-site and laboratory detection was established. (bvsalud.org)
Monoclonal antibodies were used for detection of the. (lu.se)
Monoclonal antibodies were used for detection of the proteoglycans syndecan-1, -2 and -4, glypican, CD44 and perlecan. (lu.se)

The efficiency of airway-delivered anti-HA bnAbs had been extremely depending on anti-viral neutralization exercise with little dependence on the effector operate of the antibody. (bd-academy.org)
In distinction, effectiveness of systemically-delivered anti-HA bnAbs weren't depending on anti-viral neutralization, however critically depending on antibody effector capabilities. (bd-academy.org)
These mutations result in differential glycosylation, allowing the virus to evade previously-formed immunologic responses or monoclonal antibody neutralization. (moleculardevices.com)
which allow Omicron to be more infectious and transmissible than the Delta variant and resist neutralization by vaccine and infection induced antibodies. (cdc.gov)

The recently discovered broadly neutralizing monoclonal antibodies provide near-term hope effective for variant-independent prevention and treatment as we await the discovery of highly active antiviral drugs. (forbes.com)
Efficient and dependable anti-influenza remedies are acutely wanted and passive-immunizations utilizing broadly neutralizing anti-influenza monoclonal antibodies (bnAbs) are a promising rising method. (bd-academy.org)
As a result of influenza vaccination may be poorly efficient some years, and the immune system of probably the most prone populations are sometimes compromised, passive immunization remedies utilizing broadly- neutralizing antibodies is a promising therapeuti c method. (bd-academy.org)

While target-specific therapy is not available, non-target-specific treatments currently are used. (medscape.com)
For the past 30 years, monoclonal antibodies have transformed the way we treat various diseases - they proved to be more effective, better tolerated and easier to deliver than other treatments. (iavi.org)
Your doctor will review your specific type of cancer and past treatment history and other available treatments to determine if pembrolizumab is right for you. (medlineplus.gov)

By the 1990s research was making progress in using monoclonal antibodies therapeutically, and in 2018, James P. Allison and Tasuku Honjo received the Nobel Prize in Physiology or Medicine for their discovery of cancer therapy by inhibition of negative immune regulation, using monoclonal antibodies that prevent inhibitory linkages. (wikipedia.org)

Each clone is a long-term source of substantial quantities of a single highly specific antibody. (scientificamerican.com)

This antibody recognizes an epitope found between amino acids 216-375 in the DNA-binding domain of PARP. (thermofisher.com)

Rituximab is an anti-CD20 monoclonal antibody indicated for adults with pemphigus vulgaris in combination with short-term corticosteroid therapy. (medscape.com)

Monoclonal antibodies are being used on a clinical level for both the diagnosis and therapy of several diseases. (wikipedia.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
For example, the side effects of monoclonal antibodies used for targeted therapy are not like those used for immunotherapy. (cancer.net)
Some types of non-Hodgkin lymphoma are treated with a group of targeted therapy drugs called monoclonal antibodies. (cancercouncil.com.au)
Madasu further explains: "With the convalescent plasma therapy, A) you are expecting that the donor is still producing neutralizing antibodies, and B) Donor is producing sufficient amounts to be effective at all. (moleculardevices.com)

Western blotting: Positive material: seminal plasma, reducing conditions, recommended antibody dilution: 2-5 μg/ml. (abeomics.com)
Optimal dilution for a specific application should be determined. (biotium.com)

Recognition of malignant melanoma by monoclonal antibody HMB-45. (enzolifesciences.com)

Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin. (justia.com)
In one embodiment disclosed herein, a neutralizing antibody specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin is provided. (justia.com)
Also disclosed herein is a pharmaceutical formulation for neutralizing influenza virus comprising an antibody specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin. (justia.com)
Also disclosed herein is a method of treating influenza virus infection in a subject in need thereof comprising administering a therapeutically effective amount of the neutralizing antibody specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin and thereby treating said influenza virus infection in said subject. (justia.com)
Since each subset has a specific binding epitope, the mutations can quickly be recognized by one or a combination of mAb subsets. (moleculardevices.com)

The present application is drawn to neutralizing monoclonal antibodies for preventing and treating influenza virus infection and methods of treating influenza virus infection. (justia.com)
We found that the binding of antibodies from the blood of donors who had recently recovered from a severe GAS infection could greatly enhance this fibronectin binding. (lu.se)

Studies on HCV genotypes in people of HCV-specific antibodies and the latter with haemophilia have identified types 1, was used for molecular analysis. (who.int)

The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)

Our current knowledge of hFSH microheterogeneity and the assays available indicates the urgent need to select antibodies with specific binding to the biological active forms of the hormone. (ucl.ac.uk)
Functional assays (Ref.1): Antibody JL-1 was administered to mice resulting in depletion of circulating C1q, glomerular deposition of C1q and induction of anti-C1q autoantibodies in susceptible mice. (origene.com)

Monoclonal antibodies are one of the most powerful tools for treating viruses and other infectious diseases. (forbes.com)

They target specific surface structures and either eliminate the virus from the host bloodstream or destroy the infected cell in which it resides. (forbes.com)

In HCPS patients, high hantavirus-specific neutralizing antibodies correlate strongly with survival, milder disease outcomes, and faster recovery ( 7 , 8 ). (cdc.gov)

What are monoclonal antibodies and immune checkpoint inhibitors? (cancer.net)
Many checkpoint inhibitors are approved by the U.S. Food and Drug Administration (FDA) for specific cancers. (cancer.net)

A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. (wikipedia.org)
All subsequent antibodies derived this way trace back to a unique parent cell. (wikipedia.org)

When the immune system detects something harmful, it makes antibodies. (cancer.net)

Monoclonal antibodies specific for class i and class ii molecules cont" by S Tewarson, F Figueroa et al. (jax.org)
The molecules have specific functions during developmental processes as well as in diseases, such as cancer and inflammation. (lu.se)

Anatomy27

Organisms15

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Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes38

Disciplines and Occupations3

Technology, Industry, Agriculture1

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Antigen17

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MAbs17

Antigens6

Proteins10

Recombinant1

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Immunogen1

Reactivity1

IgG11

Natural antibodies2

Thermo Fisher Sci2

Cells16

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Reacts1

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Ebola7

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Therapies1

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Conjugates4

20201

Detection4

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Broadly3

Treatments3

Discovery1

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Recognizes1

CD201

Therapy5

Dilution2

Malignant1

Epitope5

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Molecular1

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Strongly1

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