• In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. (wikipedia.org)
  • Immunohistochemical analyses using an anti-Gau monoclonal antibody revealed strict co-localization of Gau proteins and a mitochondrial marker. (biomedcentral.com)
  • Fluorescent reporter proteins in the Drosophila model system offer a degree of specificity that allows monitoring cellular and biochemical phenomena in vivo, such as autophagy, mitophagy, and changes in the redox state of cells. (intechopen.com)
  • Rapid and comprehensive analysis of putative proteinous allergens ( allergenome ) by applying such a proteomic strategy … With allergenomics, we can not only detect and assign the putative allergens (proteins specifically interacting with IgE antibodies in a patient's blood) in a short time, but also analyze the quantitative and qualitative change of the antigens, depending on the surroundings and environmental conditions of an allergenic causative. (genomicglossaries.com)
  • A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
  • An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)
  • We used our platform based on retrovirus-derived enveloped virus-like particles (eVLPs) harnessed with variable surface proteins (VSPs) from the intestinal parasite Giardia lamblia, affording them resistance to degradation and the triggering of robust mucosal cellular and antibody immune responses after oral administration. (bvsalud.org)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
  • A monoclonal antibody specifically recognizing the 23.5-kd yeast YPT1 protein cross-reacted with a protein of identical size on protein blots of mouse, rat, pig, bovine and human cell lines. (embl.de)
  • The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. (joplink.net)
  • Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
  • Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
  • First identified in Drosophila, the conserved Polycomb group (Pc-G) protein complexes were shown to be both writers (Polycomb Repressive Complex 2, PRC2) and readers (Polycomb Repressive Complex 1, PRC1) of H3K27me3 [ 19 , 20 , 21 ]. (biomedcentral.com)
  • Polyclonal antibodies against PfRAMA are able to inhibit P. falciparum growth and interact synergistically when combined with antibodies against P. falciparum reticulocyte-binding protein 5 (PfRh5) or cysteine-rich protective antigen (PfCyRPA). (bvsalud.org)
  • We used the amyotrophic lateral sclerosis-associated protein TDP-43 as a primary model to investigate the effects of clusterin on protein aggregation and neurotoxicity in complementary in vitro, neuronal cell and Drosophila systems. (biomedcentral.com)
  • Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg hybridoma library. (tcd.ie)
  • The reference genome sequence of Saccharomyces cerevisiae: Then and now. (joplink.net)
  • Transposable elements (TEs) are major constituents of eukaryotic genomes and are important catalysts of evolution [1] , [2] . (prolekarniky.cz)
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
  • This provides a strong rational for applying blood-stage antigen components in a multivalent vaccine, as the induced antibodies in combination can enhance protection. (bvsalud.org)
  • Genome polyprotein Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
  • The complete sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt GTPases in this organism. (embl.de)
  • The cysteine engineered antibodies may be conjugated with chemotherapeutic drugs, toxins, affinity ligands such as biotin, and detection labels such as fluorophores. (justia.com)
  • In view to find putative mitochondrial genes in alternative reading frames on both coding and "presupposed" non-coding strands, numerous complete mtDNA genomes have been analyzed. (biomedcentral.com)
  • In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. (aacrjournals.org)
  • ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. (abcam.com)
  • The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
  • Here we present a panel of anti-CyRPA monoclonal antibodies that strongly inhibit parasite growth in in vitro assays. (bvsalud.org)
  • The pathogenesis of malaria is associated with blood-stage infection and there is strong evidence that antibodies specific to parasite blood-stage antigens can control parasitemia. (bvsalud.org)
  • Our results confirmed previous finding of synergy between PfRAMA-, PfRh5- and PfCyRPA-specific antibodies, thereby paving the way of testing these antigens (or fragments of these antigens) in combination to improve the efficacy of blood-stage malaria vaccines. (bvsalud.org)
  • We have investigated its subcellular localization in mammalian cells, Drosophila melanogaster and Arabidopsis thaliana and found that intracellular CREG resides in all these organisms within lysosomes or its functional equivalents. (boku.ac.at)
  • These subcellular organelles contain a genome that differs from the nuclear genome and is referred to as mitochondrial DNA (mtDNA). (biomedcentral.com)
  • Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm. (joplink.net)
  • This partitioning is conserved in different tissues and determines replication timing in Drosophila. (sdbonline.org)
  • Principles of modern biotechnology together with immunological knowledge for medical application, including antibody engineering, immunotherapy, gene therapy, vaccine and regenerative medicine. (chula.ac.th)
  • In a genome-wide survey for potential Notch pathway targets, the second intron of the numb gene was found to contain a statistically significant cluster of binding sites for Suppressor of Hairless, the transducing transcription factor for the pathway. (silverchair.com)
  • The PLU gene product controls DNA replication early in Drosophila development. (sdbonline.org)
  • We established genome-wide patterns of H3K27me3 and H3K9me3 modifications, and found these marks mutually exclusive within gene-rich regions but not within repeats. (biomedcentral.com)
  • Drosophila melanogaster presents a simpler model system in which to study FGF signaling, with only three ligands and two FGF receptors (FGFRs) identified. (biologists.com)
  • Here we analyze the specificity of FGFR [Heartless (Htl) and Breathless (Btl)]activation by each of the FGF ligands [Pyramus (Pyr), Thisbe (Ths) and Branchless (Bnl)] in Drosophila . (biologists.com)
  • Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. (bvsalud.org)
  • Immunogens which elicit such synergistic antibody mixtures could increase the potency of vaccine-elicited responses to provide robust and long-lived immunity against challenging disease targets. (bvsalud.org)
  • The frizzled (fz) locus of Drosophila coordinates the cytoskeletons of epidermal cells, producing a parallel array of cuticular hairs and bristles. (wikipedia.org)
  • During Drosophila sensory bristle development, precursor cells segregate Numb asymmetrically to one of their progeny cells, rendering it unresponsive to reciprocal Notch signaling between the two daughters. (silverchair.com)
  • Actin antibody: The specific visualization of actin filaments in non-muscle cells. (cshlpress.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
  • The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
  • By analysing tum/RacGAP50C mutant Drosophila embryos we show that cells lacking Tum do not form furrows and fail to localise the key cytokinetic components Pebble (a RhoGEF), Aurora B kinase, Diaphanous, Pav-KLP and Anillin. (biologists.com)
  • These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)
  • We also showed that in Drosophila photoreceptor cells, clusterin co-expression gave ER stress-dependent protection against proteotoxicity arising from both Huntingtin-Q128 and mutant (R406W) human tau. (biomedcentral.com)
  • This modification is associated with genome stability by preventing either expression of transposable elements or mitotic recombination. (biomedcentral.com)
  • The following is a list of the ten known human frizzled receptors: Frizzled-1 (FZD1) Frizzled-2 (FZD2) Frizzled-3 (FZD3) Frizzled-4 (FZD4) Frizzled-5 (FZD5) Frizzled-6 (FZD6) Frizzled-7 (FZD7) Frizzled-8 (FZD8) Frizzled-9 (FZD9) Frizzled-10 (FZD10) Vantictumab is a monoclonal antibody against five frizzled receptors that is under development for the treatment of cancer. (wikipedia.org)
  • These antibodies bind to neighbouring epitopes on CyRPA and form lateral, heterotypic interactions which slow antibody dissociation. (bvsalud.org)
  • The results emphasize the importance of directing antibody responses towards protective epitopes, as the majority of anti-PfRAMA mAbs were unable to inhibit merozoite invasion of erythrocytes. (bvsalud.org)
  • In vertebrates, several stop codons have been found in the mt gau region, and potentially functional gau regions have been found in nuclear genomes. (biomedcentral.com)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
  • We demonstrate that the Drosophila FGFs have different activities and that cell migration and differentiation have different ligand requirements. (biologists.com)
  • Using a Gem-specific antibody, we show that the bulk of Gem/Ca v 1.3a immunoreactivity in HCs is restricted to basally located focal spots. (jneurosci.org)
  • The invention relates generally to antibodies engineered with reactive cysteine residues and more specifically to antibodies with therapeutic or diagnostic applications. (justia.com)
  • Enteroviruses (EVs) belong to the Picornaviridae family, and their genomes are made up of single-stranded, positive-sense RNA. (tuni.fi)
  • Histones are subjected to a variety of post-translational covalent modifications [ 1 ] that may impact the overall degree of packing of the genome. (biomedcentral.com)
  • Methods of design, preparation, screening, and selection of the cysteine engineered anti-MUC16 antibodies are provided. (justia.com)
  • Thorpe, (1985) "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review," in Monoclonal Antibodies '84: Biological And Clinical Applications, A. Pinchera et al (ed.s), pp. 475-506). (justia.com)
  • CusabioSTK16 Antibody is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send quotation to [email protected]. (joplink.net)
  • We further showed that the expression of TDP-43 in transgenic Drosophila neurons induced ER stress and that co-expression of clusterin resulted in a dramatic clearance of mislocalized TDP-43 from motor neuron axons, partially rescued locomotor activity and significantly extended lifespan. (biomedcentral.com)