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  • applications
  • 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. (kobo.com)
  • binds
  • Canevari S., Fossati G., Balsari A., Sonnino S., Colnaghi M.I.: Immunochemical analysis of the determinant recognized by a monoclonal antibody (MBr1) which specifically binds to human mammary epithelial cells. (springer.com)
  • Our working hypothesis was that a highly specific norovirus antibody that binds to the outer surface of the virus particle might prevent the ability of the virus to infect susceptible host cells. (asm.org)
  • We evaluated MEDI8852, a human IgG1 monoclonal antibody that binds a highly conserved influenza A hemagglutinin stalk epitope, in outpatients with uncomplicated influenza A infection. (asm.org)
  • Important insights from the production and selection of the new antibody include a close fix on where the antibody binds to West Nile virus. (rxpgnews.com)
  • In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject. (google.ca)
  • Mouse monoclonal antibody that binds to domain III of the envelope glycoprotein of dengue virus type 1 was purified from hybridoma supernatant by protein G affinity chromatography. (atcc.org)
  • Tumors
  • After cloning by limiting dilution, three hybridoma lines secreting antiestrophilin were expanded in suspension culture and as ascites tumors in athymic mice to provide substantial quantities of monoclonal antibodies that recognize mammalian but not avian estrophilin and that show different degrees of reactivity with receptor from nonprimate sources. (pnas.org)
  • antigens
  • Horan-Hand P., Nuti M., Colcher D., Schlom J.: Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor associated antigens. (springer.com)
  • However, while one cell line of the splenic stromal cells has been established (CF-1 cells) and its cytological characteristics have been studied, specific antibodies that recognize the surface antigens of these cells have never been prepared, nor have their characteristics been elucidated yet in any way. (google.com)
  • In a previous study, we showed that antigens secreted by S. schenckii induced a specific humoral response in infected animals, primarily against a 70-kDa molecule, indicating a possible role of specific antibodies against this molecule in infection control. (frontiersin.org)
  • reagents
  • Monoclonal reagents with selected specificities are therefore available in increasing number, and their potential for applications in the diagnosis and characterization of breast cancer is under investigation. (springer.com)
  • human
  • Colcher D., Horan Hand P., Nuti M., Schlom J.: A spectrum of monoclonal antibodies reactive with human mammary tumor cells. (springer.com)
  • Schlom J., Wunderlich D., Teramoto Y.A.: Generation of human monoclonal antibodies reactive with human mammary carcinoma cells. (springer.com)
  • Taylor-Papadimitriou J., Peterson J.A., Arklie J., Burchell J., Ceriani R.L., Bodmer W.F.: Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. (springer.com)
  • Mènard S., Tagliabue E., Canevari S., Fossati G., Colnaghi M.I.: Generation of monoclonal antibodies reacting with normal and cancer cells of human breast. (springer.com)
  • Accordingly, they are useful as antibodies that recognize human Integrin. (google.com)
  • Serum from a Lewis rat immunized with this partially purified estradiol-receptor complex contained antiestrophilin antibodies that reacted not only with nuclear and extranuclear estradiol-receptor complexes from MCF-7 cells but also with estrophilin from rat, calf, and monkey uterus, hen oviduct, and human breast cancers. (pnas.org)
  • These monoclonal antibodies should prove useful in the study of estrogen receptors of human reproductive tissues, in particular for the radioimmunochemical assay and immunocytochemical localization of receptors in breast cancers. (pnas.org)
  • But he and his colleagues are excited both by the apparent potency of the antibody and its potential to help them explore new possibilities for treating related viruses that are more prolific causes of human disease and death. (rxpgnews.com)
  • The human immune system would clear out these foreign antibodies quickly, so when they had identified a potent antibody, scientists at Macrogenics clipped out the genetic material that controls the antibody's targeting and cloned it into a human antibody. (rxpgnews.com)
  • The "humanized" antibody should be less likely to induce an adverse human immune system response. (rxpgnews.com)
  • Neuberger MS, Williams GT, Mitchell EB, Jouhal SS, Flanagan JG, Rabbitts TH (1985) A hapten-specific chimaeric IgE antibody with human physiological effector function. (springer.com)
  • Lonberg N, Huszar D (1995) Human antibodies from transgenic mice. (springer.com)
  • myeloma cells
  • The key idea was to use a line of myeloma cells that had lost their ability to secrete antibodies, come up with a technique to fuse these cells with healthy antibody producing B-cells and be able to select for the successfully fused cells. (mdanderson.org)
  • Here, B lymphocytes that produce the desired antibody (and that could stem from a population that produced polylonal antibodies ), are fusioned with myeloma cells and consecutively cultivated. (doccheck.com)
  • bind
  • all the non-neutralizing antibodies that bind this domain adhere to different areas. (rxpgnews.com)
  • Some antibodies can bind to an invader but do so in a way that fails to slow the invader down or trigger a response from macrophages. (rxpgnews.com)
  • potent
  • In a placebo-controlled, randomized study, the monoclonal antibody PRO 140 had a prolonged, potent, and dose-dependent antiviral effect, Jeffrey Jacobson, M.D., of Drexel University in Philadelphia, reported at the Interscience Conference on Anti-microbial Agents and Chemotherapy here. (medpagetoday.com)
  • Cite
  • Publications should cite the Core grant in the acknowledgment section, if publications use antibodies or data generated by the Core facility. (mdanderson.org)
  • lymphocytes
  • When such a procedure starts, It trigger the N lymphocytes to reproduce it self style a clone that manufactures a huge quantity of its antibody. (dailystrength.org)
  • CHICAGO, Sept. 19 -- An antibody that blocks HIV entry to its target T-lymphocytes was found to be well tolerated and effective in the first study to test its activity in humans. (medpagetoday.com)
  • infection
  • They successfully tested two of the antibodies against norovirus infection in chimpanzees. (asm.org)
  • In a strain of mice that normally only has about a 10 percent survival rate after West Nile infection, scientists found that single doses of the antibodies given soon after infection could boost survival rates to 90 percent or higher. (rxpgnews.com)
  • We could give a single dose of this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them," says Diamond. (rxpgnews.com)
  • Unlike the West Nile virus antibody, though, the RSV antibody has to be given prior to infection. (rxpgnews.com)
  • In one rare case that involves the dengue fever virus, antibodies can adhere to the virus in a way that accelerates the infection. (rxpgnews.com)
  • patents
  • The Federal Circuit opinion - applauded by some, and criticized by others - is the most important development in patent law, as far as monoclonal antibody patents are concerned, in many years. (fenwick.com)
  • What about all the monoclonal antibody patents that have been issued over the years under the USPTO's 'antibody exception' and therefore could, in theory, lack written description support? (fenwick.com)
  • These processes can be protected by trade secret or patent, and, in either instance, may sometimes require licensing of antibody-engineering patents from others. (fenwick.com)
  • humans
  • The creation of a monoclonal antibody, on the other hand, especially one that will be used in humans, is never as straightforward. (fenwick.com)
  • Diamond points out that Macrogenics Inc., of Rockville, Md., a company that contributed to the study and licensed the antibody from Washington University, must complete other preliminary studies before the antibody can be tested in humans. (rxpgnews.com)
  • substance
  • Antibodies typically work by attaching to a piece of a foreign cell or substance, which causes immune system cells known as macrophages to pick up the substance and clear it from the body. (rxpgnews.com)
  • possible
  • In this article we will give an overview of monoclonal antibody patenting, briefly review the Janssen case, discuss the 'antibody exception,' and then provide some possible strategic directions for antibody patenting going forward, focusing on the critical issue of the interplay between the post-Janssen antibody exception and the recently enacted America Invents Act. (fenwick.com)
  • form
  • Focus groups captured participant understandings (in narrative form) of plant-produced monoclonal antibodies, how they come about, how they are manufactured, how they differ from other anti-HIV actives, etc. (clinicaltrials.gov)
  • clone
  • By growing the clone from Sp2/0 in the presence of [35S]methionine, radiolabeled monoclonal IgG has been prepared. (pnas.org)
  • treatment
  • If further studies confirm the effectiveness and safety of the antibody, it could become one of the first monoclonal antibodies used as a treatment for an infectious disease. (rxpgnews.com)
  • An antibody against respiratory syncytial virus (RSV) is approved for use as a prophylactic treatment in children at risk of the disease in hospitals. (rxpgnews.com)