• Monkey Brain 'Hardwired' for Simple Math ( Rhesus macaques have neurons dedicate. (bio-medicine.org)
  • A German team of neurobiologists has found that rhesus macaques can en. (bio-medicine.org)
  • To assess primate math skills and isolate the neurology behind them, the team trained two rhesus monkeys to assess when groups of various objects, such as dots, were either "greater than" or "less than" another grouping of the same object. (bio-medicine.org)
  • Rhesus monkey model for AIDS used to establish the effectiveness of early administration of AZT in cases of diagnosed infection. (wisc.edu)
  • Rhesus and cynomolgus monkey kidneys developed for use in diagnosing influenza. (wisc.edu)
  • Rhesus monkeys are prime model for development of HIV treatments and potential vaccines. (wisc.edu)
  • The three rhesus monkeys used in the study at the Wisconsin National Primate Research Center had a lesion in a brain region that causes the movement disorder Parkinson's disease, which afflicts up to 1 million Americans. (redorbit.com)
  • Discovering that dysfunction of PGC-1a-dependent metabolic pathways contributes to skeletal muscle aging (sarcopenia) in rhesus monkeys. (wisc.edu)
  • Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. (wisc.edu)
  • Sex differences in rhesus monkeys' digit ratio (2D:4D Ratio) and its association with maternal social dominance rank. (ucdavis.edu)
  • Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease. (ucdavis.edu)
  • Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline. (ucdavis.edu)
  • Here, a global metabolomics approach was used to find and identify metabolites differentially regulated in the cerebrospinal fluid (CSF) of rhesus macaques with SIV-induced CNS disease, as we hypothesized that this might provide biomarkers of virus-induced CNS damage. (jci.org)
  • Sixteen rhesus monkeys were lethally infected with MARV or RAVV and treated with NP siRNA-LNP, with MARV-infected animals beginning treatment four or five days after infection and RAVV-infected animals starting treatment three or six days after infection. (jci.org)
  • By sequencing greater than 100 rhesus monkeys from various research colonies we have discovered functionally significant genetic variation that can be used to examine the effects of specific genes on various disease-related phenotypes. (bcm.edu)
  • In one study, we are analyzing the genetics of individual variation among juvenile rhesus monkeys in response to a standardized test procedure, examining genetic effects on behavioral reactivity, brain metabolic activity measured by FDG-PET imaging and structural variation in neural circuits measured by DTI imaging. (bcm.edu)
  • The new study, which was undertaken at the Yerkes National Primate Research Center of Emory University in Georgia, looked at female rhesus monkeys. (healthizmo.com)
  • Marburg virus (MARV) causes Marburg virus disease in humans and nonhuman primates , a form of viral hemorrhagic fever . (wikipedia.org)
  • MARV is one of two Marburg viruses that causes Marburg virus disease (MVD) in humans (in the literature also often referred to as Marburg hemorrhagic fever, MHF). (wikipedia.org)
  • Adenoviruses commonly infect humans, causing colds, flu-like symptoms and sometimes even death, but now UC San Francisco researchers have discovered that a new species of adenovirus can spread from primate to primate, and potentially from monkey to human. (healthcanal.com)
  • Adenoviruses to date have not generally been linked to cross-species infections between monkeys and humans," Chiu said. (healthcanal.com)
  • From 1960 to 2013, 159 cases of rabies infections in humans have been documented as a result of monkey bites. (wikipedia.org)
  • Monkeys and humans share many reproductive and developmental features that emphasize their importance as translational models. (ucdavis.edu)
  • The Gillespie lab is one of the few investigating the ecology and epidemiology of infectious disease in natural systems where domesticated animals, humans and wildlife overlap. (blogspot.co.il)
  • These species are widely used as animal models of disease because they are so similar genetically and physiologically to humans. (bcm.edu)
  • Remote viewing of infant primates is available through UW video monitoring, where investigators can watch the wasting agony, dementia, and death of infant Macaque monkeys infected with a Simian virus that has no application to humans. (wordpress.com)
  • Like humans, animals console each other in times of distress: monkeys hug and kiss, and prairie voles groom each other. (emoryhealthsciblog.com)
  • We discuss how neurophysiological recordings in macaque monkeys and in humans can help us understand the computations performed by visual cortex. (jci.org)
  • Another risk factor is contact with nonhuman primates, although only one outbreak of MVD (in 1967) was due to contact with infected monkeys. (wikipedia.org)
  • Last year, Duke University researchers working with macaque monkeys found that the primates are capable of basic math despite their lack of language skills. (bio-medicine.org)
  • So while the idea that monkeys can perhaps specifically engage in abstract mathematical reasoning is, I believe, something new, there have been many previous experiments that have shown that primates do engage in abstractions," he added. (bio-medicine.org)
  • The research is the first to observe the connection between plant-based estrogenic compounds, or phytoestrogens, and behavior in wild primates - in this case, a group of red colobus monkeys in Uganda. (healthcanal.com)
  • For 11 months, the researchers followed a group of red colobus monkeys in Uganda's Kibale National Park and recorded what the primates ate. (healthcanal.com)
  • Our investigator saw injured and sick monkeys who were deprived of veterinary care and primates who were slammed into their cages and sprayed with pressurized hoses. (peta.org)
  • In addition, PETA is actively campaigning to end the shipment of monkeys to Covance-one of the U.S.' largest importers of primates for use in experiments-and other cruel facilities. (peta.org)
  • You can help us stop the flow of monkeys to Covance and other laboratories by contacting the few remaining airlines that still ship primates to laboratories and urging them to end this cruel practice. (peta.org)
  • Most primates live in regions with high levels of human poverty and inequality, which contributes to the decline of the animals, says Thomas Gillespie, an Emory expert in the disease ecology of primates. (blogspot.co.il)
  • We are at a turning point where we must take action or lose many species during the next 50 years," says co-author Thomas Gillespie, an associate professor in Emory University's Department of Environmental Sciences and an expert in the disease ecology of primates. (blogspot.co.il)
  • Here, we assessed the therapeutic efficacy of lipid nanoparticle (LNP) delivery of a single nucleoprotein-targeting (NP-targeting) siRNA in nonhuman primates at advanced stages of MARV or RAVV disease to mimic cases in which patients begin treatment for fulminant disease. (jci.org)
  • For studies of neurobiology and behavior, infectious diseases, metabolic diseases and other common health problems, nonhuman primates provide unique and valuable experimental models. (bcm.edu)
  • The SAEN investigation uncovered nine primate escapes including one where two escaping primates fought and injured each other requiring euthanasia for one of the monkeys. (wordpress.com)
  • Approximately sixty thousand monkeys and apes are used each year in the U.S. The U.S. is the world's top consumer of primates. (wordpress.com)
  • Monkeys in the less social group had significantly less vasopressin in their cerebrospinal fluid than nonhuman primates in the more social group. (nprc.org)
  • Doses of Doxycycline are injected into the skulls of Macaque monkeys to see if the antibiotic can penetrate the blood/brain barrier of a primate's brain. (all-creatures.org)
  • Simian herpes B virus is endemic in some species of Asian monkeys. (wikipedia.org)
  • The spectacular success of CMV vectors in protecting monkeys against highly virulent Simian immunodeficiency virus (SIV) has put CMV-vectored vaccines at the forefront of AIDS vaccine development. (ohsu.edu)
  • In a new study , which appears July 24 in the online journal PLOS One , UCSF scientists exposed three marmoset monkeys to the same virus. (healthcanal.com)
  • Marmoset monkeys are the PD vivisectors' victims of choice. (all-creatures.org)
  • Marmoset monkeys are over-dosed with MPTP, a neurotoxin, and injected with the street drug Ecstasy until they develop PD symptoms. (all-creatures.org)
  • Marmoset monkeys are injected with much higher doses of a toxic drug mixture in order to induce uncontrolled movements, psychotic behavior and hallucinations. (all-creatures.org)
  • Energy and Metabolic Disease Group members view a marmoset MRI at the Wisconsin Institutes for Medical Research, as part of a study exploring links between energy metabolism and neural function. (wisc.edu)
  • Researchers have found a nifty new use for Google -- the popular search tool may be able to track the spread of the deadly bacterial disease, MRSA (methicillin-resistant Staphylococcus aureus). (the-scientist.com)
  • UCSF researchers previously identified a new adenovirus in New World titi monkeys that killed most of the monkeys infected during an outbreak in a closed monkey colony in California in 2009. (healthcanal.com)
  • EMCD researchers benefit from the WNPRC's well-characterized aged monkey colony, which serves as a resource for many biological, behavioral, social, and clinical studies on the processes, conditions, and characteristics relevant to aging and diseases of aging. (wisc.edu)
  • Core WNPRC staff associated with the EMCD Working Group are fully integrated into a new campus-wide program known as the Morgridge Institute Metabolism Initiative, which harnesses the expanding interest among campus researchers in the role of metabolism in disease. (wisc.edu)
  • To sift out characteristics that best indicate whether the monkeys were conscious or unconscious, the researchers used machine learning. (nprc.org)
  • The federal government pays to maintain primate breeding colonies at a number of the PRCs to provide many federally funded researchers and labs with a steady supply of monkeys. (wordpress.com)
  • First animal model for research on Parkinson's disease, enabling doctors to more accurately research human Parkinson's disease. (wisc.edu)
  • Gene that boosts dopamine production and strengthens brain cells used to successfully treat monkeys showing symptoms of Parkinson's Disease, a neurodegenerative disorder. (wisc.edu)
  • Parkinson's Disease (PD) is caused by degeneration of a specific part of the brain found in the basal ganglia and is the 14th leading killer in the United States. (all-creatures.org)
  • I'm gratified that the Parkinson's Disease Foundation took a risk as the primary funder for this small study. (redorbit.com)
  • A robot's gentle nudge could add just the right amount of force to improve walking for patients with mobility-impairing ailments such as Parkinson's disease, multiple sclerosis, and stroke. (the-scientist.com)
  • Dr. P Set from different Cynomolgus monkey normal tissues are available. (bio-medicine.org)
  • We administered a HFD rich in saturated fats and cholesterol to nonpathogenic (African green monkeys) and pathogenic (pigtailed macaques) SIV hosts. (jci.org)
  • Intravenous Ig (IVIg), plasma exchange, and immunoadsorption are frequently used in the management of severe autoimmune diseases mediated by pathogenic IgG autoantibodies. (jci.org)
  • Here, we address the hypothesis that production of IFN-γ is a key pathogenic mechanism of disease using a mouse model of rotavirus-induced biliary atresia. (jci.org)
  • The results conclusively demonstrate that the new virus is capable of infecting and causing disease across primate species, according to Charles Chiu , MD, PhD, director of the UCSF-Abbott Viral Diagnostics and Discovery Center, and the lead scientist of the new study. (healthcanal.com)
  • Wild primate species help characterize emerging infectious diseases. (wisc.edu)
  • In addition, it's unclear whether she has fallen ill with the disease that the monkeys contracted, but does have symptoms that are associated with it since spread of the disease is possible between species, but very rare. (wdsu.com)
  • The HFD had a negative impact on SIV disease progression in both species. (jci.org)
  • [1] MVD is a viral hemorrhagic fever (VHF), and the clinical symptoms are indistinguishable from Ebola virus disease (EVD). (wikipedia.org)
  • The most detailed study on the frequency, onset, and duration of MVD clinical signs and symptoms was performed during the 1998-2000 mixed MARV/RAVV disease outbreak. (wikipedia.org)
  • The disease can cause bleeding (haemorrhage), fever and other symptoms much like Ebola. (wikipedia.org)
  • The monkeys are confined to their cages alone where they suffer extreme pain while their movements and symptoms are recorded. (all-creatures.org)
  • And their studies demonstrated that CID2950007 blocked Hantavirus infection in monkey kidney cells. (redorbit.com)
  • both of these diseases are also associated with systemic inflammation, similar to HIV infection. (jci.org)
  • Microglia are not only vital cells in maintaining CNS homeostasis, but also respond to injury, infection, and disease by undergoing proliferation and changes in transcription and morphology. (jci.org)
  • More than 1,600 of them were different in lower-ranking than higher-ranking monkeys, particularly in a type of white blood cell, natural killer cells, which is the first line of defense against an infection. (healthizmo.com)
  • Blood tests show she was possibly exposed to a bacteria that causes an infectious disease known as Whitmore's Disease. (wdsu.com)
  • The dMAb approach provides an important local delivery platform for the in vivo generation of HIV-1 bNAbs and for other infectious disease antibodies. (jci.org)
  • If you help a local human population become healthier, you also reduce the potential for infectious disease in the surrounding wildlife," Gillespie says. (blogspot.co.il)
  • Scientists favor this virus as a vaccine because it triggered high levels of West Nile antibodies and did not produce measurable levels of virus in monkeys. (bio-medicine.org)
  • Core Scientists mentor the next generation of investigators in the use of nonhuman primate models for human health and disease, and serve as collaborative hubs and in the formation of multidisciplinary partnerships and teams. (ucdavis.edu)
  • The scientists put 45 unrelated monkeys that had never met into new social groups, and watched how the monkeys treated each other to see who did the bullying and who cowered. (healthizmo.com)
  • Marburg virus disease (MVD) is the official name listed in the World Health Organization 's International Statistical Classification of Diseases and Related Health Problems 10 (ICD-10) for the human disease caused by any of the two marburgviruses Marburg virus (MARV) and Ravn virus (RAVV). (wikipedia.org)
  • Both disease names are derived from the German city Marburg , where MARV was first discovered. (wikipedia.org)
  • Two different marburgviruses, MARV and Ravn virus (RAVV), cocirculated and caused disease. (wikipedia.org)
  • Once reprogrammed, a patient's own cells could potentially be used to treat conditions such as peripheral artery disease, or to form vascular grafts. (emoryhealthsciblog.com)
  • Subsequent work by our group and others has unveiled complex associations between ROS generation and vascular disease. (jci.org)
  • The second major line of research in my laboratory is the genetic analysis of nonhuman primate neurobiology and primate models of risk for psychiatric disease. (bcm.edu)
  • PETA's investigation revealed that workers at Covance were striking, choking, and screaming curses at confused and terrified monkeys. (peta.org)
  • Contract labs such as Bioqual and Covance also maintain large populations of monkeys and are among the primary consumers of the twenty or so thousand monkeys imported into the U.S. each year for research purposes. (wordpress.com)
  • Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other autoimmune diseases. (jci.org)
  • These results warrant further evaluation of this therapeutic approach in IgG-driven autoimmune diseases. (jci.org)
  • A virus cocktail is injected into the monkeys' brains forcing them to live with brain damage and unspeakable pain until they are killed by the vivisectors. (all-creatures.org)
  • My laboratory is working on various aspects of primate genomics, including both basic comparative analyses and targeted research using primate models of human disease, with special emphasis on the genetics of brain function and risk factors for psychiatric disorders. (bcm.edu)
  • Inflammation in the brain is a feature of several neurological diseases, ranging from Parkinson's and Alzheimer's to epilepsy. (emoryhealthsciblog.com)
  • In the PNAS paper, Varvel and his colleagues include a cautionary note about using these mice for studying situations of more prolonged brain inflammation, such as neurodegenerative diseases: the monocytes may turn down production of the red protein over time, so it's hard to tell if they're still in the brain after several days. (emoryhealthsciblog.com)
  • As Kevin Costa, Novoheart's Chief Scientific Officer said in an interview, "We're exceptionally good at curing heart disease and cancer in mice and rats, but a lot of those same therapies are not effective, and even toxic, when delivered to patients. (all-creatures.org)
  • Yet despite this profound difference in underlying physiology, scores of mice and other animals, including monkeys, dogs, cats, sheep, rabbits, and rats are being dismembered and used in unconscionable ways in the pursuit of studying human heart disease. (all-creatures.org)
  • It is also done on rats, sheep, and monkeys. (all-creatures.org)
  • genetic and rare diseases. (bio-medicine.org)
  • Ischemic stroke and coronary heart disease (CHD) may share genetic factors contributing to a common etiology. (bcm.edu)
  • Prevention also includes the surveillance for the presence of rabies within monkey populations. (wikipedia.org)
  • In addition to habitat loss and poaching, disease is a major threat to many primate populations, and is often intertwined with the other two issues, Gillespie says. (blogspot.co.il)
  • A study of monkeys was undertaken after previous studies suggest that social status could affect the way genes switch on and off within immune cells. (healthizmo.com)
  • The immune cells were then taken from the monkeys and measured the activity of around 9,000 genes. (healthizmo.com)
  • For instance, other rare animals - such as jaguars, leopards and harpy eagles - include monkeys in their diets. (blogspot.co.il)
  • Nonetheless, previous research in laboratory and agricultural settings found that eating estrogenic plants could disrupt fertility and affect behavior in animals such as rodents, monkeys and sheep. (healthcanal.com)
  • At the time, a research scientist who worked closely with the monkeys and a family member, both of whom were found to have antibodies to the virus, also became ill. (healthcanal.com)
  • Currently, transmission of the virus through a monkey bite almost always is the result of an occupational exposure by biomedical research workers. (wikipedia.org)
  • Research is lacking in the assessment of the impact of monkey bites. (wikipedia.org)
  • Monkey model developed for diabetes research. (wisc.edu)
  • Human pluripotent stem cell discoveries based on research in monkeys makes dramatic advances, moves into clinical trials. (wisc.edu)
  • A woman is being monitored after possibly being exposed to a bacteria that was found and resulted in the death of a monkey at the Tulane National Primate Research Center. (wdsu.com)
  • During the news conference, health officials said that a woman is being monitored after becoming ill while investigating the death of a monkey at the Tulane research center in Covington. (wdsu.com)
  • According to GOHSEP, the investigation began in November when two monkeys became ill at the Tulane research center. (wdsu.com)
  • Substantial preclinical and clinical research into chronic graft-versus-host disease (cGVHD) has come to fruition in the last five years, generating a clear understanding of a complex cytokine-driven cellular network. (jci.org)
  • The result is high quality genomic information that facilitates both disease-related research and analyses of genome evolution. (bcm.edu)
  • Yuri Saalmann, a University of Wisconsin-Madison psychology and neuroscience professor, and his research team recorded electrical activity in about 1,000 neurons surrounding each of 100 sites throughout the brains of a pair of monkeys at the Wisconsin National Primate Research Center (WiNPRC). (nprc.org)
  • Dramatic advances in the field of stem cell research have raised the possibility of using these cells to treat a variety of diseases. (jci.org)
  • While all untreated animals succumbed to disease, NP siRNA-LNP treatment conferred 100% survival of RAVV-infected macaques, even when treatment began just 1 day prior to the death of the control animals. (jci.org)
  • Not only is the UW unable to keep the monkeys in the cages, they are unable to prevent serious injuries during the escapes, some of which required euthanasia. (wordpress.com)
  • Contrary to Ebola virus disease (EVD) , which has been associated with heavy rains after long periods of dry weather, [18] [21] triggering factors for spillover of marburgviruses into the human population have not yet been described. (wikipedia.org)
  • This is far from a complete list but furnishes a window into the terrible suffering and extraordinarily high cost to animal life extracted by attempting to replicate human heart disease. (all-creatures.org)
  • This differs greatly from the complex and progressive development of human cardiovascular disease. (all-creatures.org)
  • Nonetheless, the new study represents a real step forward that may benefit human patients suffering from several diseases, says Emborg. (redorbit.com)
  • But just picture one animal-one monkey or one rabbit-writhing in pain after being purposely infected with a disease or dosed with chemicals, covered with gaping wounds or burns, starving and thirsty, aching with loneliness and longing to be free from invasive experiments, and overcome with terror any time a human walks past the cage that they're locked inside. (peta.org)
  • Primate Aging Database, Linking Animal Models to Human Disease Initiative and Primate Portal). (wisc.edu)
  • It was first identified by an investigator was bitten by what appeared to be a healthy monkey. (wikipedia.org)
  • Our investigator documented unthinkable abuse and miserable conditions for the hundreds of monkeys who were unfortunate enough to be imprisoned in this facility. (peta.org)
  • Neider and his team found that the monkeys were able to successfully execute the "greater than" and "less than" rules -- and switch back and forth between the two -- between 83 and 92 percent of the time. (bio-medicine.org)
  • The 12 monkeys that received a version of the West Nile/dengue 4 virus developed high levels of neutralizing antibodies that successfully fought the West Nile virus. (bio-medicine.org)
  • Video footage obtained by PETA reveals that experimenters at Texas A&M University deliberately bred dogs to develop crippling canine muscular dystrophy, a disease that ravages their bodies and causes progressive muscle wasting and weakness. (peta.org)
  • They showed that treatment with an antibody, on top of antiretroviral drugs, could lead to long-term viral suppression in SIV-infected monkeys. (emoryhealthsciblog.com)
  • Assessed safety and gene transfer efficiency of a lentiviral vector in fetal and juvenile monkeys. (ucdavis.edu)
  • German workers were exposed to tissues of infected grivet monkeys ( Chlorocebus aethiops ) at the city's former main industrial plant, the Behringwerke, then part of Hoechst , and today of CSL Behring . (wikipedia.org)
  • These diseases are the focus of the Energy Metabolism and Chronic Disease (EMCD) program at the WNPRC. (wisc.edu)
  • Associations with disease progression, full length AR (AR-FL) expression, response to therapy, and gene expression was determined. (jci.org)
  • Although the clinical progression of the disease is well defined, the molecular events responsible for glaucoma are currently poorly understood and current therapeutic strategies are not curative. (jci.org)
  • It encompasses a spectrum of pathologies that affect vision, from mild disease that resolves spontaneously to severe disease that causes retinal detachment and subsequent blindness. (jci.org)
  • Health officials with the Centers for Disease Control and Prevention identified an illness known as melioidosis, which is caused by a bacterial strain known as burkholderia pseudomallei. (wdsu.com)
  • In cardiovascular disease, many clinical trials have been performed using bone marrow cells that were not reprogrammed. (emoryhealthsciblog.com)
  • Similar responses could help explain why poor and working class people have higher rates of inflammatory disorders such as heart disease and diabetes, said study co-author Luis Barreiro, assistant professor of immunogenomics at the University of Montreal. (healthizmo.com)
  • These numbers were gathered from records of traveler's injuries and the prevalence of monkey bites in area residents is assumed to be much higher. (wikipedia.org)
  • The eye is an excellent target organ for such cell-based therapeutics due to its ready accessibility, the prevalence of vasculo- and neurodegenerative diseases affecting vision, and the availability of animal models to demonstrate proof of concept. (jci.org)
  • In monkeys and dogs, surgically added pacemakers artificially increase or decrease heart rate, permanently damaging the animal's heart as the organ is forced to grow or atrophy. (all-creatures.org)
  • Monkey model developed to study the effects of malaria in pregnant women and their offspring. (wisc.edu)
  • Our study demonstrates that dietary intake has a discernable impact on the natural history of HIV/SIV infections and suggests that dietary changes can be used as adjuvant approaches for HIV-infected subjects, to reduce inflammation and the risk of non-AIDS comorbidities and possibly other infectious diseases. (jci.org)
  • Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. (bcm.edu)
  • The findings of this study were compared with the pharmacodynamics profile elicited by efgartigimod in cynomolgus monkeys. (jci.org)
  • His current studies involves poisoning pregnant monkeys to toxic levels of methanol and methylmercury, and studies the long-term effects of the disabilities and deformities on the infants, for which he received $426,567 in NIH grant money for the 2010-2011 budget year of this long-term project. (wordpress.com)
  • However, the feasibility of these approaches for dominantly inherited diseases - where treatment may require reduction in the expression of a toxic mutant protein resulting from a gain-of-function allele - is unclear. (jci.org)