Diazepam (Valium) and Phenytoin (Dilantin): Nexium can alter the levels of these medications in your body. (wowio.com)
The free acid form of phenytoin is used in DILANTIN-125 Suspension and DILANTIN Infatabs. (drugs.com)
DILANTIN extended capsules and parenteral DILANTIN are formulated with the sodium salt of phenytoin. (drugs.com)
Periodic measurement of serum phenytoin concentrations should be performed during pregnancy, and the DILANTIN dosage should be adjusted as necessary. (drugs.com)
Phenobarbital4
Seizures during surgery: A 2018 meta-analysis found that early antiepileptic treatment with either phenytoin or phenobarbital reduced the risk of seizure in the first week after neurosurgery for brain tumors. (wikipedia.org)
Treatment with first-line antiepileptic medicines (phenobarbital, phenytoin, carbamazepine and valproic acid) is among the identified "best buys" for neurological diseases with the cost of treatment with phenobarbital as low as US$ 5 per person per year.2 All the medicines are included in the WHO Model List of Essential Medicines. (who.int)
Concentrations9
Due to decreased drug concentrations as a result of plasma volume expansion during pregnancy, dose of phenytoin may need to be increased if only option for seizure control. (wikipedia.org)
Breastfeeding: The manufacturer does not recommend breastfeeding since low concentrations of phenytoin are excreted in breast milk. (wikipedia.org)
Monitor unbound phenytoin concentrations in these patients. (nih.gov)
Estimating phenytoin concentrations by the Sheiner-Tozer method in adults with pronounced hypoalbuminemia. (globalrph.com)
Therapeutic effect without clinical signs of toxicity occurs more often with serum total concentrations between 10 and 20 mcg/mL (unbound phenytoin concentrations of 1 to 2 mcg/mL), although some mild cases of tonic-clonic (grand mal) epilepsy may be controlled with lower serum levels of phenytoin. (drugs.com)
Decreased serum concentrations of phenytoin may occur during pregnancy because of altered phenytoin pharmacokinetics. (drugs.com)
0.01), being carbamazepine (CBZ) and phenytoin (PHT), the AEDs showing the most prominent influence in reducing LTG plasma concentrations. (bvsalud.org)
Sodium12
Efficacy of individualized phenytoin sodium loading doses administered by intravenous infusion. (globalrph.com)
Drug interactions are reported among people who take Phenytoin sodium and Ibuprofen. (ehealthme.com)
The phase IV clinical study analyzes what interactions people who take Phenytoin sodium and Ibuprofen have. (ehealthme.com)
It is created by eHealthMe based on reports of 109 people who take Phenytoin sodium and Ibuprofen from the FDA, and is updated regularly. (ehealthme.com)
109 people who take Phenytoin sodium and Ibuprofen together, and have interactions are studied. (ehealthme.com)
It is based on phenytoin sodium and ibuprofen (the active ingredients of Phenytoin sodium and Ibuprofen, respectively), and Phenytoin sodium and Ibuprofen (the brand names). (ehealthme.com)
Because there is approximately an 8% increase in drug content with the free acid form over that of the sodium salt, dosage adjustments and serum level monitoring may be necessary when switching from a product formulated with the free acid to a product formulated with the sodium salt and vice versa. (drugs.com)
Phenytoin was first made in 1908 by the German chemist Heinrich Biltz and found useful for seizures in 1936. (wikipedia.org)
Though phenytoin has been used to treat seizures in infants, as of 2023, its effectiveness in this age group has been evaluated in only one study. (wikipedia.org)
Phenytoin injection may also be used to control certain types of seizures in people who cannot take oral phenytoin. (medlineplus.gov)
In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil were performed. (bvsalud.org)
Renal2
Because the fraction of unbound phenytoin is increased in patients with renal or hepatic disease, or in those with hypoalbuminemia, the monitoring of phenytoin serum levels should be based on the unbound fraction in those patients [see Warnings and Precautions (5.11) and Use in Specific Populations (8.6) ]. (drugs.com)
Renal function should be monitored through daily measurements of serum creatinine. (janusinfo.se)
Intravenous use is contraindicated in patients with sinus bradycardia, sinoatrial block, second- or third-degree atrioventricular block, Stokes-Adams syndrome, or hypersensitivity to phenytoin, other hydantoins or any ingredient in the respective formulation. (wikipedia.org)
Monitor for signs of hypersensitivity, including elevated liver transaminases, and treat as needed. (positivelyaware.com)
Epilepsy1
Phenytoin, employed mainly in the management of epilepsy, requires frequent blood monitoring due to its narrow therapeutic range and inter-individual variability in metabolism. (reportlinker.com)
Dosage5
Phenytoin dosage individualization--five methods compared in the elderly. (globalrph.com)
If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of dihydrocodeine until stable drug effects are achieved. (pdr.net)
If zafirlukast is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. (pdr.net)
With recommended dosages, a period of seven to ten days may be required to achieve phenytoin steady-state blood levels, and changes in dosage (increase or decrease) should not be carried out at intervals shorter than seven to ten days. (drugs.com)
Thus patients coadministered with inhibitors of CYP3A4 such as macrolide antibiotics (e.g., erythromycin), azole antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritanovir) while receiving Buprenex should be carefully monitored and dosage adjustment made if warranted. (druglib.com)
Dose8
Patients should be monitored carefully for dose-related adverse reactions, particularly nervous system symptoms (see sections 4.3 and 4.4). (who.int)
Monitor closely, especially upon initiation or following a dose increase. (drugs.com)
You will receive each dose of phenytoin injection in a medical facility, and a doctor or nurse will monitor you carefully while you are receiving the medication and afterwards. (medlineplus.gov)
Monitor or titrate P-gp substrate dose if coadministered. (medscape.com)
Moderate) Consider a reduced dose of hydrocodone with frequent monitoring for respiratory depression and sedation if concurrent use of zafirlukast is necessary. (pdr.net)
Concomitant use or discontinuation of CYP2B6/CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling). (oncologynurseadvisor.com)
monitor within first 24-72hrs of initiating therapy and following dose increases. (oncologynurseadvisor.com)
After dose reduction, heart rate should be monitored (see section 4.4). (medicines.org.uk)
Digoxin1
Digoxin toxicity: Intravenous phenytoin formulation is a medication of choice for arrhythmias caused by cardiac glycoside toxicity. (wikipedia.org)
Concomitant1
All factors must be considered: addition of interacting drugs, changes in absorption (eg enteral feeding + oral administration of phenytoin), concomitant disease state(s) which may alter phenytoin kinetics, etc. (globalrph.com)
Pharmacokinetics2
Phenytoin: pharmacokinetics and bioavailability. (globalrph.com)
15. Martin E, Tozer TN, Sheiner LB, Riegelman S. The clinical pharmacokinetics of phenytoin. (globalrph.com)
tell your doctor and pharmacist if you are allergic to phenytoin, other hydantoin medications such as ethotoin (Peganone) or fosphenytoin (Cerebyx), any other medications, or any of the ingredients in phenytoin injection. (medlineplus.gov)
Your doctor may need to change the dosages of your medications and will monitor you carefully. (prescriptiongiant.com)
Patients6
Monitor patients for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. (nih.gov)
2. Bachmann KA, Belloto RJ Jr. Differential kinetics of phenytoin in elderly patients. (globalrph.com)
Related ArticlesComparison of eight phenytoin dosing methods in institutionalized patients. (globalrph.com)
Patients receiving this drug should be informed by the physician of the risk and should be closely monitored. (nih.gov)
Patients should be monitored carefully for compliance, treatment response, and toxicity. (cdc.gov)
Assess patient's risk before prescribing and monitor closely for these behaviors and conditions ( 5.6 ). (drugs.com)
Narrow therapeutic1
Phenytoin has a narrow therapeutic index. (wikipedia.org)
Principally2
GT measurement is principally used to diagnose and monitor hepatobiliary disease. (cdc.gov)
Because phenytoin is principally bound to albumin, we also explored the effect of albumin on the V max and K m values obtained, in vitro . (aspetjournals.org)
Pregnancy1
Because of potential changes in protein binding during pregnancy, the monitoring of phenytoin serum levels should be based on the unbound fraction. (drugs.com)
Metabolism2
The effect of bovine serum albumin (BSA) on human liver metabolism, in vitro , of 14 C-phenytoin (PHT) was studied. (aspetjournals.org)
These findings for phenytoin metabolism suggest that the addition of albumin to incubation media for slices or microsome experiments may yield K m estimates that are more representative of in vivo values. (aspetjournals.org)
Medication3
Phenytoin is available as a generic medication. (wikipedia.org)
The most common cause of phenytoin intoxication is self‑medication, which accounts for more than thirty percent of the cases. (wikipedia.org)
Your doctor will probably not want you to receive phenytoin injection if you are taking this medication. (medlineplus.gov)
Carefully3
Your doctor may need to monitor you carefully for side effects. (medlineplus.gov)
Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to nabumetone. (prescriptiongiant.com)
Your doctor will monitor you carefully during your treatment. (prescriptiongiant.com)
Drug3
Appropriateness of sampling times for therapeutic drug monitoring. (globalrph.com)
Thought you might appreciate this item(s) I saw in Therapeutic Drug Monitoring. (lww.com)
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. (ehealthme.com)
Reactions1
People given injections should be observed for approximately 10 minutes afterwards to monitor for potential reactions. (positivelyaware.com)
Levels2
Prediction of free phenytoin levels based on [total phenytoin]/[albumin] ratios. (globalrph.com)
Regular monitoring of your blood clotting levels is crucial if you're on this combination. (wowio.com)
Treatment1
It is recommended that the decision to initiate or titrate treatment takes place with the availability of serial heart rate measurements, ECG or ambulatory 24-hour monitoring. (medicines.org.uk)
Phenytoin injection comes as a solution (liquid) to be slowly injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)