• The effects of sodium monensin and protein supplements on volatile fatty acid production were studied in a 4 x 4 Latin Square design, using four female bovines equipped with rumen fistulae and fed Brachiaria brizantha Marandu cultivar hay. (scielo.org.za)
  • It was hypothesized that monensin feeding would decrease proteolysis and deamination of amino acids in the rumen and lead to increased amounts of peptides and amino acids reaching the lower gastrointestinal tract via increased water flux through the rumen brought about by feeding sodium bicarbonate. (illinois.edu)
  • Monensin in contrast, did not affect rumen fluid dilution rate but increased the molar proportion and production of propionate in the rumen. (illinois.edu)
  • One hundred ninety-two male broiler chicks were dosed with monensin at concentrations of 0, 121, or 242 mg/kg feed throughout the normal growing period (50 days). (nih.gov)
  • Monensin given in combination with MiADMSA potentiated its lead chelation ability especially from brain, along with maintaining the normal copper concentrations in the organ unlike MiADMSA monotherapy. (sigmaaldrich.com)
  • The dietary inclusion of monensin-Na decreased the vaccenic-, linoleic- and CLA (cis-9, trans-11 isomer) concentrations of both lamb subcutaneous fat and muscle tissues significantly. (scielo.org.za)
  • Chickens received feed treated with maduramycin at concentrations of 5, 10 and 15 mg kg -1 , monensin at 125, 225 and 325 mg kg -1 or diclazuril at 1, 5 and 10 mg kg -1 . (slovetres.si)
  • Administration of different concentrations of maduramycin, monensin and diclazuril did not affect the concentration of the parameters AST, UA, GLU, BA, TP, ALB, GLOB and PHOS in experimental groups of broilers in relation to the control group. (slovetres.si)
  • We have investigated the potentiation of transferrin [Tfn]-toxin [Tfn-ricin toxin A chain (RTA) and Tfn-So6 saporin toxin] and monoclonal antibody-RTA conjugates by monensin (Mo) and by a human serum albumin (HSA)-monensin conjugate in vitro. (univr.it)
  • We found that the binding of monensin-specific mAb to thioether-cross-linked or disulfide-cross-linked protein-monensin conjugates is negatively affected by serum, as indicated by immunoenzymic (ELISA) and radioimmunobinding analysis. (univr.it)
  • Investigations on the nature of the interactions between serum proteins and monensin leading to monensin inactivation were conducted by affinity chromatography of serum on immobilized human-serum-albumin-monensin conjugates, size-exclusion chromatography, SDS/PAGE analysis of serum-treated human-serum-albumin-monensin conjugates, and evaluation of the stability of immobilized human-serum-albumin-bound 125I-monensin following treatment with serum. (univr.it)
  • We conclude that serum proteins block the immunotoxin-enhancing effect of monensin and of human-serum-albumin-monensin conjugates by multiple mechanisms involving hydrophobic and covalent interactions and enzyme-mediated cleavage of protein-bound monensin. (univr.it)
  • Finally, hydrolysis of the methyl ester under basic conditions furnished the sodium salt of monensin, completing the synthesis of this challenging natural product. (wikipedia.org)
  • Our results suggest a novel mechanism for the mode of action of monensin and salinomycin on coccidial parasites, in which the drug activates an MSH-1-dependent cell cycle checkpoint by an unknown mechanism, ultimately leading to the death of the parasite. (asm.org)
  • According to Chalupa (1977) the effect that monensin in increasing propionate and decreasing acetate and methane is advantageous metabolically, since propionate production is energetically more efficient. (scielo.org.za)
  • In this study we have therefore investigated the interaction between serum proteins and monensin leading to the inactivation of monensin function as immunotoxin potentiator. (univr.it)
  • Subepicardial hemorrhage and congestion occurred in 40% of the hearts from the chickens fed the high monensin dose and were nonexistent in the other treatments. (nih.gov)
  • The aim of this study was to monitor the biochemical and chemical parameters of the blood of commercial chickens following treatment with one of three coccidiostats: maduramycin, monensin or diclazuril. (slovetres.si)
  • Monensin and salinomycin derivatives such as esters and amides are also active against the strains of Gram-positive bacteria, including hospital S . aureus strains, i.e. methicillin-susceptible (MSSA) and methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) strains (Antoszczak et al . (pjmonline.org)
  • Monensin A is able to transport these cations across lipid membranes of cells in an electroneutral (i.e. non-depolarizing) exchange, playing an important role as an Na+/H+ antiporter. (wikipedia.org)
  • Monensin catalyzes the exchange of Na + for H + across cellular membranes, and it has been shown to be effective against a number of parasites in the phylum Apicomplexa, including members of the genera Plasmodium , Toxoplasma , and Eimeria ( 17 , 23 , 25 ). (asm.org)
  • Likewise, authors have speculated that resistance to monensin may be due to changes in fluidity or other components of membrane structure ( 5 , 37 ), which would prevent the association of monensin with the cell membrane, but experimental evidence for this is currently lacking. (asm.org)
  • The birds were allotted into four groups--three groups given monensin and one group of controls--in two experimental trials. (ndsl.kr)
  • Nonetheless, the relation between disruption of this gene and monensin resistance was confirmed by phenotypic complementation using a wild-type copy of the gene ( 13 ). (asm.org)
  • Monensin is used extensively in the beef and dairy industries to prevent coccidiosis, increase the production of propionic acid and prevent bloat. (wikipedia.org)
  • Post-weaning Eimeria zuernii coccidiosis in beef calves was treated prophylactically with monensin from intra-ruminal continuous release devices. (gsajournals.org)
  • The treatments were organized in a 2 X 2 factorial array (with or without 160 mg of sodium monensin/animal/day and with or without protein supplements). (scielo.org.za)
  • Six mice, eight weeks of age, from each line or reciprocal cross were assigned to one of two treatments, 1) drinking water containing 20 mmol/L monensin dissolved in 0.5% V/V ethanol, and 2) drinking water containing 0.5% V/V ethanol (control) for two weeks. (koreascience.or.kr)
  • A. HuczyƄski, M. Ratajczak-Sitarz, A. Katrusiak, B. Brzezinski, "Molecular structure of the 1:1 inclusion complex of Monensin A lithium salt with acetonitrile", J. Mol. (wikipedia.org)
  • In addition, monensin appears to interfere with vesicular traffic ( 35 ), by an undescribed mechanism. (asm.org)
  • Severe disease also occurred in calves subsequent to elimination of oocyst shedding by monensin during the initial treatment trial. (gsajournals.org)
  • Two lines of mice, M16 selected for rapid growth and a randomly selected control ICR as well as their reciprocal crosses were used to study the effects of genotype on whole-body energetics and intestinal responses to monensin. (koreascience.or.kr)
  • 2007, 871, 92-97, doi:10.1016/j.molstruc.2006.07.046 M. Pinkerton, L. K. Steinrauf, "Molecular structure of monovalent metal cation complexes of monensin", J. Mol. (wikipedia.org)
  • Figure 1: (A) Molecular structure and (B) Potential surface of Monensin A (MONA). (clytojournals.com)
  • Animals were exposed to 0.1% lead in drinking water for 16 weeks and then treated with either MiADMSA at 50mg/kg body weight, or monensin at 10mg/kg, or both in combination for a period of 5 days was administered. (sigmaaldrich.com)
  • However, this effect is inhibited by the addition of monensin-Na to the same diet. (scielo.org.za)
  • In addition, experiments utilizing a monensin-resistant T. gondii mutant show that this effect of monensin is dependent on the function of a mitochondrial homologue of the MutS DNA damage repair enzyme (TgMSH-1). (asm.org)
  • In addition, experiments utilizing a monensin-resistant T. gondii mutant show that this effect of monensin is dependent on the function of a mitochondrial homologue of the Mut-S DNA damage repair enzyme (TgMSH-1). (blogspot.com)
  • There appeared to be an inverse relationship between monensin dose and liver weight. (nih.gov)
  • This is especially pronounced in horses, where monensin has a median lethal dose 1/100th that of ruminants. (wikipedia.org)
  • Birds receiving 4.7 mg monensin/kg developed ataxia after the third dose and rear limb paresis and paralysis after the fifth dose. (ndsl.kr)
  • Production Performance and Milk Composition of Dairy Cows Fed Whole or Ground Flaxseed With or Without Monensin. (flaxcouncil.ca)
  • T. gondii is highly susceptible to monensin, and indeed, monensin has been used to treat toxoplasmosis in several animal species ( 23 ). (asm.org)
  • Having united these two complex fragments, Still was able to complete the synthesis of monensin in three additional steps. (wikipedia.org)
  • Monensin causes osmotic swelling of apicomplexan parasites ( 7 ), presumably due to the inability to regulate ionic homeostasis as a result of Na + influx ( 38 ). (asm.org)
  • This approach explains ionophoric ability and in consequence antibacterial properties of not only parental monensin, but also its derivatives that do not possess carboxylic groups. (wikipedia.org)
  • Monensin was an effective prophylactic and the intra-ruminal devices were a convenient method of continuous administration over a one to two month period. (gsajournals.org)