Loading...
  • Viral
  • Env is the receptor binding protein, facilitating the early steps in the virus-cell interaction and additionally drives the fusion process between the viral and cellular membranes. (mdpi.com)
  • infections
  • The Splicing History of an mRNA Affects Its Level of Translation and Sensitivity to Cleavage by the Virion Host Shutoff Endonuclease during Herpes Simplex Virus Infections. (nih.gov)
  • integration
  • The NTD is essential for 3' processing and strand transfer, however determining its role in the integration process in lentiviruses and oncogenic viruses has been difficult due to the absence of the full-length structure of IN and the complexity of the protein-protein and protein-DNA interactions involved in the synaptic complex. (biomedcentral.com)
  • We mapped Toca 511 integration sites and sequenced integrated Toca 511 genomes from patient samples with detectable virus. (aacrjournals.org)
  • Modulation
  • Despite these genetic and functional differences, however, the C -terminal domains of these viruses share a common feature in the modulation of Env ectodomain conformation. (mdpi.com)
  • diverse
  • Retroviruses are a diverse family of enveloped RNA viruses that can be broadly categorized into two groups based on genome complexity: the simple retroviruses and the complex retroviruses. (mdpi.com)
  • process
  • Env is primarily responsible for binding the cellular receptor and for effecting the fusion process, with these functions mediated by protein domains localized to the exterior of the virus. (mdpi.com)