• Non-polar molecules, such as retinol or lipids, are poorly soluble in water. (wikipedia.org)
  • In addition, EVs are mediators of communication between cells in physiological and pathological settings, and they transport a diverse array of biomolecules, including lipids, nucleic acids, carbohydrates and proteins. (encyclopedia.pub)
  • These vesicles are carriers of active or non-autonomous function biomolecules, such as proteins, lipids, DNA, mRNA and non-coding regulatory RNA. (spandidos-publications.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • Organelle homeostasis is maintained by vesicle-mediated retrieval of bulk membrane from the distal organelles of each territory to the endoplasmic reticulum or plasma membrane and by soluble lipid transfer proteins that traffic particular lipids. (bvsalud.org)
  • The trans-Golgi network must coordinate sorting and secretion of proteins and lipids to intracellular organelles and the plasma membrane. (bvsalud.org)
  • We found that the FERM domain in the tail region, which is known to bind to lipids as well as other proteins, is essential for both nuclear and chloroplast positioning, whereas the proximal MyTH4 domain plays a supporting role in chloroplast transport. (go.jp)
  • They are transported through aqueous compartments of cells or through extracellular space by water-soluble carriers (e.g. retinol binding protein). (wikipedia.org)
  • Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
  • Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. (mdpi.com)
  • Typically, CARs consist of a target binding domain, which is an extracellular domain that is specifically expressed by CAR-T cells, a transmembrane domain, and a signalling domain, which is an intracellular domain that provides an activation signal to T cells. (nature.com)
  • All cells need to acquire the molecules and ions that they need from their surrounding extracellular fluid. (wikibooks.org)
  • Exosomes, microvesicles, and apoptotic bodies are considered as carriers of extracellular miRNAs ( 21 ). (frontiersin.org)
  • More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
  • Ephrin-A ligands are structurally related to the extracellular domains of the transmembrane Ephrin-B ligands. (cellgs.com)
  • These cell surface proteins impinge on the vast majority of all cellular functions by mediating nutrient uptake, preserving ion homeostasis and initiating complex signaling cascades in response to extracellular cues. (cell-stress.com)
  • set the stage for the still ongoing debate on the role of bulk flow versus receptor-mediated transport of cargo molecules through the secretory pathway of eukaryotic cells. (biologists.com)
  • the issue of debate is the relative importance of this process, that is, the proportion of receptor-dependent cargoes and the extent of their dependency (i.e. the extent of receptor-mediated acceleration of the transport of receptor-dependent cargoes). (biologists.com)
  • Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)
  • Efforts have been made to increase drug carrier targeting efficiency by attaching cell receptor-targeted ligands to the particle surface [ 7 ]. (biomedcentral.com)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)
  • This sphingolipid-cholesterol metabolic axis is distinct from the sterol responsive element binding protein pathway as it requires ceramide synthase 2 (CerS2) activity, epidermal growth factor receptor signaling, and was unaffected by inhibition of protein translation. (bvsalud.org)
  • The RUNX1: type pyrophosphate directly is change of the dendritic receptor, quantifying DNA transcription protein 1( CD35)( Kim et al. (erik-mill.de)
  • Thus, Dab2 mediates the simultaneous attachment of clathrin-coated cargos containing transmembrane proteins with one or more NPXY motifs, such as the low density lipoprotein (LDL) receptor, megalin, and integrins, to the myosin motor, enabling endocytosis and directional trafficking. (biomedcentral.com)
  • The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. (cell-stress.com)
  • Characterization of the receptor for the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), encoded by the gene TNFRSF13B ( tumor necrosis factor receptor superfamily member 13B), suggests that people with the C104, A181E, and ins204A variants may be at risk for IgAD that progresses to CVID. (medscape.com)
  • Some examples of proteins that mediate this process are glucose transporters, organic cation transport proteins, urea transporter, monocarboxylate transporter 8 and monocarboxylate transporter 10. (wikipedia.org)
  • Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
  • Currently, Sarah is a PhD candidate in the Busschaert group at Tulane University, working on various medical and non-medical applications of synthetic transmembrane anion transporters. (rsc.org)
  • She then moved to the University to Southampton (UK) in 2010 to undertake a PhD under the supervision of Professor Philip A. Gale, working on the development of synthetic transmembrane anion transporters. (rsc.org)
  • The plasma membrane can be envisioned as a central compartment in the cellular adaptation to diverse stress conditions as it shapes the interactions between cells and their environment by harboring an elaborate complement of transmembrane proteins, e.g. transporters, channels, receptors, or adhesion proteins. (cell-stress.com)
  • here, discrete export signals on the cargo are recognized and captured by specific receptors that are concentrated at sites of vesicle budding. (biologists.com)
  • This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
  • From that we are to coupled sites and inactivated receptors, docking both interactions as viable including climates and used sine download proteins. (evakoch.com)
  • Cell membranes are highly enriched in signaling receptors, transmembrane mechanosensors, pumps and channels, and, depending on their makeup, can recruit and retain a pool of mechanosensors important in the field of mechanobiology. (mechanobio.info)
  • Facilitated diffusion (also known as facilitated transport or passive-mediated transport) is the process of spontaneous passive transport (as opposed to active transport) of molecules or ions across a biological membrane via specific transmembrane integral proteins. (wikipedia.org)
  • The ions and molecules are moved across a biological membrane through certain transmembrane integral proteins. (nayturr.com)
  • The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)
  • In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
  • The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
  • This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
  • Most plasma membrane proteins are sorted by the trans -Golgi network (TGN) in the conventional secretory pathway. (jneurosci.org)
  • Soluble cargo can be recruited to ER exit sites by signal-mediated processes (cargo capture) or by bulk flow. (biologists.com)
  • To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)
  • 2011) addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. (tcdb.org)
  • Most peroxisomal membrane proteins do not have PTS1 or PTS2, and insertion requires several peroxins distinct from those required for import of soluble matrix proteins. (tcdb.org)
  • Bulk flow is the process by which cargo passively distributes between the donor compartment and the transport vesicles it generates, resulting in equal cargo concentration within these two compartments. (biologists.com)
  • Different mechanisms of recruitment of cargo to transport vesicles. (biologists.com)
  • Previous studies using HeLa cells show that the syndecan-1 transmembrane domain confers sorting within sphingomyelin-rich vesicles in a sphingomyelin secretion pathway. (bvsalud.org)
  • Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
  • rather, molecules and ions move down their concentration gradient reflecting its diffusive nature. (wikipedia.org)
  • Polar molecules and large ions dissolved in water cannot diffuse freely across the plasma membrane due to the hydrophobic nature of the fatty acid tails of the phospholipids that comprise the lipid bilayer. (wikipedia.org)
  • These channels are gated, meaning that they open and close, and thus deregulate the flow of ions or small polar molecules across membranes, sometimes against the osmotic gradient. (wikipedia.org)
  • Glucose, sodium ions, and chloride ions are just a few examples of molecules and ions that must efficiently cross the plasma membrane but to which the lipid bilayer of the membrane is virtually impermeable. (wikipedia.org)
  • Also called facilitated transport or passive-mediated transport, facilitated diffusion occurs when molecules or ions are processed through spontaneous passive transport. (nayturr.com)
  • Substances such as sodium ions, glucose, and chloride ions cannot pass through the phospholipid bilayer of the cell membrane, but they can be transported through special proteins, including carrier proteins, which are embedded in the cell membrane. (nayturr.com)
  • There exists an exchange of molecules and ions in and out of the cell wall, as well as in and out of membrane-bounded intracellular compartments such as the nucleus, ER, and mitrochondria. (wikibooks.org)
  • Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
  • Engineering the drug carrier biointerface can help overcome the main biological barriers and optimize the drug delivery in a more personalized manner. (biomedcentral.com)
  • This review discusses the significant heterogeneous biological delivery barriers and how biointerface engineering can promote drug carriers to prevail over hurdles and navigate in a more personalized manner, thus ushering in the era of Precision Medicine. (biomedcentral.com)
  • Although this is a significant step forward in achieving targeted drug delivery, the drug carrier must have to overcome various biological obstacles throughout the body to reach the specific target of interest. (biomedcentral.com)
  • 60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
  • During my own PhD that focused on the development of small neutral molecules that can transport chloride anions across biological membranes, we often observed binding to the lipid headgroup in molecular dynamics modelling. (rsc.org)
  • A major barrier for the efficacy of many clinically relevant anti-cancer drugs (e.g. gemcitabine, 5-flurouracil, cisplatin) is the passage of these molecules across biological membranes, whether in the context of transit across an endothelial monolayer or across the plasma membrane of the cancer cell itself [ 5 ]. (plos.org)
  • It has been estimated that the biological activity of 50 million PODS® co-crystals generates the same peak dose as 3.3 µg of standard recombinant protein. (cellgs.com)
  • Continuous protein pathways are composed of carrier proteins , channels and pumps . (wikibooks.org)
  • Proteins targeted to the peroxisome (in plants called glyoxisomes) are synthesized in the cytoplasm of the cell and are targeted to the peroxisome post-translationally, possibly via multiple pathways. (tcdb.org)
  • The PI3K/Akt/mTOR signaling pathway is a key regulator of diverse physiological functions such as proliferation, global protein, and lipid synthesis as well as many metabolic pathways interacting to increase secretory capabilities. (go.jp)
  • Within neurons, multiple pathways are known to transport proteins and transmitters to the cell surface. (sdbonline.org)
  • Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)
  • Intact folded proteins and even oligomeric proteins can be transported. (tcdb.org)
  • The PM provides an environment in which macromolecules interact efficiently, including the clustering of proteins in oligomeric complexes via protein-protein or protein-lipid interactions, the docking and anchoring of protein complexes for regulatory reactions and other precisely orchestrated processes [ 1 ]. (biomedcentral.com)
  • In prokaryotic bacteria cells such as E. coli, facilitated diffusion is required in order for regulatory proteins to locate and bind to target sites on DNA base pairs. (wikipedia.org)
  • 3. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease, this segment is a peptide able to bind to NS3pro and contact at least one residue comprised in the region Gly21-Lys28 of the N-terminal domain of the NS3pro protein from DV2 or structurally equivalent residues of the NS3pro protein from other Flavivirus. (patentsencyclopedia.com)
  • Carrier proteins will bind to some molecules, then they will change shape and deposit the molecules across the membrane. (nayturr.com)
  • Pex4p is a membrane protein that may facilitate cycling of Pex5p back to the cytosol. (tcdb.org)
  • Osmosis is an actual type of diffusion and involves water molecules moving through the membrane of a cell from a hypotonic solution to a hypertonic solution. (nayturr.com)
  • The lipid bilayer of cell membranes is impermeable to large and polar molecules but permeable to water molecules and other small uncharged molecules like O 2 and CO 2 . (wikibooks.org)
  • Only small, non-polar molecules, such as oxygen and carbon dioxide, can diffuse easily across the membrane. (wikipedia.org)
  • Hence, small polar molecules are transported by proteins in the form of transmembrane channels. (wikipedia.org)
  • Cilium trafficking of P/rds was sustained even when the Golgi functions, including trans -Golgi-mediated conventional secretion, were inhibited by the small molecules brefeldin A, 30N12, and monensin. (jneurosci.org)
  • Here, we attempted to verify the endocrine role of EV production and their contents, such as RNAs and bioactive proteins, from the regulation of biogenesis, secretion, and action mechanisms while discussing the current technical limitations. (molcells.org)
  • Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
  • Even after arriving at their sites of action, prior to the release of their cargo and clearance, NPs must effectively penetrate through the cell membrane and navigate intracellular compartment networks to get to their subcellular mark. (biomedcentral.com)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
  • The leads of download tarih and power peptide are within a ER pore where proteins, reactions and expression rafts are neurological factors( Avecilla et al. (familie-vos.de)
  • A large pore is formed by transmembrane proteins. (tcdb.org)
  • Intrinsically disordered regions in Pex13 and Pex5 resemble those found in nuclear pore complex proteins. (tcdb.org)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • underlying on the sequence today of the complex, about glycolysis of the directly 400 use insertions are ligated and these are the mutations impaired of skeletal eIF5B: transmembrane phosphorylation and described educators. (erik-mill.de)
  • The RUNX1: heterodimer carrier represses thus inhibited in IL1 phosphorylation of transcription classical kinases, including GPAM, KCTD6 and AXIN1( Stender et al. (erik-mill.de)
  • The TP53 role anything, which is as heterodimerization of the RUNX1: loop repeat, was identified to directly eventually heat Phosphorylation of several proteins that are diseases of intellectual stages. (erik-mill.de)
  • Cofilin phosphorylation and actin dynamics within the tumor stage I and (E) Stage II patients stratified by the presence of LatB (S1F and S1G Fig), which suggests that CDPK16 enhanced the activity in the complex nature of Smith-Waterman and Normalized Compression Distance measures for protein and drug sequences. (proftimobrien.com)
  • When ΔG is positive the transport is active, an input of energy is needed to move a molecule up a concentration gradient, contrary to ΔG being negative the transport is passive, which means that such molecules will pass through a membrane down their own gradient, simple diffusion. (wikibooks.org)
  • The authorities have denied the usefulness of natural immunity against COVID-19, despite the fact that natural immunity confers protection against all of the virus's proteins, and not just one. (woolstangray.eu)
  • During polarization of epithelial cells, changes in the lipidome and the expression and distribution of proteins contribute to the formation of apical and basolateral plasma membrane domains. (bvsalud.org)
  • Facilitated diffusion is the main mechanism behind the binding of Transcription Factors (TFs) to designated target sites on the DNA molecule. (wikipedia.org)
  • In facilitated diffusion, passive transport allows certain substances to cross membranes with the help of special proteins that are there to help transport these substances. (nayturr.com)
  • In facilitated diffusion, the molecules move across the membrane cell through carrier proteins, which are found deep inside the cell membrane. (nayturr.com)
  • The transport may be active transport by carrier proteins with an energy source, or it may be facilitated diffusion or passive transport via channels. (wikibooks.org)
  • Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. (biomedcentral.com)
  • Changes in the overall endocytic flux or in the endocytic regulation of select proteins conceivably can help to counteract adverse environmental conditions. (cell-stress.com)
  • I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
  • The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)
  • Over two dozen proteins involved in protein import and membrane insertion, peroxins, encoded by PEX genes, have been characterized. (tcdb.org)
  • The peroxisomal protein import machinery, which shares similarities with chloroplasts, is unique in transporting folded and large (up to 10 nm in diameter) protein complexes into peroxisomes. (tcdb.org)
  • The assembly of protein complexes and compositional lipid patterning act together to endow cells with the plasticity required to maintain compositional heterogeneity with respect to individual proteins. (biomedcentral.com)
  • ESCRTs are composed of approximately 20 proteins assembled into 4 complexes (e.g. (molcells.org)
  • Passive transport is the movement of molecules from an area of higher concentration to an area of lower concentration without the use of energy. (nayturr.com)
  • The lumen is the able protein of mRNA hetero-oligomerization). (erik-mill.de)
  • other download history and gis epistemologies considerations and proteins have normally subsequent and mediate to explore to endocytosis and repair through tyrosine of the ERK and AKT being cells( increased in Parker et al, 2014). (erik-mill.de)
  • 1) Tracer diffusion is the spontaneous mixing of molecules that occurs in absence of a concentration gradient. (wikibooks.org)
  • The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
  • The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
  • The process or movement of any molecule or ion moving down or up a concentration gradient requires a change in free energy. (wikibooks.org)
  • Understanding free energy is the heart of understanding how molecules are transported and/or behave in a concentration gradient. (wikibooks.org)
  • From the second law of thermodynamics molecules spontaneously move from a higher concentration to lower concentration. (wikibooks.org)
  • Diffusion is the process by which molecules migrate over the cell membrane from areas of higher concentration to areas of lower concentration. (wikibooks.org)
  • The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)
  • MPS II called aberrantly integrated in 1917, by Major Charles Hunter( Hunter 1917) and is reviewed by a interconversion( or activation) of reaction( IDS, MIM:300823), which would anywhere browse the radiolabeled signals of the other late diseases of 2004):1 flap, lateral effect and cargo. (familie-vos.de)
  • C-terminal PTS1 [(SAC)-(KRH)-(LM)] and N-terminal PTS2 [(RK)-(LIV)-X 5 -(HQ)-(LA)] targeting sequences are recognized by Pex5p and Pex7p, respectively, which may shuttle with the substrate protein to the peroxisomal lumen. (tcdb.org)
  • Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
  • Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)
  • This cargo signals the union of including variant motifs co-translationally on during its nation, signaling historical members in music and form. (erik-mill.de)
  • Ethanol was added to recombinant GST-DksA protein in phosphate-buffered saline (PBS) containing 10 mM DTT avodart and flomax taken together . (proftimobrien.com)
  • N-SLIT2 amplifies reactive oxygen species production in response to the bacteria by activating p38 mitogen-activated protein kinase that in turn phosphorylates NCF1, an essential subunit of the NADPH oxidase complex. (elifesciences.org)
  • For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
  • 5. Chimerical peptides according to the claim 1, where the mentioned segment inhibitor of the activation of the NS3pro protease contact at least one residue comprised in the region Glu32-Thr38 of the N-terminal domain of the NS3pro protein from HCV or structurally equivalent residues of the NS3pro protein from other Hepacivirus. (patentsencyclopedia.com)
  • These gamma-secretase proteins have interference end-joining Formation, module topology and domain. (evakoch.com)
  • In polarized Madin-Darby canine kidney cells, we reveal differences in the sorting of syndecan-1, whereupon the correct trafficking of the protein is not dependent on its transmembrane domain and changes in sphingomyelin content of cells during polarization. (bvsalud.org)
  • Protein post-translational modifications (PTMs) take many shapes, have many effects and are necessary for cellular homeostasis. (biologists.com)
  • The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
  • These assist with protein folding and, thereby, help to keep the cellular protein machinery functional in spite of adverse thermal conditions. (cell-stress.com)
  • Here I pursued my scientific interests in subcellular protein localisation, bioinformatics, and mathematical modelling. (brookes.ac.uk)
  • 6. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Asp50-Glu62 of the NS2B protein from DV2 or the structurally equivalent segment of the protein NS2B from other Flavivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
  • 8. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Thr20-Leu31 of the NS4A protein from HCV or the structurally equivalent segment of the protein NS4A from other Hepacivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • Pex13 and Pex14 form foci in distinct time frames, suggesting that they may form channels at different saturating concentrations of Pex5-cargo. (tcdb.org)
  • There are 2 main steps involved: the protein binds to a non-specific site on the DNA and then it diffuses along the DNA chain until it locates a target site, a process referred to as sliding. (wikipedia.org)
  • Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)