Molecules protein domain carrier proteins. Medical search. Frequent questions

Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. (mdpi.com)
The extracellular region of FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region which includes a death domain (DD). (biolegend.com)
COMP is a non-collagenous glycoprotein and is belongs to the thrombospondin family of extracellular proteins. (prospecbio.com)
Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)
BCAM contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. (neuromics.com)
Human GITR Ligand consists of a 50 amino acid cytoplasmic domain, a 21 aa transsmembrane segment, and a 128 aa extracellular domain (ECD). (genscript.com)
Bacterial siderophores are small molecules with unmatched capacity to scavenge iron from proteins and the extracellular milieu, where it mostly occurs as insoluble Fe 3+ . (biomedcentral.com)
Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein. (prosci-inc.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. (biolegend.com)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)

Small molecules capable of acylating this prosthetic group will provide a simple and reversible means of introducing novel functionality onto carrier protein domains. (rsc.org)
At Biogen, we are developing a diverse portfolio consisting of small molecules, proteins, antisense oligonucleotides and gene therapy to target many neurodegenerative diseases. (chi-peptalk.com)
Most aquaporins are selectively permeated by water, although some family members are permeated by other small molecules. (shadowebike.com)

Click molecule labels to explore molecular sequence information. (nih.gov)
The structures were solved by molecular replacement, using isolated macro domain structures as search models. (rcsb.org)
The 397 amino acid recombinant protein has a predicted molecular mass of approximately 44.7 kD. (biolegend.com)
Pick-up, Transport and Release of a Molecular Cargo using a Small-Molecule Robotic Arm' ' Salma Kassem, Alan T. L. Lee, David A. Leigh, Augustinas Markevicius and Jordi Solà, Nature Chem , 8 , 138-143 (2016). (websitehome.co.uk)
2 However, up to now there have been no small-molecule machines (as opposed to proteins or DNA) that can transport molecular fragments in a similar manner. (websitehome.co.uk)
Cartoon representation of a programmable small-molecule robot able to transport a molecular cargo (shown in red) in either direction from blue-to-green or green-to-blue platform sites. (websitehome.co.uk)
4 The relocation of molecular fragments with a nanoscale robotic arm-making and breaking chemical bonds in a process during which the cargo is unable to exchange with others in the bulk-is the first step towards the controlled manipulation of molecular-level structures through programmable small-molecule robotics. (websitehome.co.uk)
Small-molecule robots should be able to manipulate substrates to control molecular construction, in a manner reminiscent of that observed in biology and factory assembly lines (Figure 3). (websitehome.co.uk)
Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm. (websitehome.co.uk)
The big challenge presented by the data analysis is to assign the signals in the measured spectrum to specific molecules or molecular groups. (nanowerk.com)
Eukaryotic lipid and fatty acid metabolism remains a critical challenge for studies at the atomic, molecular and cellular scale: In contrast to simple prokaryotic systems, fatty acid metabolism in eukaryotes builds upon large multienzymes, which integrate multiple catalytic activities into giant proteins. (unibas.ch)
However, there are significant challenges due to inherent molecular complexity of proteins. (chi-peptalk.com)
A fully biologically active molecule, rhGITRL has a molecular mass of 50 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript. (genscript.com)
I proposed the establishment of the 'gasotransmitter' concept and framework firstly in 2002 to characterize and clarify a class of endogenous gas molecules, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S), that function as signaling molecules to direct various molecular and cellular events. (rsc.org)

Intact COMP is pentameric, with 5 equal subunits and the carboxy-terminal globular domain of native COMP binds to collagens I, II, and IX. (prospecbio.com)
Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10 - 16). (rndsystems.com)
The chromo-domain binds histone H3 tails methylated on lysine 9. (cipsm.de)
As SynCAM-1 (synaptic cell adhesion molecule-1) it binds homotypically across synaptic clefts and, like neuroligin/neurexin adhesion pairs, promotes formation of neural cell synapses (7, 8). (rndsystems.com)

abstract = 'Proteins containing PSD-95/Discs-large/ZO-1 homology (PDZ) domains play key roles in the assembly and regulation of cellular signaling pathways and represent putative targets for new pharmacotherapeutics. (ku.dk)

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)
Using time-resolved infrared spectroscopy, they measured the structural changes in the bacterial membrane protein MsbA and its interaction partner ATP. (nanowerk.com)
This lays the foundation for the study of the whole membrane protein, which we are going to tackle next", says Professor Hofmann. (nanowerk.com)
This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
A membrane protein is a protein molecule that is attached to, or associated with, the membrane of a cell or an organelle. (shadowebike.com)

Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Adaptor Proteins, Signal Transducing" by people in this website by year, and whether "Adaptor Proteins, Signal Transducing" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles. (childrensmercy.org)
The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)

This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. (wikipedia.org)
The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. (wikipedia.org)
In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
These unusual ORFs are maternally inherited, and effectively translated into novel mitochondrial proteins, with the resulting failure to produce functional pollen as the sole observed phenotype ( Chen and Liu, 2014 ). (frontiersin.org)
In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)

We have structurally characterized the final peptidyl carrier protein domain of the teicoplanin non-ribosomal peptide synthetase machinery: this domain is believed to mediate the interactions with tailoring Oxy enzymes in addition to its function as a shuttle for intermediates between multiple non-ribosomal peptide synthetase domains. (rcsb.org)
The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. (nih.gov)
Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)

Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. (nature.com)
Our analysis of this data reveals an absolute protein-to-RNA ratio of 10 2 -10 4 for bacterial populations and 10 3 -10 5 for an archaeon, which is more comparable to Eukaryotic representatives' humans and yeast. (nature.com)
Indeed, the protein-to-RNA ratio per sample of the bacterial populations matched previous calculations for the existing example from axenically cultured E. coli 2 . (nature.com)
In contrast to expectations, none of the major S-layer proteins of the IPEC-1 -adhering strains mediated bacterial adherence. (biomedcentral.com)
They are composed of numerous identical (glyco)protein subunits (with a 25-71 kDa size in lactobacilli), which form a regular, symmetric and porous array, completely covering the bacterial cell surface. (biomedcentral.com)

deletion of an exon encoding the transmembrane domain results in a soluble FAS molecule that blocks apoptosis. (biolegend.com)
Like many Chinese medicinal herbs, licorice root has high content of soluble proteins, some of which are glycated and remain soluble even in the boiling decoction. (springer.com)
Siderophores are key molecules in low soluble iron conditions. (biomedcentral.com)
The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. (prosci-inc.com)
The subunits are held together and connected to the underlying cell surface by non-covalent interactions, and they spontaneously reassemble in vitro by an entropy-driven process, i.e. the subunit proteins are very poorly water-soluble [ 8 ]. (biomedcentral.com)

Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)
The three main types of proteins embedded in the cell membrane are receptors, channels and markers. (shadowebike.com)
They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex. (bvsalud.org)

ABC transporters are membrane proteins that transport various substances from one side of the cell membrane to the other. (nanowerk.com)
Although the architecture of the nanomachines is known, a detailed understanding of how the splitting of the energy carrier ATP dynamically enables the transport of various substances across biological membranes has so far been lacking. (nanowerk.com)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

Polar molecules can easily interact with the outer face of the membrane, where the negatively charged head groups are found, but they have difficulty passing through its hydrophobic core. (khanacademy.org)
Moreover, COMP has a storage and delivery function for hydrophobic cellsignaling molecules such as vitamin D. Mutations of the COMP gene cause Pseudoachondroplasia and some forms of multiple epiphyseal dysplasia which implicates that it is vital that COMP develops and functions normally. (prospecbio.com)
Integral membrane proteins are embedded in the membrane, usually via α-helical regions of 20 to 25 hydrophobic amino acids. (shadowebike.com)
By forming a continuous protein pathway across the membrane, these proteins enable specific hydrophilic solutes to cross the membrane without coming into direct contact with the hydrophobic interior of the lipid bilayer. (shadowebike.com)

Water molecules, for instance, cannot cross the membrane rapidly (although thanks to their small size and lack of a full charge, they can cross at a slow rate). (khanacademy.org)
osmosis is the movement of water molecules through a semi-permeable membrane that separates two compartments of differing solute concentration. (shadowebike.com)
These pores allow water molecules through in a single file. (shadowebike.com)
Lund University, P.O. Box 124 results from the free duplex with those from its complex with netropsin, S-22100, Lund, Sweden water molecules in the ``spine of hydration'' in the AATT region of the minor groove could be distinguished from hydration water elsewhere in the duplex. (lu.se)
The 2H and 17O relaxation dispersions yield a model-indepen- dent residence time of 0.9(Æ0.1) ns at 4C for ®ve highly ordered water molecules in the spine. (lu.se)
The NMRD data show that all water molecules associated with the duplex, except the ®ve molecules in the spine, have residence times signi®cantly shorter than 1 ns at 4C. (lu.se)
Usually, the NOE and NMRD in B-DNA is expected to be less ``integral'' than methods can only provide bounds on the residence water molecules buried inside proteins. (lu.se)

They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. (childrensmercy.org)
The two complexes share the defining core mTOR protein but employ characteristic subunits, Raptor for mTORC1 and Rictor for mTORC2, for capturing input signals controlling and localization, as well as for recognizing specific targets for phosphorylation. (unibas.ch)
Cyanobacterial phycobilisome (PBS) pigment-protein complexes harvest light and transfer the energy to reaction centers. (osti.gov)

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)

A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. (childrensmercy.org)

The inhibitor bound the PICK1 PDZ domain with an affinity similar to that observed for endogenous peptide ligands (K(i) approximately 10.1 microM). (ku.dk)

Thus, HERA is a novel cellular assay that can be used to predict how FcRn-binding proteins are rescued from intracellular degradation. (nature.com)
The intracellular protein extracts of a fungal strain Pycnoporus sanguineus was used as reducing and stabilizing agents to synthesize AuNPs with various shapes and dimensions, which present good catalyzing ability on the degradation of 4-nitroaniline [ 11 ]. (springer.com)
The protease not only releases small peptides, such as the amyloid-β peptide, which drives Alzheimer's disease pathogenesis, but also intracellular domains, which can have critical functions in nuclear signaling. (cipsm.de)

Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules' loading and spatial arrangement. (mdpi.com)
The outer Ig-like domain most likely mediates adhesion, with altered affinity for splice variants that have either shorter spacing of this domain from the plasma membrane or varied glycosylation (1, 6). (rndsystems.com)

In cells, some molecules can move down their concentration gradients by crossing the lipid portion of the membrane directly, while others must pass through membrane proteins in a process called facilitated diffusion. (khanacademy.org)
Major downstream targets include fatty acid and lipid metabolism, protein and nucleotide biosynthesis. (unibas.ch)
Later steps of lipid metabolism are occurring in membrane space and rely on membrane-integral or -associated proteins. (unibas.ch)
For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
What are the two types of proteins embedded in lipid bilayer of plasma membrane? (shadowebike.com)
There are three major classes of membrane lipid molecules-phospholipids, cholesterol, and glycolipids. (shadowebike.com)
Some (more…) Many integral membrane proteins (called transmembrane proteins) span the lipid bilayer, with portions exposed on both sides of the membrane. (shadowebike.com)

Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. (nih.gov)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
In most gram-positive bacteria, this operon consists of five genes dltXABCD but the involvement of the first ORF ( dltX ) encoding a small protein of unknown function, has never been investigated. (frontiersin.org)

If this is successful, you can see which groups of molecules are structurally changed and when. (nanowerk.com)
3. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease, this segment is a peptide able to bind to NS3pro and contact at least one residue comprised in the region Gly21-Lys28 of the N-terminal domain of the NS3pro protein from DV2 or structurally equivalent residues of the NS3pro protein from other Flavivirus. (patentsencyclopedia.com)
5. Chimerical peptides according to the claim 1, where the mentioned segment inhibitor of the activation of the NS3pro protease contact at least one residue comprised in the region Glu32-Thr38 of the N-terminal domain of the NS3pro protein from HCV or structurally equivalent residues of the NS3pro protein from other Hepacivirus. (patentsencyclopedia.com)
6. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Asp50-Glu62 of the NS2B protein from DV2 or the structurally equivalent segment of the protein NS2B from other Flavivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)
8. Chimerical peptides according to the claim 1, characterized by containing a segment inhibitor of the activation of the NS3pro protease which comprise the region Thr20-Leu31 of the NS4A protein from HCV or the structurally equivalent segment of the protein NS4A from other Hepacivirus, or an amino acid sequence showing a sequence similarity higher of equal to the 80% identity. (patentsencyclopedia.com)

To elucidate this assumption, one of the major proteins from Radix glycyrrhiza , namely GP, was purified and used to construct NPs with aconitine embedded. (springer.com)

Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
set the stage for the still ongoing debate on the role of bulk flow versus receptor-mediated transport of cargo molecules through the secretory pathway of eukaryotic cells. (biologists.com)
The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)

However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. (nih.gov)
As a test of the physiologic role of the NLR molecule NLRP3 during RNA viral infection, we explored the in vivo role of NLRP3 inflammasome components during influenza virus infection. (nih.gov)

Bacteria have not only devised ways of biosynthesizing "proprietary" siderophore molecules, but have evolved transport mechanisms that allow them to utilize foreign siderophores, or xenosiderophores, as well [ 8 , 9 ]. (biomedcentral.com)
Adaptive immune mechanisms recognize and neutralize foreign molecules or microorganisms in a specific manner. (lu.se)

Fas-activated DCs increase the expression of MHC II, B7 co-stimulatory molecules, and DC-lysosome-associated membrane proteins (DC-LAMP), and secrete proinflammatory cytokines such as IL-1β and TNF-α. (biolegend.com)
Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). (rndsystems.com)

Larger charged and polar molecules, like sugars and amino acids, also need help from proteins to efficiently cross the membrane. (khanacademy.org)

We demonstrated adhesive and significant pathogen inhibitory efficacies among the swine intestinal L. amylovorus strains studied, pointing to their potential use as probiotic feed supplements, but no independent role could be demonstrated for the major S-layer proteins in adherence to epithelial cells. (biomedcentral.com)

We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)

Aquaporins are membrane-channel proteins that are present at all levels of life, from bacteria to mammals. (shadowebike.com)

FAS is a type I transmembrane protein and belongs to the TNF receptor superfamily. (biolegend.com)

Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
1 Indeed, the concept of using molecules to manipulate other molecules in robotic fashion is an intriguing one that has some precedence in biology: for example, in metazoan fatty acid synthase a growing fatty acid chain, tethered to an embedded carrier protein, is passed between enzyme domains in the protein superstructure in a manner reminiscent of the way a robotic arm manipulates objects on a factory assembly line (Figure 1). (websitehome.co.uk)
A landmark example are giant eukaryotic fatty acid synthases (FASs), which comprise seven types of functional domains and carry out more than 40 reaction steps for the biosynthesis of fatty acids from acetyl- and malonyl-CoA. (unibas.ch)

It has been discovered that albumin not only acts as a carrier protein for drugs, but also participates in catabolic activity such as hydrolysis. (artscolumbia.org)
Our data also provides important clues as to how the protein moves during ATP hydrolysis. (nanowerk.com)

In addition, mice lacking NEPH1 develop a nephrotic syndrome that resembles NPHS mutations, suggesting that all three proteins are essential for the integrity of glomerular podocytes. (nih.gov)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)

Mouse IGSF4A cDNA encodes 445 amino acids including a signal peptide, three Ig-like domains (a V-type, a divergent C1-type and an I-type), a transmembrane domain and a cytoplasmic domain with protein 4.1 and PDZ domain binding sites. (rndsystems.com)

The PPR protein family is consequently divided in subfamilies depending on the number and type of repeats present in their sequence as well as optional C-terminal domains. (frontiersin.org)
Moreover, speci®c hy- found in narrow minor groove regions in a variety dration patterns seem to play a role in nucleotide sequence recognition by proteins (Otwinowski of oligonucleotide duplexes (PriveÂ et al. (lu.se)

The structures exhibit the same general fold as the majority of known carrier protein structures, in spite of the complex biosynthetic role that PCP domains from the final non-ribosomal peptide synthetase module must play in glycopeptide antibiotic biosynthesis. (rcsb.org)
These structures thus support the hypothesis that it is subtle rearrangements, rather than dramatic conformational changes, which govern carrier protein interactions and selectivity during non-ribosomal peptide synthesis. (rcsb.org)
These opportunities are surveyed here against a background of the immunobiology of allergic sensitization and current state-of-the-art approaches to measurement of peptide/protein reactivity. (cdc.gov)

He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)

Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

Metabolic reactions are spatially organized not only into organelles but also by the transient formation of localized protein assemblies in the cytosol. (unibas.ch)

A method based on atomic force microscopy is used to delineate the properties that determine single-molecule adhesion onto solid substrates in aqueous environment. (cipsm.de)

We report now that NEPH1 belongs to a family of three closely related proteins that interact with the C-terminal domain of podocin. (nih.gov)
The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)

Podocin interacts with the C-terminal domain of nephrin and facilitates nephrin-dependent signaling. (nih.gov)
Simultaneously, the method also records changes in the molecules the protein interacts with - in this case ATP. (nanowerk.com)

Combining experimental structural studies with functional analysis, we elucidate fundamental principles of multienzyme architecture & regulation and the role of protein assemblies for spatial organization of metabolism. (unibas.ch)
The finding that the SIRT6 protein suppresses tumour formation by regulating metabolism adds weight to this view. (natureasia.com)
In this context, the exploration of temporal interplay between populations with different lifestyles (comprising metabolism, motility, sporulation, etc.) becomes of primary importance to interpret the changes in fundamental quantities in a microbial community, such as the protein-to-RNA ratio that ultimately impacts the overarching community phenotype(s). (nature.com)

Lipids are the major structural elements of all biological membranes, serving as signaling molecules within and between cells. (biomedcentral.com)

The splitting process can be tracked in the infrared spectrum (above), in which the various ATP intermediate products leave characteristic bands (red: ATP, yellow: split-off phosphate, white: protein). (nanowerk.com)
The biophysicists marked the phosphate groups of the ATP molecule, so that they left characteristic signals in the spectrum. (nanowerk.com)

Graves disease autoantigen), member 16 is a protein in humans that is encoded by the SLC25A16 gene. (wikipedia.org)

First, the sugar moiety of PGL-1 from M. leprae is unique in its capacity to bind the lectin domain of complement receptor 3 (CR3) for efficient invasion of human macrophages. (bvsalud.org)
Second, the trisaccharide domain of the PGLs from M. tuberculosis and M. leprae share the capacity to inhibit Toll-like receptor 2 (TLR2)-triggered NF-κB activation, and thus the production of inflammatory cytokines. (bvsalud.org)
Proteins that do not bind the receptor are directed to lysosomal degradation. (nature.com)
The specificity of FSC231 for the PICK1 PDZ domain was supported by the lack of binding to PDZ domains of postsynaptic density protein 95 (PSD-95) and glutamate receptor interacting protein 1 (GRIP1). (ku.dk)
Glicoproteínas que forman parte de la superfamilia de la inmunoglobulina que participa en la adhesión y activación de los linfocitos T. Se expresan en la mayoría de los linfocitos periféricos, los linfocitos citotóxicos naturales y timocitos, y actúan como correceptores y moléculas accesorias en el complejo del receptor del linfocito T. (bvsalud.org)

Moreover, the role of the L. amylovorus surface (S) -layers - symmetric, porous arrays of identical protein subunits present as the outermost layer of the cell envelope - in adherence to IPEC-1 cells was assessed using a novel approach which utilized purified cell wall fragments of the strains as carriers for the recombinantly produced S-layer proteins. (biomedcentral.com)

The researchers led by Prof. Dr. Eckhard Hofmann and Prof. Dr. Klaus Gerwert from the Biophysics Department report on the results in the current issue of the Journal of Biological Chemistry ( 'Time-resolved Fourier Transform Infrared Spectroscopy of the Nucleotide-binding Domain from the ATP-binding Cassette Transporter MsbA' ). (nanowerk.com)

Proteins which bind to DNA. (lookformedical.com)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. (prosci-inc.com)

Basal Cell Adhesion Molecule (BCAM) which is a product of alternate splicing of the Lutheran blood group molecule is a part of the immunoglobulin superfamily. (neuromics.com)

Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)

Our findings suggest that macro domain tags can be employed in recombinant protein expression in E. coli, and in carrier-driven crystallization. (rcsb.org)
Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
For example, when Escherichia coli is grown axenically in steady state, we can expect that each RNA molecule corresponds to 10 2 -10 4 of the matching protein (absolute protein-to-RNA ratio, hereafter referred protein-to-RNA ratio) and the variation in the level of cellular RNA explains ~29% of the variation in the amount of detectable protein 2 . (nature.com)

Our structural studies have revealed the intricate interlinking, coupling and crosstalk between domains that result in emergent properties beyond the functionality of their isolated building blocks and shed light on the evolution of this family of multienzymes (Maier et al. (unibas.ch)

Integral membrane proteins are permanently embedded within the plasma membrane. (shadowebike.com)
A transport protein in the plasma membrane of a plant or animal cell that specifically facilitates the diffusion of water across the membrane (osmosis) concentration gradient. (shadowebike.com)
Proteins embedded within the phospholipid bilayer carry out the specific functions of the plasma membrane, including selective transport of molecules and cell-cell recognition. (shadowebike.com)

The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. (prosci-inc.com)

Reductive protein methylation of the fusion protein yielded a new crystal form diffracting to 2.1 Å. (rcsb.org)

Anatomy10

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Phenomena and Processes81

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Secretory5

Viral2

Mechanisms2

Proinflammatory2

Cross the membrane1

Epithelial cells1

Amino acid residues1

Bacteria1

Transmembrane protein1

Fatty acid3

Hydrolysis2

Mutations2

Cytoplasmic domain1

Sequence2

Peptide3

Double-stranded1

Mice1

Cytosol1

Substrates1

Interact2

Interacts2

Metabolism3

Biological membranes1

Characteristic2

Humans1

Receptor5

Subunits1

Nucleotide-bindin1

Bind4

Adhesion1

Drosophila2

Coli3

Structural1

Plasma membrane3

Freeze-thaw cycles1

Methylation1