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  • small-molecule
  • Dr. Qihong Huang, co-senior author of the study, says that the group has identified a small molecule that blocks the pathway of a particular miRNA, called miR-21, which is implicated in brain cancer, as well as lung, colon, breast, and ovarian cancer. (medindia.net)
  • The cell-based assay that we have established can potentially be used to screen for additional small-molecule inhibitors that can block miRNA," he says. (medindia.net)
  • Small molecule inhibitors targeting selected protein kinases and monoclonal antibodiestargeting cell-surface receptors have shown promising results in the fight againstcancer, including breast cancer, in the past decade. (biomedcentral.com)
  • Collectively, our study provides the detailed profiling for a set of chemicals to manipulate EZH2 and EZH1 and establishes specific enzymatic inhibition of PRC2-EZH2 and PRC2-EZH1 by small-molecule compounds as a novel therapeutics for MLL-rearranged leukemia. (jove.com)
  • specific microRNAs
  • After dipping it in a sample of blood or another body fluid, the scientist measures the change in the nanoprism's optical property to determine the levels of specific microRNAs. (nanowerk.com)
  • Animals from different branches of the evolutionary tree - different lineages - possess specific microRNAs that evolved only in their lineage, but they also have microRNAs in common: ones which they inherited from their last common ancestor, and which have been conserved throughout animal evolution. (dailygalaxy.com)
  • different microRNAs
  • By looking at where in the body different microRNAs evolved, we can build a picture of ancestors for which we have no fossils, and uncover traits that fossils simply cannot show us,' says Detlev Arendt, who headed the study: 'But uncovering where these ancient microRNAs are expressed in animals from different branches of the evolutionary tree has so far been very challenging. (dailygalaxy.com)
  • By contrast, the process developed at IUPUI is simpler, quantitative, more sensitive and highly specific even when two different microRNAs vary in a single position. (technologynetworks.com)
  • tumor
  • After a 21-day study on lab animals, researchers concluded that the compound reduced the production of microRNA-96, encouraging bad cells to kill themselves and slowing tumor growth. (cancercenter.com)
  • Indeed, the expression of this class of RNAs is very often deregulated in tumor cells, and the level of a set of them is modified in animal models of cardiac hypertrophy and diabetes. (ahajournals.org)
  • Recently, miR-21 is found to be aberrantly expressed in CRC and miR-21 has been recognized to perform significantly in CRC, where miR-21 can regulate several different target genes and pathways involving tumor proliferation, invasion and metastasis. (iospress.com)
  • highly conserved
  • The E26 transformation-specific sequence (ETS) factors are a family of transcription factors that share a highly conserved DNA binding domain and regulate cell development, senescence, death, and tumorigenesis. (ahajournals.org)
  • regulation
  • The objective of the research project lead by Marko Kallio, Principal Scientist at VTT, was to identify novel microRNAs participating in the regulation of cell division among the over 1000 microRNAs found in human. (eurekalert.org)
  • Objective- MicroRNA plays important roles in vascular biology, but the regulation of endothelial-specific microRNA is not well characterized. (ahajournals.org)
  • 27,28 We have also shown that miR-126 plays a role in vascular inflammation through the regulation of the adhesion molecule vascular cell adhesion molecule-1 (VCAM-1). (ahajournals.org)
  • As an important member of microRNA family, miR-126 plays an important role in the regulation of vascular integrity, endothelial cell proliferation, migration ability, etc [ 2 , 3 ]. (alliedacademies.org)
  • It also uncovered two microRNAs that contribute to the regulation of renin - a hormone long thought to play to part in controlling blood pressure. (medindia.net)
  • scientists
  • A molecule that can regulate microRNAs has been identified by US scientists. (medindia.net)
  • Scientists were especially interested in MicroRNA-96, a troublesome molecule linked by some studies to multiple types of cancers and other diseases. (cancercenter.com)
  • Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, discovered that these molecules are found in the exact same tissues in animals as diverse as sea anemones, worms, and humans, hinting at an early origin of these tissues in animal evolution. (dailygalaxy.com)
  • The EMBL scientists looked at the marine annelid Platynereis dumerilii, which is thought to have changed little over the past 600 million years.They found that in Platynereis these microRNAs are highly specific for certain tissues and cell types and, what is more, discovered that tissue specificity was conserved over hundreds of millions of years of evolutionary time. (dailygalaxy.com)
  • The scientists reasoned that if an ancient microRNA is found in a specific part of the brain in one species and in a very similar location in another species, then this brain part probably already existed in the last common ancestor of those species. (dailygalaxy.com)
  • Knowing where microRNAs were expressed in our ancestors could also help scientists understand the role of specific microRNA molecules today, as it gives them a clue of where to look. (dailygalaxy.com)
  • Last fall Dr. Peter Sarnow and a team of Stanford University scientists reported that the hepatitis C virus needs a specific microRNA, named miR-122, in order to replicate in cultured liver cells. (innovations-report.com)
  • When the scientists inactivated the microRNA, the amount of hepatitis C virus RNA was reduced by approximately 80 percent. (innovations-report.com)
  • modulate
  • Recently, it has been reported that microRNAs can modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involved in bone remodeling process. (hindawi.com)
  • viral
  • Specifically, we have found that miR-122 interacts with the 5' end of the viral RNA and is essential for viral replication. (stanford.edu)
  • Consequently, sequestration of miR-122 by antisense-oligonucleotides results in rapid loss of viral RNA. (stanford.edu)
  • In the future we hope to apply this strategy to target other disease-causing RNAs, which range from incurable cancers to important viral pathogens such as Zika and Ebola," Scripps research associate Sai Pradeep Velagapudi says in the statement. (cancercenter.com)
  • vascular
  • The vascular system can be characterized into functional entities that are specialized either in converting the intermittent ejection of blood into continuous flow (aorta), conducting blood to organs (conduit vessels), regulating blood pressure and local blood flow (resistance vessels), controlling the exchange of volume and solutes (exchange vessels), or forming a reservoir of blood, which determines cardiac filling pressures (capacitance vessels) ( 65 ). (physiology.org)
  • Because certain statin drugs - a class of medications that lower cholesterol levels - are known to influence this microRNA, the discovery will empower researchers to develop new treatments for vascular disease, according to the study. (yaledailynews.com)
  • annotation
  • miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. (mirbase.org)
  • We hope that experts on particular microRNA sequences will use the links to Wikipedia below to edit the annotation of individual microRNAs, to add information about function, evolution, discovery, and literature references, for example. (mirbase.org)
  • role
  • The team's results eventually suggested a rather surprising mechanism, according to Siekmann, because the role of microRNA in the process was unexpected prior to the study. (yaledailynews.com)
  • By isolating the role of microRNA in this process, the researchers were able to fill in the missing steps in the pathway regulating CXCR4. (yaledailynews.com)
  • The functional role of microRNAs in extracellular fluids is not yet precisely established. (ahajournals.org)
  • We have defined R-spondins as dominant regulators of the ISC niche with Wnts playing a more permissive role using lineage tracing, bioengineered Wnts and single cell RNA-seq approaches (Yan et al. (stanford.edu)
  • play
  • Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved in the pathological process of postmenopausal osteoporosis. (hindawi.com)
  • 3 Many microRNAs are ubiquitously expressed, but some of them are restricted to a limited number of tissues where they play specific roles. (ahajournals.org)
  • regulatory
  • Besides their recognized regulatory function accomplished inside the cells, microRNAs have also recently been detected in extracellular fluids, including blood. (ahajournals.org)
  • inflammation
  • First, endothelial dysfunction and increased permeability facilitate the entry of diverse inflammation-triggering molecules and particles such as low-density lipoproteins into the artery wall from the arterial lumen and vasa vasorum (VV). (frontiersin.org)