Molecules like calcium. Medical search. Frequent questions

Homer proteins are components of postsynaptic density (PSD) and play a crucial role in coupling diverse target molecules. (jneurosci.org)
Several EF-hand containing calcium-binding proteins (CaBPs) have been identified from E. histolytica. (rcsb.org)
We examined fluorescent protein-labeled nuclear proteins, such as transcription factors, RNA polymerase II and nucleosome remodeling factors, by simultaneous multi-color single-molecule imaging using HILO microscopy. (nii.ac.jp)
Free Ca 2+ is then rapidly sequestered by the action of calcium pumps and exchangers and also with buffering by cytosolic calcium binding proteins. (jneurosci.org)
We offer a fully equipped radiochemistry laboratory where we can label everything from liposomes, antibodies and proteins and all the way down to small molecules. (lu.se)

We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
J Biol Chem 2004;279:12898-12908) The crystal structure of the Entamoeba histolytica calcium binding protein-1 (EhCaBP1) has been determined at 2.4 A resolution. (rcsb.org)
Stratton studies Ca2+/calmodulin dependent protein kinase II (CaMKII), a calcium-sensitive protein encoded by four genes in mammals. (umass.edu)
Some studies suggest that the MRP6 protein stimulates the release of a molecule called adenosine triphosphate (ATP) from cells through an unknown mechanism. (medlineplus.gov)
Further experiments used a mutant form of the TERT protein that cannot interact with other TERT molecules and found that complexes that contain this mutant protein still have normal enzyme activity. (elifesciences.org)
Their general structure is a combination of a protein called collagen and a molecule called calcium phosphate. (webmd.com)
As you can see, the calcium ion is highly represented, and in fact, this messenger is recycled for many different purposes to mediate the actions (for example) of G protein-coupled receptors, receptor tyrosine kinases, voltage-operated calcium channels, among others. (hstalks.com)
From the MRD data, the rotational correlation time of detergent-solubilized BR was determined to 35 ns at 300 K, con- sistent with a monomeric protein in complex with about 150 detergent molecules. (lu.se)
While the locations and inferred H-bond connec- water molecules in a membrane protein, despite tivities of these internal water molecules are essen- being deeply buried and extensively H-bonded to tial, one would also like to quantify their mobility. (lu.se)

This fact sheet answers the most frequently asked health questions (FAQs) about sodium and calcium hypochlorite. (cdc.gov)
HIGHLIGHTS: The general public can be exposed to small amounts of sodium and calcium hypochlorite by using household products that contain these chemicals. (cdc.gov)
Sodium and calcium hypochlorite can cause irritation of the eyes, skin, respiratory and gastrointestinal tract. (cdc.gov)
Sodium and calcium hypochlorite have been found 6 times each in the 1,585 National Priorities List sites identified by the Environmental Protection Agency (EPA). (cdc.gov)
What are sodium and calcium hypochlorite? (cdc.gov)
Sodium hypochlorite is generally used dissolved in water at ` Sodium and calcium hypochlorite do not accumulate in the various concentrations. (cdc.gov)
How might I be exposed to sodium and calcium of chlorine. (cdc.gov)
You can be exposed to low levels of sodium and calcium naturally in the environment. (cdc.gov)
Sodium and calcium hypochlorite are used primarily as these chemicals were added to kill bacteria. (cdc.gov)
What happens to sodium and calcium hypochlorite when they enter the environment? (cdc.gov)
In water and soil, sodium and calcium hypochlorite primarily to the corrosive properties of hypochlorite. (cdc.gov)
hypochlorite solutions you may experience nasal irritation, ` Household products containing sodium or calcium sore throat, and coughing. (cdc.gov)
The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)
As the beans brine in the salt water, the sodium ions replace some of the calcium and magnesium ions in the skins, causing the pectin to weaken. (americastestkitchen.com)
Because sodium ions are more weakly charged than calcium and magnesium ions, they allow more water to penetrate the skins, leading to a softer texture. (americastestkitchen.com)
Calcium moves across the plasma membrane through pathways such as the plasma membrane calcium ATPase (PMCA), or the sodium calcium exchanger, these are important in expelling calcium from the cell. (hstalks.com)
This fact sheet answers the most frequently asked health questions about sodium and calcium hypoclorite. (cdc.gov)
Sodium and calcium hypochlorite are used primarily as bleaching agents or disinfectants. (cdc.gov)
When released to air, sodium and calcium hypochlorite are broken down by sunlight and compounds commonly found in the air. (cdc.gov)
In water and soil, sodium and calcium hypochlorite separate into sodium, calcium and hypochlorite ions (an ion is an electrically charged atom or molecule). (cdc.gov)
Sodium and calcium hypochlorite do not accumulate in the food chain. (cdc.gov)
You can be exposed to low levels of sodium and calcium hypochlorite if you use disinfectants like household bleach. (cdc.gov)
The toxic effects of sodium and calcium hypochlorite are due primarily to the corrosive properties of hypochlorite. (cdc.gov)
How likely are sodium and calcium hypochlorite to cause cancer? (cdc.gov)
the mass of 1 mole of a substance is its atomic weight in grams (eg, 1 mole of sodium = 23 g, 1 mole of calcium = 40 g). (msdmanuals.com)

When the neuron is in a pre-synapse phase, it explodes in electrical activity that opens a channel allowing positively charged calcium ions to go to the balloon-shaped vesicles inside the presynapse to trigger the release of neurotransmitter. (sciencedaily.com)
The trigger for this is the flux of calcium ions into the nerve terminal. (sciencedaily.com)
Its C2B domain binds at the top site to calcium ions, allowing the subsequent attachment to of the two membranes. (sciencedaily.com)
The pectin molecules in bean skins are tightly bound by calcium and magnesium ions. (americastestkitchen.com)

In this study, we discovered a small molecule inhibitor of kidney ADPR-cyclase. (elsevierpure.com)
Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. (medchemexpress.com)
LA JOLLA, Calif., Aug. 1, 2018 /PRNewswire/ -- CalciMedica announced that the first patients in a Phase 2a clinical study for acute pancreatitis have been dosed with its proprietary calcium release-activated calcium (CRAC) channel inhibitor CM4620. (biospace.com)

All of this transport activity is, of course, exceedingly important in shaping the intracellular calcium signal. (hstalks.com)

it furnishes a wide array of molecules that restrict microbes, such as antibodies, bactericidins, and inhibitors of bacterial adherence. (lu.se)

The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. (degruyter.com)
A primary challenge in biology is to explain how complex phenotypes arise from individual molecules encoded in genes. (imsc.res.in)

Characterization of the compound in a cell-based system revealed that an extracellular calcium-sensing receptor (CaSR)-mediated cADPR production and a later long-lasting increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ) in mouse mesangial cells were inhibited by the pre-treatment with this compound. (elsevierpure.com)
Welcome to this lecture on extracellular calcium signaling. (hstalks.com)
Through their secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium concentrations. (medscape.com)

Decorin is also a ligand of TLR2 and TLR4 and can stimulate the production of proinflammatory molecules [25]. (researchdataservice.com)

2.2 SLRPs in renal inflammation and diabetic nephropathy Several studies have shown that biglycan acts as a proinflammatory danger molecule by signaling through the LRR-containing receptors TLR2 and TLR4 [24 106 For a comprehensive review of the literature on the subject see our recent publication [60]. (researchdataservice.com)
A low level of signaling was also obtained when functionalizing the blocked SLBs with adhesion molecules binding to receptors on the T cell. (lu.se)

E-cadherin is a calcium dependent adhesion molecule with important roles in epithelial intercellular adhesion and cellular structure. (cdc.gov)
In the final part of the thesis, the interaction of TCR-pMHC in the presence of adhesion molecules of different length and density is studied. (lu.se)
Adhesion molecule pairs of similar height as TCR-pMHC have been argued to facilitate the TCR-pMHC interaction by physically keeping the opposing membranes at an optimal distance for binding. (lu.se)
To better understand how, and if, adhesion molecules of different lengths influences TCR-pMHC binding the 2D Kd of TCR-pMHC in the presence of differently-sized adhesion molecules was studied. (lu.se)
In addition, the TCR-pMHC distributed non-homogeneously in the cell-SLB contacts when having height-mismatched adhesion molecules, but homogeneously when having height-matched adhesion molecules. (lu.se)
Furthermore, even for height-matched adhesion molecules the 2D Kd of the TCR-pMHC interaction was found to be dependent on the relative density fraction of TCR to adhesion molecules, with low fractions of TCR molecules giving 2-3 times weaker binding. (lu.se)
A family of calcium-independent cell adhesion molecules of the immunoglobulin superfamily. (bvsalud.org)

A CIC biomaGUNE team led by Ruiz-Cabello, together with Ikerbasque research professor Susana Carregal -both members of the biomedical research networking center CIBERES-, has developed contrast agents to achieve the selective molecular imaging of atherosclerotic plaques using ultrasmall amorphous calcium carbonate nanoparticles. (nanowerk.com)
CM4620 is a potent and selective small molecule calcium release-activated calcium (CRAC). (biospace.com)

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. (wikipedia.org)
the molecule used as energy currency in all living things), which results in increased pyrophosphate levels in joints, is thought to be one reason why crystals may develop. (wikipedia.org)
Arthrocentesis, or removing synovial fluid from the affected joint, is performed to test the synovial fluid for the calcium pyrophosphate crystals that are present in CPPD. (wikipedia.org)
ATP can be broken down into other molecules, including adenosine monophosphate (AMP) and pyrophosphate. (medlineplus.gov)
Pyrophosphate helps control deposition of calcium and other minerals in the body. (medlineplus.gov)
As a result, little pyrophosphate is produced, and calcium and other minerals accumulate in elastic fibers of the skin, eyes, blood vessels and other tissues affected by PXE. (medlineplus.gov)

The molecule is turned on and interacts with both membranes. (sciencedaily.com)
Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. (hmdb.ca)

Alternatively, a lack of functioning MRP6 may impair the transport of a substance that would normally prevent mineralization, leading to the abnormal accumulation of calcium and other minerals characteristic of PXE. (medlineplus.gov)

A simple, fast, and precise reverse phase, isocratic HPLC method was developed for the separation and quantification of Rosuvastatin calcium and Olme sartan medoxomil in bulk drug and pharmaceutical do sage form. (jascoinc.com)
We have demonstrated that clear visualization of single molecules in cells enables their molecular quantification. (nii.ac.jp)

citation needed] Medical imaging, consisting of x-ray, CT, MRI, or ultrasound may detect chondrocalcinosis within the affected joint, indicating a substantial amount of calcium crystal deposition within the cartilage or ligaments. (wikipedia.org)
But just as it had originally been the case in other fields of synthetic chemistry, such as molecular or solid state chemistry, the outcome of such a deposition with respect to the structure of the individual molecule or the structural arrangement of many molecules is very hard to predict without prior experimental input. (degruyter.com)
Similarly, the a priori design of optimal deposition routes leading to desired specific patterns of molecules on surfaces is still further in the future. (degruyter.com)

Our parathyroid glands ramp up their production of parathyroid hormone, which sends a signal to our kidneys to ramp up their conversion of 25(OH)D to calcitriol, the most active form of vitamin D. Calcitriol then increases serum calcium in two ways: preventing loss of calcium in the urine and feces, and extracting calcium from bone. (westonaprice.org)
An elevated intact parathyroid hormone level with an elevated ionized serum calcium level is diagnostic of primary hyperparathyroidism. (medscape.com)

Humoral hypercalcemia happens when cancer cells cause parathyroid hormone-related molecules to overproduce. (healthline.com)
The secretion of parathyroid hormone is regulated directly by the plasma concentration of ionized calcium. (medscape.com)
The main effects of parathyroid hormone are to increase the concentration of plasma calcium by increasing the release of calcium and phosphate from bone matrix, increasing calcium reabsorption by the kidney, and increasing renal production of 1,25-dihydroxyvitamin D-3 (calcitriol), which increases intestinal absorption of calcium. (medscape.com)
Thus, overproduction of parathyroid hormone results in elevated levels of plasma calcium. (medscape.com)
The serum level of parathyroid hormone, calcium, phosphorus, and 25-hydroxyvitamin D should be measured. (medscape.com)
Patients with secondary hyperparathyroidism usually have low-normal calcium and elevated parathyroid hormone. (medscape.com)

Or one could splice it three ways: we absorb more calcium from our food, and we lose more from our bones into our blood, but we lose less from our blood into our urine. (westonaprice.org)
The usual chemicals used for chelation create a molecular "cage" that ensnares certain sorts of molecules and carries them away in the urine. (forbes.com)
A 24-hour urine calcium measurement is necessary to rule out familial benign (hypocalciuric) hypercalcemia (FHH). (medscape.com)

Since calcium is one of the components of plaques in heart arteries, and chelation can carry away calcium, then chelation helps heart disease. (forbes.com)

Click molecule labels to explore molecular sequence information. (nih.gov)

The functional properties and localization of the channels as well as the pumps, exchangers, and buffers are thought to play a crucial role in generating a range of calcium signals that vary from a brief local increase to repetitive calcium spikes and waves spreading over a larger region. (jneurosci.org)

In this review, we discuss in detail such small molecules that play a pertinent role in affecting the p53-MDM2 signaling axis and analyze their potential as cancer chemotherapeutics. (iassist2012.org)
Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. (tocris.com)

Similarly, the powerful global search techniques that have been applied to, and sometimes specifically developed for, the structure prediction of crystals and single molecules in vacuum or solvent can also be employed for the prediction of the structure(s) of molecules on surfaces. (degruyter.com)

Calcium carbonate (CaCO 3 ) is a safe, biocompatible material with a long history of use in textiles, cosmetics and foodstuffs. (nanowerk.com)
In this work, recently published in the journal ACS Nano ( 'A Comparative Study of Ultrasmall Calcium Carbonate Nanoparticles for Targeting and Imaging Atherosclerotic Plaque' ), the team compared various nanoparticles specifically designed for different features of atherosclerosis (such as calcification or inflammation), which provide useful information about the phase or stage of plaque development. (nanowerk.com)
Our work shows that Gd(III)-doped amorphous calcium carbonate nanoparticles are an effective tool due to their high magnetic resonance contrast and physicochemical properties. (nanowerk.com)
As a reinforcement agent, calcium carbonate from avian eggshell waste was used, at 10 ph of micro particles, 125 μm. (intechopen.com)

Calcium can enter through pathways such as store-operated, voltage-operated, or receptor-operated calcium channels. (hstalks.com)

Overall, this work defines human telomerase DNA binding and synthesis properties at single-molecule level and establishes conserved telomerase subunit architecture from single-celled organisms to humans. (elifesciences.org)
In this area, we have developed a methodology for the incorporation of protected isocyanates into organic molecules and this chemistry is being applied to the synthesis of a diverse set of biologically important, nitrogen-containing heterocycles. (exeter.ac.uk)
My teaching activities cover all aspects of organic chemistry from basic structure and bonding in organic molecules, to complex organic synthesis. (exeter.ac.uk)

This arrangement allows the EF-hand motif of one molecule to interact with that of an adjacent molecule to form a two EF-hand domain similar to that seen in the N-terminal domain of the NMR structure of CaBP1, calmodulin and troponin C. The oligomeric state of EhCaBP1 results in reduced flexibility between domains and may be responsible for the more limited set of targets recognized by EhCaBP1. (rcsb.org)

Plasma samples that have been anticoagulated with citrate or oxalate should be avoided because amylase is a calcium-containing enzyme and false low levels can be obtained with such specimens. (medscape.com)
Most of what is understood about the activities of enzymes has been deduced by studying solutions containing many enzyme molecules. (elifesciences.org)
It had previously been suggested that TERT is only an active enzyme when it is bound to another TERT molecule, but Wu et al. (elifesciences.org)

The Ca 2+ signal is characterized by a rapid increase in the concentration of free cytosolic calcium ([Ca 2+ ] i ) attributable to the opening of calcium channels located in the plasma membrane and in the membranes of intracellular calcium stores. (jneurosci.org)

In parallel, we carried out single-molecule force measurement and molecular dynamics simulations on the same subjects. (nii.ac.jp)

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response. (biospace.com)
Most of the other pathways in this list rely on metabolic reactions for their initiation and termination, calcium differs in an important way from these other pathways in that as an inorganic cation, calcium can be neither created nor destroyed. (hstalks.com)
Sirtuine5 (SIRT5) is an important molecule involved in the pathology of inflammatory diseases. (bvsalud.org)

For the older ones, the instant chemical change explores the science of cross-linking long chains of molecules. (stevespanglerscience.com)

Examples of these minerals include calcium, phosphorus, and vitamin D. (webmd.com)

However, an interesting corollary of these plasma membrane fluxes is that they can potentially lead to significant alterations in local calcium concentration at the extracellular face of the cell. (hstalks.com)

Preusser: "Potential treatment strategies could therefore be to chemically inhibit the tumour cell network using calcium blockers or substances that affect connexin 43 or GAP 43. (sciencedaily.com)

But we are still far away from an unbiased structure prediction of thermodynamically and/or kinetically stable structures of molecules on surfaces. (degruyter.com)

Chemical interaction with matrix molecules is hypothesized, based on SEM images and considering the low or absent anti-microbial activity on planktonic bacteria showed by flow cytometry. (frontiersin.org)
It was found that the 2D Kd of the TCR-pMHC interaction could be up to an order of magnitude higher (weaker) than the corresponding value for TCR-pMHC alone when having height-mismatched molecules. (lu.se)

In this study, we describe new approaches of subunit labeling for single-molecule imaging, applied to determine the TERT content of complexes assembled in cells or cell extract. (elifesciences.org)
So it's powerful signaling actions can only be controlled by moving the calcium ion about in different locations inside and outside the cell, or by temporarily buffering it. (hstalks.com)
In today's talk, I'm going to discuss the emerging idea that these calcium fluctuations outside the cell may serve as signals in their own right. (hstalks.com)

22 water molecules with bulk water. (lu.se)

Sound starts as waves of mechanical vibrations that travel through the air from their source to a person's ear through the compression of air molecules. (news-medical.net)

The research has applications beyond understanding the molecular foundation of memory since CaMKII also is found in other calcium-coupled cells in the body, including cardiomyocytes in the heart and oocytes in the ovaries. (umass.edu)
55 It was found that the solventfree reaction of ETFAA 1a, benzaldehyde, and ammonium acetate at 100 C proceeded with the loss of the water molecule to aff ord partially dehydrated 2-hydroxy-2,6-bis(trifl uoromethyl)-1,2,3,4-tetrahydropyridine-3,5-dicarboxylate 6. (researchgate.net)

Calcium hypochlorite is a white solid that readily decomposes in water releasing oxygen and chlorine. (cdc.gov)
The proton-conducting pathway of bacteriorhodopsin (BR) contains at University, PO Box 124 least nine internal water molecules that are thought to be key players in SE-22100 Lund, Sweden the proton translocation mechanism. (lu.se)
The relevance of water exchange kinetics is underscored by recent crystallographic ®ndings of substantial variations in the number and locations of internal water molecules during the photocycle. (lu.se)

Let's begin by considering one of the "bad" things that can cause low 25(OH)D besides a deficiency of vitamin D itself: a deficiency of calcium. (westonaprice.org)
In order to understand why a deficiency of calcium can cause low 25(OH)D, we need only consider the most well established and best understood role of vitamin D: to regulate the level of calcium in our blood. (westonaprice.org)
For us to be able to produce our own vitamin D, our skin must be exposed to ultraviolet light of the type UV-B. Vitamin D, which is actually a hormone, is produced when a cholesterol molecule in the skin is reached by sun light. (lu.se)

Free radicals are unstable molecules that can damage cells and lead to inflammation. (vitanetonline.com)

Pseudoxanthoma elasticum (PXE) is a progressive disorder that is characterized by the accumulation of deposits of calcium and other minerals (mineralization) in elastic fibers. (medlineplus.gov)

We should expect, then, that a deficient intake of calcium will lead to increased production of calcitriol, and thereby to depletion of 25(OH)D. (westonaprice.org)

It exhibits strong adsorption effects on CO2 molecules and mercaptan. (actionext.com)

Quasi-statical unfolding of single molecules of staphylococcal nuclease and double-stranded DNA by constant-rate mechanical stretching. (nii.ac.jp)

Anatomy25

Organisms15

Diseases6

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes63

Disciplines and Occupations3

Information Science4

Health Care1

Proteins5

Protein10

Sodium25

Ions4

Inhibitor3

Intracellular calcium signal1

Inhibitors1

Individual molecules2

Extracellular calcium3

Stimulate the produc1

Receptors2

Adhesion7

Selective2

Pyrophosphate6

Interacts2

Abnormal accumulation of calcium1

Quantification2

Deposition3

Serum calcium2

Parathyroid hormone6

Urine3

Components1

Sequence1

Play a crucial role1

Small2

Similarly1

Carbonate4

Receptor1

Synthesis3

Arrangement1

Enzyme3

Membranes1

Measurement1

Important3

Chains1

Phosphorus1

Concentration1

Substances1

Stable1

Interaction2

Cell3

Bulk1

Waves1

Found2

Water3

Vitamin3

Cells1

Minerals1

Calcitriol1

Effects1

Single1