Molecules histocompatibility antigens class i. Medical search. Frequent questions

Major histocompatibility complex class I chain-related antigen A (MICA) proteins are like HLA class I gene products. (loinc.org)
The tests referred to right here demonstrate that mCD1 can acquire peptide antigens from prepared proteins intracellularly certainly, and, furthermore, they claim that peptide and nonpeptide antigens may bind differently to mCD1. (eprf.ca)
MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. (embl-heidelberg.de)
Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing MHC_II_alpha domain in the selected taxonomic class. (embl-heidelberg.de)
Antigens are usually proteins or polysaccharides . (wikidoc.org)
Non-microbial exogenous (non-self) antigens can include pollen, egg white, and proteins from transplanted tissues and organs or on the surface of transfused blood cells. (wikidoc.org)
The RNA Vaccines 3D Model Making Kit shows how RNA vaccines make vaccinated cells produce viral proteins (antigens), display them on their cell surface in Major Histocompatibility Complex (MHC) molecules and stimulate an immune response. (fishersci.com)
Their encoded proteins are involved in presenting antigen derived from pathogens to immune cells, which then trigger a cascade of immune responses [ 3 , 4 ]. (biomedcentral.com)
In the responsive immune system major histocompatibility complex class I (MHC I) proteins plays a key role in the recognition of intracellular pathogens (virus and cancer). (lu.se)
The main task of the MHC-I proteins is to present antigens, which may impose a hazard to the cell. (lu.se)
The mechanism of this antigen presentation involves the formation of a so-called MHC-I peptide-loading complex (PLC) where several proteins are involved. (lu.se)

The HLA class I histocompatibility antigen, A-24 alpha chain (HLA-A) is a α- or alpha protein sometimes glycoprotein present in blood.Antigens are peptides or recombinant or native dependent on the production method. (hla-a.com)
Due to these data displaying that mCD1 trafficks to endosomes, where it could bind peptides produced from exogenous protein, we conclude that peptide antigen display by mCD1 may very well be a normally occurring sensation. (eprf.ca)
class II molecules present exogenously derived antigenic peptides (~15 amino acids) to helper T cells. (embl-heidelberg.de)
In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). (rcsb.org)
The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
the modulation of epitope immunodominance and the processing and presentation of HIV peptides for MHC class I recognition were shown to be dependent on flanking residues that were N terminal to the natural epitopes (see the related article beginning on page 3563). (jci.org)
Endogenous antigens degraded into peptides within cytosol by proteasomes. (oneclass.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) must be processed into peptides and complexed with surface class II MHC molecules on professional APCs (which specialize in presenting antigens to T cells) to be recognized by CD4 helper T (Th) cells. (msdmanuals.com)

Besides antigen presentation, growing evidence is showing thatligation of MHC class II molecules also activates intracellular signalingpathways, frequently leading to apoptosis. (embl-heidelberg.de)
Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). (rcsb.org)
Endogenous antigens are antigens that have been generated within the cell, as a result of normal cell metabolism , or because of viral or intracellular bacterial infection . (wikidoc.org)
We used a novel in vitro degradation assay involving cytosolic extracts as well as endogenous intracellular processing assays to examine 2 well-characterized HIV-1 Gag overlapping epitopes presented by the same HLA class I allele, one of which is consistently immunodominant and the other subdominant in infected persons. (jci.org)
The MHC genes are divided into two principal classes: class I, which is responsible for immune defence against intracellular pathogens such as viruses, and class II, which is responsible for dealing with extracellular pathogens such as bacteria and nematodes [ 2 ]. (biomedcentral.com)
Williams, DB, Swiedler, SJ & Hart, GW 1985, ' Intracellular transport of membrane glycoproteins: Two closely related histocompatibility antigens differ in their rates of transit to the cell surface ', Journal of Cell Biology , vol. 101, no. 3, pp. 725-734. (johnshopkins.edu)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
The antigen processing and loading onto MHC-I molecules takes place in the intracellular environment, when the antigen-MHC-I complex is transferred to the cell surface for detection by circulating CD8 + T cells. (lu.se)

Mhc encodes class i, ii molecules functioning in antigen presentation to t cells, class iii molecules with diverse functions. (oneclass.com)

This boosts the relevant queries relating to whether peptide antigen display by mCD1 is certainly a KRas G12C inhibitor 3 sensation occurring normally and, if so, whether mCD1 substances can handle intracellularly buying peptide antigens. (eprf.ca)

During pregnancy the formation of alloreactive anti-human leukocyte antigen (HLA) antibodies are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion. (frontiersin.org)
Alloreactive anti-human leukocyte antigen (HLA) antibodies formed during pregnancy are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion, such as febrile non-hemolytic transfusion reactions, immunological platelet refractoriness or transfusion-related acute lung injury (TRALI) ( 1 , 2 ). (frontiersin.org)
Major histocompatibility complex class III associations have also been observed, as has a high frequency of anti-human leukocyte antigen antibodies. (medscape.com)

The main function of major histocompatibility complex (MHC) class IImolecules is to present processed antigens, which are derived primarilyfrom exogenous sources, to CD4(+) T-lymphocytes. (embl-heidelberg.de)
Exogenous antigens are antigens that have entered the body from the outside, for example by inhalation, ingestion, or injection. (wikidoc.org)
Class ii molecules present exogenous antigen to cd4+ th cells. (oneclass.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
It is hypothesized that among decidual antigen presenting cell (APC) populations (classical macrophages, classical mature dendritic cells (DC), immature DC and myeloid DC), specialized APCs present fetal antigens to the maternal immune system. (frontiersin.org)
Class II MHC glycoproteins are expressed on the surface of antigen-presenting cells (APC), including macrophages, dendritic cells and B cells. (embl-heidelberg.de)
The innate immune system is the "first line of defense" against pathogens and includes macrophages and dendritic cells that function in part to present antigens to the cells in the adaptive immune system. (mhmedical.com)
Dendritic cells (DCs) are highly specialized and efficient antigen-presenting cells (APCs). (mhmedical.com)
Class ii molecules restricted to b cells, macrophages & dendritic cells * apc. (oneclass.com)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage, do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

Bishop, GA, Warren, WD & Berton, MT 1995, ' Signaling via major histocompatibility complex class II molecules and antigen receptors enhances the B cell response to gp39/CD40 ligand ', European Journal of Immunology , vol. 25, no. 5, pp. 1230-1238. (uthscsa.edu)
iNKT cells recognize lipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like antigen presenting molecule. (wikipedia.org)
0.01), resolution of complement deposits on capillaries, and a reduction in the expression of intercellular adhesion molecule 1 and major-histocompatibility-complex class I antigens. (nih.gov)
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. (rcsb.org)
Immunohistochemical and immunoelectron study of major histocompatibility complex class-II antigen in canine cutaneous histiocytoma: its relation to tumor regression. (illumina.com)
Abnormal expression of major histocompatibility complex class II molecules in the placenta may trigger the initiating immunologic event in this organ, which is followed by cross-reactivity with an antigen present in the skin and the characteristic cutaneous signs of the disease. (medscape.com)
A role for the involvement of major histocompatibility complex class II antigens seems likely because of the association with human leukocyte antigens DR3 and DR4. (medscape.com)

MSCs are able to evade the host cell immune system due to their low expression of major histocompatibility complex (MHC) class I molecules and complete lack MHC class II molecules and other costimulatory molecules (CD40, CD40L, CD80, and CD86) required for immune cell stimulation [ 15 - 17 ]. (hindawi.com)

Constitutive expression of MHCclass II molecules is confined to professional antigen-presenting cells(APC) of the immune system, and in nonprofessional APCs MHC class IImolecules can be induced by a variety of immune regulators. (embl-heidelberg.de)
By endocytosis or phagocytosis , these antigens are taken into the antigen-presenting cells (APCs) and processed into fragments. (wikidoc.org)
APCs then present the fragments to T helper cells ( CD4 + ) by the use of class II histocompatibility molecules [2] on their surface. (wikidoc.org)
T cells cannot bind native antigens, but require that they are processed by APCs, while B cells can be activated by native ones. (wikidoc.org)

Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
Some reports also implicate autophagy in the presentation of extracellular, endocytosed antigen by MHC class I molecules, a pathway termed "cross-presentation. (edu.au)

The process of immune response to bacteria challenge needs GILT to catalyze the reduction of disulfide bond and unfolding native protein antigens, promoting their hydrolysis by proteases. (bvsalud.org)

Tumor immunogenicity results from the processing, and subsequent presentation of tumor antigens released from dead or dying tumor cells on MHC molecules expressed on antigen-presenting cells (APC). (aacrjournals.org)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. (rcsb.org)
These studies illustrate the complementary roles played by phage display library methods, peptide analogue SAR, peptide mimetics substitutions, and structure-based drug design in the discovery of inhibitors of antigen presentation by MHC class II HLA-DR molecules. (rcsb.org)
Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. (edu.au)
Autophagy is a route that enables the presentation of cytosolic antigen by MHC class II molecules. (edu.au)
However, the contribution of autophagy to cross-presentation varied depending on the form of antigen: it was negligible in the case of cell-associated antigen or antigen delivered via receptor-mediated endocytosis, but more prominent when the antigen was a soluble protein. (edu.au)
These findings highlight the differential use of autophagy and its machinery by primary cells equipped with specific immune function, and prompt careful reassessment of the participation of this endocytic pathway in antigen cross-presentation. (edu.au)
The first step of peptide selection in antigen presentation by MHC class I molecules. (expasy.org)
The enzyme gamma-interferon-inducible lysosomal thiol reductase (GILT) plays an important role in promoting the processing and presentation of major histocompatibility complex (MHC) class II-restricted antigens. (bvsalud.org)
The major histocompatibility complex and antigen presentation (chapter 8) summary. (oneclass.com)
The project is done in collaboration with Kajsa M. Paulsson, head of the Antigen Presentation group at the Faculty of Medicine. (lu.se)

Activated T cells induce proliferation and differentiation of resting B cells in vitro through their CD40 molecules and lymphokine receptors. (uthscsa.edu)
To test this hypothesis, both an Ag‐specific mouse B cell clone CH12.LX, and freshly isolated resting splenic B cells were cultured with either soluble or membrane‐bound forms of the T cell ligand for CD40 (CD40L), in the presence or absence of additional signals provided by Ag or anti‐IgM, interleukin‐4, and class II‐specific monoclonal antibody (mAb). (uthscsa.edu)
The ability of class II MHC‐mediated signals to enhance Ag‐specific B cell responsiveness to CD40‐mediated signaling may selectively promote the activation of B cell clones capable of cognate interactions with helper T cells. (uthscsa.edu)
Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self and foreign lipids and glycolipids. (wikipedia.org)
They and other CD1d-restricted T cells ('type 2' NKT) recognize lipids and glycolipids presented by CD1d molecules, a member of the CD1 family of antigen-presenting molecules, rather than peptide-major histocompatibility complexes (MHCs). (wikipedia.org)
The best known antigen of iNKT cells is alpha-galactosylceramide (αGalCer), which is a synthetic form of a chemical purified from the deep sea sponge Agelas mauritianus. (wikipedia.org)
NKT cells recognize protected microbial lipid agents which are presented by CD1d-expressing antigen presenting cells. (wikipedia.org)
Eosinophils function as antigen presenting cells as they express major histocompatibility complex (MHC) class II molecules. (medscape.com)
Recently, a major inhabitants of the mCD1 autoreactive T cells, the ones that exhibit the NK1 namely.1 molecule and an invariant V14 TCR, have already been proven to recognize the glycolipid -galactosylceramide (-GalCer) presented by mCD1 (8, 9). (eprf.ca)
In fact, as antigen-presenting cells (APC), microglia are endowed with the ability to release pro-inflammatory cytokines and chemokines into the CNS tissue microenvironment. (atlasantibodies.com)
Antigen-presenting cells survey their environment and present captured antigens bound to major histocompatibility complex (MHC) molecules. (edu.au)
This may be due to studies using different types of antigen presenting cells for which the use of autophagy is not well defined. (edu.au)
The number of cells expressing TNF-α, IFN-γ and MHC II molecules was also reduced. (unab.edu.co)
MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and inflammatory T cells (cause the release of lymphokines that attract other cells to site of infection) ( PUBMED:15120183 ). (embl-heidelberg.de)
Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune responses. (embl-heidelberg.de)
Interestingly,activated T cells from many species, with the exception of mice,synthesize and express MHC class II molecules at their cell surface. (embl-heidelberg.de)
Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). (rcsb.org)
Cells present their antigens to the immune system via a histocompatibility molecule . (wikidoc.org)
Depending on the antigen presented and the type of the histocompatibility molecule, several types of immune cells can become activated. (wikidoc.org)
Tumor antigens or Neoantigens are those antigens that are presented by MHC I or MHC II molecules on the surface of tumor cells . (wikidoc.org)
These antigens can sometimes be presented by tumor cells and never by the normal ones. (wikidoc.org)
More common are antigens that are presented by tumor cells and normal cells, and they are called tumor-associated antigens (TAAs) . (wikidoc.org)
Cytotoxic T lymphocytes that recognize these antigens may be able to destroy the tumor cells before they proliferate or metastasize . (wikidoc.org)
Tumor antigens can also be on the surface of the tumor in the form of, for example, a mutated receptor, in which case they will be recognized by B cells . (wikidoc.org)
This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3+ T cells. (jci.org)
To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
The molecular components of pathogens that are recognized by T and B cells are referred to broadly as antigens. (mhmedical.com)
Class i molecules expressed on almost all nucleated cells. (oneclass.com)
Class i molecules present endogenous antigen to cd8+ tc cells. (oneclass.com)
The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. (lu.se)
Загальні відомості про імунну систему The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
Class ii molecules large glycoprotein chain and 2-microglobulin, protein. (oneclass.com)

Like the HLA system, MICA molecules can elicit antibody responses during pregnancy, blood product transfusion, or organ transplant rejection. (loinc.org)
We have previously determined the structure of the MHC class I molecule HLA-A1 bound to a melanoma antigen-encoding gene (MAGE)-A1-derived peptide in complex with a recombinant antibody fragment with TCR-like specificity, Fab-Hyb3. (rcsb.org)
Here, we compare the X-ray structure of HLA-A1:MAGE-A1 with that complexed with Fab-Hyb3 to gain insight into structural changes of the MHC molecule that might be induced by the interaction with the antibody fragment. (rcsb.org)
Maternal blood serum was screened for HLA class I and II antibodies, identification of Donor Specific Antibody (DSA), activation of complement measured by C1q and IgG4 concentrations. (frontiersin.org)
An antigen (from antibody-generating ) or immunogen is a molecule that sometimes stimulates an immune response. (wikidoc.org)

Therefore, conformational changes within the HLA-A1:MAGE-A1:Fab-Hyb3 complex include MHC residues that are also involved in reorientations in complexes with natural ligands, pointing to their central importance for the peptide-dependent recognition of MHC molecules. (rcsb.org)
Formation of MHC-antigen complexes occurs in specialized compartments where multiple protein trafficking routes, still incompletely understood, converge. (edu.au)

Residue 65 is frequently and residues 72 and 146 are occasionally involved in TCR binding-induced conformational changes, as revealed by a comparison with MHC class I structures in TCR-liganded and -unliganded forms. (rcsb.org)

We examined if these effects were associated with a reduced renal expression of CD54 and its ligands, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and MHC class II molecules. (unab.edu.co)
MHC class I and II molecules are assembled and loaded with their peptide ligands via different mechanisms. (embl-heidelberg.de)
Immune escape is mainly caused by histocompatibility complex (MHC) class I, abnormal antigen signaling mechanism, immunosuppressive components (such as HLA-G), Fas and its ligands to activate apoptosis and overexpression of other immunosuppressive molecules, such as lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3) ( Steven and Seliger, 2018 ). (techscience.com)

Antibodies and Antigens. (eprf.ca)
Mothers were genotyped for HLA class Ib ( HLA-E, -F and -G ). Anti-HLA class I and II antibodies were identified in 24% of the women. (frontiersin.org)

It is also involved in MHC I-restricted antigens catalyzing disulfide bond reduction in fishes' adaptive immunity. (bvsalud.org)
One of the main functions of the innate immune system is to present antigens to the adaptive immune system to orchestrate a functional immune response. (mhmedical.com)
Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics. (biomedcentral.com)

Apart from the expulsion of several water molecules from the interface, Fab-Hyb3 binding results in major rearrangements (up to 5.5 A) of heavy chain residues Arg65, Gln72, Arg145, and Lys146. (rcsb.org)

Proteasomes and transporters involved in antigen processing (before t cell recognition) Mhc alleles influence immune responsiveness and antigen presenting ability also susceptibility to many diseases. (oneclass.com)

The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)

The present study was designed to test the hypothesis that signals delivered via the B cell antigen (Ag) receptor (membrane immunoglobulin, mIg) and major histocompatibility complex (MHC) class II molecules enhance B cell responsiveness to CD40‐mediated signals, providing specificity to the Ag‐nonspecific, MHC‐unrestricted CD40 signal. (uthscsa.edu)
mCD1 substances are exclusive within their capability to present well described peptide and nonpeptide antigens chemically, even though the non-classical H-2M3 molecule also could be with the capacity of this duality of function (12). (eprf.ca)
If present, private alleles generally occurred at very low frequencies in each population, except for the private alleles of MHC class I in one island population (Puerto Rico, lineage tenuirostris ). (biomedcentral.com)

HLA-G belongs to the HLA class I heavy chain paralogues. (thermofisher.com)
This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). (thermofisher.com)

MHC class II molecules are comprised of two membrane-spanning chains, alpha and beta, of similar size. (embl-heidelberg.de)

The highly conserved TCR is made of Va24-Ja18 paired with Vb11 in humans, which is specific for glycolipid antigens. (wikipedia.org)
Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)

In this case, they are called tumor-specific antigens (TSAs) and, in general, result from a tumor-specific mutation. (wikidoc.org)

Although the expression of MHC class I and II molecules can be upregulated by MSC exposure to inflammatory cytokines interferon-gamma (IFN- γ ) and tumor necrosis factor-alpha (TNF- α ), they are still unable to induce an immunological response [ 18 ]. (hindawi.com)

Molecular features of ligand binding to MHC class II HLA-DR molecules have been elucidated through a combination of peptide structure-activity studies and structure-based drug design, resulting in analogues with nanomolar affinity in binding assays. (rcsb.org)
Whereas binding was undetectable in solution, the affinity of the CD4/pMHC II interaction could be measured in 2D using CD4- and adhesion molecule-functionalized, supported lipid bilayers, yielding a 2 D Kd of ∼5,000 molecules/μm 2 . (lu.se)

Click molecule labels to explore molecular sequence information. (nih.gov)
The differences found in the patterns of selection between the class I and II loci are consistent with the hypothesis that different mechanisms shape the sequence evolution of MHC class I and class II genes. (biomedcentral.com)

Here, we assess the allelic diversity and patterns of selection for MHC class I and class II loci in a threatened shorebird with highly flexible mating and parental care behaviour, the Snowy Plover ( Charadrius nivosus ) across its broad geographic range. (biomedcentral.com)

The results support an association of certain HLA class Ib alleles with allo-immunization during pregnancy. (frontiersin.org)
We found 40 alleles at MHC class I and six alleles at MHC class II, with individuals carrying two to seven different alleles (mean 3.70) at MHC class I and up to two alleles (mean 1.45) at MHC class II. (biomedcentral.com)

Compact disc1 substances are a category of antigen-presenting substances distantly linked to main histocompatibility complicated (MHC)-encoded course I and course II substances. (eprf.ca)
Compact disc1 substances have several specific features, including too little KRas G12C inhibitor 3 polymorphism, nearly similar degrees of homology with both course I and course II substances (1), and appearance that is indie of either the peptide transporter connected with antigen display (Touch) (2, 3) or the invariant string (Ii). (eprf.ca)
These specific features, as well as the conservation of Compact disc1 substances through a lot of the mammalian purchase, justify their categorization as another, third category of antigen-presenting substances. (eprf.ca)

Tolerogen - An antigen that invokes a specific immune non-responsiveness due to its molecular form . (wikidoc.org)

This shows that, although both lipid and peptide display may occur normally, mCD1 may connect to both of these types of antigens differently. (eprf.ca)

These findings suggest that expression of adhesion molecules plays a critical role in CSS and underline the importance of cellular immunity in this experimental model. (unab.edu.co)

The fragments are then presented on the cell surface in the complex with MHC class I molecules. (wikidoc.org)

Using pulse-chase radiolabeling, the kinetics of appearance of the class I histocompatibility antigens, H-2K(k) and H-2D(k), at the cell surface were compared and found to be remarkably different. (johnshopkins.edu)

The purpose of the study was to identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization in pregnancy and the degree of tolerance estimated by IgG4 expression. (frontiersin.org)
Immunostaining techniques were used to follow CSS and to study the expression of CD54, CD18, CD1lb/c, IFN-γ, TNF-α and MHC class molecules. (unab.edu.co)

Anatomy32

Organisms14

Diseases8

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes55

Disciplines and Occupations2

Information Science3

Named Groups1

Health Care2

Proteins12

Peptides11

Intracellular8

Functioning in antigen presentation1

Peptide antigens1

Leukocyte antigen3

Exogenous3

Dendritic8

Major histocompatib7

Costimulatory molecules1

APCs4

Extracellular2

Protein antigens1

Presentation12

Cells32

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Antibody5

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Conformational1

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Adaptive3

Residues1

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Present3

Heavy chain2

Membrane1

Humans2

Mutation1

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Expression2