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  • novel
  • In pre-clinical research published in the journal Chemistry & Biology ( 'Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13' ), Dr Florian Hollfelder from the Department of Biochemistry at Cambridge and Dr Lutz Jermutus,Senior Director, Research and Development at MedImmune, led a study to map a list of human enzymes (proteases) against potential protein drug targets. (nanowerk.com)
  • proteases
  • Work will be presented for discovery of small molecule activators for the apoptotic proteases known as caspases, as well a Ser-Thr kinase PDK-1. (aacrjournals.org)
  • In pre-clinical research published in the journal Chemistry & Biology , Dr Florian Hollfelder from the Department of Biochemistry at Cambridge and Dr Lutz Jermutus,Senior Director, Research and Development at MedImmune, led a study to map a list of human enzymes (proteases) against potential protein drug targets. (cam.ac.uk)
  • specific
  • Restriction enzymes, also known as restriction endonucleases, recognise specific nucleotide sequences and cut the DNA at these sites. (sciencephoto.com)
  • found
  • The enzyme horseradish peroxidase (HRP), found in the roots of horseradish, is used extensively in biochemistry applications. (wikipedia.org)
  • human
  • Lysozyme is an anti-bacterial enzyme widely distributed in human body fluids, including tears and saliva. (sciencephoto.com)
  • A collaboration between the University of Cambridge and MedImmune, the global biologics research and development arm of AstraZeneca, has led researchers to identify a potentially significant new application for a well-known human enzyme, which may have implications for treating respiratory diseases such as asthma. (cam.ac.uk)
  • active
  • This leads to a conclusion that the enzyme's active site conformation is less stable than the whole enzyme conformation in response to the two denaturants. (wikipedia.org)
  • the enzyme active sites are almost all occupied and the reaction rate is determined by the intrinsic turnover rate of the enzyme. (wikipedia.org)
  • function
  • My lab has been focusing on discovering ways to activate enzymes leading to gain-of-function phenotypes. (aacrjournals.org)
  • Because the enzyme already had a 'name' and a function, nobody thought to see if it had a promiscuous side. (cam.ac.uk)
  • example
  • An appropriate example is pyruvate kinase (see first figure), a glycolytic enzyme that plays an important role in regulating the flux from fructose-1,6-biphosphate to pyruvate. (wikipedia.org)
  • known
  • Of particular interest was how MMP8 was able to disable a molecule known as IL-13, which is known to play an important role in several inflammatory diseases such as asthma and dermatitis. (cam.ac.uk)
  • Our approach is new: we 'recycle' known enzymes and ask whether they can do other things than the ones they are known for," adds Dr Jermutus. (cam.ac.uk)