Molecules cell cardiac. Medical search. Frequent questions

While many other treatments inhibit viral proliferation in myocytes, sCAR-Fc prevents the virus entering the cell by competitively binding to coxsackie virus and adenovirus receptors (CAR) on the membrane of myocytes. (wikipedia.org)
Internalization of the virus into myocytes occurs by binding to coxsackievirus-adenovirus receptors (CAR) located in tight junctions on cell membranes. (wikipedia.org)
Extensive cardiac necrosis can occur by day three after infection as incubated viruses lyse myocytes, resulting in severe and rapid cardiac decompensation. (wikipedia.org)
The arrival of natural killer cells (NK cells) at the site of infection limits viral proliferation in myocytes. (wikipedia.org)
T-cells not only lyse and destroy infected myocytes, but due to molecular mimicry, they also destroy normal, healthy cardiac cells, further driving the heart towards dilated cardiomyopathy. (wikipedia.org)
Essentially, sCAR-Fc mimics CAR receptors on cardiac cells, competitively inhibiting viral attachment and entry into myocytes. (wikipedia.org)
Stem cell-derived cardiac myocytes are potential sources for testing cardiocytoprotective molecules against ischemia/reperfusion injury in vitro. (nih.gov)
Here we performed a systematic analysis of two different induced pluripotent stem cell lines (iPSC 3.4 and 4.1) and an embryonic stem cell (ESC) line-derived cardiac myocytes at two different developmental stages. (nih.gov)
It has previously been demonstrated that phosphatidylinositol‑3‑kinase (PI3K)/Akt and cleaved caspase‑3 serve critical roles in the apoptosis of cardiac myocytes following ischemia/reperfusion injury. (spandidos-publications.com)
Epigallocatechin‑3‑gallate (EGCG), the predominant catechin component of green tea, has been reported to have potential cardioprotective effects in primary cultures of cardiac myocytes exposed to I/R injury, mediated through inhibition of signal transducers and activators of transcription‑1 activity. (spandidos-publications.com)
Since EGCG + Zn2+ may, at least in part, protect cardiac myocytes against H/R‑induced apoptotic cell death, the PI3K/Akt pathway of EGCG may be enhanced by its interactions with zinc during H/R injury. (spandidos-publications.com)
Previous studies have identified apoptosis as a significant mechanism underlying cell death during I/R injury in cultured cardiac myocytes ( 6 , 7 ), and that the inhibition of this apoptosis is able to prevent I/R injury ( 8 ). (spandidos-publications.com)
In addition, Townsend et al ( 12 ) reported that EGCG reduced signal transducers and activators of transcription-1 phosphorylation and protected cardiac myocytes against I/R-induced apoptotic cell death in isolated rat hearts. (spandidos-publications.com)

OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and. (koreamed.org)
BACKGROUND: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. (koreamed.org)
The protein is a cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. (nih.gov)

Katrine's experience building dynamic, science-driven companies will serve as a critical resource for Arrakis as we realize our vision of targeting RNA with small molecules to unlock new ways to treat human disease," said Michael Gilman, Ph.D., CEO of Arrakis. (cbinsights.com)
Arrakis is leading the creation of RNA-targeted small molecules, an entirely new class of medicines. (cbinsights.com)
It's rare to have a platform that significantly expands target space while also leveraging all of the benefits of a well-established modality, small molecules. (cbinsights.com)
We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects. (vanderbilt.edu)
Small molecules, identified by screening, have been used to switch differentiated cells directly from one tissue type to another - cardiac fibroblasts to muscle, say - both outside and inside the body. (chemistryworld.com)

After analysis of full embryoid bodies (EBs) and cardiac marker (VCAM and cardiac troponin I) positive cells of three lines at 6 conditions (32 different conditions altogether), we found significant SI/R injury-induced cell death in both full EBs and VCAM+ cardiac cells at later stage of their differentiation. (nih.gov)
More specifically, AL amyloidosis can be classified as stage I, II or III based on cardiac biomarkers like Nt-proBNP and cardiac troponin. (onteenstoday.com)
This review discusses troponin as a marker of cardiac injury, its testing, utility, appropriateness use criteria, and interpretation of abnormal values. (medscape.com)
The 99th percentile cutoff point for cardiac troponin T (cTnT) is well-known at 0.01 ng/mL (with 10% coefficient of variance value at the 99th percentile of 0.03 ng/mL), as only one cTnT assay exists. (medscape.com)
In contrast, several different assays are commercially available for cardiac troponin I (cTnI), so the 99th percentile cut point varies based on the assay being used. (medscape.com)
The 99th percentile of a reference decision limit (medical decision cutoff) for cardiac troponin (cTn) assays should be determined in each local laboratory with internal studies using the specific assay that is used in clinical practice or validating a reference interval that is based on findings in the literature. (medscape.com)
For PCI in patients with normal baseline troponin values, elevations of cardiac biomarkers above the 99th percentile upper reference limit indicate periprocedural myocardial necrosis. (medscape.com)
An initial small elevation occurs when troponins are released from the cytosolic pool, when troponin molecules in the cytosol of cardiac muscle diffuse across the sarcolemma into the surrounding lymphatics and blood vessels, becoming detectable in blood. (medscape.com)

Using genetic, biochemical, and electrophysiologic techniques in cells, model organisms, and human subjects, we investigate the mechanisms that drive neurologic and cardiac dysfunction in patients with IEMs. (upenn.edu)
Our findings further support the concept that the novel class of phosphodiesterase-5 inhibitors, or PDE-5 inhibitors, including Levitra and Viagra, may have a new utility in cardiac protection, in addition to their well-known use for the management of erectile dysfunction in men," said Rakesh C. Kukreja, Ph.D., professor of medicine, physiology, biochemistry and emergency medicine at VCU. (health.am)
however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
Additionally, it may clinically manifest with myocardial necrosis, cardiac arrhythmia, myocardial stunning and microvascular dysfunction ( 5 ). (spandidos-publications.com)
Damage to ECs is catastrophic and induces endothelial cell dysfunction. (koreamed.org)
Indeed, evidence that TLR activation contributes to the development and progression of atherosclerosis, cardiac dysfunction in sepsis, and congestive heart failure, is convincing. (medscape.org)
Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
Gene and Cell Therapy for Sinus and AV Nodal Dysfunction. (heartandcoeur.com)

2010), we discovered that RhoU regulates the cell junctions between cardiomyocytes through the Arhgef7b/Pak kinase pathway in order to guide atrioventricular canal development and cardiac looping. (psu.edu)
Overall, these findings reveal a cardiac developmental pathway involving RhoU/Arhgef7b/Pak signaling, which helps coordinate cell junction formation between atrioventricular cardiomyocytes to promote cell adhesiveness and cell shapes during cardiac morphogenesis. (psu.edu)
Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al. (stemcell.com)
Furthermore, administration of EGCG in vitro was observed to prevent apoptosis of cardiomyocytes by regulating pro-apoptotic and anti-apoptotic proteins, including B cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein, and by simultaneously regulating caspase-3 in isolated rat hearts ( 13 ). (spandidos-publications.com)
As a demonstration of the versatility of the Swarm, we also developed an assay measuring cardiac action potential and calcium waveform properties simultaneously under paced conditions using human induced pluripotent stem (iPS) cell-derived cardiomyocytes as an additional counter screen for cardiac toxicity. (frontiersin.org)
We compared this data with existing murine and 3D cardiac organoid scRNA-seq data and confirmed the dominance of left ventricular cardiomyocytes (>90%) in our hiPSC-derived progeny. (stanford.edu)
Embryonic stem cell-derived cardiomyocytes as a model for arrhythmia. (heartandcoeur.com)

In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (nii.ac.jp)
Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. (koreamed.org)
Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)
Fig. 2 Schematic presentation of the role of autophagy in endothelial cells. (koreamed.org)
Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime! (koreamed.org)
Central role of metabolism in endothelial cell function and vascular disease. (koreamed.org)
EndoDB: a database of endothelial cell transcriptomics data. (koreamed.org)
New findings show that injury also induces fibroblasts to become endothelial cells, helping to mend damaged blood vessels. (natureasia.com)
This study shows that cardiac injury induces cardiac fibroblasts to undergo mesenchymal-endothelial transition and acquire an endothelial-cell like fate, a process mediated, in part, by a p53-dependent mechanism - use of a small molecule activator of p53 increases mesenchymal-endothelial transition, leading to reduced scarring and better preservation of heart function. (natureasia.com)
Our previously-obtained impressive results of highly increased C2C12 mouse myoblast adhesion to amine plasma polymers (PPs) motivated current detailed studies of cell resistance to trypsinization, cell proliferation, motility, and the rate of attachment carried out for fibroblasts (LF), keratinocytes (HaCaT), rat vascular smooth muscle cells (VSMC), and endothelial cells (HUVEC, HSVEC, and CPAE) on three different amine PPs. (nature.com)
We demonstrated the striking difference in the resistance to trypsin treatment between endothelial and non-endothelial cells. (nature.com)
The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. (nature.com)
Natural products from traditional Chinese medicine have shown promising therapeutic potential against atherosclerosis by means of regulating the expression of specific genes, stabilizing arterial plaques and protecting vascular endothelial cells. (bvsalud.org)

Nearly all etiologies of heart disease involve pathological myocardial remodeling characterized by excessive deposition of extracellular matrix (ECM) proteins by cardiac fibroblasts (CFs), which reduces tissue compliance and accelerates the progression to heart failure. (onteenstoday.com)
As demonstrated on LF fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media, i.e., medium without cell adhesion-mediating proteins. (nature.com)

Myocardial fibrosis is a common postmortem finding among young individuals with sudden cardiac death. (onteenstoday.com)
What causes sudden cardiac death? (onteenstoday.com)
Techniques of Prediction of Arrhythmia Occurrence and Stratification for Sudden Cardiac Death. (heartandcoeur.com)
BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)

Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al. (stemcell.com)
Human induced pluripotent stem cells (hiPSCs) present an exciting alternative for modeling early human embryogenesis due to their well-established ability to differentiate into all embryonic germ layers. (stanford.edu)
In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. (umcutrecht.nl)
Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. (umcutrecht.nl)
But that's far enough to produce embryonic stem cells that can be harvested for research and medicine - without the ethical quandaries presented by taking stem cells from human embryos discarded in IVF. (chemistryworld.com)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
Embryonic stem cells are stem cells derived from the inner cell mass of an early, preimplantation stage embryo known as a blastocyst. (bvsalud.org)

To identify specific Rho proteins that may regulate this process, we analyzed cardiac expression profiling data and discovered that RhoU was expressed at the atrioventricular canal during the time when it forms. (psu.edu)
The cytoskeleton is also important for certain processes inside the cells, such as the movement of proteins within the cell and the breakdown of unneeded proteins. (medlineplus.gov)
Filamin A can also bind to many other proteins in the cell to carry out various functions, including the attachment of cells to one another (cell adhesion), cell movement (migration), determination of cell shape, the relay of signals within cells, and cell survival. (medlineplus.gov)
Filamin A is also involved in the organization of the extracellular matrix, which is the lattice of proteins and other molecules outside the cell. (medlineplus.gov)
Filamin A binds to proteins called integrins, which span the cell membrane and anchor cells to the extracellular matrix. (medlineplus.gov)
Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
Exosomes are used to transfer RNA, DNA, and proteins to other cells in the body by making alteration in the function of the target cells. (pharmiweb.com)
Based on all the results, the increased resistance to trypsinization of C2C12, LF, HaCaT, and VSMC cells on amine PPs can be explained most probably by a non-specific cell adhesion such as electrostatic interaction between the cells and amine groups on the material surface, rather than by the receptor-mediated adhesion through serum-derived proteins adsorbed on the PPs. (nature.com)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
Blood platelets are cells which lack a nucleus and which do not produce their own proteins", says Olof Gidlöf. (lu.se)
MicroRNA is short RNA molecules which do not code for any proteins. (lu.se)
Tubular transport mechanisms separate drugs from their binding proteins, which normally protect cells from toxicity. (msdmanuals.com)

Scientists from the Max Planck Institute for Heart and Lung Research have now succeeded in identifying a key molecule in the molecular signalling cascade responsible for this growth. (mpg.de)
Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now identified a crucial interface in the signalling cascade that controls the emergence of cardiac hypertrophy at molecular level. (mpg.de)
Here we present a theoretical framework for analysing the filter of general porins in relation to translocating molecules with the aid of enhanced molecular simulations quantitatively. (ibecbarcelona.eu)
Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
Journal of molecular cell biology. (vanderbilt.edu)
These receptorsâ€''pattern recognition receptors' (PRRs)â€' detect pathogen-associated molecular patterns (PAMPs) that remain largely unvaried, such as lipopolysaccharide found on the cell surface of Gram-negative bacteria, or double-stranded RNA present in viruses. (medscape.org)
In vivo visualization and molecular targeting of the cardiac conduction system. (stanford.edu)

CDMG treatment of amputated zebrafish hearts reduces nuclear β-catenin in injured heart tissue, increases cardiomyocyte (CM) proliferation, and expedites wound healing, thus accelerating cardiac muscle regeneration. (vanderbilt.edu)
This transmission of impulses makes cardiac muscle tissue similar to nerve tissue, although cardiac muscle cells are notably connected to each other by intercalated discs . (wikidoc.org)
Intercalated discs support synchronized contraction of cardiac tissue. (wikidoc.org)
Our results demonstrate that miR-146a transcript levels were sharply increased in cardiac ventricular tissue of transgenic mice with specific overexpression of TNF-α in the heart, and also in a cardiomyocyte cell line of human origin (AC16) exposed to TNF-α. (jefferson.edu)
that are foundational to cell- and tissue-damage responses resulting from protein deposition or aggregation associated with fibrotic and neurodegenerative diseases. (lelezard.com)
Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue. (uni-lj.si)
Effects of electrode-tissue proximity on cardiac lesion formation using pulsed field ablation. (uni-lj.si)
Therefore, many laboratories try with great effort to develop resorbable tissue scaffolds that could support the patient´s cells. (nature.com)
ECM provides mechanical support for cells and also determines the shape of tissue 9 . (nature.com)
The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)
The kidneys have the highest oxygen and glucose consumption per gram of tissue and are therefore vulnerable to toxins affecting cell energy metabolism. (msdmanuals.com)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Cardiac muscle is one of three major types of muscle, the others being skeletal and smooth muscle . (wikidoc.org)
Unlike skeletal muscle , which contracts in response to nerve stimulation, and like single unit smooth muscle, cardiac muscle is myogenic , meaning that it is self-excitable stimulating contraction without a requisite electrical impulse coming from the central nervous system. (wikidoc.org)
In contrast to skeletal muscle , cardiac muscle cannot contract in the absence of extracellular calcium ions as well as extracellular potassium ions. (wikidoc.org)
It is present in cardiac and skeletal muscle and may play an important role in development of these tissues. (nih.gov)
Troponins are protein molecules that are part of cardiac and skeletal muscle. (medscape.com)

Vardenafil, like sildenafil, stabilizes the mitochondria and protects against damage of the heart by opening the mitochondrial KATP channels in cardiac cells. (health.am)
Cells need it to produce energy from nutrients and oxygen -- a function performed by tiny structures, known as mitochondria, within cells. (sciencedaily.com)
Mitochondria are the powerhouses of the cells and produce the energy that fuels us and makes everything in the body run. (mindbodygreen.com)
Unlike microtubules, IFs distribution in cells show no good correlation with the distribution of either mitochondria or endoplasmic reticulum. (pearltrees.com)
These very aggressive molecules can then attack, among other things, the mitochondria, the power plants of the cells. (press-news.org)

The cardiac conduction system (and AV node part of it) coordinates myocyte mechanical activity. (wikipedia.org)

Arrakis Therapeutics Appoints Katrine Bosley as Chairman of the Board of Directors Entrepreneurial leader brings expertise growing biotech platform companies as former CEO of Editas Medicine and Avila Therapeutics Waltham, Mass., November 21, 2019 - Arrakis Therapeutics , a biopharmaceutical company pioneering the discovery of a new class of small-molecule medicines that directly target RNA, announced today that it has appointed Katrine Bosley as Chairman of its Board of Directors. (cbinsights.com)

The fibrinolytic potential of human urine was first described in 1947, and the active molecule was named urokinase. (medscape.com)

But the researchers were surprised to find no signs of elevated oxidative damage to cell membranes or DNA from free radicals, the sometimes-harmful molecules created by the oxygen chemistry during metabolism. (sciencedaily.com)
This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
They can participate in the occurrence and development of atherosclerosis through inflammation, oxidative stress, lipid metabolism, cell proliferation and migration, macrophage polarization and autophagy respectively. (bvsalud.org)

Various cells and molecules are involved in this process, providing targets for potential drug therapies. (onteenstoday.com)
We also evaluate the efficacy of a number of new therapeutic strategies for IEM (including small-molecule, network-directed, and gene therapies). (upenn.edu)
Blade expects to advance a differentiated pipeline of oral, small-molecule therapies that include a non-competitive autotaxin inhibitor and inhibitors of dimeric calpains designed for potential treatment of lung, liver and cardiac fibrosis or neurodegenerative diseases. (lelezard.com)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

Moreover, full EBs of the iPS 4.1 cell line after oxidative stress induction by SNAP was protected at day-8 samples. (nih.gov)
The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. (koreamed.org)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

The FLNA gene provides instructions for producing the protein filamin A, which helps build cells' extensive internal network of protein filaments called the cytoskeleton. (medlineplus.gov)
Bone morphogenetic protein (BMP) cell signaling plays a key role in diverse aspects of cardiac differentiation and morphogenesis. (wikipedia.org)
RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. (mpg.de)
Histamine and its receptors represent a complex system of immunoregulation with distinct effects mediated by four GPCRs (G protein-coupled receptors HRs 1-4) and their differential expression, which changes according to the stage of cell differentiation and microenvironmental influences. (hindawi.com)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)

miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)

Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration, highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. (vanderbilt.edu)

Decreased lesions in cardiac tissues, reduced cell necrosis, and diminished inflammatory responses are observed in sCAR-Fc treated cells (CITE). (wikipedia.org)
There are intense interests in discovering proregenerative medicine leads that can promote cardiac differentiation and regeneration, as well as repair damaged heart tissues. (vanderbilt.edu)
Engineering complex tissues requires high-throughput, three-dimensional patterning of materials and cells. (natureasia.com)
In addition to being expressed in immune cells, TLRs are expressed in other tissues, such as those of the cardiovascular system. (medscape.org)
Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
These agents also damage all tissues (e.g., gut epithelium, bone marrow) where rapid cell division is occurring, creating other undesirable side effects, thus often may not be suitable for use in medical nanorobotics. (nanomedicine.com)
All tissues originate from stem cells. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)

Most sudden cardiac deaths are caused by abnormal heart rhythms called arrhythmias. (onteenstoday.com)
Information regarding health effects in humans that can be associated with exposure to higher-than- normal levels of stable cesium is restricted to an account of decreased appetite, nausea, and diarrhea in a man who repeatedly ingested experimental amounts of cesium chloride and reports of prolonged QT syndrome and associated cardiac arrhythmias in patients who ingested cesium chloride as a component of homeopathic remedies. (cdc.gov)

In another case, a patient suffered cardiac arrest at home and was brought to the Medical Center - University of Freiburg by helicopter after first responder resuscitation. (press-news.org)

Loss of RhoU function recapitulated the atrioventricular canal and cardiac looping defects observed in the ROCK inhibitor treated zebrafish. (psu.edu)
Inhibition of this pathway resulted in similar underlying cardiac defects and conversely, overexpression of a PAK kinase was able to rescue the loss of RhoU cardiac defect. (psu.edu)
Failure to properly form these cell adhesions during cardiac development may lead to structural heart defects and mechanistically account for the cellular events that occur in certain human congenital heart diseases. (psu.edu)
With loss of cardiac cells increasing progressively, infected individual will experience abnormalities in left ventricular systolic and diastolic function, as well as electrical conduction defects manifesting as cardiac dysrhythmias. (wikipedia.org)
The triggers for this pathological change can include, for example, high blood pressure, arteriosclerosis and cardiac valve defects. (mpg.de)
1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
A particular PID can be caused by defects in any one of several molecules that are required for certain responses, because a defect in any of the sequential steps can impair the system. (lu.se)

2013). Although many genetic factors that participate in patterning the heart have been elucidated (Tu and Chi, 2012), the cellular events that drive cardiac morphogenesis have been less clear. (psu.edu)
From a chemical genetic screen to identify cellular pathways that control cardiac morphogenesis in zebrafish, we observed that inhibition of the Rho signaling pathways resulted in failure to form the atrioventricular canal and loop the linear heart tube. (psu.edu)
This irreversible reaction prevents the virus from interacting with cellular receptors (CAR) on cardiac cells, decreasing infectivity of CVB3. (wikipedia.org)
Even though cells replicate to survive, they undergo a process of cellular senescence , where the dividing slows down and the cell eventually "retires. (healthnews.com)
ATP is the main energy molecule used as power for all cellular processes. (mindbodygreen.com)
Together, our results show devCellPy to be a useful tool for automated cell prediction across complex cellular hierarchies, species, and experimental systems. (stanford.edu)
By integrating technologies, approaches, models and data into a common standardized framework, the Allen Institute for Cell Science is creating dynamic, visual models of how genetic information is transformed into cellular behavior, and how the molecules and organelles within each cell interact and function as systems. (alleninstitute.org)

Surprisingly, our reporter system and scRNA-seq analysis revealed a predominance of FHF differentiation using the small molecule Wnt-based 2D differentiation protocol. (stanford.edu)
To ensure researchers have success working with our human induced pluripotent stem cell lines in their lab, our Angel Nelson highlights nuanced techniques and helpful tips while demonstrating our cardiac differentiation protocol for the WTC parental line and our gene-edited cells. (alleninstitute.org)

The approaches that inhibit myofibroblast formation have been demonstrated to prevent cardiac fibrosis, including systemic delivery of antifibrotic drugs, localized delivery of biomaterials, localized delivery of biomaterials and antifibrotic drugs, and localized delivery of cells using biomaterials. (onteenstoday.com)
A study finds that the cells lining the gut are modified in response to systemic infection, increasing the host's tolerance to infection in a manner that is dependent on the microorganisms that inhabit the gut. (natureasia.com)
Coordinated contractions of cardiac muscle cells during systole propel blood out of the atria and ventricles to the blood vessels of the systemic and pulmonary circulatory systems . (wikidoc.org)
In an era of advanced nanomedicine, it should be possible to restrain or reprogram the immune system directly using genetic engineering (Chapters 19 and 23 ), or by using other means (e.g., temporary systemic white cell sequestration), to reduce or eliminate immunoresponsiveness during the period of nanomedical treatment. (nanomedicine.com)
At least 3 half-lives must have elapsed from any prior systemic inhibitory/stimulatory immune checkpoint molecule therapy at the time the subject is planned for leukapheresis (e.g. ipilimumab, nivolumab, pembrolizumab, atezolizumab, OX40 agonists, 4- 1BB agonists etc). 107. (who.int)

Further research published in BMC Neuroscience found that selenium preserves mitochondrial function 2 and can even prevent hypoxic cell damage, an event that happens as a result of cardiac disease or hypotension. (mindbodygreen.com)
As a result of cardiac arrest, blood vessels in the brain swell, making them less permeable to gas exchange. (press-news.org)

Together, our work provides the scientific community with a powerful new genetic lineage tracing approach as well as a single cell transcriptomic atlas of hiPSCs undergoing cardiac differentiation. (stanford.edu)
The immune system consists of a large number of molecules and processes, and immunodeficiencies can therefore be caused by genetic alterations at many loci. (lu.se)

MicroRNAs are short molecules which are distributed throughout our cells. (lu.se)
So far, around 2000 different kinds of microRNAs have been found in the cells around the human body. (lu.se)

In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al. (stemcell.com)

The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)

Cardiac fibrosis is a process of pathological extracellular matrix (ECM) remodeling, leading to abnormalities in matrix composition and quality, as well as an impaired heart muscle function [4]. (onteenstoday.com)
The main goal of this study consisted of studying new roles of miR-146a in cardiac pathological processes caused by the pro-inflammatory cytokine TNF-α. (jefferson.edu)

Furthermore, we conduct a cross-species prediction of cardiomyocyte subtypes from in vitro-derived human induced pluripotent stem cells and unexpectedly uncover a predominance of left ventricular (LV) identity that we confirmed by an LV-specific TBX5 lineage tracing system. (stanford.edu)

Interestingly, AP-1 inhibition was accompanied by a reduction in matrix metalloproteinase (MMP)-9 mRNA levels in human cardiac cells. (jefferson.edu)

Contraction of heart muscle cells requires depolarization and repolarization of their cell membranes. (wikipedia.org)
Movement of ions across cell membranes causes these events. (wikipedia.org)
These healthy sources of fats are critical for brain health, reduce inflammation, and are absorbed by cell membranes," says Wells. (mindbodygreen.com)

To demonstrate the power of devCellPy, we construct a murine cardiac developmental atlas from published datasets encompassing 104,199 cells from E6.5-E16.5 and train devCellPy to generate a cardiac prediction algorithm. (stanford.edu)

The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)

AV conduction during normal cardiac rhythm occurs through two different pathways: the first "pathway" has a slow conduction velocity but shorter refractory period the second "pathway" has a faster conduction velocity but longer refractory period. (wikipedia.org)
In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)

Through this binding, cells are correctly positioned and signals can be exchanged between the cell and the extracellular matrix. (medlineplus.gov)

PURPOSE: This study aimed to investigate the effect of adipose-derived stem cell (ADSC) transplantation on atherosclerosis (AS) and its underlying mechanisms. (koreamed.org)

Conversely, while certain cytokines released from immune cells have protective effects, others such as tumor necrosis factor-alpha (TNFα) have deleterious effects on heart cells. (wikipedia.org)

Cell viability in simulated ischemia/reperfusion (SI/R)-induced injury and a known cardiocytoprotective NO-donor, S-nitroso-n-acetylpenicillamine (SNAP) was tested. (nih.gov)

In order to exploit the pharmacological potential of natural bioactive molecules with low water solubility, such as curcumin, it is necessary to develop formulations, such as amorphous polymer dispersions, which allow a constant release rate and at the same time avoid possible toxicity effects of the crystalline form of the molecule under scrutiny. (ibecbarcelona.eu)

Recent studies in several rodent models of cardiac fibrosis have documented reversal of fibrosis by treatment with relaxin peptide or virally mediated relaxin gene delivery. (onteenstoday.com)
Gene Therapy for Cardiac Tachyarrhythmias. (heartandcoeur.com)

BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. (koreamed.org)
Mesoglea, also known as mesohyl, is the translucent, non-living, jelly-like substance found between the two epithelial cell layers (i.e., between the ectoderm and endoderm) in the bodies of cnidarians and sponges. (pearltrees.com)
Other nerve and muscle cells lie just under the epithelial layers. (pearltrees.com)

Two related compounds with novel structures, named as Cardiomogen1 and 2 (CDMG1 and CDMG2), were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population. (vanderbilt.edu)

What causes cardiac fibrosis? (onteenstoday.com)
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. (onteenstoday.com)
Can you reverse cardiac fibrosis? (onteenstoday.com)
Why is cardiac fibrosis bad? (onteenstoday.com)
How does cardiac fibrosis lead to heart failure? (onteenstoday.com)
What are the symptoms of cardiac fibrosis? (onteenstoday.com)
Cardiac fibrosis results from the thickening of cardiac muscles or heart valves. (onteenstoday.com)

In due course, the stem cells in the bone marrow reconstitute the peripheral lymphoid system but the newly formed T cells seem to accept the graft as self [ 403 ]. (nanomedicine.com)

Coxsackievirus B3 can cause cardiac damage, eventually resulting in a weakened and enlarged heart that is termed dilated cardiomyopathy. (wikipedia.org)
The cytolytic destruction of heart cells can lead to dilated cardiomyopathy if not treated appropriately. (wikipedia.org)
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy. (upenn.edu)

Effective clearance of inflammatory cells is required for resolution of inflammation. (koreamed.org)

Furthermore, once sCAR-Fc binds the virus, macrophages and other phagocytic immune cells with Fc receptor recognition bind to the sCAR-Fc-viral complex to eliminate the virus. (wikipedia.org)
Immune checkpoints transient third-degree atrioventricular block, and are costimulatory and coinhibitory molecules usually a right hemicorporeal clonic seizure, after which expressed on the surface of immune cells and modu- mental status was persistently altered. (cdc.gov)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

The vertebrate heart undergoes early complex morphologic events in order to develop key cardiac structures that regulate its overall function (Fahed et al. (psu.edu)
Research suggests that decreased filamin A function may affect the shape of cells in the smooth muscles of the gastrointestinal tract during development before birth, causing abnormalities in the layering of these muscles. (medlineplus.gov)
For example, many processed foods contain high sodium levels, which can lead to heart and kidney function difficulties, cardiac disease, diabetes, and hypertension. (healthnews.com)
The popular dietary supplement ubiquinone, also known as Coenzyme Q10, is widely believed to function as an antioxidant, protecting cells against damage from free radicals. (sciencedaily.com)
These biological nanopores have been designed to protect the interior of the bacterial cell from leakage of toxic compounds while selectively allowing the entry of the molecules needed for cell growth and function. (ibecbarcelona.eu)

Since cardiac muscle is myogenic, the pacemaker serves only to modulate and coordinate contractions. (wikidoc.org)

Moreover, peak concentrations of T cells in the myocardium during days 7-14 play important roles in both viral clearance and immune mediated cardiac damage. (wikipedia.org)
Moreover, no cytotoxicity towards mammalian and red blood cells at the concentrations tested was observed for any of the compounds under investigation. (ibecbarcelona.eu)
When urine is concentrated, the luminal surfaces of tubular cells may be exposed to molecule concentrations 300 to 1000 times greater than those of plasma. (msdmanuals.com)

Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. (frontiersin.org)
miR-146a targets Fos expression in human cardiac cells. (jefferson.edu)

The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. (umcutrecht.nl)

To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
In the present study, the protective effects of EGCG with zinc were assessed on cultures of rat cardiac myoblasts exposed to hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
H9c2 cells were subjected to 3‑h hypoxia, followed by 1‑h reperfusion. (spandidos-publications.com)

Cardiac muscle is a type of involuntary striated muscle found in the walls of the myocardium . (wikidoc.org)

Press-News.org) Around 50,000 people suffer sudden cardiac arrest in Germany every year. (press-news.org)
One of the first persons treated with CARL therapy successfully survived a cardiac arrest after about 120 minutes of resuscitation. (press-news.org)
After decades of research, we were able to develop a new treatment method to reduce the physical damage that would otherwise occur after cardiac arrest and resuscitation. (press-news.org)
This raises the prospect of people surviving much longer and better after cardiac arrest than was previously thought," Beyersdorf said. (press-news.org)
With CARL we can treat the damage caused by cardiac arrest and the associated lack of oxygen. (press-news.org)

Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (nii.ac.jp)

It is very important to lower the body temperature of the patients as quickly as possible in order to slow down metabolic processes," explains the Freiburg cardiac surgeon, who published the study together with colleagues from Yale University, USA, and Max Planck Institute for Metabolic Research, Germany. (press-news.org)

In diabetes, more fat and less carbohydrate is used, due to the reduced induction of GLUT4 glucose transporters to the cell surfaces. (wikidoc.org)

Anatomy27

Organisms14

Diseases34

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes58

Disciplines and Occupations3

Information Science4

Health Care12

Myocytes13

Adhesion molecule3

Small Molecules5

Troponin8

Dysfunction9

Cardiomyocytes7

Endothelial14

Fibroblasts2

Sudden cardi4

Embryonic7

Proteins12

Molecular7

Tissue14

Skeletal5

Mitochondria5

Conduction system1

20191

Active molecule1

Metabolism3

Therapies5

Oxidative4

Protein6

Induced by pro-inflammatory1

Proliferation1

Tissues8

Arrhythmias2

Suffered cardiac arrest1

Defects7

Cellular7

Differentiation protocol2

Systemic5

Result of cardiac2

Genetic2

MicroRNAs2

Induces2

Biologically active1

Pathological2

Pluripotent Stem1

Inhibition1

Membranes3

Developmental1

Ventricular1

Pathways2

Extracellular1

Atherosclerosis1

Necrosis1

Ischemia1

Toxicity1

Gene2

Epithelial3

Progenitor1

Fibrosis7

Stem cells in the bone ma1

Dilated cardiomyopathy3

Inflammation1

Immune cells3

Function5

Modulate1

Concentrations3

Expression2

Genetics1

Hypoxia3

Myocardium1

Arrest5

Coronary1

Processes1

Induction1