Molecules cadherins. Medical search. Frequent questions

The researchers focused on DSCAM's self-avoidance function in the mouse retina, but DSCAM and members of the cadherin superfamily have also emerged as key contributors to a variety of neurodevelopmental disorders, including autism, schizophrenia, bipolar disease, Down syndrome and intellectual disability. (jax.org)
DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members. (jax.org)
The classical cadherins mediate homophilic calcium-dependent cell adhesion and are founding members of the large and diverse cadherin superfamily. (rupress.org)
Cowin P. Unraveling the cytoplasmic interactions of the cadherin superfamily. (bdbiosciences.com)
Protocadherin-1 (PCDH1) is a single-pass transmembrane protein belonging to the Cadherin superfamily of adhesion molecules. (bham.ac.uk)
Members of cadherin superfamily involved in cell adhesion and cell-cell interactions in neural development. (bvsalud.org)

Cadherins (named for "calcium-dependent adhesion") are cell adhesion molecules important in forming adherens junctions that let cells adhere to each other. (wikipedia.org)
Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrence. (ox.ac.uk)
Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma. (medscape.com)
Placental Cadherin (P-Cadherin or PCAD) is a member of the cadherin family of cell adhesion molecules, designated CDH3. (rndsystems.com)
Subsequently, rosmarinic acid treatment significantly reversed oxLDL‑induced overexpression of adhesion molecules and monocyte‑EC adhesion, oxLDL‑induced endothelial junction hyperpermeability and monocyte transmigration through the endothelial monolayer under HG conditions, in a dose‑dependent manner. (spandidos-publications.com)
DSCAM interacts with other cell adhesion molecules to prevent their running amok. (jax.org)
Cell adhesion molecules (CAMs) make a kind of "cell" call, sending connecting signals between neurons. (jax.org)
Certain cell adhesion molecules, such as cadherins and integrins, mediate contact-mediated guidance. (imsaethics.org)
The overarching hypothesis is that cadherin adhesion molecules specify the code that enables the premotor brainstem breathing circuits to innervate the phrenic motor neurons that control the primary breathing muscle, the diaphragm. (elifesciences.org)
During embryonic morphogenesis, adhesion molecules are required for selective cell-cell interactions. (rupress.org)
Cadherins are a family of Ca2+-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. (bdbiosciences.com)
Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)

Sera from 40 patients with newly diagnosed bladder cancer (28 superficial tumours (pTa and pT1) and 12 muscle-invasive tumours) were assessed by enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of soluble E-cadherin (sE-cadherin), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). (ox.ac.uk)
ECs were treated with oxLDL under HG conditions in the presence or absence of ROS scavengers mitoTEMPO and NAC, p38 inhibitor SB203580, FOXO1 inhibitor AS1842856 or transfected with the TXNIP siRNA, before protein expression levels of intercellular adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule‑1 (VCAM‑1), phosphorylated vascular endothelial‑cadherin (VE‑cadhedrin), VE‑cadherin and zonula occludens‑1 (ZO‑1) were measured by western blotting. (spandidos-publications.com)
Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)
E-cadherin is a calcium dependent adhesion molecule with important roles in epithelial intercellular adhesion and cellular structure. (cdc.gov)
Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins. (embl.de)
Anti-cadherin antibodies that block theformation of adherens junctions, for example, also block the formation of tightjunctions.Desmosomes Connect Intermediate Filaments from Cell toCellDesmosomes are buttonlike points of intercellular contact that rivet cellsTogether. (ostatic.com)
Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)

We show that DSCAM can functionally interact with other CAMs, called cadherins and protocadherins, and acts like a general 'nonstick' signal. (jax.org)

The loss of E-cadherin (E-cad), an epithelial cell adhesion molecule, has been implicated in the epithelial-mesenchymal transition (EMT), promoting invasion and migration of cancer cells and, consequently, metastasis. (nih.gov)

Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the intracellular cytoplasmic tail associates with numerous adaptors and signaling proteins, collectively referred to as the cadherin adhesome. (wikipedia.org)
Each cadherin has a small C-terminal cytoplasmic component, a transmembrane component, and the remaining bulk of the protein is extra-cellular (outside the cell). (wikipedia.org)
Once the cell-cell adhesion between cadherins present in the cell membranes of two different cells has formed, adherens junctions can then be made when protein complexes, usually composed of α-, β-, and γ-catenins, bind to the cytoplasmic portion of the cadherin. (wikipedia.org)
Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. (rndsystems.com)
Intriguingly, loss of N-cadherin caused a significant decrease in VE-cadherin and its cytoplasmic binding partner, p120ctn. (rupress.org)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
Cytoplasmic interactions can influence the function of the ectodomain by a number of potential mechanisms, including redistribution of binding sites into clusters, providing cytoskeletal anchorage, and mediating physiological regulation of cadherin function. (embl.de)

Cadherins are a class of type-1 transmembrane proteins, and they depend on calcium (Ca2+) ions to function, hence their name. (wikipedia.org)
The intracellular portion of classical cadherins interacts with a complex of proteins that allows connection to the actin cytoskeleton. (wikipedia.org)
The adaptor proteins that associate with desmosomal cadherins are plakoglobin (related to β {\displaystyle \beta } -catenin), plakophilins (p120 catenin subfamily), and desmoplakins. (wikipedia.org)
Cadherins are synthesized as polypeptides and undergo many post-translational modifications to become the proteins which mediate cell-cell adhesion and recognition. (wikipedia.org)
Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition phenomena. (rcsb.org)
Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. (rndsystems.com)
To do so, the team focused on cadherins, a group of proteins which allow cells to attach to one another. (elifesciences.org)
Newborn mice in which phrenic motor neurons lacked a specific combination of cadherins experienced respiratory failure, showing that these proteins were needed for breathing circuits to develop normally. (elifesciences.org)
We investigated the use of e-cadherin immunofluorescence in different species (rat and mouse), with different fixatives (10% neutral buffered formalin, 4% paraformaldehyde, and 2.5% glutaraldehyde ), with and without antigen retrieval, and as a dual label with immunofluorescence for other proteins. (cdc.gov)
E-cadherin immunofluorescent double labeling can also be used with activated caspase 3 or â-catenin immunofluorescence to localize the expression of these proteins in damaged airways. (cdc.gov)
However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. (embl.de)
This entry represents the extracellular repeated domains found in cadherins and related proteins. (embl.de)
Affected individuals make antibodiesagainst one of their own desmosomal cadherin proteins. (ostatic.com)
The transmembrane adhesion proteins in these cell-matrixjunctions are integrins a large family of proteins distinct from the cadherins.Focal adhesions enable cells to get a hold on the extracellular matrix through integrins that link intracellularly to actin filaments. (ostatic.com)
P. gingivalis HSP60 at a concentration of 10 ng/l significantly decreased the expression levels of VE‑cadherin and eNOS protein at 24 h stimulation, whereas no difference in these proteins was identified following a low dose of P. gingivalis HSP60 (1 ng/l). (spandidos-publications.com)

Selective loss of E-cadherin can cause de-differentiation and invasiveness in human carcinomas, leading this marker to be classified as a tumor suppressor ( 5 ). (iiarjournals.org)

Binding of p-120 catenin and β {\displaystyle \beta } -catenin to the homodimer increases the stability of the classical cadherin. (wikipedia.org)
P-Cadherin is a classical cadherin molecule. (rndsystems.com)

Here we use a combination of X-ray crystallography, analytical ultracentrifugation, surface plasmon resonance and double electron-electron resonance (DEER) electron paramagnetic resonance spectroscopy to identify the molecular determinants of type I cadherin dimerization affinities. (rcsb.org)
Here, we show that coordinated activity of a type I cadherin (N-cadherin) and type II cadherins (Cadherin-6, -9, and -10) is required in both MNs and Dbx1-derived neurons to generate robust respiratory motor output. (elifesciences.org)

Mouse N-Cadherin aa. (bdbiosciences.com)

There was no correlation between high levels of soluble E-cadherin in sera and abnormal E-cadherin expression by the tumour (P = 0.077). (ox.ac.uk)
We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 µg/mL is essential. (who.int)

Molecular and functional analysis of cadherin-based adherens junctions. (embl.de)
Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. (embl.de)

The components that build an atypical cadherin are flamingo (seven pass transmembrane) and Dcad102F-like cadherins. (wikipedia.org)
Loss of FAT Atypical Cadherin 4 Expression Is Associated with High Pathologic T Stage in Radically Resected Gastric Cancer. (antikoerper-online.de)

The levels of vascular endothelial (VE)‑cadherin, endothelial nitric oxide synthase (eNOS) and cysteinyl aspartate‑specific protease‑3 (caspase‑3) were measured using western blot analysis. (spandidos-publications.com)
Vascular endothelial growth factor A (VEGFA) and inflammatory cytokines both induce adherens junction disassembly by Src family kinase-mediated phosphorylation of Vascular endothelial (VE)-cadherin. (icgeb.org)

Corresponding frozen sections of primary tumour were analysed for E-cadherin expression using the monoclonal antibody, HECD-1 and standard immunohistochemistry. (ox.ac.uk)
Abnormal E-cadherin expression was associated with increasing tumour stage (P = 0.009) and grade (P = 0.03). (ox.ac.uk)
Constitutive P-Cadherin expression is found in the epidermis, mesothelium, corneal epithelium, and uterine decidua. (rndsystems.com)
The study investigated the connection between EGFR signaling and E-cadherin expression, a crucial molecule for cell adhesion. (news-medical.net)
The researchers discovered that EGFR and Src suppressed E-cadherin expression, thereby affecting cell migration. (news-medical.net)
In addition, oxLDL‑stimulated ECs under HG conditions exhibited increased phosphorylated VE‑cadherin protein levels and decreased ZO‑1 protein expression levels compared with those in untreated ECs, suggesting increased endothelial permeability. (spandidos-publications.com)
The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification. (iiarjournals.org)
Conclusion: E-Cadherin expression is not stable during the metastatic process. (iiarjournals.org)
E-Cadherin expression in primary sites positively correlates with E-cadherin from LNM. (iiarjournals.org)
Mouse monoclonal anti-e-cadherin antibodies (BD Biosciences, San Jose, CA) in conjunction with fluorochrome-conjugated donkey anti-mouse antibodies clearly delineated sites of e-cadherin expression in lungs of rats or mice. (cdc.gov)
Low levels of e-cadherin expression in type I cells allowed the double labeled type I cells to be distinguished from lymphatic endothelium and facilitated diagnosis of lymphangiectasia. (cdc.gov)
Contrary to previous studies, we found that N-cadherin localizes to endothelial cell-cell junctions in addition to its well-known diffusive membrane expression. (rupress.org)
These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane. (rupress.org)
In this study, we genetically manipulate N-cadherin expression in vivo and in vitro to examine its function in ECs. (rupress.org)
Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. (bdbiosciences.com)
P. gingivalis HSP60 at 100 ng/l significantly downregulated the expression levels of VE‑cadherin and eNOS protein at 12 h in HUVECs. (spandidos-publications.com)
These results indicated that P. gingivalis HSP60 may induce dysfunction and apoptosis in HUVECs via downregulating the expression levels of VE‑cadherin and eNOS, and promoting the cleavage of caspase‑3. (spandidos-publications.com)
Finally, we found that PAK3 regulated EMT-related molecule expression and EMT-related TGF-β/smad signaling pathway. (jcancer.org)

Knockout of E-cadherin has been associated with non-viability and abnormal epithelial morphogenesis ( 4 ). (iiarjournals.org)

Similar to classical cadherins, desmosomal cadherins have a single transmembrane domain, five EC repeats, and an intracellular domain. (wikipedia.org)

N-cadherin is expressed by stem cells, myeloblasts, endothelial cells, and fibroblasts, and also is expressed in neural and muscle tissues and some types of carcinoma cells. (biolegend.com)
This specificity is achieved through the recognition of specific molecules on the surface of target cells, ensuring precise and functional connections within the neural circuitry. (imsaethics.org)
Miyatani S, Shimamura K, Hatta M. Neural cadherin: role in selective cell-cell adhesion. (bdbiosciences.com)
Miembros de la superfamilia de cadherinas implicados en la adhesión celular y las interacciones intercelulares en el desarrollo neural. (bvsalud.org)

The cadherin family is essential in maintaining cell-cell contact and regulating cytoskeletal complexes. (wikipedia.org)
NE cleaves and activates protease-activated receptor-2, leading to actomyosin cytoskeletal activation, cell junction molecule VE-cadherin degradation, and increased endothelial permeability. (bu.edu)

Although the role of E-cadherin as a tumor suppressor has been established, in recent years, alternative roles for E-cadherin in tumor progression have become apparent. (iiarjournals.org)
The experimental and physiological observations regarding the tumor-suppressor role of E-cadherin are often interpreted in the context of the epithelial-mesenchymal transition. (iiarjournals.org)

This association links the cadherin protein to the cytoskeleton. (rndsystems.com)
The adherens junction provides strong cell-cell adhesion mediated by the cadherin-catenin complex via its linkage to the actin cytoskeleton ( Wheelock and Johnson, 2003 ). (rupress.org)

In ultrastructure studies, E-cadherin and beta-catenin have been noted at the cell membrane in the epithelial invaginations, while P-cadherin is restricted to basal cells. (medscape.com)
Tyrosine phosphorylation of β-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. (bdbiosciences.com)
However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates β-catenin and promotes N-cadherin/actin association. (bdbiosciences.com)
In this work, we show several previously unknown features of p120-catenin in a cadherin-catenin complex that are critical for our understanding of cadherin-based adhesion and signaling. (northwestern.edu)
We show that in human epithelial A-431 cells, nearly all p120 molecules engage in high-affinity interaction with E-cadherin-catenin complexes located at the cellular surface. (northwestern.edu)
p120 is positioned in proximity to α-catenin in the complex with cadherin. (northwestern.edu)
These findings suggest a functional cooperation between p120 and α-catenin in cadherin-based adhesion. (northwestern.edu)
Finally, we present compelling evidence that p120 is a key linker cementing the E-cadherin-catenin complex with the transmembrane protease γ-secretase. (northwestern.edu)
Kiss, A, Troyanovsky, RB & Troyanovsky, SM 2008, ' p120-catenin is a key component of the cadherin-γ-secretase supercomplex ', Molecular biology of the cell , vol. 19, no. 10, pp. 4042-4050. (northwestern.edu)

It comprises a significant physical barrier to small molecule forms of ingress, such as HIV, due to the thick multilayered structure [ 18 ]. (hindawi.com)

Typical cadherins are different from other types of cadherins and consist of one or more extracellular repeat domains. (wikipedia.org)

Immunofluorescent double-labeling with e-cadherin can be used with immunofluorescent detection of podoplanin, a lymphatic endothelial cell marker that is also expressed by alveolar type I cells in the lung. (cdc.gov)
We also show that N-cadherin is important for endothelial cell proliferation and motility. (rupress.org)

Additional reported applications (for the relevant formats) include: immunofluorescence 1,3,6 , motility inhibition of N-cadherin-expressing cells 2 , and Western blot 2,4 . (biolegend.com)
The use of e-cadherin immunofluorescence in pulmonary toxicologic pathology studies. (cdc.gov)
Thus, in the lung, e-cadherin immunofluorescence can demonstrate abnormal and normal epithelial cell junctions, facilitate demonstration of airway epithelial changes, and distinguish podoplaninexpressing alveolar type I cells from lymphatic endothelium. (cdc.gov)

One current model proposes that cells distinguish cadherin subtypes based on kinetic specificity rather than thermodynamic specificity, as different types of cadherin homotypic bonds have different lifetimes. (wikipedia.org)

Classical cadherins maintain the tone of tissues by forming a homodimer in cis while desmosomal cadherins are heterodimeric. (wikipedia.org)
Although classical cadherins take a role in cell layer formation and structure formation, desmosomal cadherins focus on resisting cell damage. (wikipedia.org)
Desmosomal cadherins maintain the function of desmosomes that is to overturn the mechanical stress of the tissues. (wikipedia.org)
There are two types of desmosomal cadherins: desmogleins and desmocollins. (wikipedia.org)

In practical applications, E-cadherin is used as a phenotypic marker of the lobular subtype of cancer, where loss of hetero zygosity in chromosome region 16q22.1, the gene region encoding E-cadherin ( CDH1 ) is frequent ( 6 ). (iiarjournals.org)
With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)

Next, the MDC researchers want to find out to what extent E-cadherin also regulates human embryonic stem cells. (sciencedaily.com)
Loss of N-cadherin in endothelial cells results in embryonic lethality at mid-gestation due to severe vascular defects. (rupress.org)

There are multiple classes of cadherin molecules, each designated with a prefix for tissues with which it associates. (wikipedia.org)
N-cadherin is involved in organogenesis and maintenance of organ architecture by contributing to the sorting of heterogeneous cell types and in the cell adhesion needed to form tissues. (biolegend.com)
It is a calcium-regulated adhesion molecule expressed in most normal epithelial tissues ( 2 ). (iiarjournals.org)
E-cadherin could be demonstrated in formalin or paraformaldehyde fixed tissues but not in glutaraldehyde fixed tissue. (cdc.gov)

Sections were immunostained for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her2), basal cytokeratin CK5, nuclear protein Ki67 and E-cadherin with a Leica Bond-Max autostainer. (iiarjournals.org)
Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G. (cdc.gov)

In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) N-Cadherin, recombinant mouse (rm) VE-Cadherin, rhCadherin-8, or rhCadherin-17 is observed. (rndsystems.com)

Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. (embl.de)

Patients with bladder cancer had significantly higher concentrations of sE-cadherin compared with a control group (P = 0.017). (ox.ac.uk)
Our findings reveal that E-cad adhesion molecule significantly reprograms cellular metabolism, promoting tumor growth and metastasis of breast cancers. (nih.gov)
Indeed, VE-cadherin was significantly down-regulated in the mutant embryos, demonstrating that N-cadherin is genetically upstream of VE-cadherin. (rupress.org)

Both MN- and Dbx1-specific cadherin inactivation in mice during a critical developmental window results in perinatal lethality due to respiratory failure and a striking reduction in phrenic MN bursting activity. (elifesciences.org)
To investigate the role of N-cadherin in vascular development, N-cadherin was specifically deleted from endothelial cells in mice. (rupress.org)

In structure, they share cadherin repeats, which are the extracellular Ca2+-binding domains. (wikipedia.org)
Because cadherins are Ca2+ dependent, they have five tandem extracellular domain repeats that act as the binding site for Ca2+ ions. (wikipedia.org)
Cadherin repeats. (embl.de)

This is an extremely thorough investigation of the role of cadherins in generating a functional motor circuit. (elifesciences.org)
however, the interrelationship and functional contribution of the individual cadherins in cell adhesion and signaling is poorly understood. (rupress.org)

Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events. (bdbiosciences.com)

Using these, models, we have studied the role of VE-cadherin phosphorylation and adherens junction disintegration in a number of diseases including cancer, retinopathy and myocardial infarction. (icgeb.org)

The MDC researchers found that in contrast to the original cells, the new pluripotent cells derived from mouse connective tissue contained E-cadherin. (sciencedaily.com)
Cadherins play a role in development, specifically in tissue formation. (rndsystems.com)
The distribution of cadherin and alkaline phosphatase in the gut tissue was also examined. (unboundmedicine.com)
Cadherins are a group of such molecules involved in the Ca2+-dependent cell-cell adhesion mechanism and are found in most kinds of tissue. (wikigenes.org)

The extracellular domains of cadherins form parallel dimers that possess intrinsic homophilic-binding activity. (embl.de)

Cadherins are cell-cell interaction molecules (By similarity). (antikoerper-online.de)

Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion. (embl.de)

Additionally, we are performing biochemical characterization of this molecule to determine how it may affect cell adhesion and other cell functions. (cincinnatichildrens.org)

The down-regulation of both VE-cadherin and p120ctn was confirmed in cultured endothelial cells using small interfering RNA to knockdown N-cadherin. (rupress.org)

The B7 family molecules in oral squamous cell carcinoma: a systematic review. (cdc.gov)
Genotyping of 41 chimpanzees and examination of 24 published chimpanzee genomes from subspecies across Africa showed universal homozygosity for the cadherin-related family member 3 CDHR3 -Y 529 allele, which increases risk for rhinovirus C infection and asthma in human children. (cdc.gov)
The elevated virulence of rhinovirus C derives from its unique reliance on the cadherin-related family member 3 (CDHR3) receptor for host cell binding ( 6 ). (cdc.gov)

Anatomy31

Organisms15

Diseases2

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes46

Disciplines and Occupations1

Information Science3

Superfamily6

Adhesion Molecules12

Intercellular7

Protocadherins1

Epithelial cell adhesion1

Cytoplasmic7

Proteins15

Loss of E-cadherin1

Classical cadherin2

Type I cadherin2

Mouse N-cadherin1

Soluble E-cadherin2

Adherens junctions2

Atypical cadherin2

Vascular endothelial2

Expression18

Morphogenesis1

Single transmembrane domain1

Neural4

Cytoskeletal2

Tumor suppressor2

Cytoskeleton2

Catenin9

Small molecule1

Consist1

Endothelial Cell2

Immunofluorescence3

Subtypes1

Desmosomal4

CDH13

Embryonic2

Tissues4

Ki672

Recombinant1

Mediate1

Significantly3

Mice2

Repeats3

Functional2

Interactions1

Phosphorylation1

Tissue4

Homophilic1

Interaction1

Residues1

Biochemical1

Regulation1

Family3