• BIND-related tools include BIND BLAST (for BLASTing against the proteins found in the BIND database) and PreBIND, a tool that searches the scientific literature for possible interactions and then submits bona fide interactions to BIND. (biomedcentral.com)
  • The 'visualize interaction' feature in the search results is entertaining - clicking on a protein unleashes a series of connecting boxes identifying all the proteins known (to BIND) to interact with it. (biomedcentral.com)
  • The microbial insecticide Bacillus thuringiensis (Bt) produces Cry toxins, proteins that bind to the brush border membranes of gut epithelial cells of insects that ingest it, disrupting the integrity of the membranes, and leading to cell lysis and insect death. (unboundmedicine.com)
  • The information molecules released by the transmitter nano-machine into the environment can degrade in the channel via a first-order degradation reaction and those that reach the receiver nano-machine can participate in a reversible bimolecular reaction with receiver receptor proteins. (embs.org)
  • Using single-molecule tracking, we show that all three Y-complex proteins exhibit three distinct mobilities, including movement through the cytosol and confined motion, predominantly at membrane-proximal sites but also within the cell center. (uni-marburg.de)
  • Thus, HERA is a novel cellular assay that can be used to predict how FcRn-binding proteins are rescued from intracellular degradation. (nature.com)
  • Proteins that do not bind the receptor are directed to lysosomal degradation. (nature.com)
  • Cooperative binding is observed in many biopolymers, including proteins and nucleic acids. (wikipedia.org)
  • The ability of Brucella protein Bp26 to bind to extracellular matrix (ECM) proteins was determined by enzyme-linked immunosorbent assay (ELISA) and biolayer interferometry (BLI). (ntu.ac.uk)
  • The Sec61 complex also mediates membrane integration of many proteins, including most cell surface receptors and cell adhesion molecules. (biorxiv.org)
  • The LE can contain over half of the cellular cholesterol and, as a major sorting station, can contain many cholesterol-binding proteins from the ABCA, STARD, and ORP families. (vu.nl)
  • Protein stabilization upon ligand binding has frequently been used to identify ligands for soluble proteins. (nih.gov)
  • Here the authors used MsbA (an adenosine triphosphate binding cassette transporter), CorA (a Mg(++) channel), and CpxA (a histidine kinase) as model proteins and show that DSLS is not sensitive to the presence of detergents or protein hydrophobicity and can be used to monitor thermodenaturation of membrane proteins, assess their stability, and detect ligand binding in a 384-well format. (nih.gov)
  • Immunoblot analysis identified two plasminogen binding proteins of 57 and 42 kDa. (lu.se)
  • Formation of H. pylori cell surface-bound plasmin may be important to provide a powerful proteolytic mechanism for gastric tissue penetration in type B gastritis and peptic ulcer disease, since plasmin degrades not only fibrin but also extracellular matrix proteins such as various collagens and fibronectin. (lu.se)
  • Work-related asthma may be triggered by large molecules (such as proteins from fish or from natural rubber latex) as well as by small, highly reactive molecules, such as diisoccyanates (including TDI and MDI). (cdc.gov)
  • While prior information suggests that small molecules cause allergic responses by binding to large proteins in the body, the exact mechanism is not known. (cdc.gov)
  • However, most drugs act as haptens, binding covalently to serum or cell-bound proteins, including peptides embedded in major histocompatibility complex (MHC) molecules. (msdmanuals.com)
  • [ 5 ] The Fc region of IgG facilitates interaction with and signaling through Fc receptors on phagocytes, B cells, and other cells and with Fc-binding plasma proteins (eg, components of the complement system). (medscape.com)
  • Furthermore, both the mouse and human receptors bind more strongly to mouse serum albumin (MSA) than to HSA. (nature.com)
  • Since HveA also mediates HSV entry by interacting with gD, we compared both structurally unrelated receptors for their binding to gD. (nih.gov)
  • Thus, we propose that HSV entry can be mediated by two structurally unrelated gD receptors through related but not identical binding with gD. (nih.gov)
  • A low level of signaling was also obtained when functionalizing the blocked SLBs with adhesion molecules binding to receptors on the T cell. (lu.se)
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
  • It can specifically bind target molecules (e.g., antibodies, enzymes or receptors). (bvsalud.org)
  • Cooperativity can be homotropic, if a ligand influences the binding of ligands of the same kind, or heterotropic, if it influences binding of other kinds of ligands. (wikipedia.org)
  • Collagen and vitronectin bound to peptides from several regions of Bp26, with many of the binding sites for the ligands overlapping. (ntu.ac.uk)
  • Specifically, we look individually at the quantum properties of small clusters of hydrogen and water molecules and confined hydrogen within water cages, known as clathrate hydrates, which serves as a more practical application. (uwaterloo.ca)
  • In liquid water, each water molecule is hydrogen bonded to four other water molecules. (mcmaster.ca)
  • In a water-ethanol solution, free water molecules vary according the concentration of ethanol. (highdilution.org)
  • OBJECTIVE To see whether different homeopathic potencies having fixed ethanol content show variation in free water molecules. (highdilution.org)
  • The decrease in intensity at 3630 cm-1 and subsequent rise in intensity at lower frequency region represent the level of free water molecules and strong alcoholic O-H band around 3250 cm-1, respectively. (highdilution.org)
  • The drugs have different levels of bound and free water molecules although their ethanol concentration is same. (highdilution.org)
  • 2Department of Biochemistry ity water molecules. (lu.se)
  • The dispersion amplitude requires only three (apo) or four (holo) long-lived and ordered water molecules (residence time 0.01-4 ms at 300 K). Comparison of MRD pro®les from the different complexes indicates that the displaced cavity water molecules are short-lived. (lu.se)
  • 10 ns) water molecules required by the MRD data are tentatively assigned to crystallographic hydration sites on the basis of accessibility, positional order, and H-bonding. (lu.se)
  • The amplitude of the high- frequency dispersion corresponds to 10-20 moderately ordered water molecules, with a correlation time of ca. 1 ns that may re¯ect a transient opening of the cavity required for exchange with external water. (lu.se)
  • NOESY, nuclear Overhauser fatty acid, only eight water molecules are effect spectroscopy. (lu.se)
  • Single-molecule dynamics suggest that ribosomes assemble at sites of translation in Bacillus subtilis by: Stoll, Joshua, et al. (uni-marburg.de)
  • The single molecule conductances of a series of bis-2,2′:6′,2″-terpyridine complexes featuring Ru(II), Fe(II), and Co(II) metal ions and trimethylsilylethynyl (Me3SiC≡C-) or thiomethyl (MeS-) surface contact groups have been determined. (lancs.ac.uk)
  • The stochastic nature of single-molecule charge transport measurements requires collection of large data sets to capture the full complexity of a molecular system. (imperial.ac.uk)
  • Here we present such an approach based on multivariate pattern analysis and apply it to simulated and experimental single-molecule charge transport data. (imperial.ac.uk)
  • Here, we synthesized a novel Fc-binding ARM (Fc-ARM) that targets folate receptor (FR)-positive cancer cells, Reo-3, using a recently developed monocyclic peptide 15-Lys8Leu, which binds strongly to the Fc region of an antibody. (rsc.org)
  • In the first scenario, we assume that the entire surface of the receiver is covered by receptor molecules. (embs.org)
  • Then, in the second scenario, we consider the case where the number of receptor molecules is finite and the uniformly distributed receptor molecules cover the receiver surface only partially. (embs.org)
  • In both cases, the long half-life is due to their molecular size above the renal clearance threshold and their interaction with a membrane-bound receptor named the neonatal Fc receptor (FcRn). (nature.com)
  • This approach also estimates the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process. (mdpi.com)
  • Cooperative binding occurs in a molecular binding system where two or more ligand molecules can bind to a receptor molecule. (wikipedia.org)
  • Binding can be considered "cooperative" if the actual binding of the first molecule of the ligand to the receptor changes the binding affinity of the second ligand molecule. (wikipedia.org)
  • The binding of ligand molecules to the different sites on the receptor molecule do not constitute mutually independent events. (wikipedia.org)
  • Cooperativity can be positive or negative, meaning that it becomes more or less likely that successive ligand molecules will bind to the receptor molecule. (wikipedia.org)
  • A receptor molecule is said to exhibit cooperative binding if its binding to ligand scales non-linearly with ligand concentration. (wikipedia.org)
  • If several ligand binding sites exist, but ligand binding to any one site does not affect the others, the receptor is said to be non-cooperative. (wikipedia.org)
  • Further examination by molecular docking analysis pinpointed the targets of the tannins in the fivefold axis canyon region of the CVA16 capsid near the pocket entrance that functions in cell surface receptor binding. (tmu.edu.tw)
  • For this purpose, a SLB functionalized with TCR and an adhesion ligand, was allowed to bind cell with pMHC and the corresponding adhesion receptor. (lu.se)
  • Calcium molecules attach (bind) to CaSR, turning on (activating) the receptor. (medlineplus.gov)
  • When calcium binds to the CaSR protein in cells of the parathyroid gland, the activated receptor sends signals that block the production and release of parathyroid hormone. (medlineplus.gov)
  • ABSTRACT BACKGROUND Homeopathic potencies 12CH and above cross the Avogadro number, and as such do not contain any original drug molecules in their aquous ethanol medium. (highdilution.org)
  • article{647bc080-7535-4010-966a-3d1fad12c300, abstract = {{The binding of iodine-labelled plasminogen to Helicobacter pylori CCUG 17874 was characterized. (lu.se)
  • Wilson, D. S., Keefe, A. D. & Szostak, J. W. The use of mRNA display to select high-affinity protein-binding peptides. (nature.com)
  • The strongest binding for anti-Bp26 mouse serum, collagen and vitronectin was to the peptides at the C-terminus of Bp26. (ntu.ac.uk)
  • Fibronectin did not bind to any of the peptides, although it bound to the whole Bp26 protein. (ntu.ac.uk)
  • The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. (ox.ac.uk)
  • Human histocompatibility leukocyte antigen E (HLA-E) and mouse major histocompatibility complex (MHC) class Ib antigen, Qa-1, share the same substitutions at two normally conserved positions 143 and 147, which are likely to affect binding of the C terminus of peptides. (ox.ac.uk)
  • We demonstrate that HLA-E binds, although poorly, the peptide which binds to Qa-1 and that it also binds nonamer signal sequence-derived peptides from human MHC class I molecules. (ox.ac.uk)
  • The high level of expression of PECAM-1 on CD34+ cells suggests that this glycoprotein may function as a heterotypic adhesion molecule, possibly mediating multipotential, myeloid, and early-B-lymphoid precursor cell interactions with stromal cells and extracellular matrix molecules via heparan sulfate proteoglycans. (ox.ac.uk)
  • Targeting specific protein-protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable for PPI inhibition. (rcsb.org)
  • Antibody-recruiting molecules (ARMs) are bispecific molecules composed of an antibody-binding motif and a target-binding motif that redirect endogenous antibodies to target cells to elicit immune responses. (rsc.org)
  • The lack of binding of mIgG to hFcRn explains why murine antibodies are rapidly removed from the circulation in humans, despite long half-life in mice 32 . (nature.com)
  • Competition assays with neutralizing anti-gD monoclonal antibodies (MAbs) showed that MAbs from group Ib prevented HveC and HveA binding to virions. (nih.gov)
  • After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
  • Bispecific antibodies could bind to particular neoantigen targets found on tumor cells and recruit T-cells to destroy the cancer. (eurekalert.org)
  • Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
  • natural antibodies can frequently bind to different antigens. (medscape.com)
  • This thesis presents the study of weakly bound clusters in the ground state (or the zero-temperature limit) using path integral molecular dynamics. (uwaterloo.ca)
  • Bp26 bound weakly to soluble fibronectin but did not bind to immobilized fibronectin. (ntu.ac.uk)
  • Although the association constants are generally lower, guests of biological significance such as aspirin and nicotine show similar behaviour, with a substantial difference between neutral (strongly binding) and charged (weakly binding) forms, irrespective of the sign of the charged species. (shu.ac.uk)
  • This study revealed that Bp26 binds to both immobilized and soluble type I collagen and vitronectin. (ntu.ac.uk)
  • It also binds to soluble but not immobilized fibronectin. (ntu.ac.uk)
  • Herein, we described a strategy integrating high-throughput (HT) sequencing with conventional SELEX followed by bioinformatic analysis to identify aptamers with high binding affinity and target specificity to unravel the sequence-structure motifs of pre-miRNA, which is essential for binding to the recently developed new water-soluble small-molecule CMBL3aL. (elsevierpure.com)
  • Complex formation between soluble gD and HveC appears to involve one or two gD molecules for one HveC protein. (nih.gov)
  • A soluble form of PECAM-1 also binds heparin-sepharose. (ox.ac.uk)
  • Small clusters of the individual molecules themselves are then focused on. (uwaterloo.ca)
  • The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. (degruyter.com)
  • 6FA4: Antibody derived (Abd-7) small molecule binding to KRAS. (rcsb.org)
  • A potential solution to these problems is to select intracellular antibody fragments to block PPIs, use these antibody fragments for target validation in disease models and finally derive small molecules overlapping the antibody-binding site. (rcsb.org)
  • Here, we explore this strategy using an anti-mutant RAS antibody fragment as a competitor in a small-molecule library screen for identifying RAS-binding compounds. (rcsb.org)
  • To enhance the translational potential of ARMs, it is crucial to design antibody/target-binding motifs that have strong affinity and are easy to synthesize. (rsc.org)
  • Reo-3 bound to the Fc region of the antibody with a K d of 5.8 nM, and recruited a clinically used antibody mixture to attack FR-positive IGROV-1 cells as efficiently as Fc-ARM2, in which a bicyclic Fc-binding peptide was used. (rsc.org)
  • The antibody recognizes a unique molecule of the pathogen, called an antigen . (wikipedia.org)
  • [2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
  • Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
  • To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
  • The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
  • Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
  • The platelet-endothelial cell adhesion molecule-1 (PE-CAM-1), defined by the CD31 monoclonal antibody (MoAb), was initially described as a cell-cell adhesion molecule mediating both homotypic and heterotypic adhesion. (ox.ac.uk)
  • The binding makes the protein-drug complex immunogenic, stimulating antidrug antibody production, T-cell responses against the drug, or both. (msdmanuals.com)
  • This accounts for what appears to be an anomalously high boiling point for water when compared with the values observed for the neighbouring hydride molecules NH 3 and HF. (mcmaster.ca)
  • Adhesion molecule pairs of similar height as TCR-pMHC have been argued to facilitate the TCR-pMHC interaction by physically keeping the opposing membranes at an optimal distance for binding. (lu.se)
  • The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes. (ox.ac.uk)
  • It may also act as a homotypic adhesion molecule by interacting with PECAM-1 on bone marrow stromal macrophage-like cells and endothelial cells or on endothelial cells during stem/progenitor cell migration. (ox.ac.uk)
  • Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells. (bvsalud.org)
  • We previously demonstrated that the activated leukocyte cell adhesion molecule ( ALCAM /CD166) can interact with galectin -8 (Gal-8) in endothelial cells . (bvsalud.org)
  • Importantly, exogenously added Gal-8 provoked ALCAM segregation, probably trapping this adhesion molecule at the surface of breast cancer cells . (bvsalud.org)
  • Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
  • Finally, the results from this statistical analysis will be used to setup a protein-ligand docking run targeting the predicted binding sites. (bonvinlab.org)
  • Cooperativity can be positive (if binding of a ligand molecule increases the receptor's apparent affinity, and hence increases the chance of another ligand molecule binding) or negative (if binding of a ligand molecule decreases affinity and hence makes binding of other ligand molecules less likely). (wikipedia.org)
  • The concept of cooperative binding only applies to molecules or complexes with more than one ligand binding sites. (wikipedia.org)
  • Throughout the 20th century, various frameworks have been developed to describe the binding of a ligand to a protein with more than one binding site and the cooperative effects observed in this context. (wikipedia.org)
  • It also means that binding sites always exhibit the same affinity, and cooperativity does not arise from an affinity increasing with ligand concentration. (wikipedia.org)
  • In general, molecular binding is an interaction between molecules that results in a stable physical association between those molecules. (wikipedia.org)
  • The initial hits are optimized by structure-based design, resulting in potent RAS-binding compounds that interact with RAS inside the cells, prevent RAS-effector interactions and inhibit endogenous RAS-dependent signalling. (rcsb.org)
  • The Biomolecular Interaction Network Database (BIND) was developed to undertake the mammoth task of providing a public database of all known biomolecular interactions. (biomedcentral.com)
  • Although BIND currently only accepts protein-protein and protein-nucleic acid interactions, tools are being developed for the site to accept small-molecule data. (biomedcentral.com)
  • BIND is still in the early stages of development and therefore contains a limited number of interactions (5,843 as of 8 July 2001). (biomedcentral.com)
  • The properties observed for matter on the macroscopic level are determined by the properties of the constituent molecules and the interactions between them. (mcmaster.ca)
  • The polar or non-polar character of a molecule will clearly be important in determining the nature of its interactions with other molecules. (mcmaster.ca)
  • Thus the observation of a large vapour pressure at a low temperature implies that relatively little kinetic energy is required to overcome the potential interactions between the molecules in the condensed phase. (mcmaster.ca)
  • The only potential interactions possible between non-polar, covalently bonded molecules are of the van der Waals' type as previously discussed for the interaction between two helium atoms at large internuclear separations. (mcmaster.ca)
  • The small polarizations of the charge densities induced by the long-range interactions of closed shell atoms or molecules result in only weak forces of attraction. (mcmaster.ca)
  • The interactions between polar molecules such as HF and H 2 O will be much larger and their normal boiling points greater than those observed for the non-polar molecules. (mcmaster.ca)
  • In the limiting case of the strong interactions which exist between the ions in an ionic crystal, the concept of a discrete molecule in the solid phase ceases to exist. (mcmaster.ca)
  • Moreover, indications of some of the possible interactions that may take place in the binding sites were also identified. (lu.se)
  • This temperature reduction allows hybridization to occur between the deoxyadenosine region on the capture oligomer and the poly-deoxythymidine molecules that are covalently attached to the magnetic particles. (cdc.gov)
  • The capture oligomers contain sequences complementary to specific regions of the target molecules as well as a string of deoxyadenosine residues. (cdc.gov)
  • During the hybridization step, the sequence specific regions of the capture oligomers bind to specific regions of the target molecules. (cdc.gov)
  • The microparticles, including the captured target molecules bound to them, are pulled to the side of the reaction vessel using magnets and the supernatant is aspirated. (cdc.gov)
  • We noted previously that the dipole moment in the HA molecules increased as A was made more electronegative. (mcmaster.ca)
  • The strong correlation is observed between the PA and dipole moment, that is, a polar molecule with a large dipole moment has a large PA value. (epj.org)
  • The critical dipole moment of neutral amino acid molecules for binding a positron was found at about 3.46 Debye. (epj.org)
  • From the systematic analysis of twenty kinds of amino acid molecule, we theoretically confirmed the possibility of positron binding to conformers of amino acid molecules with strong dipole moment. (epj.org)
  • Binding of atoms and stability of molecules in Hartree and Th. (iaea.org)
  • Binding of atoms and stability of molecules in Hartree and Thomas-Fermi type theories. (iaea.org)
  • There is considerable academic and practical interest in the interaction of antimatter with atoms and molecules. (abdn.ac.uk)
  • In general, a DEL has been considered as a massive binding assay to identify physical binders for individual protein targets. (nature.com)
  • We developed a peptide binding assay in vitro to compare the binding specificity of HLA-E with the mouse MHC class Ib molecule Qa-1. (ox.ac.uk)
  • Studies have shown that APN-1 has a relatively weak affinity and a very narrow specificity to Cry1Ac, the only Cry1A toxin that it binds. (unboundmedicine.com)
  • Biolayer interferometry showed high binding affinity of Bp26 to immobilized type I collagen and no binding to fibronectin or laminin. (ntu.ac.uk)
  • This is measured on individual cell-SLB contacts, providing an accurate new means of measuring binding affinity and to study differences in the 2D Kd in the cell population. (lu.se)
  • All amino acid molecules in the intramoleculear HB structures have positive positron affinity (PA, the binding energy of a positron) values, which means that a positron can be attached to parent molecules, while in the GM structures only three amino acid molecules of Gln, Trp, and His have positive PA values. (epj.org)
  • Hint: tRNA is an adaptor molecule made up of RNA that acts as the physical connexion between the mRNA and the protein amino acid chain, usually 76 to 90 nucleotides in length. (edu.vn)
  • Seven computational hits were evaluated in biochemical binding assays. (suny.edu)
  • We performed binding assays by surface plasmon resonance to study the interaction between Gal-8 and the recombinant glycosylated ALCAM ectodomain or endogenous ALCAM from MDA-MB-231 breast cancer cells . (bvsalud.org)
  • It is thought H-bonded water structures preserved by ethanol carry the information of initial drug molecules. (highdilution.org)
  • A tubulin binding molecule drives differentiation of acute myeloid leukemia cells. (ox.ac.uk)
  • IFABP and the binding thermodynamics (Richieri growth and differentiation (Glatz & van der et al. (lu.se)
  • Qa-1 is able to bind a peptide derived from the leader sequence of H-2 D and H-2 L molecules. (ox.ac.uk)
  • The amino acid binding site of tRNA is-A. AnticodonB. (edu.vn)
  • Aminoacyl tRNA synthetase (AATS), the enzyme that chemically binds a tRNA to an amino acid via a high-energy bond, recognises the anticodon loop. (edu.vn)
  • 1] Every amino acid has its own specific aminoacyl-tRNA synthetase, which is utilized to chemically bind to the tRNA that it is specific to, or in other words, "cognate" to. (edu.vn)
  • The feature of positron binding to twenty neutral amino acid molecules with the global minimum (GM) and intramoleculear hydrogen-bonded (HB) structures was analysed using the ab initio multi-component molecular orbital method. (epj.org)
  • Analysing the positronic orbitals of each positronic amino acid molecule and the electrostatic potential maps of the corresponding parent molecules, we found that long-range electrostatic interaction is the most crucial role in positron binding to neutral amino acid molecules. (epj.org)
  • A large pool of research has been aimed at characterizing this interaction by measuring the binding kinetics and relating it to the T cell response. (lu.se)
  • In the absence of electrochemical gating, these complexes behave as tunneling barriers, with conductance properties determined more by the strength of the electrode-molecule contact and the structure of the "linker" than the nature of the metal-ion or redox properties of the complex. (lancs.ac.uk)
  • In persons with Kawasaki disease and dermatomyositis, IVIG is thought to inhibit the generation of membrane attack complexes (C5b-C9) and subsequent complement-mediated tissue damage by binding the activated components C3b and C4b, thus preventing their deposition on target surfaces. (medscape.com)
  • The low boiling points (the temperature at which the vapour pressure above the liquid phase equals one atmosphere) observed for substances composed of molecules which can interact only through a van der Waals' type force are, therefore, understandable. (mcmaster.ca)
  • Inhibition of the binding was observed after preincubation of H. pylori cells with nonradiolabelled plasminogen, lysine, or the lysine analogue -aminocaproic acid. (lu.se)
  • Mini-plasminogen caused total inhibition of the plasminogen binding, while the other fragments caused only partial inhibition. (lu.se)
  • A range of organic molecules with acidic or basic groups exhibit strong pH-dependent binding inside the cavity of a polyhedral coordination cage. (shu.ac.uk)
  • The antigen binding site is circled. (wikipedia.org)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
  • Plasminogen binding to H. pylori seems to be independent of culture media and independent of the presence of the cytotoxin-associated CagA antigen. (lu.se)
  • Here we present near-atomic-resolution structures of the human Sec61 channel inhibited by a comprehensive panel of structurally distinct small molecules- cotransin, decatransin, apratoxin F, ipomoeassin F, mycolactone, cyclotriazadisulfonamide (CADA) and eeyarestatin I (ESI). (biorxiv.org)
  • The molecules were assayed in vitro to-ward T. cruzi epimastigotes, L. braziliensis promastigotes and L. amazonensis promastigotes. (lu.se)
  • Researchers have known how small molecules penetrate cell membranes, typically by binding to the membrane and then diffusing through it. (scitechdaily.com)
  • 1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)
  • Here we show that a truncated form of HveC directly binds to HSV glycoprotein D (gD) in solution and at the surface of virions. (nih.gov)
  • The 'related databases' page contains links to over 60 interaction and small-molecule databases. (biomedcentral.com)
  • An in silico docking approach was employed to screen for novel small-molecule compound that bind to the hemopexin domain of MMP-9. (suny.edu)
  • Selective targeting of biologically relevant RNAs with small molecules is a long-standing challenge due to the lack of clear understanding of the binding RNA motifs for small molecules. (elsevierpure.com)
  • In this study, we identified the tannins chebulagic acid (CHLA) and punicalagin (PUG) as small molecules that can efficiently disrupt the CVA16 infection of human rhabdomyosarcoma cells. (tmu.edu.tw)
  • Several natural and synthetic small molecules specifically inhibit the Sec61 channel, generating cellular effects that are potentially useful for therapeutic purposes, but their inhibitory mechanisms remain unclear. (biorxiv.org)
  • Cryo-EM structures of the human Sec61 complex inhibited by various small-molecule inhibitors. (biorxiv.org)
  • Currently, no small-molecule drugs are available that prevent disease following exposure to preformed toxins. (cdc.gov)
  • The GEN-PROBE TMA reaction replicates a specific region of the small ribosomal subunit from trichomonas vaginalis via DNA and RNA intermediates and generates RNA amplicon molecules. (cdc.gov)
  • Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes. (wikipedia.org)
  • The Cry1A toxin-binding sites were confined to the apical surface of the gut epithelial cells with intense labeling of the apical tips of the microvilli. (unboundmedicine.com)
  • The topographical relationship between the Bt Cry toxin-binding molecules BTR-270 and APN-1 and the Cry1A toxin-binding sites that were confined to the apical brush border of the midgut cells is consistent with findings implicating their involvement in the mechanism of the action of Bt Cry toxins. (unboundmedicine.com)
  • The IEEE Transactions on NanoBioscience publishes basic and applied papers dealing both with engineering, physics, chemistry, modeling and computer science and with biology and medicine with respect to molecules, cells, tissues. (embs.org)
  • Thus, this molecule has the potential importance of directing both lineage commitment and trafficking of early hematopoietic progenitor cells. (ox.ac.uk)
  • Here, we analyzed the physical interaction between both molecules in breast cancer cells and the functional relevance of this phenomenon. (bvsalud.org)
  • We also analyzed the binding of ALCAM -silenced or control breast cancer cells to immobilized Gal-8 by SPR. (bvsalud.org)
  • Moreover, ALCAM -silenced breast cancer cells exhibited reduced binding to Gal-8 relative to control cells . (bvsalud.org)
  • The other arm binds to T-cells," Weidanz said. (eurekalert.org)
  • Haptens may also bind directly to class II MHC molecules, directly activating T cells. (msdmanuals.com)
  • However, more effort is needed to identify and characterize the sequence-structure motifs in the aptamers important for binding to the target. (elsevierpure.com)
  • To confirm the fidelity of this approach, we investigated the binding of CMBL3aL to the identified motifs by surface plasmon resonance (SPR) spectroscopy and its potential regulatory activity on dicer-mediated cleavage of the obtained aptamers and endogenous pre-miRNAs comprising the identified motif in its hairpin loop. (elsevierpure.com)
  • This new approach would significantly accelerate the identification process of binding sequence-structure motifs of pre-miRNA for the compound of interest and would contribute to increase the spectrum of biomedical application. (elsevierpure.com)
  • Electron binding motifs in cluster anions of primary amides, (acetamide) n - and (propionamide) n - , were studied with photoelectron spectroscopy. (elsevierpure.com)
  • Static and dynamical effects of alkyl groups on the electron binding motifs are discussed in comparison with the previous study on formamide cluster anions. (elsevierpure.com)
  • The 20 tRNAs are roughly L-shaped molecules with two distinct and widely separated regions. (edu.vn)
  • But we are still far away from an unbiased structure prediction of thermodynamically and/or kinetically stable structures of molecules on surfaces. (degruyter.com)
  • Remarkably, all inhibitors bind to a common lipid-exposed pocket formed by the partially open lateral gate and plug domain of the channel. (biorxiv.org)
  • Mutations conferring resistance to the inhibitors are clustered at this binding pocket. (biorxiv.org)
  • As the interaction free energies between the redox centres scale linearly with overall ring charge and in conjunction with fast intramolecular electron transfer (∼107 s−1), these molecules can be considered as uniformly charged nanorings (diameter ∼1-2 nm). (imperial.ac.uk)
  • Scatchard plot analysis revealed one binding mechanism with a Kd value of 7 × 107 M. Conversion of H. pylori cell-bound plasminogen to plasmin in the presence of a tissue-type plasminogen activator was demonstrated by digestion of the chromogenic substrate S-2251. (lu.se)
  • A statistical analysis of the docking models in terms of most contacted residues will then be performed to identify and visualize putative binding sites. (bonvinlab.org)
  • Notably, the DNA-binding and FtsZ-binding interfaces of MipZ comprise residues from both monomeric subunits and are located on opposite sides of the dimer. (mpg.de)
  • We also found that the DNA-binding region mainly consists of positively charged arginine and lysine residues. (mpg.de)
  • A specific and different tRNA molecule exists in the cell for each of the 20 amino acids. (edu.vn)
  • A mechanistic analysis revealed that the tannins particularly targeted the CVA16 entry phase by inactivating cell-free viral particles and inhibiting viral binding. (tmu.edu.tw)
  • In addition, the TCR-pMHC distributed non-homogeneously in the cell-SLB contacts when having height-mismatched adhesion molecules, but homogeneously when having height-matched adhesion molecules. (lu.se)
  • This indicates that TCR-pMHC binding in cell contacts depends significantly on the local environment and not only on the protein-protein interaction per se. (lu.se)
  • A single molecular weight species was generally observed with enriched membrane preparations, whereas two PECAM-1 molecules were present in whole-cell lysates of cell lines and the CD34+ bone marrow cell subset. (ox.ac.uk)
  • Preliminary studies show that a proportion of the PECAM-1 molecules on the lymphomyeloid/multipotential progenitor cell line, KG1, and on the monocytic cell line, U937, binds to heparin-sepharose. (ox.ac.uk)
  • One arm can recognize the cancer cell and bind to it. (eurekalert.org)
  • Click molecule labels to explore molecular sequence information. (nih.gov)
  • Indeed, 12 species are currently included in the BIND database (including human, mouse and yeast), and there are a further 96 alternatives currently listed in the submission section. (biomedcentral.com)
  • Cooperative binding occurs in molecular binding systems containing more than one type, or species, of molecule and in which one of the partners is not mono-valent and can bind more than one molecule of the other species. (wikipedia.org)
  • The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)
  • In the preceding part, the authors proved the binding of arbitrary neutral systems for Thomas-Fermi type theories and of planar neutral systems for the Hartree model. (iaea.org)
  • In this part, they manage to get rid of this restriction and thus prove the binding and the stability of arbitrary neutral systems for the Hartree model. (iaea.org)
  • The Parkinson's drug 1-amino-adamantane ('amantadine') binds with an association constant of 104 M−1 in the neutral form (pH greater than 11), but the stability of the complex is reduced by three orders of magnitude when the guest is protonated at lower pH. (shu.ac.uk)
  • Monitoring the uptake of the guests into the cage cavity was facilitated by the large upfield shift for the 1H NMR signals of bound guests due to the paramagnetism of the host. (shu.ac.uk)