Molecule resistance nuclear localization signals. Medical search. Frequent questions

Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
Many signal transduction pathways are composed of modules that are remarkably conserved across species, such that lessons from different experimental model organisms have contributed to the understanding of molecular hierarchies that control signal communication in many cellular contexts. (biomedcentral.com)
The first step in the Wnt signal occurs when extracellular Wnt ligand binds Frizzled receptors on the cell surface, leading to the activation of several distinct transduction pathways (see Figure 1 ). (biomedcentral.com)
The intracellular protein Dishevelled is common to both canonical and non-canonical signaling pathways, raising the question of how this mysterious protein acts at the signal crossroads. (biomedcentral.com)
Wnt signals via canonical and non-canonical pathways. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Open up in another window Amount 1 Canonical HH signaling and non-canonical GLI gene activation ACTIVATION OF GLI BY ONCOGENIC, NON-CANONICAL SIGNALING PATHWAYS Non-canonical, oncogene-driven signaling pathways converge over the activation of GLI genes and additional converge on the specific downstream goals[3, 18, 21, 22] (find Figure ?Amount1).1). (acancerjourney.info)
All these modulations were found to be reversed by BTE, which inhibits iAs induced SCC of skin by quenching excess ROS, promoting Smad mediated TGF-β signalling, downregulating signalling intermediates of PI3K-AKT and MAPK pathways and inhibiting EMT. (jcpjournal.org)
Induction of canonical autophagy is mainly controlled by the AKT/mTOR and AMPK signaling pathways and relies on the activation and assembly of two macromolecular complexes, the ATG1/ULK1 and the Class III phosphatidylinositol 3-kinase (PI3K) complex (Figure 1 ) [ 5 ]. (hindawi.com)
LPA activates at least six G-coupled protein receptors (LPA 1-6 ) stimulating different signaling pathways through heterotrimeric G proteins such as G i/0 , G 12/13 , G q/11 , and G s . (hindawi.com)

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)
Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Abnormal activation of this pathway plays an essential role in chemoradiotherapy resistance ( 12 ). (frontiersin.org)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
Following the first member of the Wnt family identified over the last four decades ( 25 ), several recent studies have focused on the Wnt/β-catenin signaling pathway ( 26 , 27 ). (frontiersin.org)
ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? (babraham.ac.uk)
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
Now, in Journal of Biology [ 1 ], Sergei Sokol and colleagues show that the Dishevelled (Dsh) protein of the Wnt signaling pathway can shuttle in and out of the nucleus (see 'The bottom line' box for a summary of the work and 'Background' for further explanations and definitions). (biomedcentral.com)
Studies of the Wnt pathway provide a wonderful example of how researchers from different fields have contributed to a detailed understanding of a key signal transduction pathway [ 2 ]. (biomedcentral.com)
The Wnt signaling machinery is tightly regulated, and disruption of components of the signaling pathway have been implicated in diseases including cancer [ 2 , 4 ]. (biomedcentral.com)
Various kinds human cancers possess proven aberrant activation from the HH pathway by ligand-independent signaling such as for example, amplification of GLI1 or GLI2, mutations in PTCH or SMO, or dysregulated gene manifestation[1, 3]. (acancerjourney.info)
After 330 days of iAs treatment, development of invasive SCC of skin probably due to excess ROS generation, elevation of TGF-β, downregulation of the Smad pathway, upregulation of PI3K-AKT and MAPK signalling molecules and induction of EMT was observed. (jcpjournal.org)
Furthermore, ATL induced apoptosis by activating the cytochrome c (cyt c)/caspase cascade signaling pathway. (biomedcentral.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)
Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)
Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)
The results show that the combination of TMZ and KC7F2 can be a promising anti-cancer agent for the treatment of glioblastoma through the Wnt / β-catenin signaling pathway. (researchsquare.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells. (researchsquare.com)

The next step (4 in Fig. 3) was to reverse mutations in the nuclear localization signal (NLS) that is required to import the transposase enzyme from the cytoplasm where it is made to the nucleus where it acts. (wikipedia.org)
The bound complex is internalized and translocates into the oocyte nucleus thanks to an SV40 nuclear localization signal, enhanced by an adjacent casein kinase phosphorylation site. (biologists.com)
XPO1, the main nuclear export protein, transports cargo proteins containing nuclear localization signals out of the nucleus ( 1-3 ). (aacrjournals.org)
In binding assays, ORA59 and RAP2.3 interacted in the nucleus and showed ethylene-dependent nuclear localization. (figshare.com)
such studies have defined the molecules that ensure signals initiated at the cell surface are efficiently transmitted to the cell nucleus, where they often result in the induction of a specific gene-expression program. (biomedcentral.com)
Bora is really a nuclear protein that is excluded from the nucleus throughout prophase in a Cdc2 dependent manner. (others-signal.com)
Immune system Nevertheless, nuclear launch of Bora isn't the only system by which its service of Aurora A is controlled since the bora mutant phenotype can be rescued by Bora fused to a signal, which keeps the protein in the cytoplasm, or fused to a localization signal, which maintains the protein in the nucleus until nuclear envelope breakdown. (others-signal.com)

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
ATL exerts its anti-tumor effects in human GBM cells at least in part via NF-κB/COX-2-mediated signaling cascades by inhibiting IKKβ kinase activity. (biomedcentral.com)

In this study, we show that selinexor induces nuclear localization of IκB. (aacrjournals.org)
Ectopic expression of UvGHF1 in rice induces pattern-triggered immunity and enhances rice resistance to fungal and bacterial diseases. (bvsalud.org)
Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
During this process, ATX-LPA signaling induces production of proinflammatory cytokines. (hindawi.com)
Further, western blotting, flow cytometry, and an in vivo xenograft model were used to evaluate the function of Nek2 in HCC sorafenib resistance, whereas rescue experiments were performed to confirm that Nek2 induces sorafenib resistance via β-catenin. (biomedcentral.com)
Our study proves that Nek2 induces HCC sorafenib resistance via β-catenin and suggests a novel therapeutic strategy to improve the anti-tumor effects of sorafenib in HCC. (biomedcentral.com)

The key regulation of these motifs might be phosphorylation of a portion of MA molecules on the C-terminal tyrosine at the time of virus maturation, by virion-associated cellular tyrosine kinase. (proteopedia.org)

Membrane-spanning proteins often function as receptors involved in recognition and cell adhesion, whereas nuclear proteins frequently play a role in regulating gene expression and transcription. (biomedcentral.com)
But it is becoming increasingly clear that protein subcellular localization can be extremely dynamic, allowing key proteins to play different roles in different compartments. (biomedcentral.com)
The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
The autophagophore membrane then elongates and encloses the molecules to be degraded forming an autophagosome, which occurs in two separate conjugation reactions catalyzed by autophagy-related proteins (ATGs). (hindawi.com)
Small molecule GSK-3β inhibitors and GSK-3β knockdown using siRNA promote the expression of autophagy-related proteins. (mdpi.com)
Consequently, it can't be excluded that distinctive proteins also bind to the core protein or signaling molecules in the core protein induced cascade and block its effect. (mi-rna.com)
Uptake of FQs from the blood into kidney proximal tubule cells is mainly regulated by organic cation transporters and organic anion transporters, whereas FQ clearance from kidneys to urine is mediated by multidrug and toxin extrusion transporters, organic cation/zwitterion transporters and ABC transporters such as P-glycoprotein or multi-drug resistance-associated proteins ( 2 ). (bruker-webdev.de)
Further, a xenograft tumor model showed that Nek2 knockdown could improve the anti-tumor effect of sorafenib, whereas an analysis of tumor proteins showed that Nek2 regulates β-catenin protein levels and its nuclear translocation in vivo. (biomedcentral.com)

Our data indicate that plakoglobin promotes tumor cluster formation in IMPC and downregulates apoptosis in the cell clusters through activation of PI3K/Akt/Bcl-2 signaling. (jcancer.org)
Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)
We find that a structurally rigid IgG4H and CD28TM domain brings the two D4 fragments in proximity, driving CAR dimerization and leading to enhanced T-cell signaling and tumor regression in pancreatic cancer models with low antigen density in female mice. (nature.com)
Furthermore, by investigating the impact of hinge (CD8 and IgG4) and TM (CD8 and CD28) on D4 CAR T cells, we discover that IgG4H-CD28TM mediated D4 CAR dimerization, leading to enhanced T-cell signaling and tumor regression in pancreatic cancer models with low antigen density. (nature.com)
Desmin, vimentin and VWF co localisation scientific studies Desmin and vimentin double immunostaining was carried out on 17 tumor samples to assess co localisation. (mi-rna.com)
Desmin and VWF double staining frequently a b c showed co localisation to blood vessel walls during the tumor tissue and from the typical mucosa from some stage III and IV tumors, but not from early stage tumors. (mi-rna.com)
For example, in multiple myeloma, the inhibition of canonical Wnt signaling suppresses tumor growth and sensitizes cells to anti-tumor drugs [ 14 ]. (biomedcentral.com)

SAFe 360 combines SAFe 180 illumination to a dual camera detection to achieve unprecedented 3D single-molecule and multi-color imaging for localization microscopy. (axiomoptics.com)
SAFe technology corrects artefacts from 3D single-molecule detection and its extremely large field of view transform any type of inverted microscope into a first-class high-throughput multimodal microscope. (axiomoptics.com)
Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH. (antibodiesinc.com)

Octadecanoid-responsive arabidopsis 59 (ORA59) is an ethylene response factor (ERF) transcription factor and has been suggested to integrate ethylene and jasmonic acid signaling and regulate resistance to necrotrophic pathogens. (figshare.com)
Structure-function analysis of the Dishevelled (Dsh) protein in frog embryos has defined sequences that regulate Dsh nuclear localization, which proves critical for Wnt signaling. (biomedcentral.com)
Multicellular organisms (such as animals, plants, and fungi) produce signalling molecules called hormones that move through their bodies to regulate developmental and physiological processes. (botany.one)

Innate or acquired resistance to small molecule BRAF or MEK1/2 inhibitors (BRAFi or MEKi) typically arises through mechanisms that sustain or reinstate ERK1/2 activation. (babraham.ac.uk)
These resistance mechanisms frequently involve reinstatement of ERK1/2 signalling and BRAFi are now deployed in combination with one of three approved MEK1/2 inhibitors (MEKi) to provide more durable, but still transient, clinical responses. (babraham.ac.uk)
Furthermore, inhibitors to ERK1/2 (ERK1/2i) have also been developed to counteract ERK1/2 signalling. (babraham.ac.uk)
Little molecule inhibitors of SMO have already been examined in preclinical versions, and put on the treating numerous kinds of malignancies in human beings[4, 9, 11-14]. (acancerjourney.info)
Those tumors delicate to SMO inhibitors, such as basal cell carcinoma[15, 16] and medulloblastoma[11, 17], depend on canonical HH signaling for mobile survival. (acancerjourney.info)
Intrinsic level of resistance to SMO inhibitors is normally regular[11-14, 18, 19], and obtained level of resistance to GDC-0449 pursuing initial response continues to be reported in medulloblastoma (heterozygous mutation, Asp- His at aa 473 in SMO)[20]. (acancerjourney.info)
Therefore, strategies focused on inhibiting the inflammatory reaction using specific small molecule inhibitors could offer significant therapeutic value in the treatment of malignant tumors. (biomedcentral.com)
Our objectives are to investigate the synergistic effects of GSK-3β in combination with autophagy inhibitors to evade GSK-3β drug resistance. (mdpi.com)

Mutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and timing are poorly understood. (babraham.ac.uk)
While loss-of-function mutations in PTCH and gain-of-function mutations in SMO activate HH signaling[1], obtained mutations in SMO or non-canonical GLI activation render cancers cells resistant to SMO antagonists. (acancerjourney.info)

Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance. (babraham.ac.uk)
Here, we investigate amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COLO205 cells, a well-characterized model for reproducible emergence of drug resistance, and show that amplifications acquired are the primary cause of resistance. (babraham.ac.uk)
Drug resistance is seen in many cancer treatments. (researchsquare.com)
The dysfunction of LSD1 contributes to poor prognosis, poor patient survival, drug resistance, immunosuppression, etc., making it a potential epigenetic target for cancer therapy. (biomedcentral.com)
We use this platform to detect MTB and identify drug-resistance strains from mechanically processed sputum samples within 2.5 hours. (cdc.gov)

Thus, a systematic understanding of the mechanisms associated with sorafenib resistance is critical to improve treatment options for HCC patients. (biomedcentral.com)

Mechanistically, downstream of GLI1 and GLI2 inhibition, H2AX (a marker of DNA dual strand breaks) manifestation was upregulated, and H2AX nuclear foci had been proven in cells that indicated GLI3R. (acancerjourney.info)
Activation from the ATM/Chk2 axis with co-localization of H2AX and p-Chk2 nuclear foci had been demonstrated pursuing GLI1/GLI2 inhibition. (acancerjourney.info)

The myristoylation signal and the NLS thus exert conflicting influences its subcellular localization. (proteopedia.org)

Thus, this novel mechanism by which selinexor suppresses NFκB signaling provides unique opportunities for cancer therapy, especially when this drug is combined with a proteasome inhibitor. (aacrjournals.org)

Nevertheless, the part of HH signaling and its own importance in traveling mobile survival in cancer of the colon aren't well defined. (acancerjourney.info)
The outcome of LPA signaling is dependent on cellular context and impacts on biological processes such as wound healing, differentiation, neurogenesis, and survival, to name a few [ 4 ]. (hindawi.com)

For this, the Sfmbt protein complex was affinity purified from the nuclear extract, followed by highly specific peptide sequencing (IP/LC-MS). As a result, a number of previously uncharacterized Sfmbt interactions were discovered. (sdbonline.org)
All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)

Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. (frontiersin.org)
Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes (Ruppert, 2017). (sdbonline.org)

At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)

Wnt signaling regulates cell proliferation, cell polarity and cell-fate determination. (biomedcentral.com)
Chronic exposure to inorganic arsenic (iAs) elevates reactive oxygen species (ROS) generation and up-regulates TGF-β signalling. (jcpjournal.org)

Selinexor, a small molecule that inhibits nuclear export protein XPO1, has demonstrated efficacy in solid tumors and hematologic malignancies with the evidence of clinical activity in sarcoma as a single agent. (aacrjournals.org)

However, the cellular signaling process upon which hang acts remains unclear, and how the broadly expressed hang protein mediates specific behavioral changes in response to global increases of cellular stressors such as ethanol remains an open question (Ruppert, 2017). (sdbonline.org)

Thus, activated, type I subunits recruit and phosphorylate receptor SMADs (R-smad), which are the first intracellular mediators of TGF-β signalling. (springer.com)

A signal sequence domain essential for processing, but not import, of mitochondrial pre-ornithine carbamyl transferase. (mcmaster.ca)
Within this respect the localization of your mature core protein at the outer mitochondrial membrane may be of importance. (mi-rna.com)
Even though we didn't observe the release of cytochrome c during the Tet off UC cell line an interaction of the core protein with other molecules from the apoptotic machinery localized in the mitochondrial membranes might come about. (mi-rna.com)
Notably, Debcl modulates Drp1 mitochondrial localization during apoptosis. (sdbonline.org)

ATL, which is a natural small molecule inhibitor, is a promising candidate for clinical applications in the treatment of CNS tumors. (biomedcentral.com)
As a result, AP24534 also holds effectiveness against other imatinib resistant ABL mutants in bioactive small molecule library addition to ABL. (others-signal.com)

Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. (hindawi.com)
Lnc408-CBY1-β-catenin signaling axis might serve as a new diagnostic and therapeutic target for breast cancer. (nature.com)

Transposition is a precise process in which a defined DNA segment is excised from one DNA molecule and moved to another site in the same or different DNA molecule or genome. (wikipedia.org)
The second function is to play a role in nuclear localization of the viral genome at the very start of cell infection. (proteopedia.org)

LPA production, metabolism, and signaling. (hindawi.com)

Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)
The hang gene encodes a large, approximately 210-kDa nuclear zinc finger protein that is expressed in most, if not all, neurons in the adult brain (Scholz, 2005). (sdbonline.org)
Hence concentrating on the GLI genes downstream of SMO, that constitute the primary of HH-dependent gene legislation, may provide a substantial advantage in getting rid of HH signaling. (acancerjourney.info)

At the physiological pH range, FQs exist predominantly as ionized molecules either in anionic, cationic or zwitterionic form. (bruker-webdev.de)

Conceptually, it is an efficient way to treat cancer involved the hijacking of PTMs of the key molecules in Wnt/β-catenin. (frontiersin.org)
In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression. (hindawi.com)

cAMP-dependent phosphodiesterases (PDEs) are essential components of the cAMP signaling cascade and fine-tune cyclic nucleotide signaling. (sdbonline.org)

Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
During growth, development and disease, extracellular signals are communicated, or transduced, into the cell and in such a way as to elicit a particular cellular response. (biomedcentral.com)
Graphical abstract of the Cell article that studied the external signals that stressed plants emit after drought stress or wounding. (botany.one)
Matrix protein p17 has two main functions: in infected cell, it targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. (proteopedia.org)
It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
We further confirmed that Nek2 could induce sorafenib resistance in HCC cell lines, and that β-catenin was the key element involved in this process. (biomedcentral.com)

Single RNA molecules comprised of both crRNA and tracrRNA sequences. (idtdna.com)

The induction of autophagy is a mechanism of secondary resistance to various anticancer treatments. (mdpi.com)

Insulin resistance leading to high blood sugar, a hallmark of pre-diabetes, is a complex condition with many genetic and environmental determinants. (asbmb.org)
The analysis showed that, despite individual environmental and genetic variation, a combination of three unrelated metabolites (C22:1-CoA, C2-carnitine and C16-ceramide) together formed an accurate signature for predicting insulin resistance. (asbmb.org)

The gaseous plant hormone ethylene is a key signaling molecule regulating plant growth, development, and defense against pathogens. (figshare.com)
These are human health and plant resistance to pathogens and to biotic and abiotic stress factors. (mdpi.com)

Our results demonstrated that NIMA-related kinase 2 (Nek2) binds β-catenin, blocking the interaction between this protein and the destruction complex, and ultimately contributing to sorafenib resistance for HCC. (biomedcentral.com)

The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)

PCR-amplified mycobacterial genes are sequence-specifically captured on microspheres, labeled by magnetic nanoprobes, and detected by nuclear magnetic resonance. (cdc.gov)

However, the mechanism underlying the dysregulation of β-catenin during sorafenib resistance is still inconclusive, and thus, more studies are required to improve the efficacy of this agent. (biomedcentral.com)

ORA59 played a positive role in ethylene-regulated responses, including the triple response, featured by short, thick hypocotyl and root, and exaggerated apical hook in dark-grown seedlings, and resistance to the necrotrophic pathogen Pectobacterium carotovorum, as shown by the increased and decreased ethylene sensitivity and disease resistance in ORA59-overexpressing (ORA59OE) and null mutant (ora59) plants, respectively. (figshare.com)
The study aims to investigate the role of BTE in prevention of iAs-induced SCC of skin in Swiss albino mice via the modulation of TGF-β signalling and EMT. (jcpjournal.org)
Western blotting, flow cytometry, and an evaluation of IC 50 values were used to confirm the role of β-catenin in HCC sorafenib resistance. (biomedcentral.com)

Anatomy28

Organisms23

Diseases1

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes78

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Pathways10

Pathway21

Nucleus7

Cascades2

Induces6

Phosphorylation1

Proteins8

Tumor7

Single-molecule3

Regulate3

Inhibitors8

Mutations2

Drug resistance5

Mechanisms1

Inhibition2

Subcellular1

Suppresses1

Survival2

Peptide2

Regulation3

Receptors1

Regulates2

Inhibits1

Cellular signali1

Intracellular1

Mitochondrial4

Small2

Axis2

Genome2

Metabolism1

Gene3

Predominantly1

Cancer2

Cascade1

Cell6

Sequences1

Induction1

Insulin resistance2

Pathogens2

Interaction1

Extracellular1

Genes1

Efficacy1

Role3