Molecule magnetic resonance. Medical search. Frequent questions

Electron spin resonance (ESR) spectroscopy is a crucial tool, through spin labelling, in investigations of the chemical structure of materials and of the electronic structure of materials associated with unpaired spins. (ewha.ac.kr)
He brought nuclear magnetic resonance (NMR) spectroscopy to organic chemistry, allowing chemists to determine the structures of complex biological molecules. (caltech.edu)
Through the years, Roberts helped develop more complex methods for NMR spectroscopy and ultimately was able to use the technique to obtain structural information for large biological molecules, such as steroids and enzymes. (caltech.edu)
Slow motion of confined molecules: NMR and broadband dielectric spectroscopy investigations. (mpg.de)
The research activity focussed on experimental study of the structural and dynamic properties of short-lived intermediates of biologically important molecular systems and photoprocesses using novel techniques of magnetic resonance spectroscopy. (europa.eu)
Using virology techniques and nuclear magnetic resonance spectroscopy (NMR), they pieced together the exact structure and configuration of the molecule. (health.am)
3. Demonstrate knowledge of mass spectroscopy (MS), ultraviolet-visible (UV-VIS) spectroscopy, infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. (aber.ac.uk)
Structure Determination - the importance of molecular shape and how chemists determine the structure of compounds using spectroscopic techniques including ultraviolet, infrared and nuclear magnetic resonance spectroscopy. (edu.au)
Rutgers provides students with access to many analytical and spectroscopic methods, my favorite being nuclear magnetic resonance spectroscopy. (rutgers.edu)
We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate our structural understanding into further mechanistic and functional studies. (stanford.edu)
While various methods have investigated these deviations, only proton magnetic resonance spectroscopy (1H MRS) enables noninvasive measurement of small-molecule metabolites in the living human. (lu.se)
Specifically, analysing urine samples using Nuclear Magnetic Resonance (NMR) spectroscopy and based on the output identify a metabolic profile (with individual molecules being markers for specific foods). (lu.se)

By taking advantage of small molecule libraries, scientists searched over 65 000 compounds for hits that interfered with various functions of Nef, namely activation of the haematopoietic cell kinase Hck, trafficking of CD4 and MHC-I molecules, hyperinduction of NFAT and enhancement of infectivity. (europa.eu)
Using this YaxAB nanopore, we demonstrate label-free, single-molecule detection of interactions between the anticancer Bcl-xL protein and small-molecule drugs as well as the Bak-BH3 peptide. (nature.com)
Distinctive nanopore event distributions observed in the two-dimensional (ΔI/I o -versus-I N ) plot illustrate the ability of the YaxAB nanopore to discriminate individual small-molecule drugs bound to Bcl-xL from non-binders. (nature.com)
Among them, ABT-737 is well-known as a potent small-molecule inhibitor of the Bak-BH3/Bcl-xL interaction 24 . (nature.com)

My group exploits the complementary nature and distance dependence of nuclear magnetic resonance (NMR) and single molecule fluorescence, in particular single molecule Förster Resonance Energy Transfer (FRET), to study the conformational landscape and dynamics of IDPs at molecular resolution. (fu-berlin.de)

The concept relies on the different diffusion behavior that water molecules exhibit in bulk and nanoconfined conditions, e.g., in nanopores. (springer.com)
The tests looked specifically at the movement of water molecules in areas that are considered superhighways within the brain for relaying commands and information. (bostonglobe.com)
Magnetic resonance imaging works by using a magnetic field and radio waves to probe the environment of hydrogen atoms in water molecules in the body. (scienceblog.com)
The proton-conducting pathway of bacteriorhodopsin (BR) contains at University, PO Box 124 least nine internal water molecules that are thought to be key players in SE-22100 Lund, Sweden the proton translocation mechanism. (lu.se)
22 water molecules with bulk water. (lu.se)
The relevance of water exchange kinetics is underscored by recent crystallographic ®ndings of substantial variations in the number and locations of internal water molecules during the photocycle. (lu.se)
While the locations and inferred H-bond connec- water molecules in a membrane protein, despite tivities of these internal water molecules are essen- being deeply buried and extensively H-bonded to tial, one would also like to quantify their mobility. (lu.se)

Two potent small molecules capable of disrupting the association of Nef with SH3 protein domains were identified and their chemical structures were used as models to generate additional inhibitors. (europa.eu)
1. study of photochemical reactions involving proteins and protein related molecules. (europa.eu)
Over the last decades, a variety of RNA methods have been developed for the study of RNA-DNA, RNA-RNA, and RNA-protein interactions including RNA complexes with ligand molecules. (biosyn.com)
RNA molecules are functionally diverse and involved in many cellular processes such as catalysis, ligand binding, and protein recognition. (biosyn.com)
Within the cellulosome cellular structure, the protein molecules dockerin and cohesin were the focus of this study. (phys.org)
My interest in protein structures expanded as a post-doctoral fellow, where I learned how to use NMR (nuclear magnetic resonance) to study proteins. (uoguelph.ca)
NMR is an extremely powerful technique for understanding protein structure and function, especially since it is able to characterize the flexibility of biological molecules. (uoguelph.ca)
From the MRD data, the rotational correlation time of detergent-solubilized BR was determined to 35 ns at 300 K, con- sistent with a monomeric protein in complex with about 150 detergent molecules. (lu.se)

The NMR Center provides access to equipment for high resolution and solid state Nuclear Magnetic Resonance (NMR), as well as imaging, for studies on several topics, ranging from material science, diffusion, studies of small organic or inorganic molecules, to advanced studies of biomolecular structure and dynamics. (lu.se)

The fluorescence spectrometer is used for fluorescent measurements of photosensitive molecules with high sensitivity. (uwec.edu)

In chemistry and molecular physics, fluxional (or non-rigid) molecules are molecules that undergo dynamics such that some or all of their atoms interchange between symmetry-equivalent positions. (wikipedia.org)
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models. (ox.ac.uk)
Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molecular level. (ox.ac.uk)
Polyisocycanides were found to give anisotropic molecular alignment in the magnetic field and are useful to measure residual dipolar couplings (RDCs) from analytes, e.g. strychnine. (acs.org)
Here we extend this technique to single coordination complexes-iron phthalocyanines (FePc)-and investigate the magnetic interactions between their molecular spin with either another molecular spin (in FePc-FePc dimers) or an atomic spin (in FePc-Ti pairs). (ewha.ac.kr)
At the time I arrived Rabi was rather discouraged about the future of molecular beam research, but this discouragement soon vanished when he invented the molecular beam magnetic resonance method which became a potent source for new fundamental discoveries in physics. (nobelprize.org)
In the future we would like to study molecular Rydberg states in which the electronic structure of a molecule mimics that of a hydrogenic (single-electron) atom. (evansville.edu)
An LC spectrometer is used to separate molecules in a solution mixture and accurately determine the molecular masses of each of the molecules in the mixture. (uwec.edu)
For example, the team at Trinity included technical specialists in Molecular Thermodynamics, Synthetic Chemistry, Nuclear Magnetic Resonance and Machine Learning and Mathematical Modelling. (tcd.ie)
NIST studies show that molecular nanomagnets create concentration-dependent contrast in magnetic resonance imaging (MRI). (science20.com)

A Fourier-transform infrared spectrometer is used to analyze vibrational motions within a molecule, and can be used to identify molecules and groups of atoms within molecules. (uwec.edu)
The ability to "see" the atoms and molecules and the chemistry around me shaped my entire career. (rutgers.edu)
As with standard MRI, fMRI machines create magnetic fields that vary slightly throughout the brain, providing a different magnetic environment for hydrogen atoms in different areas. (scienceblog.com)
The differing magnetic field strengths make the spin of each hydrogen atom precess at different rates, so that when a pulse of radio waves is focused on the head, the atoms respond differently depending on location and on their particular environment. (scienceblog.com)
With EPI, a single pulse of radio waves is used to excite the hydrogen atoms, but the magnetic fields are rapidly reversed several times to elicit about 50 to 100 echoes before the atoms settle down. (scienceblog.com)
Specifically, hydrogen atoms, which have their own magnetic field based on the direction of their spin, are aligned to a strong magnetic field generated by the MRI machine. (medscape.com)
[ 3 ] This absorbed pulse causes the hydrogen atoms to enter an excited state, thereby changing the spin of the hydrogen atoms and misaligning them from the magnetic field. (medscape.com)
With time, hydrogen atoms return to their original relaxed state and become aligned with the magnetic field once again. (medscape.com)

The technique had high potential for determining the structural and magnetic resonance properties and the reactivity of the radicals of proteins, nucleic acids and their building blocks. (europa.eu)
RNA molecules in solution may adopt secondary structures that are only partially determined by thermodynamics since RNA molecules can undergo conformational changes during interaction with other RNAs, RNA binding proteins or RNA binding peptides. (biosyn.com)
Here, we develop a biological nanopore sensor for single-molecule detection of proteins and PDIs using the pore-forming toxin YaxAB. (nature.com)
I began to appreciate that complex biological process can be understood in terms of the interaction of proteins and other biological molecules, an idea which still intrigues me to this day. (uoguelph.ca)

Nuclear magnetic resonance (NMR) and isothermal titration calorimetry (ITC) were used to describe the distinct features of this interaction. (phys.org)

Temperature dependent changes in the NMR spectra result from dynamics associated with the fluxional molecules when those dynamics proceed at rates comparable to the frequency differences observed by NMR. (wikipedia.org)
H-1 NMR signal broadening in spectra of alkane molecules adsorbed on MFI-type zeolites. (mpg.de)
The work involved the application of the nuclear magnetic resonance (NMR) technique termed Chemically induced dynamic nuclear polarisation (CIDNP) that allowed for high sensitivity and spectral resolution in crowded spectra combined with optical initiation of chemical intermediates. (europa.eu)
Such models have been used in literature in analysis of spectra of axially symmetrical molecules and cylindrical quantum dots. (degruyter.com)

Magnetic resonance imaging (MRI) of autism populations is confounded by the inherent heterogeneity in the individuals' genetics and environment two factors difficult to control for. (ecolowood.com)
Magnetic resonance imaging (MRI) is significantly more sensitive to the presence of tumor, as well as its associated findings, in the inclusion of peritumoral edema, and is the modality of choice for the examination of a patient with suspected or confirmed glioblastoma. (medscape.com)
Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. (ox.ac.uk)
We hypothesized that antibody-conjugated MPIO would enable magnetic resonance imaging (MRI) of endothelial cell adhesion molecules in mouse atherosclerosis. (ox.ac.uk)
My personal expertise is in imaging the human gastrointestinal (GI) tract using magnetic resonance imaging (MRI). (nottingham.ac.uk)
Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans. (nottingham.ac.uk)
Back in the 1950s, long before magnetic resonance imaging (MRI) machines became a staple of orthopedic clinics, Roberts's work with NMR revolutionized organic chemistry, enabling chemists to characterize the structure of organic molecules and to study rapidly equilibrating conformations, or shapes, of molecules in solution. (caltech.edu)
Nanoscale magnets in the form of iron-containing molecules might be used to improve the contrast between healthy and diseased tissue in magnetic resonance imaging (MRI)--as long as the concentration of nanomagnets is carefully managed--according to a new report* by researchers at the National Institute of Standards and Technology (NIST) and collaborators. (science20.com)
Efficacy of the single-molecule magnet Fe8 for magnetic resonance imaging contrast agent over a broad range of concentration. (science20.com)
The former players, who were not identified, submitted to advanced magnetic resonance imaging exams of their brains. (bostonglobe.com)
An international team of physicists and neuroscientists has reported a breakthrough in magnetic resonance imaging that allows brain scans more than seven times faster than currently possible. (scienceblog.com)
Magnetic resonance imaging (MRI) is a type of medical imaging that uses a strong magnetic field and very high frequency radio waves to produce highly detailed images. (msdmanuals.com)
Paramagnetic Contrast Agents Radiographic contrast agents are substances used to distinguish between internal structures in medical imaging, such as various types of x-rays and magnetic resonance imaging (MRI). (msdmanuals.com)
Magnetic resonance imaging (MRI) is a noninvasive technique used for diagnostic imaging. (medscape.com)
These changes in the brain can be seen with magnetic resonance imaging (MRI), though they usually do not cause symptoms in people with this disorder. (medlineplus.gov)

Because virtually all molecules are fluxional in some respects, e.g. bond rotations in most organic compounds, the term fluxional depends on the context and the method used to assess the dynamics. (wikipedia.org)
The aim of the course is to enable students to acquire basic knowledge of how information about the structure and dynamics of molecules can be obtained through common magnetic resonance methods. (lu.se)

During Gary Frost's talk "Improving the accuracy of dietary intake assessment: From molecules to cameras" given at the Nordic Nutrition Conference 2020, he mentioned how many fantastic scientific breakthroughs we've had during the last 60-70 years, and yet, we have not figured out how to accurately assess what people eat in their day to day life. (lu.se)

A nuclear magnetic resonance spectrometer is used to determine the structures of molecules. (uwec.edu)
An X-ray diffractometer is used to determine the three-dimensional structures of molecules in the crystal state. (uwec.edu)
RNA molecules are structural flexible and can adopt different structures. (biosyn.com)
RNA molecules are generally folded into compact and defined tertiary structures. (biosyn.com)
In a long and distinguished career, Hodgkin developed techniques - still applied today - which she used to solve the structures of numerous complex biological molecules. (iop.org)

5. Be able to explain the fundamentals and core principles in organic chemistry including hybridization, geometry, structure and stability of organic molecules, functional group reactivity, synthesis and chemical reactions of selected biologically important molecules. (aber.ac.uk)
The phenomenon of nuclear magnetic resonance is exploited in several different fields, e.g. chemistry, medicine and geology. (lu.se)

They were based on the effects of electron and nuclear spins in particular and on magnetic interaction in general, on the rates and yields of chemical and biological reactions. (europa.eu)
But others have been added to gain further insight into biological molecules. (iop.org)

The agency is pioneering methods for manipulating and measuring the magnetic properties of these compounds and is developing instrumentation for understanding how contrast agents work and how to control contrast properties. (science20.com)
Virologists at the University of Missouri now are testing the next generation of medications that stop HIV from spreading, and are using a molecule related to flavor enhancers found in soy sauce, to develop compounds that are more potent than Tenofovir. (health.am)

Within the TEM field, cryo-electron microscopy (cryo-EM) allows visualization of intact molecules/complexes under near native conditions. (utmb.edu)

Antimicrobial peptides (AMPs) are a class of promising antibiotic molecules as they present broad action spectrum, potent activity, and do not easily induce resistance. (frontiersin.org)

A gas chromatograph/mass spectrometer is used to separate a mixture of molecules in the gas state then determine the masses of the molecules and their fragments. (uwec.edu)

Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. (ox.ac.uk)

There was linear correlation between hyperfine coupling constants and polarisation amplitude for the geminate reaction products yielding the sign and value of hyperfine coupling constants (HFCC) while the position and coupling in NMR spectrum provided assignment of individual nuclear spins in the molecule. (europa.eu)

For the case of a shallow lattice, we give the dependence of the atomto-molecule conversion efficiency on tunnelling strength and atomic interaction by taking a double-well as an example. (degruyter.com)
We find that one can obtain a high atom-to-molecule conversion by tuning the tunnelling and interaction strengths of the system. (degruyter.com)

The pulse technique of nuclear magnetic resonance is used for measuring the coefficient of the translational self-diffusion of molecules in a liquid. (dtic.mil)
Atom-to-molecule conversion by the technique of optical Feshbach resonance in a magnetic lattice is studied in the mean-field approximation. (degruyter.com)

Alongside synchrotrons, two other forms of crystallography can probe molecules in different ways: neutron diffraction and electron diffraction. (iop.org)

Nuclear magnetic resonance (NMR) was employed to identify inhibitors that bind Nef and results pointed to a binding 'pocket' central to Nef function. (europa.eu)

A nuclear magnetic resonance (NMR) platform for real-time metabolic monitoring of bioprocesses. (ufz.de)

4. dynamic nuclear polarisation (DNP) experiments with stable radicals utilising fast magnetic field cycling with high resolution NMR detection with the aim to increase the sensitivity of NMR studies of biomolecules that did not participate in photoreactions. (europa.eu)

We are studying the structure of electronic excited states of small molecules in the gas phase using a nitrogen-pumped dye laser. (evansville.edu)
Determining the structure and magnetic resonance parameters of radicals formed in this way, as well as the kinetics of multistep reactions of peptides and oligonucleotides. (europa.eu)

Strategies for synthesis and properties of biologically significant molecules will also be addressed. (edu.au)

More precisely, the spatial distribution of protons in CH+ 5 is many times broader than its parent molecule CH4, methane. (wikipedia.org)
But when protons are surrounded by a strong magnetic field, as in an MRI scanner, they line up with the magnetic field. (msdmanuals.com)
As the protons line up with the magnetic field again, they release energy (called signals). (msdmanuals.com)

UV/Visible spectrophotometers are used to measure the absorption of visible and ultraviolet light by molecules dissolved in a solution. (uwec.edu)

With nuclear magnetic resonance as well, researchers have an arsenal of different ways to examine the molecules that make up the cells of an organism. (iop.org)

T1-weighted axial gadolinium-enhanced magnetic resonance image demonstrates an enhancing tumor of the right frontal lobe. (medscape.com)
In this paper we investigate the effects of external electric and magnetic fields on a three-dimensional harmonic oscillator with axial symmetry. (degruyter.com)

OBJECTIVE: Microparticles of iron oxide (MPIO) distort magnetic field creating marked contrast effects far exceeding their physical size. (ox.ac.uk)
This invention gave me the unique opportunity to be the first graduate student to work with Rabi and his associates, Zacharias, Kellogg, Millman and Kusch, in the new field of magnetic resonance and to share in the discovery of the deuteron quadrupole moment. (nobelprize.org)
The energy spectrum of such a system is non-degenerate due to the presence of the magnetic field. (degruyter.com)
The degeneracy of the energy spectrum in the absence of a magnetic field is discussed. (degruyter.com)
During an MRI, a computer records changes in the magnetic field around a person's body to create cross-sectional, detailed images. (msdmanuals.com)
For MRI, a person lies on a motorized table that is moved into the narrow interior of a large tubular scanner, which produces a strong magnetic field. (msdmanuals.com)
Examiners can change how various tissues appear on a scan by varying the radio wave pulses, the strength and direction of the magnetic field, and other factors. (msdmanuals.com)
Gadolinium agents change the magnetic field in a way that makes images clearer. (msdmanuals.com)
All metal objects (such as keys, jewelry, and cell phones) and other objects that could be affected by the magnetic field (such as credit cards and watches) should be left outside the MRI scanning room. (msdmanuals.com)
The magnetic field strength varies between 400 - 800 MHz 1H frequency. (lu.se)

METHODS AND RESULTS: MPIO (4.5 microm) were conjugated to monoclonal antibodies against vascular cell adhesion molecule-1 (VCAM-MPIO) or P-selectin (P-selectin-MPIO). (ox.ac.uk)

In addition, this review may contribute towards improving the understanding of rationally designing new molecules, targeting functional AMPs that may have a therapeutic application. (frontiersin.org)

Researchers found that changing the pH from 4.8 to 7.5 resulted in the cohesin-binding sites on the dockerin molecule switching from one site to the other. (phys.org)
Researchers additionally noted that the affinity, or the attraction between the molecules, was found to change along with the pH. (phys.org)

The influence of electric and magnetic fields, as well as the frequencies of the oscillator on the probability distribution function is analyzed. (degruyter.com)

During the last decade Shimon embarked on yet another venture: understanding the mechanism of dynamic nuclear polarization (DNP) at high magnetic fields. (weizmann.ac.il)

Magnetic ions, which alter the nuclear properties of hydrogen in water, offer the advantage of consistent identical design but provide low contrast. (science20.com)
they provide contrast variation in a larger region but have irregular designs and magnetic properties that are difficult to control. (science20.com)
In addition, they might be modified to act as "smart" materials whose contrast could be turned on only when bonded to a target molecule or cell. (science20.com)

Anatomy32

Organisms8

Diseases20

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology9

Phenomena and Processes51

Disciplines and Occupations6

Technology, Industry, Agriculture3

Information Science11

Health Care18

Spectroscopy12

Small molecule4

Single molecule fluorescence1

Water molecules7

Protein8

Solid-state nuc1

Fluorescence1

Molecular10

Atoms8

Proteins4

Isothermal titration c1

Spectra4

Imaging15

Dynamics2

20201

Structures5

Chemistry2

Biological2

Compounds2

Allows visualization1

Potent1

Spectrometer1

Endothelial1

Nuclear spins1

Interaction2

Technique2

Electron1

Inhibitors1

Metabolic1

Experiments1

Structure2

Synthesis1

Protons3

Ultraviolet1

Organism1

Axial2

Field10

Methods1

Functional1

Researchers2

Frequencies1

High1

Contrast3