• Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. (wikipedia.org)
  • DNA polymerases also play key roles in other processes within cells, including DNA repair, genetic recombination, reverse transcription, and the generation of antibody diversity via the specialized DNA polymerase, terminal deoxynucleotidyl transferase. (definitions.net)
  • As a member of the X family of DNA polymerase enzymes, it works in conjunction with polymerase λ and polymerase μ, both of which belong to the same X family of polymerase enzymes. (wikipedia.org)
  • Further, TdT is the only polymerase that is known to catalyze the synthesis of 2-15nt DNA polymers from free nucleotides in solution in vivo. (wikipedia.org)
  • TdIF1 is another protein that interacts with TdT to inhibit its function by masking the DNA binding region of the TdT polymerase. (wikipedia.org)
  • A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. (lookformedical.com)
  • What does dna polymerase mean? (definitions.net)
  • This dictionary definitions page includes all the possible meanings, example usage and translations of the word dna polymerase . (definitions.net)
  • Cells contain several types of DNA polymerase, some of which are required for replication of DNA, and are indispensable for multipliation and division of cells. (definitions.net)
  • DNA polymerase is an enzyme that plays a crucial role in DNA replication, assisting in the process of duplicating DNA strands accurately and efficiently. (definitions.net)
  • DNA polymerase also possesses proofreading capabilities, allowing it to correct any potential mistakes made during the replication process. (definitions.net)
  • A DNA polymerase is a cellular or viral polymerase enzyme that synthesizes DNA molecules from their nucleotide building blocks. (definitions.net)
  • DNA polymerases are widely used in molecular biology laboratories, notably for the polymerase chain reaction, DNA sequencing, and molecular cloning. (definitions.net)
  • How to pronounce dna polymerase? (definitions.net)
  • How to say dna polymerase in sign language? (definitions.net)
  • Are we missing a good definition for dna polymerase ? (definitions.net)
  • Generally, TdT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. (wikipedia.org)
  • The differences between TdTS and TdTL occur outside regions that bind DNA and nucleotides. (wikipedia.org)
  • This enzyme synthesizes new strands of DNA by adding nucleotides to a pre-existing DNA strand or RNA primer, following the rules of base pairing. (definitions.net)
  • During DNA REPLICATION, chromosome ends loose some of their telomere sequence (TELOMERE SHORTENING. (lookformedical.com)
  • An enzyme that assists DNA replication. (definitions.net)
  • DNA polymerases are essential for DNA replication, and usually function in pairs while copying one double-stranded DNA molecule into two double-stranded DNAs in a process termed semiconservative DNA replication. (definitions.net)
  • Although TdT was one of the first DNA polymerases identified in mammals in 1960, it remains one of the least understood of all DNA polymerases. (wikipedia.org)
  • Unlike most DNA polymerases, it does not require a template. (wikipedia.org)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • In vitro, this behaviour catalyzes the general formation of DNA polymers without specific length. (wikipedia.org)
  • an enzyme that catalyzes the formation of DNA from deoxyribonucleoside triphosphates. (definitions.net)
  • The 2-15nt DNA fragments produced in vivo are hypothesized to act in signaling pathways related to DNA repair and/or recombination machinery. (wikipedia.org)
  • An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. (lookformedical.com)
  • Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. (wikipedia.org)
  • The 2-15nt DNA fragments produced in vivo are hypothesized to act in signaling pathways related to DNA repair and/or recombination machinery. (wikipedia.org)
  • Generally, TdT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. (wikipedia.org)