ProteoglycansHyaluronicGlycosaminoglycanGlycosaminoglycansProteoglycanDermatanComponent of cartilageExtracellularOsteoarthritisSupplementsCollagenIngredientsMucopolysaccharidesNaturallyInhibitory moleculesProteinsMethylsulfonylmethaneIntercellularGlucosamine sulfateSynovialReceptorsCartilage healthGagsPure EncapsulationsGlialProteinPolysaccharideFoundEffectivenessAdhesionGAG'sConstituentsVersicanIngredientJointsJoint lubricationLargeEnzymeSpinalAmountsDietarySignificantlyImportantReceptorEvidenceStructures
Proteoglycans16
- Ph.D. dissertation title: "Inhibition of regeneration in the injured, adult spinal cord: potential role of chondroitin sulfate proteoglycans, specifically aggrecan. (assumption.edu)
- BACKGROUND: Proteoglycans (PGs) represent a large family of complex molecules. (lu.se)
- article{698fdb56-caaf-487e-8ed5-937ee49d2b06, abstract = {{BACKGROUND: Proteoglycans (PGs) represent a large family of complex molecules. (lu.se)
- The adhesion molecules tenascin, chondroitin sulfate proteoglycans, highly polysialylated neural cell adhesion molecule (PSA-NCAM), and laminin did not change significantly in the gray matter of the dorsolateral striatum after either type of lesion. (jneurosci.org)
- Sulfated proteoglycans. (pearltrees.com)
- Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
- However, the discovery of Nogo and chondroitin sulphate proteoglycans (CSPGs) in the injured nervous system in late 1980s has shifted some of the focus to inhibitory molecules. (intechopen.com)
- Misaligned scar tissue that forms at spinal cord injuries physically blocks nerve regeneration and contains molecules called chondroitin sulfate proteoglycans that inhibit nerve fiber growth. (sci-info-pages.com)
- This process combines high concentrations of hydrolyzed collagen type II protein and low molecular weight GAG's (glycosaminoglycans), such as Chondroitin Sulfate , Hyaluronic Acid and other proteoglycans that readily absorb through the gastrointestinal tract to allow for important bio-availability. (purityproducts.com)
- Chondroitin sulfate is responsible for building the ground substance of cartilage, molecules known as proteoglycans. (drvitaminsolutions.com)
- The CAQK peptide binds to components of the meshwork surrounding brain cells called chondroitin sulfate proteoglycans. (eurasiareview.com)
- Glial cells respond to AB substrate by accumulating and depositing chondroitin sulfate proteoglycans (CSPGs) which are inhibitory to neurite outgrowth. (liberty.edu)
- First, glucosamine sulfate, the functional ingredient in most supplements, is a primary building block for what is called proteoglycans. (nfsports.com)
- These have included interventions that affect myelin inhibitory molecules and their receptors, or inhibitory chondroitin sulphate proteoglycans, and treatments in which the regenerative potential of axons has been stimulated through growth-factor receptors or manipulation of internal signalling pathways. (atlantainjurylawblog.com)
- The slippery, compressible surface of cartilage is maintained by the giant water-trapping proteoglycan molecules called proteoglycans (PGs). (steedfeed.com)
- Chondroitin attracts fluids into proteoglycans, the molecules dispersed through out the cartilage that give the tissue its shock-absorber quality, and protects the cartilage against breakdown. (peacefulmind.com)
Hyaluronic7
- Endogenous molecules include hyaluronic acid, glucosamine, and chondroitin sulfate. (wikipedia.org)
- At the same time, the matrix is rich in glycosaminoglycans, hyaluronic acid and chondroitin sulfate - structural components of synovial fluid.Hyaluronic acid is found in many of the tissues of the human body such as cartilage, bones, glassy body, heart valves, skin and synovial fluid. (audioboo.fm)
- Hyaluronic acid is responsible for the consistency of fluid in the tissues and changes its viscosity depending on the action of mechanical forces: the fluid thins in case of increased exertion but remains viscous enough not to disappear from the joints as water.How is cartilaginous tissue nourished?Chondroitin is an important component of cartilage. (audioboo.fm)
- Hyaluronic acid (HA), a macromolecule, plays a vital role in the synthesis of extracellular matrix molecules and epidermal cell interactions with the surrounding environment. (jcadonline.com)
- Only hydrolyzed BioCell Collagen II™ can deliver this necessary protein to the body's resource center and is guaranteed to contain standardized levels of Hydrolyzed Collagen Type II proteins, chondroitin sulfate, important for maintaining healthy joint cartilage, and Hyaluronic Acid. (giftespot.com)
- Glucosamine's impact on chondroitin sulfate and hyaluronic acid production was first studied over forty years ago. (steedfeed.com)
- Glucosamine sulfate and hyaluronic acid are the two most common supplements used for reducing knee arthritis symptoms. (manipalhospitalsglobal.com)
Glycosaminoglycan5
- Classified as a type of glycosaminoglycan, chondroitin sulfate is rich in sulfur and is a relative of glucosamine. (criticalbench.com)
- Glucosamine promotes the synthesis of the glycosaminoglycan chondroitin sulfate. (drvitaminsolutions.com)
- Binding experiments involving enzymatically altered molecules that lack chondroitin sulfate suggested that this glycosaminoglycan is also not directly involved in binding. (rupress.org)
- Chondroitin sulfate is a glycosaminoglycan, a natural component of cartilage. (msdmanuals.com)
- References Chondroitin sulfate is a glycosaminoglycan, a natural component of cartilage. (msdmanuals.com)
Glycosaminoglycans4
- Chondroitin sulfate is one of six related substances called glycosaminoglycans (gags), which are also referred to as mucopolysaccharides. (springtimeinc.com)
- Their protein backbones are linked to different glycosaminoglycans, such as dermatan-, chondroitin-, keratan- or heparan sulphate. (lu.se)
- They consist of long-core protein molecules with glycosaminoglycans, or GAGs, growing off their sides like bristles on a hair brush. (vin.com)
- According to new research presented at the fall meeting of the American Chemical Society (ACS), sulfate groups on complex sugar molecules called glycosaminoglycans (GAGs) affect "plasticity" in the brains of mice. (healthnews.com)
Proteoglycan5
- Chondroitin Sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity. (merryclinic.com)
- These GAG bristles allow the proteoglycan molecule to soak up water like a little sponge. (vin.com)
- It has been shown to bind specifically to other extracellular matrix components including a chondroitin sulfate proteoglycan (cytotactin-binding [CTB] proteoglycan) and fibronectin. (rupress.org)
- It was found that, during neural development, both the levels of expression of cytotactin and CTB proteoglycan and of the molecular forms of each molecule varied, following different time courses. (rupress.org)
- Unlike the molecules from neural tissue, cytotactin and CTB proteoglycan isolated from non-neural tissues such as fibroblasts lacked the HNK-1 epitope. (rupress.org)
Dermatan2
- This enzyme is required for the breakdown of several GAGs, including dermatan sulfate (DS), heparan sulfate (HS), and chondroitin sulfate (CS), which are large sugar molecules. (medscape.com)
- OBJECTIVES: The expression patterns of various cell-associated heparan and chondroitin/dermatan-sulphate PGs in human skin and chronic venous ulcers were investigated. (lu.se)
Component of cartilage1
- Chondroitin sulfate is a major component of cartilage and is thought to inhibit the enzymes that contribute to the breakdown of cartilage. (peacefulmind.com)
Extracellular2
- The study of extracellular matrix (ECM) in the nervous system has longed been focused on the molecules promoting growth and migration. (intechopen.com)
- Using in vitro and in vivo models, we have studied the role of glial cells and extracellular matrix molecules m mediating the effects of AB. (liberty.edu)
Osteoarthritis5
- Objectives Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. (bmj.com)
- Chondroitin sulfate is used for osteoarthritis and cataracts. (medlineplus.gov)
- Taking chondroitin sulfate by mouth seems to provide some relief from osteoarthritis pain and improve function. (medlineplus.gov)
- Prior to that trial, only small trials had studied chondroitin sulfate alone or in combination with glucosamine to treat osteoarthritis. (msdmanuals.com)
- It is glucosamine sulfate that is used as an oral supplement for the treatment of painful inflammation and the breakdown of cartilage in the human body, generally as a result of osteoarthritis. (nfsports.com)
Supplements4
- This effect has not been shown with chondroitin sulfate supplements. (medlineplus.gov)
- The chondroitin used in dietary supplements is extracted from the cartilage and connective tissues of animals. (springtimeinc.com)
- These hair brush bristles consist of keratin sulfate and chondroitin sulfate, both of which are included in many popular over-the-counter joint supplements. (vin.com)
- Some glucosamine supplements contain other ingredients such as chondroitin sulfate, or shark cartilage. (nfsports.com)
Collagen3
- The unique synergy of the molecules found in BioCell Collagen offers multi-dimensional nutritional support for the health of connective tissues such as skin, joint, tendon and ligament. (nutraingredients.com)
- In the large PG lubricant molecules of the cartilage matrix, they trap water, help bond collagen fibers, and fight off degradative enzymes. (steedfeed.com)
- Because an abnormality in type II collagen should affect the molecules throughout the body, it remains unclear how the currently defined abnormality can translate into major structural abnormalities of the vertebrae and capital femoral epiphysis while leaving the distal femur, proximal tibia, and other regions structurally unaffected. (medscape.com)
Ingredients2
- Chondroitin sulfate is possibly safe when used together with other ingredients in an eye drop. (medlineplus.gov)
- Research studies have suggested the increased availability of Glucosamine and Chondroitin when combined with these ingredients. (minitack.com)
Mucopolysaccharides2
- Chondroitin sulfate consists of repeating chains of molecules called mucopolysaccharides. (criticalbench.com)
- [ 7 ] SED tarda Toledo type is a form of SED tarda with peripheral corneal opacities and a qualitative abnormality of urinary mucopolysaccharides, mainly chondroitin-6-sulfate. (medscape.com)
Naturally5
- Chondroitin sulfate is a naturally occurring molecule found in the cartilage and connective tissues of people and animals. (springtimeinc.com)
- Glucosamine 1000 mg and Chondroitin Sulfate 134 mg are substances found naturally in the body. (merryclinic.com)
- Infusing a naturally occurring anti-scarring agent called decorin into the damaged spinal cords of rats suppresses key molecules that block nerve regeneration after spinal cord injury, said Baylor College of Medicine (BCM) researchers in a study published today in the European Journal of Neuroscience. (sci-info-pages.com)
- Chondroitin sulfate is a molecule naturally found in cartilage. (redcon1.com)
- Chondroitin Sulfate is a molecule that naturally find in the body. (esdlife.com)
Inhibitory molecules1
- One of the biggest hurdles in neural regeneration is the formation of glial scar and the highly up-regulated inhibitory molecules present in the area. (intechopen.com)
Proteins1
- Sequestration of malaria parasite in the human placenta is mediated by interactions between chondroitin sulphate A (CSA) on the syncytiotrophoblasts and proteins expressed on the surface of infected human erythrocytes. (biomedcentral.com)
Methylsulfonylmethane1
- Sulfur-containing methylsulfonylmethane (MSM) is included in this glucosamine and chondroitin combination to provide an enhanced spectrum of nutrients for optimal cartilage matrix composition, connective tissue strength, and joint comfort. (drvitaminsolutions.com)
Intercellular1
- such receptors include endothelial receptor of protein C (ePCR), gC1qR, intercellular adhesion molecule-1, CD36, chondroitin sulfate A, or complement receptor 1 ( 10 ). (cdc.gov)
Glucosamine sulfate4
- It's also not clear if this interaction occurs with other forms of glucosamine, such as glucosamine sulfate. (medlineplus.gov)
- There are several forms of glucosamine that include glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine. (nfsports.com)
- Another form of glucosamine, glucosamine hydrochloride, is considered just as effective as glucosamine sulfate. (nfsports.com)
- Glucosamine sulfate (GS) , a nutrient derived from sea shells, contains a building block needed for the repair of joint cartilage. (peacefulmind.com)
Synovial1
- Japanese researchers have found that Chondroitin sulfate in synovial fluid collected from the temporomandibular joint provides a useful indicator of the degree of damage there, and that chondroitin may play a role in determining the viscosity and elasticity of tissues and fluids. (criticalbench.com)
Receptors1
- Together with the identification of their receptors, we now have a better understanding on the mechanism of how these molecules control and limit regeneration in the central nervous system (CNS). (intechopen.com)
Cartilage health1
- The finest chondroitin sulfate promotes joint and cartilage health. (springtimeinc.com)
Gags2
- Chondroitin Sulfates Chondroitin sulfates (CS) are part of the family of natural body lubricants called GAGs. (steedfeed.com)
- GAGs are formed by attaching other chemical structures, including sulfate groups. (healthnews.com)
Pure Encapsulations2
- Various studies have indicated the combination of glucosamine, chondroitin, and MSM in Pure Encapsulations Glucosamine with MSM provides the needed nutrients for optimal cartilage composition, connective tissue strength, and joint mobility & function. (drvitaminsolutions.com)
- Pure Encapsulations Glucosamine and Chondroitin with MSM offers highly purified constituents for healthy cartilage formation and joint movement ease. (drvitaminsolutions.com)
Glial1
- Using immunohistochemical techniques, we have examined the effects of cortical lesions induced either by aspiration of the frontoparietal cortex or by thermocoagulation of pial blood vessels on axonal and glial molecules associated with neuronal plasticity in the striatum. (jneurosci.org)
Protein2
- The growth associated protein GAP-43, a molecule present in axons and growth cones, decreased in the dorsolateral striatum after aspiration but not after thermocoagulatory lesions. (jneurosci.org)
- Using bioinformatics tools and biochemical experiments, we have identified the heparin-binding haemagglutinin (HbhA) protein of Mtb as a novel sequence-independent DNA-binding protein which has previously been characterised as an adhesion molecule required for extra-pulmonary dissemination. (bvsalud.org)
Polysaccharide2
- Sulfated polysaccharide. (pearltrees.com)
- Notwithstanding the enormous efforts of academic researchers, numerous problems and difficulties also astrict the utilization of marine fucosylated chondroitin sulfates, including digestive absorption of the macromolecular polysaccharides, polysaccharide modifications, the novel structures and source of fucosylated chondroitin sulfates, structure-function relationships, etc. (mdpi.com)
Found6
- Chondroitin sulfate is a chemical found in human and animal cartilage. (medlineplus.gov)
- A recent in vitro study done by scientists in Belgium found that chondroitin had potentially beneficial effects on human cartilage cells. (criticalbench.com)
- Not only did we show that CAQK carries drug-sized molecules and nanoparticles to damaged areas in mouse models of acute brain injury, we also tested peptide binding to injured human brain samples and found the same selectivity," added Mann. (eurasiareview.com)
- Chondroitin sulfate is also found in cartilage. (nfsports.com)
- The same molecule found in healthy joint fluid that supports joint lubrication and smooth movement. (esdlife.com)
- The most common GAG form in the brain is chondroitin sulfate, found outside many of the brain cells. (healthnews.com)
Effectiveness1
- Can take with Chondroitin for better effectiveness. (esdlife.com)
Adhesion1
- Vascular cell adhesion molecule-1 and E-selectin played a minor role in 2 groups (P = 0.6). (ajtmh.org)
GAG's1
- One way to change a GAG's function is through patterns of sulfate groups tacked onto the sugar chains, called sulfation motifs. (healthnews.com)
Constituents1
- Chondroitin sulfate is one of the major constituents of cartilage. (criticalbench.com)
Versican1
- Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. (uni-muenster.de)
Ingredient1
- J-Flex is pure, high-grade chondroitin sulfate - a natural ingredient for healthy joint lubrication and a normal inflammatory response. (springtimeinc.com)
Joints3
- Chondroitin Guide: Helps Maintain Healthy Joints! (criticalbench.com)
- Chondroitin is the substance that enables cartilage to provide cushion to healthy joints, and it is what the body uses to make new cartilage. (springtimeinc.com)
- It combines most popular anti-inflammatory agents such as Glucosamine, Chondroitin, MSM, vitamin, mineral and some Chinese herbal medicine, such as Corydalis Yanhusuo, to help control the joints inflammation, repair the cartilage, and relieve the pain. (merryclinic.com)
Joint lubrication1
- Chondroitin can be taken as a supplement to maintain healthy cartilage, joint lubrication, and healthy skin, nails, and hair. (springtimeinc.com)
Large6
- This matrix is made up of very large molecules, which can largely retain water and thus ensure elasticity and cushioning in the event of shocks. (audioboo.fm)
- Topical creams containing HA are widely available, but their efficacy is limited by their lack of penetration into the skin due to the large molecule size of HA, the result of being formulated into a cream base. (jcadonline.com)
- Once the dry micronized molecules are embedded in solution before being incorporated into the cream, they immediately react with water and aggregate into bulky HA complexes, which are, once again, too large to permeate the skin. (jcadonline.com)
- Some formulations contain molecules that are too large to be absorbed. (giftespot.com)
- And, because the peptide can deliver nanoparticles that can be loaded with large molecules, it could enable enzyme or gene-silencing therapies. (eurasiareview.com)
- Glucosamine is a simple molecule, CS is large and complex. (steedfeed.com)
Enzyme1
- In addition, chondroitin sulfate may maintain healthy enzyme activity. (drvitaminsolutions.com)
Spinal2
- Intact aggrecan and chondroitin-sulfate depleted aggrecan inhibit axon growth in the adult rat spinal cord. (assumption.edu)
- Decorin inhibits the action of pro - inflammatory molecules released in spinal cord injuries, called transforming growth factors, which are thought to promote the formation of scar tissue. (sci-info-pages.com)
Amounts1
- Adequate amounts of chondroitin are vital for normal joint function and maintenance as well as many other self-healing mechanisms. (springtimeinc.com)
Dietary1
- Because the body makes chondroitin, the possibility of a dietary deficiency is uncertain. (criticalbench.com)
Significantly1
- Intriguingly, a crucial loop from A4 DBL 3X which provides the important Gly and Lys residues that chelate the bound sulphate is missing or significantly altered in all other DBL domains that interact with CSA. (biomedcentral.com)
Important2
- Chondroitin varies depending on the source, and scientists have separated it into three distinct classes: a, B, and C. this is important because chondroitin-a has greater health benefits than B or C, and some animal sources have more chondroitin-a than others. (springtimeinc.com)
- The most important of these chondroprotective agents are glucosamine and chondroitin sulfate (CS). (steedfeed.com)
Receptor1
- Chondroitin-4-sulfate could act as a putative receptor for malaria complications in non-pregnant women. (ajtmh.org)
Evidence3
- Chondroitin sulfate is also used for many other conditions, but there is no good scientific evidence to support these uses. (medlineplus.gov)
- Scientific evidence shows no benefit when chondroitin sulfate is taken by itself. (msdmanuals.com)
- Evidence on efficacy of chondroitin sulfate is conflicting. (msdmanuals.com)
Structures1
- Chondroitin sulfate can also form structures known as "perineuronal nets," which wrap around individual neurons and are thought to stabilize synaptic connections, which are places where neurons connect and communicate with each other. (healthnews.com)