AnatomyOrganismsChemicals and DrugsPhenomena and Processes
ChalconesChalconeAngelicaSalixMillettiaFlavanonesPlant BarkLuciferases, RenillaMolecular StructureStructure-Activity RelationshipAntiprotozoal AgentsFlavonoidsLeishmania major
DerivativesSynthesisCompoundsBioactive moleculesFlavonesFlavonoids and chalconesAnaloguesAnticancerPrecursorsIsoflavonoidsSmall MoleculesBharti SKPharmaceuticalSynthaseInhibitorsDerivativeBiologicalMolecularStructuralAromaticChemicalActivitiesPhenylExtractsMixtureOrganicHydrationActivityContrastCompoundAgentsCarbonActiveImportantResearchStructuresRolePropertiesCell
Derivatives20
  • Chalcone Derivatives: Promising starting points for drug design. (syncsci.com)
  • Chalcones (α-phenyl-ß-benzoylethylene) and their natural-source derivatives have been investigated for their remarkable biological activities, like neuroprotective, anti-inflammatory, and anti-tumor properties. (bvsalud.org)
  • In a previous study, the research group discovered a series of chalcone derivatives with stronger anticancer activities. (bvsalud.org)
  • To find better anticancer drugs, novel chalcone derivatives A1-A14, B1-B14 have continuously been designed and synthesized. (bvsalud.org)
  • A new series of octadecanoic acid [4-(3-phenyl-acryloyl)-phenyl]-amide chalcone derivatives under base-catalyzed Claisen-Schmidt condensation were design, synthesized and characterized by spectral analysis (IR, MS, 1H-NMR, 13C-NMR). (rjptonline.org)
  • Synthesis of Chalcone Derivatives as Potential Anti-Diabetic Agents. (rjptonline.org)
  • 8. Ghosh R. Das A. Synthesis and Biological Activities of Chalcones and Their Heterocyclic Derivatives: A Review. (rjptonline.org)
  • 9. Kulathooran S. Selvakumar B. Dhamodaran M. Synthesis and Biological Activities of Novel Heterocyclic Chalcone Derivatives by Two Different Methods Using Anhydrous Potassium Carbonate as an Efficient Catalyst. (rjptonline.org)
  • 10. Rasool A. Panda R. Kachroo M. Synthesis of Some New Chalcone Derivatives and Evaluation of Their Anticancer Activity. (rjptonline.org)
  • Previously, our laboratory has reported the synthesis of novel ammonium and pyridinium ferrocenyl chalcone salt derivatives, with alkylsulfate as their counterion. (emerging-researchers.org)
  • In contrast to most ferrocenyl chalcone derivatives, they showed high solubility in water, an important property of most orally administered drugs. (emerging-researchers.org)
  • I conducted all of the counterion exchanges of the ferrocenyl chalcone derivatives under study by applying ion exchange chromatography. (emerging-researchers.org)
  • Synthesis and Spectroscopic Investigation of Some New Chalcones and their transformation to pyrazoline derivatives. (koyauniversity.org)
  • In this work, molecular modeling was performed and the antiplasmodial activity was evaluated of two chalcones (HBR1, and LH2) and four derivatives of chalcones (GH3, IV4, LCH1, and LCH3). (ufpa.br)
  • For that, we determined the drug concentration inhibitory of 50% of the growth of P. falciparum in vitro as well as the physicochemical properties of derivatives of chalcones as HOMO, LUMO, electrostatic potential, C log P, hydration energy, polarizability and molecular volume through virtual calculations. (ufpa.br)
  • Thus, these molecular properties can be used in the rational planning of new chalcones and/or derivatives with antiplasmodial activity. (ufpa.br)
  • The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. (stmjournals.in)
  • The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues such as TYR46, ASP48, ASP181, ASP182, GLY200, CYS215, SER216, ALA217, ARG221, and GLN262 through hydrogen bonding. (stmjournals.in)
  • Mahapatra DK, Bharti SK, Asati V. Chalcone derivatives: Anti-inflammatory potential and molecular targets perspectives. (stmjournals.in)
  • Chalcone based derivatives have gained heed since they own simple structures, and diverse pharmacological actions. (afpm.org.my)
Synthesis6
  • reported the synthesis of thio-phene-chalcones containing two thio-phene rings and their anti-microbial and anti-cancer activities. (iucr.org)
  • Jaglan S. Bhushan S. Green Synthesis and Anticancer Potential of Chalcone Linked-1,2,3-Triazoles. (rjptonline.org)
  • Synthesis, Characterization and Antimicrobial Screening of Some Novel Chromonyl Chalcones. (rjptonline.org)
  • 13. Fernandes J. Kumar A. Kumar P. Synthesis and Biological Activity of Some Novel Quinolinyl Chalcones Derived from N- Substituted 2-Quinolones Synthesis and Biological Activity of Some Novel Quinolinyl Chalcones Derived from N-Substituted. (rjptonline.org)
  • Chalcone is important because it serves as an intermediate for the synthesis of many other flavonoids. (marignylesreullee.com)
  • In brief, we have explained the methods and catalysts used in the synthesis of chalcones along with their biological activities in a review form to provide information for the development of new-fangled processes targeting better yield, less reaction time and least side effects with utmost pharmacological properties. (afpm.org.my)
Compounds8
  • In the last few years, molecules belonging to different classes of compounds have been synthetically combined in order to obtain hybrids with enhanced biological activities. (scielo.org.ar)
  • Subbarajuc V. Kuttana R. Anticancer and Antioxidant Activity of Synthetic Chalcones and Related Compounds. (rjptonline.org)
  • All products displayed are manufactured by BioBioPha and they are small molecule compounds for scientific research use only. (biobiopha.com)
  • In this article, you will learn how to synthesize chalcone from acetophenone and benzaldehyde, two common organic compounds. (marignylesreullee.com)
  • The asymmetric units of the title compounds both contain one nonplanar molecule. (omu.edu.tr)
  • These intriguing compounds are speculated to play a pivotal role in self-defense and increasing venom toxicity and could also offer promising biotechnological applications as small bioactive molecules. (bvsalud.org)
  • In both compounds, the asymmetric unit consists of two independent molecules (Z' = 2). (bvsalud.org)
  • In synthesizing a range of therapeutic compounds, chalcones impart key role. (afpm.org.my)
Bioactive molecules3
  • A transcriptome study was performed for A. mongolicus tissues to construct and profile their metabolic pathways, especially for the important bioactive molecules. (biomedcentral.com)
  • Studies are continuing on sub-Saharan Erythrina for identifying new biological activities or bioactive molecules. (scialert.net)
  • Even so, not all scorpion species contain harmful venoms against humans but still have valuable bioactive molecules, which could be used in developing new pharmaceutical leads for treating important diseases. (bvsalud.org)
Flavones3
  • Vidal A. Azqueta A. Sagrera G. Seoane G. Synthetic Chalcones, Flavanones and Flavones as Antitumoral Agents: Biological Evaluation and Structure-Activity Relationships. (rjptonline.org)
  • They are classified as flavonoid (flavonols, flavones, flavanones, isoflavonoids, chalcones and anthocyanins) and non-flavonoid molecules (phenolic acids, stilbenoids and others). (galenolink.com)
  • Plant foods/beverages with yellow pigments: Chalcones (precursors for flavones). (effectiveselfcare.info)
Flavonoids and chalcones1
Analogues3
  • Rozmer Z, Berki T and Perjési P. Different effects of two cyclic chalcone analogues on cell cycle of Jurkat T cells. (syncsci.com)
  • In vitro antiproliferative and antiangiogenic effects of synthetic chalcone analogues. (syncsci.com)
  • 3. Sharma V. Kumar V. Kumar P. Heterocyclic Chalcone Analogues as Potential Anticancer Agents. (rjptonline.org)
Anticancer1
  • Chalcone is a common simple fragment of natural products with anticancer activity. (bvsalud.org)
Precursors1
  • Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. (afpm.org.my)
Isoflavonoids1
Small Molecules1
  • Fraction IV (FIV) contained small molecules representing over 90% of the total absorbance at 280 nm. (bvsalud.org)
Bharti SK4
  • Mahapatra DK, Bharti SK and Asati V. Anti-cancer chalcones: Structural and molecular target perspectives. (syncsci.com)
  • Mahapatra DK, Bharti SK, Asati V. Recent perspectives of chalcone based molecules as protein tyrosine phosphatase 1B (PTP-1B) inhibitors. (stmjournals.in)
  • Mahapatra DK, Bharti SK, Asati V. Anti-cancer Chalcones: Structural and molecular targets perspectives. (stmjournals.in)
  • Mahapatra DK, Bharti SK, Asati V. Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives. (stmjournals.in)
Pharmaceutical1
  • Upon formation of a pharmaceutical salt, minimal changes are induced to the molecule of the active ingredient. (emerging-researchers.org)
Synthase2
  • The activity of the enzyme chalcone synthase (CHS, EC 2.3.1.74) was measured, as it is a key enzyme for flavonoid production. (unboundmedicine.com)
  • The compound reacts with naringenin-chalcone synthase and three malonyl CoA molecules to add six carbon atoms and three more keto groups ring through PKS III. (wikipedia.org)
Inhibitors1
Derivative1
  • The title chalcone derivative, C13H10O2, adopts an E conformation about the C=C double bond. (bvsalud.org)
Biological4
  • Rozmer Z and Perjési P. Naturally occurring chalcones and their biological activities. (syncsci.com)
  • However, the physicochemical properties of these molecules, which are important for biological actions, are not well established. (ufpa.br)
  • The study of the correlation between the biological activities and the physicochemical properties showed determinating parameters for the biological activity, as LUMO, electrostatic potential, C log P and hydration energy, which may help in the selection of molecules more active against P. falciparum. (ufpa.br)
  • However, multiple studies confirm their biological effects, so it is hypothesized that they are transformed by the digestive flora into molecules with better bioavailability. (galenolink.com)
Molecular3
  • In the extended structure of the major chalcone component, mol-ecules are linked by a combination of C-H⋯O/S, Cl⋯Cl, Cl⋯ π and π - π inter-actions, leading to a compact three-dimensional supra-molecular assembly. (iucr.org)
  • An In Silico study was carried to know on a series of chalcone ligands to understand their binding pattern with various molecular targets and to evaluate the possible pharmacological potency with relevance to their literature reports. (caribjscitech.com)
  • In order for this, molecular docking was carried out on the active molecules against IMPDH and PARP1 enzymes to find out their binding pattern. (caribjscitech.com)
Structural1
  • Chalcones and their role in management of diabetes mellitus: Structural and pharmacological perspectives. (stmjournals.in)
Aromatic2
  • Chalcone is a simple aromatic ketone that has a wide range of applications in various fields. (marignylesreullee.com)
  • Chalcones are the condensation products of aromatic aldehyde with acetophenones in attendance of catalyst. (afpm.org.my)
Chemical2
  • Owing to simplicity of the chemical structures and a huge variety of pharmacological actions exhibited, the entities derived from chalcones are subjected to extensive consideration. (afpm.org.my)
  • This review article is an effort to sum up the anti-inflammatory activities of chalcone derived chemical entities. (afpm.org.my)
Activities1
  • Considering the above facts, the goal of the present study was to combine disubstituted pyrimidines with 1,3,4-thiadiazole residues in order to develop hybrid molecules with potential of enhanced activity and to test their antioxidant and antitumor activities. (ijpsonline.com)
Phenyl1
  • A triazole chalcone ligand (E)-3-(4-(dimethylamino)phenyl)-1-(4-((1-(2-(4-((E)-3-(4(dimethylamino)phenyl)acryloyl)phenoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)prop-2-en-1-one (L1) was synthesized by Cu(I)- catalysed click reaction. (bvsalud.org)
Extracts2
  • AIM OF THE STUDY: Kava extracts were used to produce the kava chalcones Flavokawain A, B and C, which have a variety of bioactivities. (bvsalud.org)
  • Natural products have been used as sources of individual molecules and extracts capable of inhibiting/neutralizing several microorganisms, including viruses. (c19early.org)
Mixture2
  • For the preparation of 4, 6-disubstituted pyrimidine- 2-thiols (2a-i) a mixture of appropriate chalcones (1a-i, Scheme 1 ) (0.01 mol) and thiourea (0.01 mol) in ethanol (50 ml) and sodium hydroxide (0.01 mol) dissolved in minimum quantity of water was refluxed on a water bath for 12 h and poured into 250 ml of cold water. (ijpsonline.com)
  • Stir the mixture vigorously to precipitate the chalcone crystals. (marignylesreullee.com)
Organic2
Hydration1
  • Specific molecule offers surface barrier support, providing hydration and enhancing dermal comfort. (niod.com)
Activity1
  • Many substances, such as the chalcones, have had their antiplasmodial activity proven. (ufpa.br)
Contrast1
  • In contrast, in compound (II), the pyridine rings of both molecules have an anti conformation and the two independent molecules are linked by carbonyl-carbonyl interactions, as well as by C-H...O and C-H...N contacts. (bvsalud.org)
Compound2
  • This compound spontaneously loses a water molecule and a hydroxide ion to form cyanidin (figure 3). (wikipedia.org)
  • In compound (I), the pyridine rings of the two independent molecules adopt different conformations, i.e. syn and anti, with respect to the methylene bridge. (bvsalud.org)
Agents1
Carbon2
  • A three carbon α, β-unsaturated carbonyl system constitutes chalcones. (afpm.org.my)
  • Chalcones (1, 3-Diphenyl-2-propen-1-one) are constituted by a three carbon α, β-unsaturated carbonyl system. (afpm.org.my)
Active3
  • A highly-purified bio-active molecule that comforts stressed skin. (niod.com)
  • Eyeliss® A combination of 3 active molecules including hesperidin methyl chalcones, dipeptide VW and lipo peptide Pal-GQPBR. (careforskin.eu)
  • The combination of these 3 active molecules decreases capillary permeability, improves lymphatic circulation and improves firmness and elasticity. (careforskin.eu)
Important1
Research2
  • The research done in the Cravens lab is inspired by a desire to understand life at a fundamental level, primarily through biophysical studies of DNA and sequence-specific DNA targeting molecules. (gonzaga.edu)
  • Moreover, chalcone itself has some interesting properties that make it valuable for research and development. (marignylesreullee.com)
Structures1
  • One of their reported structures is ( E )-1-(5-chloro-thio-phen-2-yl)-3-(3-methyl-thio-phen-2-yl)prop-2-en-1-one. (iucr.org)
Role1
  • Chalcones in Cancer: Understanding Their Role in Terms of QSAR. (rjptonline.org)
Properties1
Cell1
  • Effect of chalcones on lipid peroxidation, heme oxygenase 1(HO-1), cyclooxygenase (COX), interleukin 5 (IL-5), nitric oxide (NO) and expression of cell adhesion molecules (CAM) is summarized stepwise. (afpm.org.my)