Molecule ccn intercellular signaling proteins. Medical search. Frequent questions

Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. (curehunter.com)

A family of extracellular matrix glycoproteins that is structurally similar to LATENT TGF-BETA BINDING PROTEINS , but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. (nih.gov)

The first exon encodes 5'-UTR sequence and the first several amino acids in the secretory signal peptide. (wikipedia.org)
Full-length CYR61 protein contains 381 amino acids with an N-terminal secretory signal peptide followed by four structurally distinct domains. (wikipedia.org)

CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). (wikipedia.org)
CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, particularly in the context of wound repair. (wikipedia.org)
They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN. (jefferson.edu)
They interact with a variety of EXTRACELLULAR MATRIX PROTEINS and may play a role in the regulation of TGB-beta bioavailability. (bvsalud.org)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)

Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. (lookformedical.com)
They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)

Atherosclerotic lesion formation, endothelial inflammatory signaling, and endothelial-macrophage interaction were examined in vivo and in vitro by using cellular and molecular biological approaches. (bvsalud.org)

Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. (musc.edu)

CYR61 was first identified as a protein encoded by a serum-inducible gene in mouse fibroblasts. (wikipedia.org)

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. (wikipedia.org)
Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein). (wikipedia.org)
The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). (wikipedia.org)
These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six members of the family in vertebrates and have been renamed CCN1-6 in order of their discovery by international consensus. (wikipedia.org)
A family of cell-surface proteins found on ANTIGEN-PRESENTING CELLS. (jefferson.edu)
A family of secreted multidomain proteins that were originally identified by their association with the latent form of TRANSFORMING GROWTH FACTORS. (bvsalud.org)

The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, von Willebrand type C repeats (vWC) domain, thrombospondin type 1 repeat domain (TSR), and the C-terminal (CT) domain that contains a cysteine-knot motif. (wikipedia.org)

CYR61 activates Akt signaling in thymic epithelial cells, promoting their proliferation and thus thymic size growth. (wikipedia.org)
The proteins are lost or reduced when these cells undergo viral or chemical transformation. (musc.edu)