Molecule 4 1bb ligand. Medical search. Frequent questions

Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. (fishersci.com)
Four stimulatory checkpoint molecules are members of the tumor necrosis factor (TNF) receptor superfamily-CD27, CD40, OX40, GITR and CD137. (wikipedia.org)
Another two stimulatory checkpoint molecules belong to the B7-CD28 superfamily-CD28 itself and ICOS. (wikipedia.org)
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. (2bscientific.com)
The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the activation of T cells. (rupress.org)
R&D Systems offers products for both co-stimulatory and co-inhibitory molecules in both the Immunoglobulin superfamily (IgSF) and the Tumor Necrosis Factor (TNF) receptor superfamily. (rndsystems.com)
Apogenix has developed a proprietary technology platform for the construction of novel TNF superfamily receptor agonists (HERA-ligands). (apogenix.com)
OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. (genscript.com)
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. (genscript.com)
The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. (bioxcell.com)
Description: LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation (1) and has recently been identified as an immune checkpoint protein. (amjournals.org)

OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease. (genscript.com)

Here we show that anti-mouse 4-1BB monoclonal antibodies (mAbs) inhibit thymus-dependent antibody production by B cells. (rupress.org)
The 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling in vivo . (bioxcell.com)
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. (bioxcell.com)
2019). "Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcgammaR affinity" Nat Commun 10(1): 2141. (bioxcell.com)
Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). (bioxcell.com)
All FcgammaRs can crosslink anti-41BB antibodies to strengthen co-stimulation, but activating FcgammaR-induced antibody-dependent cell-mediated cytotoxicity compromises anti-tumor immunity by deleting 4-1BB(+) cells. (bioxcell.com)
The 4B4-1 monoclonal antibody specifically binds to CD137 which is also known as 4-1BB, and ILA (induced by lymphocyte activation). (bdbiosciences.com)
The antibody can also be used to isolate cells that have an FITC-labeled ligand on their surface. (gen9bio.com)
Hepatotoxicity of anti-h4-1BB antibody (in house) was analyzed by blood biochemical test. (biocytogen.com.cn)
Immunoadhesins: principles and applications Steven M. Chamow and Avi Ashkenazi The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin molecule. (coek.info)
is to generate an antibody-like molecule by combining framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. (coek.info)
An antibody is a Y-shaped molecule, composed of two identical light chains (grey) and two identical heavy chains (white). (coek.info)

CD40: This molecule, found on a variety of immune system cells including antigen presenting cells has CD40L, otherwise known as CD154 and transiently expressed on the surface of activated CD4+ T cells, as its ligand. (wikipedia.org)
Currently, Apogenix utilizes its HERA-ligand platform primarily for the preclinical development of CD40, GITR, and 4-1BB agonists. (apogenix.com)
Murine Ly6C high and Ly6C middle MC subsets perform pro-inflammatory functions, which are considered the counterpart of human CD14 ++ CD16 + intermediate MC or CD14 + CD40 + inflammatory MC ( 4 , 5 ). (frontiersin.org)
The second involves a network of co-inhibitory and co-stimulatory molecules pathways such as CD80/CD86-CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4), inducible co-stimulator (ICOS)-ICOS ligand (ICOSL), programmed death-1 (PD-1), programme death ligand-1/2 (PD-L1/PD-L2), 4-1BB-4-1BB ligand (4-1BBL), CD40-CD154 ligand, OX40-OX40 ligand and CD27-CD70. (biomedcentral.com)

The biotech company TG Therapeutics is working on anti-GITR antibodies ICOS: This molecule, short for Inducible T-cell costimulator, and also called CD278, is expressed on activated T cells. (wikipedia.org)
This is in contrast to other biologics targeting TNFSF pathways, such as agonistic antibodies, as these can only bind two receptors per drug molecule in a spatially undefined manner. (apogenix.com)
Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. (bioxcell.com)
While intrinsically strong agonistic anti-4-1BB can activate 4-1BB in the absence of FcgammaRs, weak agonistic antibodies rely on FcgammaRs to activate 4-1BB. (bioxcell.com)
CD137 is activated by its ligand CD137L or activating anti-CD137 antibodies enhance tumor rejection because it is upregulated on T cells following activation and its engagement increases T cell proliferation and pro-inflammatory cytokine production. (biocytogen.com.cn)
Splenocytes were collected from +/+ and homozygous mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-4-1BB antibodies. (biocytogen.com.cn)
Its broad portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric antigen receptor T cells, bi-specific checkpoint immuno-modulators, targeted cancer antibodies and small molecules. (pharmaceuticaldaily.com)
Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)

CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. (fishersci.com)
Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. (fishersci.com)
In this study, we evaluated the role of OX40L in costimulation of human antiviral CD8 T cell responses and compared it with two other important costimulators, B7.1 (CD80) and 4-1BBL (CD137L). (aai.org)
Synergistic or additive effects were observed when OX40L costimulation was combined with 4-1BBL (CD137L) or B7.1 (CD80) costimulation. (aai.org)

As a proof of this concept, we have developed LVGN6051, a humanized 4-1BB mAb-AG that shows high anti-tumor efficacy in the absence of liver toxicity in a mouse model of cancer immunotherapy. (bioxcell.com)
Tumor-associated antigens (TAAs) are antigenic molecules that are unique to or highly expressed on tumor cells and absent or lowly expressed on healthy cells. (biocytogen.com.cn)
TNFRSF9 (Tumor necrosis factor receptor super family, member 9), also called CD137 and 4-1BB, is a co-stimulatory molecule and is mainly expressed on the surface of T, B, NK and mononuclear cells. (biocytogen.com.cn)
Our results suggest that the co-expression of LAG-3, PD-1, 4-1BB, and perhaps CRTAM may identify a critical subpopulation of dysfunctional TILs that are specific for tumor antigens and contribute to an immune suppressive tumor microenvironment. (bmj.com)
The CD56 bright population produces immunoregulatory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-beta (TNF-B), tumor necrosis factor-α (TNF-α), granulocyte macrophage-colony stimulating factor (GMCSF), IL-10, and IL-13 ( 4 ). (frontiersin.org)
Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
Pre- and post-treatment tumor analysis after anti-CTLA-4 treatment demonstrated changes in a number of T cell genes, the most surprising of which was the ICOS pathway. (acir.org)
As an evasion mechanism, many tumors are able to stimulate the expression of immune checkpoint molecules, resulting in an exhausted phenotype of T cells that cannot restrain tumor progression [ 1 ]. (oncotarget.com)

CD137 is a 39 kD transmembrane protein also known as 4-1BB. (biolegend.com)

CD28: This molecule is constitutively expressed on almost all human CD4+ T cells and on around half of all CD8 T cells. (wikipedia.org)
Molecules in the IgSF are further classified as members of the B7/CD28 family, T cell immunoglobulin and mucin (TIM) family, signaling lymphocyte activation molecule (SLAM) family, butyrophilin family, and nectin and nectin-like binding receptor family. (rndsystems.com)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)

TNFSF4 is the ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. (genscript.com)

CD137: When this molecule, also called 4-1BB, is bound by CD137 ligand, the result is T-cell proliferation. (wikipedia.org)

Fortunately, new therapeutic modalities using 4-1BB targeting aptamers as well as therapeutic combinations with other immuno-modulatory and traditional anti-cancer treatments have revived excitement for the use of 4-1BB agonists in the clinical. (biocytogen.com.cn)

Negative regulatory pathways include anergy, expression of inhibitory receptors and ligands, metabolic dysregulation, and recruitment of suppressive cell populations. (bmj.com)
however the expression of inhibitory molecules (PD-L1, VISTA) increased on the newly infiltrating T cells, suggesting the need for targeting multiple pathways in prostate cancer. (acir.org)

CD27: This molecule supports antigen-specific expansion of naïve T cells and is vital for the generation of T cell memory. (wikipedia.org)
The ligand for GITR is mainly expressed on antigen presenting cells. (wikipedia.org)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
Consistent with this notion, SIY-Kb pentamer staining revealed that the vast majority of CD8+ T cells specific for this model antigen expressed LAG-3, PD-1, and 4-1BB. (bmj.com)

4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. (bioxcell.com)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)

We describe here a simple and reliable strategy for evaluating the functional activities of potential costimulatory molecules using soluble fusion protein between extracellular portion of costimulatory ligand and Fc portion of mouse IgG2a. (elsevierpure.com)
Chapoval, AI, Zhu, G & Chen, L 2002, ' Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules ', Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology , vol. 21, no. 3, pp. 259-264. (elsevierpure.com)

In total T cell cultures, at low Ag dose, 4-1BBL provided the most potent costimulus for influenza-specific CD8 T cell expansion, followed by B7.1 (CD80) and then OX40L. (aai.org)

CD27's activity is governed by the transient availability of its ligand, CD70, on lymphocytes and dendritic cells. (wikipedia.org)
Research has identified a host of co-signaling molecules that modulate the immune responses by T and B lymphocytes. (rndsystems.com)
The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES. (rush.edu)
These lymphocytes successfully eliminate the genetically unstable tumour cells with intrinsically high immunogenicity [ 4 ] through a series of successive stages [ 5 ] . (encyclopedia.pub)

This intracellular clustering allows signaling proteins (4) inside the cell to be recruited (5), thereby initiating a response from the cell. (apogenix.com)
Gene expression profiling and Egr2 ChIP-Seq analysis revealed multiple Egr2-driven cell surface proteins in T cell anergy, including LAG-3, CRTAM, and 4-1BB. (bmj.com)

Inhibitory checkpoint molecules are targets for cancer immunotherapy due to their potential for use in multiple types of cancers. (wikipedia.org)
4 xCELLigence real-time cell analysis 6 Diverse cancer immunotherapy applications 6 How does the xCELLigence real-time cell analysis assay work? (technologynetworks.com)

The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)

Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. (bioxcell.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. (2bscientific.com)

Binding with its two ligands are CD80 and CD86, expressed on dendritic cells, prompts T cell expansion. (wikipedia.org)

Combining ICOS pathway targeting with anti-CTLA-4 improved survival in mice. (acir.org)

Here we show that isotype and intrinsic agonistic strength co-determine the efficacy and toxicity of anti-4-1BB mAb-AG. (bioxcell.com)

Its ligand is ICOSL, expressed mainly on B cells and dendritic cells. (wikipedia.org)

PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)

CD122: This molecule, which is the Interleukin-2 receptor beta sub-unit, is known to increase proliferation of CD8+ effector T cells. (wikipedia.org)
The molecule seems to be important in T cell effector function. (wikipedia.org)
Here, we show that effector and memory T cells from mice expressing a dominant negative E3-inactive c-IAP2 (c-IAP2(H570A) ) have impaired signaling downstream of 4-1BB. (bioxcell.com)

4-1BBL is the high affinity ligand of 4-1BB. (2bscientific.com)
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)

The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)

Additional reported applications (for the relevant formats) include: immunoprecipitation 1,4 , inhibition of cytokine production 2,3 , and ELISA. (biolegend.com)

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. (genscript.com)
2015). "c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival" Eur J Immunol 45(9): 2672-2682. (bioxcell.com)
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
Strain specific 4-1BB protein expression analysis in wild-type (+/+) or homozygous B-h4-1BB (H/H) mice by flow cytometry. (biocytogen.com.cn)

4-1BBL induces the proliferation of activated peripheral blood T-cells. (2bscientific.com)
CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. (biolegend.com)

The clinical development of 4-1BB targeting therapy was slow due to the toxicity associated with overt immune activation. (biocytogen.com.cn)

BioNTech will acquire Medigene's next generation preclinical TCR program, which combines TCR-4 of Medigene's MDG10XX program targeting PRAME with Medigene's proprietary PD1-41BB switch receptor technology. (pressetext.com)

4 NEUROPHYSIOLOGICAL MECHANISMS LEADING TO THE DESYNCHRONIZATION OF THE D WAVE In certain patients with spinal cord tumors (usually involving a few segments) the D wave is not recordable at the beginning of surgery [27]. (forextrading-madeeasy.com)
4 How can the immune system be harnessed to target tumors? (technologynetworks.com)

For isolated CD8 T cells, 4-1BBL was also the most consistent costimulator, followed by B7.1. (aai.org)
In this study we used Egr2 targets as well as other previously defined molecules of T cell dysfunction, PD-1 and TIM-3, to characterize T cells in the context of the murine B16.SIY melanoma model. (bmj.com)
A major subset of these cells also expresses 4-1BB, TIM-3, and CRTAM. (bmj.com)
Designer T and NK cells are a modality within immunotherapy that manipulates receptor-ligand interactions to enhance cells of the immune system to destroy cancer more effectively. (encyclopedia.pub)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)

Human 4-1BB Ligand (71-254), premium grade on SDS-PAGE under non-reducing (NR) condition. (2bscientific.com)
Immobilized Human 4-1BB, Mouse IgG2a Fc Tag, low endotoxin (Cat. (2bscientific.com)
No. 41B-H5256) at 2 ug/mL (100 uL/well) can bind Human 4-1BB Ligand (71-254), premium grade (Cat. (2bscientific.com)
Immobilized Human 4-1BB, His Tag (Cat. (2bscientific.com)
Mouse 4-1BB was detectable in +/+ mice, while human 4-1BB was exclusively detectable in B-h4-1BB H/H mice. (biocytogen.com.cn)

This study aims to explore molecule signaling mediating MC subset differentiation in HHcy and control mice. (frontiersin.org)

Also, 4-1BBL may have a role in activation-induced cell death (AICD). (2bscientific.com)
Co-signaling molecules have been shown to have both positive and negative modulatory effects on T and B cell activation. (rndsystems.com)
4-1BB is a TNF receptor family member that signals via a complex that includes TRAF family members and the c-IAPs to upregulate NF-kappaB and ERK, and has been implicated in memory T-cell survival. (bioxcell.com)
Thus, c-IAP E3 activity is required for 4-1BB coreceptor signaling and maintenance of CD8(+) T-cell memory. (bioxcell.com)
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. (forextrading-madeeasy.com)

Anatomy1

Organisms2

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes3

Information Science2

Programmed cell death l1

Superfamily11

OX401

Antibody12

CD404

Antibodies9

CD137L4

Tumor9

Known as 4-1BB1

CD283

CD1341

CD137 Ligand1

Agonists1

Expression of inhibitory2

Antigen5

Transmembrane protein2

Costimulatory Molecules2

OX40L1

Lymphocytes4

Proteins2

Cancer immunotherapy2

Cytotoxic1

Pathways2

Macrophages1

CD801

ICOS1

Isotype1

ICOSL1

Lymphocyte1

Effector3

High affinity2

Fusion protein1

Cytokine production1

Protein4

Induces2

Toxicity1

Preclinical1

Tumors2

Cells5

Human5

Subset1

Cell5