• She elucidated the mechanisms through which these mutations cause hearing deficits, thus illuminating the unique biology of hair cells and informing deafness diagnosis and counseling. (bna.org.uk)
  • An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
  • In conclusion, this study demonstrated that HMGB1 is involved in NIHL pathogenesis and its molecular biology has essential and subtle influences, preserving a translational potential for pharmacological intervention. (frontiersin.org)
  • To understand the molecular biology of peptide hormone action, we studied response of budding yeast ( Saccharomyces cerevisiae ) to its peptide mating pheromones ( a -factor and α-factor). (berkeley.edu)
  • Dr. Zalups has expertise in the area of cellular and molecular biology and the toxiclogy of heavy metals such as uranium. (cdc.gov)
  • Multidisciplinary research groups working at Next Generation Chemistry Centers that are focusing on innovative medicinal chemistry, chemical biology and chemoproteomic approaches to target fusion oncoprotein-driven cancers. (cancer.gov)
  • As a clinician-scientist, it is exciting that our experiments linking preclinical animal models to the biology we see in real MS patients may have uncovered a general mechanism for how the immune system counteracts inflammation," said UCSF's Pröbstel. (scienceblog.com)
  • OCTOBER 8, 2013 Joerg Braun is awarded the 2013 Karl Lohmann Award from The Society for Biochemistry and Molecular Biology (GBM) for his doctoral research in Frankfurt am Main, Germany. (umassmed.edu)
  • I was fascinated with topics such as the central dogma of molecular biology and protein synthesis, which are about the mechanisms of gene expression. (who.int)
  • After my master's degree, I was sure I wanted to pursue research as a career, and while selecting my PhD research topic I came across the field of epigenetics, which is the branch of molecular biology that deals with gene regulation. (who.int)
  • From this research, several molecular and epigenetic mechanisms have been discovered. (wikipedia.org)
  • In coordination with these factors, molecular and epigenetic mechanisms influence the progression toward alcoholism. (wikipedia.org)
  • Research has and continues to investigate the molecular and epigenetic mechanisms underlying the downward spiral of alcoholism. (wikipedia.org)
  • The first focuses on understanding the epigenetic mechanisms of oesophageal squamous cell carcinoma (ESCC) in high-incidence populations in low- and middle-income countries in Africa, South-East Asia, and South America. (who.int)
  • The Macromolecular Structure and Mechanism Program (MSM) is a training program designed for graduate students in the Brandeis Biochemistry & Biophysics PhD Program . (brandeis.edu)
  • In a study published in PLOS Genetics , a team led by Professor Claus Schwechheimer from the Technical University of Munich (TUM) in Germany describes a molecular mechanism that allows plants to adapt their flowering time to ambient temperatures and indicate ways in which the flowering time can be predicted based on genetic information . (isaaa.org)
  • The tradition of drawing these sharp lines when patients are diagnosed probably doesn't follow the reality, where mechanisms in the brain might cause overlapping symptoms," Benjamin Neale, PhD, co-senior author, from the Broad Institute and the Analytical and Translational Genetics Unit at Massachusetts General Hospital, said in a news release. (medscape.com)
  • This pathway, called "natural transformation," is a major mechanism of gene transfer across bacteria and has a profound effect on genome evolution, including spreading antibiotic resistances and other virulence determinants. (drexel.edu)
  • For these reasons, this pathway and the mechanisms by which TORC2 and Ypk1 are regulated are under continuing intensive study. (berkeley.edu)
  • The molecular mechanism of this pathway remains unclear. (nih.gov)
  • Our work provides a molecular description of the SecA-mediated cotranslational targeting pathway and demonstrates an unprecedented role of the ribosome in shielding nascent TMDs. (nih.gov)
  • This is important - it establishes that environmental toxins work on same pathway that is in play in those genetically disposed to Parkinson's. (ucla.edu)
  • Single-walled carbon nanotube s induce fibrogenic response by promoting epithelial/fibroblast-to-myofibroblast transition: an in vitro molecular toxicity pathway based risk assessment. (cdc.gov)
  • Using genomics to investigate the mechanism, consequences and evolution of genetic recombination, especially in pathogenic bacteria. (drexel.edu)
  • Apart from the identification of the allergenic sources implicated, molecular diagnosis and detailed characterization of the culprit allergens contributes to increase our knowledge into the pathogenic mechanisms of this disorder. (cdc.gov)
  • In this review, the molecular pathways leading to splanchnic vasodilation will be discussed in detail. (karger.com)
  • To identify targetable mechanisms and pathways underlying initiation and progression of MOD. (lu.se)
  • Molecular paThwayS criTical for cancer developMenT and progreSSion, ThuS enhancing The evidence baSe direcTly relevanT To STudieS of cancer cauSaTion and prevenTion. (who.int)
  • This is achieved through mechanistic studies of functionally important epigenetic "driver" genes and molecular pathways altered by specific cancer risk agents and by the application of cutting-edge epigenomics in conjunction with unique biospecimens from population-based cohorts (Figure 1). (who.int)
  • The other project is to understand the molecular etiology of colorectal cancer in countries in Central and Southern Europe. (who.int)
  • Collectively the breakthroughs made by this year's Kavli Prize laureates have unveiled the molecular and cellular mechanisms that underlie hearing and deafness. (bna.org.uk)
  • RVC researchers reveal the molecular mechanisms that underlie a common genetic form of 'tying up' in horses. (rvc.ac.uk)
  • Personalized therapeutics are quickly becoming the future of modern medicine-increasingly, doctors can tailor treatments to tackle a patient's specific genetic flaw or bolster a molecular strength. (cornell.edu)
  • Carcinogenesis is a multi-step process, which involves the accumulation of genetic and epigenetic changes of oncogenes or tumor suppressor genes (4).Therefore, better understanding of the genetic and molecular disorders of the disease is the key to early diagnosis, appropriate treatment and improving the prognosis of patients. (unc.edu)
  • Molecular genetic methods were implemented into the screening examinations for thrombophilic disorders in the 1990's along with the first discoveries of coagulation inhibitors (AT, protein C and protein S). The discovery of the molecular cause of activated protein C (APC) resistance by Bertina in 1994 greatly expanded their utilization. (intechopen.com)
  • Uncovering the genetic influences and patterns of overlap between different genetic risk factors allows us to better understand the root causes of these conditions and potentially identify specific mechanisms appropriate for tailored treatments," first author Verneri Anttila, PhD, research fellow at the Broad Institute of the Massachusetts Institute of Techology and Harvard University, in Cambridge, told Medscape Medical News . (medscape.com)
  • The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. (medlineplus.gov)
  • However, the knowledge on mechanisms by which alcohol consumption leads to cancer progression and its aggressiveness is limited. (springer.com)
  • We conducted a global transcriptional analysis of human glioblastoma cell response to infection with WNV during peak virus production to determine the crucial virus-host interactions that take place during a severe neuroinvasive attack and identify putative mechanisms involved in WNV pathogenesis. (cdc.gov)
  • However, the precise therapeutic intervention must be based on a deeper understanding of its dynamic molecular distribution and function in cochlear pathogenesis after acoustic trauma. (frontiersin.org)
  • Newer work is using the same approach to map the genes responsible for natural variation in other pathogenesis traits, including resistance to human complement-mediated killing, as well as investigating the possibility of identifying genes involved in in vivo pathogenesis in an animal model of otitis media. (drexel.edu)
  • Third, conditioned media from SWCNT-treated macrophages promoted epithelial/fibroblast- to-myofibroblast transiition, a key molecular event in the pathogenesis of lung fibrosis. (cdc.gov)
  • These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus. (cdc.gov)
  • Mca alSo conTribuTeS To TranSlaTional STudieS, Through The diScovery of MechaniSM-baSed bioMarKerS of expoSure, early deTecTion, and riSK STraTificaTion. (who.int)
  • Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level. (news-medical.net)
  • This paper reports that certain of these dipeptide repeat proteins interfere with protein synthesis in affected cells, and this molecular derailment may contribute to motor neuron degenetion in C9orf72-ALS patients. (europa.eu)
  • This program explores the molecular structures and functional mechanisms of proteins. (lu.se)
  • Recent research has provided new insights into the function of Hox proteins in different germ layers and the mechanisms they employ to control tissue morphogenesis. (bvsalud.org)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • Moreover, since adaptation (or tolerance) to the drug likely contributes to alcohol abuse, our findings identify a potential molecular target for therapeutic intervention. (nih.gov)
  • We propose a mechanism of CaM-mediated Ca2+-induced inactivation that can be explored for therapeutic design. (columbia.edu)
  • Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia. (medlineplus.gov)
  • The book enables the reader to become progressively acquainted with the intricate networks governing in vitro and in vivo signalling mechanisms. (iospress.com)
  • I consulted Harvard geneticist Robert C. Green to get his thoughts, in part because he has done important work on how people react to receiving information about their genes. (propublica.org)
  • Our discovery of critical genes and molecular events presents interesting avenues for mechanistic studies and biomarker development for early diagnosis in low-resource settings. (who.int)
  • Furthermore, we highlight the molecular mechanisms involved the transcriptional repression of specific groups of Hox target genes, and summarize the role of Hox mediated gene silencing in tissue development. (bvsalud.org)
  • The Kavli Prizes were initiated by and named after Fred Kavli (1927-2013), founder of The Kavli Foundation, which is dedicated to advancing science for the benefit of humanity, promoting public understanding of scientific research, and supporting scientists and their work. (bna.org.uk)
  • The first indication of this natural gene variation came from the cool latitudes of Scotland, where scientists discovered a molecular mechanism that causes flowering two weeks earlier than its counterparts in warmer regions. (isaaa.org)
  • The goal of the Macromolecular Structure and Mechanism Training Program is to provide the next generation of scientists with these two intellectual tools. (brandeis.edu)
  • These diversified gene mutation combinations result in aberrations in the molecular machinery that regulate the gene expression-like miRNAs. (cornell.edu)
  • In this regard, we have recently shown that efficient activation of Ypk1 by TORC2 requires stimulation of TORC2 by the GTP-bound state of a Rab5 GTPase (Vps21/Ypt51) and that, in turn, Rab5-dependent endocytosis may be a mechanism to down-regulate TORC2 signaling after it has been activated. (berkeley.edu)
  • We investigated control mechanisms that regulate the activity, localization, and stability of Wee1, especially the bud neck-localized protein kinase Hsl1 and its more distant paralogs (Gin4 and Kcc4), in particular their recruitment to septin filaments, which assemble at the presumptive site of cell division. (berkeley.edu)
  • The Antibiotic Resistance in Communities and Hospitals (ARCH) projects aim to better understand the burden, molecular epidemiology, and drivers of resistant bacteria in humans in multiple low- and middle-income countries by tracking colonization (carrying and potentially spreading harmful pathogens without infection) in communities and healthcare settings. (cdc.gov)
  • EGE also develops epigenomic methodologies, profiling strategies, and bioinformatics tools, applicable to population-based cohorts and molecular epidemiology studies coordinated by IARC researchers and external collaborators. (who.int)
  • Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)
  • It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), works. (news-medical.net)
  • Researchers have discovered a basic molecular mechanism that sheds light on the disease process underlying amyotrophic lateral sclerosis (ALS). (news-medical.net)
  • This paper investigates the molecular mechanisms underlying a familial form of amyotrophic lateral sclerosis (ALS) associated with mutations in FUS. (europa.eu)
  • Our work sheds light on how different mutational combinations affect miRNA expression. (cornell.edu)
  • This work package explores the differences between metabolically healthy and unhealthy obesity and focuses on elucidating the mechanisms underlying type 2 diabetes improvement or remission after gastric bypass surgery. (lu.se)
  • Further insights into its molecular events indicate that the acute phase takes almost 2 weeks to complete after the incidence of the injury [ 15 ]. (hindawi.com)
  • They further offer fundamental structural insights into the control mechanisms of microtubule dynamics. (uzh.ch)
  • The work provides fresh insights into reproduction and could lead to new types of -contraceptives. (acs.org)
  • New insights gained in occupational asthma include routine evaluation of airway inflammation and identification of allergenic triggers using molecular diagnosis. (cdc.gov)
  • Now, researchers at the RVC's Comparative Neuromuscular Diseases Laboratory ( Dr Charlotte Maile and Professor Richard Piercy ), in collaboration with other groups, have explained the molecular mechanism underpinning PSSM1. (rvc.ac.uk)
  • RVC researchers are working towards improved treatments and management for this disorder. (rvc.ac.uk)
  • Researchers investigating the molecular mechanisms by which fusion oncoproteins drive childhood cancers. (cancer.gov)
  • Further work is now needed to investigate the exact molecular mechanisms behind the activation of p63. (elifesciences.org)
  • Much of his work focuses on the mechanisms by which select environmental toxicants affect the kidneys. (cdc.gov)
  • The 2018 Kavli Prize in Neuroscience has been awarded to three people for their, "pioneering work on the molecular and neural mechanisms of hearing. (bna.org.uk)
  • Several reports have shown that pulmonary exposure to SWCNT caused pulmonary fibrosis in rodents, although the molecular mechanisms of SWCNT-induced pulmonary toxicity remain largely unaddressed. (cdc.gov)
  • Funds are for monitoring, screening, analysis and Toxicity and Carcinogenesis Conference' medical treatment of WTC responders and Proceedings to be published in ' Molecular and recovery workers. (cdc.gov)
  • Let's look at the history of molecular diagnosis of thrombophilia. (intechopen.com)
  • 1. Nestler, E.J. Molecular neurobiology of addiction. (lu.se)
  • Germ cells - from which egg cells and sperm cells develop - are particularly vulnerable as they contain sensitive quality control mechanisms that kill any cell that contain damaged DNA. (elifesciences.org)
  • In this review, the clinical trials about curcumin supplementation on diabetes and DCM are presented, and the specific mechanisms by which curcumin might mitigate diabetes and DCM are fully discussed. (frontiersin.org)
  • Publishing on IntechOpen allows authors to earn citations and find new collaborators, meaning more people see your work not only from your own field of study, but from other related fields too. (intechopen.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, today announced a data presentation, at the 59th American Society of Hematology Annual Meeting & Exposition in Atlanta, demonstrating the identification of a new mechanism of action to treat non-Hodgkin lymphoma (NHL). (news-medical.net)
  • The mechanisms un- adjunct to more traditional strategies naltrexone discourages renewed responding after derlying these elevations are not involving pharmacotherapies. (lu.se)
  • Before coming to IARC, I was working as an adjunct lecturer in the Department of Biotechnology at Assam University in India, where I also obtained my PhD, in epigenomics of oral and oesophageal cancer. (who.int)
  • How long have you worked at IARC, and where did you work before? (who.int)
  • I joined IARC in 2015, and I am a molecular biologist, with a specialty in cancer epigenetics. (who.int)
  • Prevalence and risk of individual thrombophilic markers with a time line representing their discovery[ 1 ] Despite the expansion of these methods, the following years brought forth discoveries of defects on a molecular basis, which posed decreasing risks of thrombosis, as can be seen in Fig 1 . (intechopen.com)
  • When compared to functional assays, molecular assays provide clear results without different cut-off values. (intechopen.com)
  • The RVC's work was partly funded by the Petplan Charitable Trust and the Morris Animal Foundation and was done in collaboration with the University of Copenhagen, University of Minnesota, Indiana University School of Medicine and Liverpool John Moore's University. (rvc.ac.uk)
  • MMb), which worK in cloSe collaboraTion To creaTe SynergieS and beTTer exploiT and furTher expand unique reSearch ToolS and experTiSe. (who.int)
  • These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)
  • We're exploring the molecules and molecular processes that cause diseases, and working to develop better treatments. (port.ac.uk)
  • Although treatments may be years away, identifying this potential molecular mechanism in schizophrenia provides a starting point. (discovermagazine.com)
  • Past work has led to the simple hy- side--the less-studied side--of the training by implanting extra copies of pothesis that treatments that decrease mind-brain interaction. (lu.se)
  • Our research highlights include how we're seeking to better understand the underlying mechanisms of heath and disease. (port.ac.uk)
  • We summarize by discussing the challenges in this field, and explore future directions that will allow the scientific community to better understand the molecular aspects and applications of HBOT for a wide variety of neurological conditions. (mdpi.com)
  • We'll need more work and even larger sample sizes to understand these connections. (medscape.com)
  • My work involves both benchwork experimentation and the analysis of the generated data using bioinformatics tools. (who.int)
  • Here we provide biochemical and cellular evidence that artemisinins are potent inhibitors of Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K), revealing an unexpected mechanism of action. (nature.com)
  • Despite the importance of MSAs for medical applications and basic research, their molecular mechanisms of action on tubulin and microtubules remain elusive. (uzh.ch)
  • In this review we use influenza vaccine as a model in a discussion of the different mechanisms of action of the available adjuvants. (smw.ch)
  • He has knowledge of uranium and uranium compounds' physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, and quantification of risk to humans. (cdc.gov)
  • Additional collaborative work is happening through CDC's Global Action in Healthcare Network to address emerging threats in healthcare settings through rapid detection and response. (cdc.gov)
  • For more information about our work, contact Guy Hembury ( [email protected] ), Deputy Director (Commercialisation and External Partnerships) in our Research and Innovation Services department. (port.ac.uk)
  • We work collaboratively to address needs in society - our partnership with Portsmouth Hospital NHS Trust has led to the education of clinicians, placements for our students, research papers and funding, and benefited the NHS, patients and the economy. (port.ac.uk)
  • The new research suggests that progesterone works by opening a pH-sensitive calcium channel called CatSper, which resides on sperm tail membranes. (acs.org)
  • This work was supported by a research grant (NMRC 0261/1997) from National Medical Research Council of Singapore. (aspetjournals.org)
  • The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)
  • In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. (mdpi.com)
  • Accordingly, laboratory investigation of thrombophilic disorders has expanded due to incorporation of modern molecular assays. (intechopen.com)
  • The size of the study, both in terms of disorders and individuals studied, represents a considerable expansion on previous work - for many disorders, by at least an order of magnitude. (medscape.com)
  • Until now, no-one knew the precise mechanism by which the mutation caused increased enzyme activity in muscle. (rvc.ac.uk)
  • With a Master's degree in Protein Science, you are well-prepared for work in the biomedical/biotechnological industry and for starting doctoral studies. (lu.se)
  • It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. (wjgnet.com)
  • In this study, seven PolyILs were synthesized having degrees of polymerization ranging from 1 to 333, corresponding to molecular weights (MW) from 482 to 160 400 g/mol. (osti.gov)
  • The median proportion of adult cases of according to their molecular weight: agents of high and asthma attributable to occupational exposure is 10-25% low molecular weights. (cdc.gov)
  • The award recognizes Dr. Nijhawan's work identifying targets for cancer treatment. (news-medical.net)
  • Dr. Treistman adds that the microRNA process observed in this study may represent a general mechanism of neuronal adaptation to alcohol, with miR-9 playing a pivotal role in a complex regulatory network. (nih.gov)
  • Work exposures are a significant contributor to the bur- cause occupational asthma can be divided into two groups den of asthma. (cdc.gov)
  • Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
  • Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death. (news-medical.net)
  • Transmembrane and intracellular signal transduction mechanisms are the focus of our group, especially understanding how extracellular stimuli control cell growth and division, cell morphology, and gene expression at the biochemical level. (berkeley.edu)