• The absence of genomic resources renders the search for paralogous cuttlefish genes dependent upon the presence of highly conserved protein motifs within genes of interest, thus we used a degenerate primer strategy to isolate partial coding sequence from the conserved domains specific to these families. (europa.eu)
  • Both predicted proteins are highly conserved with other known homologous sequences, with the exception of two small domains present only in the Sof-RXR. (europa.eu)
  • Our data suggested that the important residues of CypA were highly conserved, which is crucial for its PPIase activity and cellular functions. (chinagene.cn)
  • Variants produced by substitution of Cys(972) and Cys(353) by Ser using site-directed mutagenesis have distinctly lower specific activities, supporting the crucial role of these highly conserved redox-sensitive amino acid residues for P-protein activity. (nih.gov)
  • Some viruses possess an outer envelope, and the outer capsid is composed of major capsid protein (MCP), which appears to be highly conserved among the family and possesses surface binding sites interacting with the surfaces of host's cells [ 2 ]. (biomedcentral.com)
  • The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
  • A common structural feature of GPCRs is the presence of a highly conserved architecture of seven stretches of transmembrane spanning residues linked by alternate extracellular and intracellular loops. (biomedcentral.com)
  • In human, AEG-1 represents a protein of 582 amino acids, and the amino acid sequences are highly conserved across vertebrates. (biomedcentral.com)
  • The cytoplasmic neck of the pore is surrounded, on the outside of the funnel, by a ring of highly conserved positively charged residues. (tcdb.org)
  • Highly conserved acidic residues found in the short periplasmic loop are not essential for CorA function or Mg 2+ selectivity but may be required for proper protein folding and stability. (tcdb.org)
  • Protein sequences of the gene's mammalian orthologs were analyzed to reveal similar results, while distant reptilian and avian ortholog sequences predicted more regions of beta sheets. (wikipedia.org)
  • This extended linker is larger than the tripeptide found in archetypal vertebrate MTs, but does not conform either with the 40-amino-acid linkers commonly found in plant MT sequences. (portlandpress.com)
  • In general, immunobiologists have developed an integrated method for vaccine development based on analyzing protein sequences and structures of target viruses [ 10 ]. (biomedcentral.com)
  • This is evident at the subfamily level comparisons since Ciona GPCR sequences are significantly analogous to vertebrate GPCR subfamilies even while exhibiting Ciona specific genes. (biomedcentral.com)
  • However, these signature sequences have not so far been extensively investigated amongst orthologous Bcl-2 family proteins. (sfr-biosciences.fr)
  • random to their competing genomic online artificial risk and the attP of the such trial in suppressor target pIRES2-EGFP-TSLC1 trait4 residues are again associated for the conditionsPrivacy of sequences for collection with a mRNA of elsewhere 50 polynucleotide among the polynomial differences( Figure 1). (scoutconnection.com)
  • This entailed mining available transcriptomic and/or genomic sequence datasets for the presence of homologues of known TIMPs, predicting secondary structures of defined protein sequences, systematic phylogenetic analyses and assessment of differential expression of genes encoding putative TIMPs in the developmental stages of A. suum , N. americanus and Schistosoma haematobium which infect the mammalian hosts. (biomedcentral.com)
  • A total of 15 protein sequences with high homology to known eukaryotic TIMPs were predicted from the complement of sequence data available for parasitic helminths and subjected to in-depth bioinformatic analyses. (biomedcentral.com)
  • To initiate V(D)J recombination for generating the adaptive immune response of vertebrates, RAG1/2 recombinase cleaves DNA at a pair of recombination signal sequences, the 12- and 23-RSS. (rcsb.org)
  • It is the key structural material making up scales , hair , nails , feathers , horns , claws , hooves , and the outer layer of skin among vertebrates. (wikipedia.org)
  • Two missense substitutions of residues conserved among vertebrates have been identified in nicastrin. (hku.hk)
  • The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. (embl.de)
  • Insertions or deletions (indels) of amino acids residues have been recognized as an important source of genetic and structural divergence between paralogous Bcl-2 family members. (sfr-biosciences.fr)
  • The PPIase activity assay indicated that there was no significant difference in the catalytic activity of prolyl peptide bond isomerization among 12 different vertebrate CypA proteins. (chinagene.cn)
  • Therefore, a more effective immunization strategy and comprehensive vaccine development for different vertebrate iridoviruses have become important for challenging agriculture environments. (biomedcentral.com)
  • The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
  • The tub gene is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. (nih.gov)
  • We analyzed molecular evolution by comparative genomics and phylogenetics of the SET genes from plant and animal genomes, grouping SET genes into several subfamilies and uncovering numerous gene duplications, particularly in the Suv, Ash, Trx and E(z) subfamilies. (psu.edu)
  • Domain organizations differ between different subfamilies and between plant and animal SET proteins in some subfamilies, and support the grouping of SET genes into seven main subfamilies, suggesting that SET proteins have acquired distinctive regulatory interactions during evolution. (psu.edu)
  • Our studies suggest that the ascidians contain the basic ancestral complement of vertebrate GPCR genes. (biomedcentral.com)
  • A detailed understanding of the molecular biology of parasitic helminths, and in particular of the structure and function of key genes and gene products playing essential roles in host-parasite interactions, could provide a basis for the design of novel therapeutics. (biomedcentral.com)
  • One of the most important forms of histone modification is methylation on lysine residues of the tails, carried out by members of the SET protein family, which are widespread in eukaryotes. (psu.edu)
  • Data derived from cephalopod studies can be used to compare and contrast known mechanisms underlying the development of analogous vertebrate structures. (europa.eu)
  • Drosophila has been a powerful system for deciphering the conserved mechanisms that regulate hormone signaling, sugar and lipid homeostasis, and the molecular mechanisms underlying the nutritional regulation of development. (sdbonline.org)
  • The molecular mechanisms of ecdysone-regulated metamorphosis and developmental timing have been studied extensively in Drosophila. (sdbonline.org)
  • Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
  • Investigating the potential molecular mechanisms associated with white spot virus resistance in Carcinus maenas. (exeter.ac.uk)
  • Since its discovery, nearly one decade of research on astrocyte elevated gene 1 (AEG-1) has witnessed expanding knowledge of this molecule, ranging from its role in cancer biology to molecular mechanisms underlying the biological functions. (biomedcentral.com)
  • Presenilin 1 (PS1), presenilin 2, and nicastrin form high molecular weight complexes that are necessary for the endoproteolysis of several type 1 transmembrane proteins, including amyloid precursor protein (APP) and the Notch receptor, by apparently similar mechanisms. (hku.hk)
  • Tricyclics are thought to exert their therapeutic effect through chronic blockade of presynaptic serotonin and/or norepinephrine transporters ( Frazer, 1997 ), but the molecular mechanisms mediating many of the deleterious side effects have not been identified. (jneurosci.org)
  • Recently, the molecular mechanisms of miRNA in host-pathogen interaction networks have been extensively studied in mammals, whereas the underlying regulatory mechanisms in fish are still poorly understood. (frontiersin.org)
  • Given the limited knowledge of the molecular mechanisms linked to the development of drug resistance in parasitic helminths [ 16 ], as well as the unavailability of effective vaccines, much attention is now directed towards the identification of novel targets for intervention [ 7 , 17 ]. (biomedcentral.com)
  • A gene was identified (1229 bp) with a putative open reading frame (204 bp) encoding a 67-amino-acid protein exhibiting several characteristic features of MT proteins, including 16 cysteine residues (24%) and only one aromatic residue. (portlandpress.com)
  • Although the protein sequence showed high identity with plant and invertebrate MTs, it contained a unique 'linker ' region (14 amino acid residues) between the two putative metal-binding domains which contained no cysteine residues. (portlandpress.com)
  • 4) Mutation of the three extracellular cysteine residues of GFKAR beta indicated that the two conserved cysteine residues (C305 and C385), located between two transmembrane segments, form a solvent-accessible disulfide bond. (aspetjournals.org)
  • ApoJ (clusterin) , also known as testosterone repressed prostate message-2, sulfated glycoprotien-2, and Sp-40 and CLU, functions as a secreted molecular chaperone protein , which may have either an intracellular or extracellular function. (wellnessadvantage.com)
  • Tissue inhibitors of metalloproteases (TIMPs) are a multifunctional family of proteins that orchestrate extracellular matrix turnover, tissue remodelling and other cellular processes. (biomedcentral.com)
  • G protein-coupled receptors (GPCRs) constitute a large family of integral transmembrane receptor proteins that play a central role in signal transduction in eukaryotes. (biomedcentral.com)
  • Most members of the MIT family are between 300 and 400 amino acyl residues in length and possess two (or three) putative transmembrane α-helical spanners (TMSs). (tcdb.org)
  • Hydropathy analysis had predicted two transmembrane α-helical spanners (TMSs) in the C-terminal regions of these proteins. (tcdb.org)
  • An S-peptide Fucus MT fusion protein expressed in Escherichia coli exhibited a relative molecular mass of ∼ 14 kDa. (portlandpress.com)
  • This clone encoded a precursor protein of 192 amino acid residues, including a sodefrin-like peptide sequence with substitutions of two amino acid residues. (wiley.com)
  • This is the first report of a peptide pheromone precursor in vertebrates. (wiley.com)
  • The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)
  • Human thymosin beta-4 (T β 4), a 43-residue peptide with an acetylated N-terminus, is widely expressed in human tissues. (hindawi.com)
  • Alphairidovirinae includes Lymphocystivirus , Ranavirus (GIV), and Megalocystivirus (TGIV), which infect vertebrate hosts and Betairidovirinae includes Iridovirus and Chloriridovirus, which infect invertebrate hosts. (biomedcentral.com)
  • Coronaviruses infect vertebrates and may cause acute respiratory distress syndrome (ARDS) with high morbidity and mortality rates, depending on species [ 1 , 2 ]. (hindawi.com)
  • Adenoviruses commonly infect vertebrates, including humans and nonhuman primates ( 1 ). (cdc.gov)
  • Once considered a unique feature of vertebrate patterning, components of the retinoic acid (RA) signalling pathway, including both RA and the retinoid (RX) class of receptors, have been found within invertebrate genomes. (europa.eu)
  • The experimental results showed that four conserved epitopes among the Iridovirideae family, one exclusive epitope for invertebrate subfamily and two exclusive epitopes for vertebrate family were predicted. (biomedcentral.com)
  • Vast arrays of vertebrate and invertebrate creatures can envenomate humans. (medscape.com)
  • In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
  • While deletion of the N-terminal extension had no significant functional impact in HeLa cells, our results suggest that the human Bcl2l10 protein evolved a calcium-binding motif in its alpha 5-alpha 6 interhelical region by acquiring critical negatively charged residues. (sfr-biosciences.fr)
  • Additional protein domains found at their C termini have been used to classify TRIM proteins into subfamilies. (elifesciences.org)
  • In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
  • O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal development of the vertebrate embryo. (rcsb.org)
  • It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)
  • Uncharacterized protein Chromosome 16 Open Reading Frame 71 is a protein in humans, encoded by the C16orf71 gene. (wikipedia.org)
  • One non-protein coding transcript variant was identified for the gene. (wikipedia.org)
  • Thus this paper describes, for the first time, an MT gene identified from macroalgae which is induced by copper exposure and whose encoded protein product binds cadmium and copper. (portlandpress.com)
  • While studying the activity of BRCA2 gene promoter in breast cancer cells, we discovered that this promoter has bi-directional activity and the product of the reverse activity (a ZAR1-like protein, we named ZAR2) silences the forward promoter at the G0/G1 phase of the cell. (biomedcentral.com)
  • The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. (biomedcentral.com)
  • The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. (biomedcentral.com)
  • Supported by the availability of gene manipulation technologies such as RNA interference and/or transgenesis, this work provides a basis for future functional explorations of helminth TIMPs and, in particular, of their role/s in fundamental biological pathways linked to long-term establishment in the vertebrate hosts, with a view towards the development of novel approaches for the control of neglected helminthiases. (biomedcentral.com)
  • Problems occur, for instance, when a key vitamin is missing from our diet or a protein is compromised by a faulty gene. (rcsb.org)
  • Hexon is the most abundant protein in the icosahedral capsid, and the hexon gene is commonly analyzed to characterize and determine adenovirus types ( 5 ). (cdc.gov)
  • To best fit the sequence data for the hexon gene, we used the DNA/Protein model test to identify the optimal evolutionary model, GTR+Γ+I (general time reversible + gamma + invariable). (cdc.gov)
  • The majority of the predicted interactions involved with the protein related to regulation of mitotic processes, cellular differentiation, proliferation, metabolism, and signaling. (wikipedia.org)
  • Protein-protein interactions (PPIs) are essential for understanding cell physiology in normal and pathological conditions, as they might involve all cellular processes. (bvsalud.org)
  • These proteins cover the surface of the virus, are the main targets of the host's cellular immune response, and play major roles in the infection process ( 1 , 3 , 4 ). (cdc.gov)
  • Although central to autophagy, targeted proteins have also a high number of connections with proteins of other cellular functions. (sfr-biosciences.fr)
  • Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
  • In protein science , Molecular Chaperones , in our body's cells, are a family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (wellnessadvantage.com)
  • Serine was the second most abundant, contributing 10.19% to the overall molecular weight. (wikipedia.org)
  • Glycine decarboxylase, or P-protein, is a pyridoxal 5'-phosphate (PLP)-dependent enzyme in one-carbon metabolism of all organisms, in the glycine and serine catabolism of vertebrates, and in the photorespiratory pathway of oxygenic phototrophs. (nih.gov)
  • Peptidylprolyl isomerases (PPIase) cyclophilin A (CypA, encoded by PPIA ) is a typical member of the Cyclophilin family and is involved in protein folding/translocation, signal transduction, inflammation, immune system regulation, apoptosis and virus replication. (chinagene.cn)
  • It is frequently associated with other domains typical for proteins in signal transduction processes. (embl.de)
  • PCC 6803 is an α2 homodimer with high homology to eukaryotic P-proteins. (nih.gov)
  • The clinical C31 online artificial coverage treatments enriched for time Integrate have aimed from the Eukaryotic transgenic vertebrate scan Purification accuracy HEK293 and CHO microRNAs, which are from artifacts of the observed Hamster. (scoutconnection.com)
  • Other missense variant is known to change same aminoacid residue: Variant chr15-89327200-G-T is described in ClinVar as [Likely_pathogenic]. (genebe.net)
  • Recent studies have suggested that conservative missense mutations distal to the OGT catalytic domain lead to X-linked intellectual disability in boys, but it is not clear if this is through changes in the O-GlcNAc proteome, loss of protein-protein interactions, or misprocessing of HCF1. (rcsb.org)
  • Computer molecular dynamics simulations showed the de novo missense mutation is likely to affect TBX1-DNA interaction. (biomedcentral.com)
  • 3) Mutations of Q12, A53, and Y54 of GFKAR beta indicate that these three residues are important for ligand binding (particularly L-glutamate), which is consistent with the sequence homology to bacterial periplasmic binding proteins. (aspetjournals.org)
  • Solid evidence, leveraging both in vivo and in vitro studies, reveals the molecular requirements for Bonus' function as a transcriptional repressor, including a key role for sumoylation. (elifesciences.org)
  • It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic proteins and proteolytic maturation of the transcriptional coregulator Host cell factor 1 (HCF1). (rcsb.org)
  • Following recognition of TLR ligands, TLRs elicit innate immunity by activating multiple intracellular signaling cascades including variable adaptor proteins and transcriptional factors. (frontiersin.org)
  • Ligand-binding characteristics and related structural features of the expressed goldfish kainate receptors: identification of a conserved disulfide bond and three residues important for ligand binding. (aspetjournals.org)
  • The observation of the disulfide bond that acts to stabilize the closed form suggests a molecular mechanism for the redox-dependent activation of glycine decarboxylase observed earlier. (nih.gov)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • The crystal structure of the CorA homologue from Thermotoga maritima has been solved at 3.9 Å resolution for the full-length protein and at 1.85 Å resolution for the cytoplasmic domain ( Lunin et al . (tcdb.org)
  • Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
  • However, only few protein structures have been currently resolved for the Iridoviridae family, none of which are associated with the outer capsid proteins. (biomedcentral.com)
  • In our body's cells, Molecular Chaperones take part in the assembly process of polypeptides, but are not components of the final structures. (wellnessadvantage.com)
  • This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
  • Liqian Ren, Wei Liu, Wenbo Li, Wenjun Liu, Lei Sun. Peptidylprolyl cis/trans isomerase activity and molecular evolution of vertebrate Cyclophilin A[J]. Hereditas(Beijing), 2016, 38(8): 736-745. (chinagene.cn)
  • Among these antibiotics Ribostamycin was identified as a potent drug against the Protein Disulphide Isomerase with a significant binding energy of -7.35Kcal/mol with formation of 5 hydrogen bonds. (ijpsr.com)
  • nature structural & molecular biology Abstract In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. (cbinsights.com)
  • 1 From the Department of Cell and Molecular Biology, Uppsala University, S-751 24 Uppsala, Sweden. (nih.gov)
  • view conditions 3 and 4 to effect the quick efficiency in the ethylene analyzed in direction This will have in the time uptake incorporated in contamination plant of protein( trait4 The comprising of the nuclear network inspection, strategy, is chosen in ultra- In intercept, it gives highly the New low produced by the hazard to generate addition model transfer 3, expression. (scoutconnection.com)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • In our body, Molecular Chaperones are able to inhibit the aggregation of partially denatured proteins and refold them. (wellnessadvantage.com)
  • Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils. (rcsb.org)
  • At the Living Systems Institute, we collaborate with biophysicists using super-resolution microscopy to describe these signalling processes in a quantitative way on a molecular level. (exeter.ac.uk)
  • Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
  • Considering the reliance of female eggs on calcium-dependent proteins and calcium-regulated processes and the exceptional longevity of oocytes in the primate lineage, we propose that this microstructural variation may be an adaptive feature associated with high maternal expression of this Bcl-2 family member. (sfr-biosciences.fr)
  • These results indicate that Notch S3-site cleavage and APP γ-site cleavage are distinct presenilin-dependent processes and support a functional interaction between nicastrin and presenilins in vertebrates. (hku.hk)
  • Among several groups of helminth molecules involved in the host-parasite interplay, protease inhibitors have been the subject of intense investigations due to their roles in a range of fundamental molecular processes, including regulation of host proteases and modulation of the host's immune response [ 18 ]. (biomedcentral.com)
  • Alanine was the most abundant amino acid, contributing to 11.54% of the molecular weight of the protein. (wikipedia.org)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • RA receptor (RAR)-gamma expression is essential for vertebrate chondrocyte differentiation. (europa.eu)
  • Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. (tcd.ie)
  • Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
  • In our body, Metallochaperone is a family of soluble metal binding proteins involved in the intracellular transport of specific metal ions and their transfer to the appropriate metalloprotein precursor. (wellnessadvantage.com)
  • Finally, we showed that Bonus SUMOylation is mediated by the SUMO E3-ligase Su(var)2-10, revealing that although SUMOylation of TIF1 proteins is conserved between insects and mammals, both the mechanism and specific site of modification is different in the two taxa. (elifesciences.org)
  • Accelerated rates of globin evolution were found in lineages of cold-blooded vertebrates, some marsupials, and early placental mammals, while slower rates were found in warm-blooded vertebrates, especially higher primates. (pharmaceuticalintelligence.com)
  • isoelectric point, 4.6) [ 6 ], is widely distributed among tissues of mammals and other vertebrates [ 7 ]. (hindawi.com)
  • So far, most caveolin-related research has been conducted in mammals, but the proteins have also been found in other animals, including Xenopus laevis, Fugu rubripes , and Caenorhabditis elegans . (biomedcentral.com)
  • HbFe(III)-OOradical dot, HbFe(III)-OONO and protein-caged [HbFe(III)-Oradical dotradical dotNO2] are proposed intermediates in a reaction mechanism that combines both O-atoms of O2 with radical dotNO to form nitrate and HbFe(III). (pharmaceuticalintelligence.com)
  • Furthermore, the Spätzle (Spz) family ligands for the Toll receptor are transcriptionally upregulated by activated JNK signalling in a non-cell-autonomous manner, providing a molecular mechanism for JNK-induced Toll pathway activation. (sdbonline.org)
  • Keratins (also described as cytokeratins ) are polymers of type I and type II intermediate filaments that have been found only in chordates ( vertebrates , amphioxus , urochordates ). (wikipedia.org)
  • Our analysis provides a framework to perform future experimental and comparative studies to understand the roles of the ancestral chordate versions of GPCRs that predated the divergence of the urochordates and the vertebrates. (biomedcentral.com)
  • On a taxonomic and phylogenetic scale, Ciona intestinalis is a protochordate belonging to the ascidian class of urochordates that diverged from a lineage leading to the vertebrates approximately 520 million years ago [ 1 ]. (biomedcentral.com)
  • These results are consistent with the notion that the ligand-binding domain has close structural similarities to bacterial periplasmic binding proteins. (aspetjournals.org)
  • In addition we have investigated components of the retinoic acid and hedgehog signalling pathways, both of which have relevant roles in vertebrate chondrogenesis. (europa.eu)
  • These findings revealed a total water flux between the bulk and the protein inside in the Meta II state, and suggested that these pathways provide water molecules to the crucial sites of the activated rhodopsin. (cusabio.com)
  • Nearly 39% of Ciona GPCRs have unambiguous orthologs of vertebrate GPCR families, as defined for the human, mouse, puffer fish and chicken genomes. (biomedcentral.com)
  • ARHGAP1, ZNFX1, and MBTPS1 are associated with regulation in signaling and metabolism while PLVAP is associated with the formation of small lipid rafts in the plasma membrane of vertebrate endothelial and adipose cells. (wikipedia.org)
  • Caveolins can serve as protein markers of caveolae ('little caves'), invaginations in the plasma membrane 50-100 nanometers in diameter. (biomedcentral.com)
  • The yeast metal resistance proteins, which are 850-900 amino acyl residues in length, also exhibit two or three putative TMSs. (tcdb.org)
  • Influenza virus A is a single-strand, negative-sense RNA virus whose genome consists of 8 RNA segments that encode 10 proteins ( 1 ). (cdc.gov)
  • Data indicate molecular dynamics simulations and site-directed fluorescence experiments on arrestin-1 interactions with rhodopsin, showing that loops within the C-edge of arrestin function as a membrane anchor. (cusabio.com)
  • Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. (ijpsr.com)
  • These 396 proteins were employed in homology modelling through the SWISS Model. (ijpsr.com)
  • The homology model of the proteins generated in this study can be exploited in further research using computational drug discovery and design to accelerate the research on disease management and pathogen control of Erysipelothrix rhusiopathiae induced swine erysipelas. (ijpsr.com)
  • This extant ascidian occupies a crucial place in the "Tree of life" as an out-group to the vertebrates and hence studies addressing evolutionary aspects of Ciona have the potential to offer insight into some of the most intriguing questions about the origin of the vertebrates from a chordate lineage. (biomedcentral.com)
  • Bcl2l10 is an antiapoptotic member of the Bcl-2 family that has evolved rapidly throughout the vertebrate lineage and which shows conserved abundant expression in eggs and oocytes. (sfr-biosciences.fr)
  • If a genetic programme for specifying cartilage cells arose only once during metazoan evolution, elements of a shared molecular fingerprint will be present in both cephalopods and vertebrates, despite their long independent evolutionary history. (europa.eu)
  • In addition, the genetic variation and molecular evolution analysis showed that these vertebrate CypA proteins had the same CsA binding site and the PPIase active sites. (chinagene.cn)
  • Positive Darwinian natural selection can bring about an increase in either component, and negative or stabilizing selection in protein evolution can lead to decreases. (pharmaceuticalintelligence.com)
  • Adult and embryonic Brugia malayi are shown to be susceptible to inhibitors of vertebrate prolyl 4-hydroxylase, with exposed parasites exhibiting pathologies consistent with a disruption in cuticle biosynthesis. (embl.de)
  • PPI network analysis, specifically host-pathogen PPI (HP-PPI), provides insights into the molecular interactions between the shrimp and pathogens. (bvsalud.org)
  • WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (embl.de)
  • In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
  • In the last four decades, toxinologists around the world have elucidated a wealth of information on the various classes of constituent proteins and peptides that provide each cone with its own distinctive, complex, and sophisticated bioarmamentarium. (medscape.com)
  • Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
  • For example, the European cuttlefish, sepia officinalis, possesses cartilage tissues with an unparalleled histological similarity with vertebrate cartilages. (europa.eu)
  • Caveolin-3 (Cav-3) has greater protein-sequence similarity to Cav-1 than to Cav-2, but it is expressed mainly in muscle cells, including smooth, skeletal, and cardiac myocytes. (biomedcentral.com)
  • TRIM/RBCC is an ancient protein family characterized by the presence of an N-terminal RING finger domain closely followed by one or two B-boxes and a coiled coil domain. (elifesciences.org)
  • Using a proline-rich domain derived from formin (a product of the murine limb deformity locus), we have identified a family of murine formin binding proteins (FBP's), each of which contains one or more of a special class of tyrosine-rich WW domains. (embl.de)
  • Keratin ( / ˈ k ɛr ə t ɪ n / [1] [2] ) is one of a family of structural fibrous proteins also known as scleroproteins . (wikipedia.org)
  • Interestingly, immunity-associated GTPase family M (IRGM), the most targeted protein, was found to interact with the autophagy-associated proteins ATG5, ATG10, MAP1CL3C and SH3GLB1. (sfr-biosciences.fr)
  • In this respect, and also with respect to topology, MIT family members resemble channel proteins. (tcdb.org)
  • Low-molecular-weight kainate receptors from nonmammalian vertebrate brain belong structurally to the ionotropic glutamate receptor superfamily. (aspetjournals.org)
  • Taxonomic distribution of proteins containing WW domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with WW domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing WW domain in the selected taxonomic class. (embl.de)
  • Ecdysone binds to the Ecdysone Receptor (EcR), which heterodimerizes with Ultraspiracle (USP), an ortholog of the vertebrate Retinoid X Receptor (RXR). (sdbonline.org)
  • Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)