MechanismsDynamicsBiochemistrySimulationsPhysiologyProteins2023MechanismCellular2017SieveBiology of tMembraneLaboratoryGeneticsRegulationMoleculesPharmacologyNeuroscienceArtificial molecular machinesATPaseNucleocytoplasmic transportPlantsCargoReceptorsJunctionsVariationalClinicallyMammalianControllingCopper transportRecognitionHumansEquilibriumPotentiallyAspectsSpatialInteractionMotorsDiffusionResearchBasisChemicalMetabolismCell
Mechanisms25
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- Further attention is given to the regulation of proton transport mechanisms and cellular mechanisms to resist damage from highly acidic environments. (powells.com)
- It is important to understand how these mechanisms are dynamically regulated by pivotal molecular targets and potentially reversed in the context of cardioprotection [ 6 ]. (hindawi.com)
- For instance, some studies have suggested that in addition to antioxidant enzymes, nitric oxide synthases (NOSs), and other traditional enzymes, novel molecular targets such as mitochondria-targeting hydrogen sulfide (H 2 S) donor AP39 and its auxiliary targets have recently been identified as critical participants in H 2 S synthesis for modulating the postischemic cardiomyocyte survival in a manner independent of classical cytosolic signaling mechanisms [ 7 , 8 ]. (hindawi.com)
- There are still many unknown aspects of MIRI's key molecular mechanisms that merit further study through both in vivo and in vitro MIRI models to discover novel functional molecular targets and identify associated cardioprotective mechanisms, which is important for improving the current treatment of AMI and MIRI. (hindawi.com)
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- The aim of this unit is to examine the molecular mechanisms of protein sorting in eukaryotes, and will review recent data demonstrating that some of these processes are fundamental to all living cells. (manchester.ac.uk)
- Mechanisms of ion transport in carbonate-based and oligoether-based liquid electrolytes will be compared with those in polyether-based linear and comb-branched binary polymer electrolytes and ionic liquids. (aiche.org)
- We analyzed the molecular mechanisms leading to glutamate release from rat primary cultures of RPE cells, under isosmotic conditions. (molvis.org)
- My main research focus is on protein transport mechanisms and rhomboid proteins. (queensu.ca)
- Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. (mdpi.com)
Dynamics10
- Diffraction from exciton density gratings has been used to study dynamics of exciton transport 21 , but this approach requires high exciton densities to be created, which introduces challenges such as exciton-exciton interactions and material damage. (nature.com)
- Depolarized dynamic light scattering, broadband dielectric spectroscopy, rheology, and differential scanning calorimetry were employed to systematically study the influence of MW on the mechanism of ionic transport and segmental dynamics in these materials. (osti.gov)
- WE STUDY POLYMERS, PROTEINS, AND THEIR HYBRIDS TO DESIGN THE NEXT GENERATION OF SOFT MATERIALS using molecular dynamics simulations, high throughout computations, and enhanced sampling methods. (ufl.edu)
- P. Palffy-Muhoray, T. Kosa and E. Weinan, Dynamics of a light driven molecular motor. (esaim-m2an.org)
- Rev. B 100 , 165412 (2019)] that captures slow diffusive relaxation inaccessible to molecular dynamics (MD) simulations. (aip.org)
- To gain insight into how this can affect nucleocytoplasmic transport, we use coarse-grained molecular dynamics simulations to study the molecular interaction of poly-PR, the most toxic DPR, with several Kapβs (importins and exportins). (rug.nl)
- Nonequilibrium molecular dynamics simulations provide an efficient way of calculating transport coefficients of molecular fluids. (aiche.org)
- Molecular dynamics (MD) simulations were performed to study the transport properties of gases (oxygen, nitrogen, and methane) in amorphous cis -1,4-polyisoprene over a wide range of temperatures. (pku.edu.cn)
- Molecular Dynamics Simulation of Gas Transport in Amorphous Polyisoprene[J]. Acta Phys. (pku.edu.cn)
- Results of molecular dynamics simulations of a number of binary and single ion conductor electrolytes will be presented. (aiche.org)
Biochemistry3
- 2022 'Biochemistry and Molecular Basis of Intracellular Flavonoid Transport in Plants' Preprints. (preprints.org)
- major program is offered jointly by the Department of Chemistry and Department of Molecular Biology and Biochemistry. (sfu.ca)
- A suggested MSc student project in bioinformatics potentially comprising also biochemistry and molecular microbiology studies. (lu.se)
Simulations1
- The COMPASS force field was used as the molecular mechanics force field in the simulations. (pku.edu.cn)
Physiology2
- This course element will cover the medically and clinically related fundamental principles of cellular and molecular physiology that form the basis for the understanding of pharmacology (use of drugs to treat human disease). (le.ac.uk)
- Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1. (bvsalud.org)
Proteins5
- This protein is part of the P-type ATPase family, a group of proteins that transport metals into and out of cells by using energy stored in the molecule adenosine triphosphate (ATP). (medlineplus.gov)
- Within liver cells, copper-transporting ATPase 2 is found in a structure called the Golgi apparatus, which modifies newly produced enzymes and other proteins. (medlineplus.gov)
- Davydov's original solitons appeared in the 1970s as a candidate for vibrational energy carriers in proteins, thanks to their association with the Fröhlich Hamiltonian and the Holstein molecular crystal model. (ntu.edu.sg)
- Davydov's solitons originated in the investigation of vibrational energy transport in proteins in the 1970s. (ntu.edu.sg)
- Sometimes various globular proteins embedded in the matrix function as receptors and help transport molecules across the membrane. (msdmanuals.com)
20231
- The 2023 Gordon Conference on Molecular Membrane Biology will focus on the latest insights into organelle biogenesis and function, membrane trafficking, the connection to metabolism, and interorganelle communication. (grc.org)
Mechanism4
- Our findings demonstrate that the mechanism of exciton transport depends strongly on the nanoscale morphology, which has wide implications for the design of excitonic materials and devices. (nature.com)
- Here, using both physiological and molecular studies, we describe the mechanism of branchial urea excretion in this species. (mcmaster.ca)
- The structures reveal the specific molecular interactions between SRP and the emerging signal sequence and the elements that regulate GTPase activity of SRP·SR. Our results suggest the molecular mechanism of how eukaryote-specific elements regulate the early and late stages of SRP-dependent protein targeting. (nih.gov)
- Fatemi N, Sarkar B. Molecular mechanism of copper transport in Wilson disease. (medlineplus.gov)
Cellular4
- The emphasis is on gastric acid secretion and the role of the H+, K+-ATPase, but molecular and cellular information on other P-, V- and F-type H+-ATPases, in bone, kidney, plants and yeast, as well as other cation ATPases, are included for important comparisons. (powells.com)
- Some examples of biologically important molecular motors: Cytoskeletal motors Myosins are responsible for muscle contraction, intracellular cargo transport, and producing cellular tension. (wikipedia.org)
- Naturwissenschaftler download copper transport and its disorders molecular and cellular Ingenieure for planning types on assignment. (aheinz.net)
- GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
20171
- Posted on August , 2017 in He is copiers of his eBooks and download copper transport and beams, studying himself both a chemistry in the calculated analysis and a 1990-06-01T12:00:00Full-Service Relationships. (aheinz.net)
Sieve8
- A molecular sieve 5A can absorb molecules whose critical size is less than 5A. (abbaworld.com)
- 5A molecular sieve may also be used to produce pressure-swing hydrogen. (abbaworld.com)
- PSA Nitrogen Carbon Molecular Sieve carbon molecular sieve (CMS) is a new nonpolar absorbent with adsorbing oxygen molecule to get nitrogen -enriched air at normal temperature. (fazendomedia.com)
- The ability of separating the air decided by propagation rate, adsorptive attraction or the same effect of each gas in carbon molecular sieve pore. (fazendomedia.com)
- PSA nitrogen generator uses a carbon molecular sieve as sorbent and produces nitrogen by making use of the PSA principle. (fazendomedia.com)
- Under certain pressure, a carbon molecular sieve has different oxygen/ nitrogen . (fazendomedia.com)
- PSA Nitrogen Adsorbent (CMS-220) Carbon Molecular Sieve Carbon Adsorbent High Adsorption Capacity Product Description Nitrogen generation by Pressure Swing Adsorption ( PSA ) process is a technology used to separate nitrogen from a mixture of gases under pressure according to the special selective adsorption characteristics of the Carbon Molecular Sieves (CMS). (fazendomedia.com)
- Pressure 0.8 Mpa Atmospheric dew point ≤－40℃ Working Principle Description: When the air pressure increases, carbon molecular sieve will adsorb a large amount of oxygen, carbon dioxide and water. (fazendomedia.com)
Biology of t1
- The Molecular Biology of the Cell 4th edn (Garland Science, 2002). (nature.com)
Membrane4
- The Molecular Membrane Biology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. (grc.org)
- The meeting will include sessions on novel techniques and their application in molecular membrane biology, and relevance for diseases. (grc.org)
- This GRC will be held in conjunction with the "Molecular Membrane Biology" Gordon Research Seminar (GRS). (grc.org)
- Transport of H2S and HS(-) across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl(-)/HS(-) exchange. (bvsalud.org)
Laboratory5
- The organs were transported in liquid nitrogen to the laboratory. (who.int)
- Before the samples are transferred to LMSE, the reference center ensures a significant proportion of TB laboratory services including microscopic examination and a molecular test for Mycobacterium tuberculosis ( M. tuberculosis) identification and detection of common mutations in rpoB gene, associated to rifampicin resistance (GeneXpert). (who.int)
- All anticoagulated samples were transported within 4 hours to the laboratory for processing. (cdc.gov)
- cytomorphologic estimation and laboratory data were provided from the local health facilities, mostly generated 1 year before this molecular analysis. (cdc.gov)
- Comparison of clinical and laboratory findings of patients with PCR-positive and -negative results showed no clear differences, possibly related to the length of time between the acute phase of illness and the sampling for molecular analysis, which was usually 1 year. (cdc.gov)
Genetics1
- This course element will introduce you to the fundamental principles of medically related cell biology and molecular and clinical genetics. (le.ac.uk)
Regulation2
- General scheme of plant transport processes and its regulation. (elte.hu)
- Regulation of intestinal iron transport. (medscape.com)
Molecules5
- Energy transport in nanostructured thin films and crystals (such as those composed of molecules, polymers and colloidal quantum dots) occurs by the motion of tightly bound electron-hole pairs, known as excitons 1 . (nature.com)
- Fig. 4: Summary of possible non-directional motions observed in mechanically interlocked molecules incorporated in extended molecular frameworks. (nature.com)
- Stoddart, J. F. Mechanically interlocked molecules (MIMs) - molecular shuttles, switches, and machines (Nobel Lecture). (nature.com)
- Interestingly, we found that exchange of solvent molecules in the carbonate-based liquid electrolytes and pyrrolidinium-based ionic liquids significantly contributes to lithium transport, while in oligoethers lithium moves primarily by vehicular motion with its first coordination shell. (aiche.org)
- Any molecular molecules which can be adsorbed using 3A and 4A molecularsieves can also be adsorbed via 5A. (abbaworld.com)
Pharmacology2
- Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
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Neuroscience1
- Molecular neuroscience has largely focused on the functions of protein-coding genes, which account for less than 2% of our DNA. (lu.se)
Artificial molecular machines2
- Molecular motors are natural (biological) or artificial molecular machines that are the essential agents of movement in living organisms. (wikipedia.org)
- Scientists have demonstrated that they can design and synthesize artificial molecular machines that operate efficiently in isolation - for example, at high dilution in solution - fuelled by chemicals, electricity or light. (nature.com)
ATPase8
- The ATP7B gene provides instructions for making a protein called copper-transporting ATPase 2. (medlineplus.gov)
- Copper-transporting ATPase 2 is found primarily in the liver, with smaller amounts in the kidneys and brain. (medlineplus.gov)
- Copper-transporting ATPase 2 is also important for the removal of excess copper from the body. (medlineplus.gov)
- Here, copper-transporting ATPase 2 supplies copper to a protein called ceruloplasmin, which transports copper to other parts of the body via the blood. (medlineplus.gov)
- If copper levels in the liver get too high, copper-transporting ATPase 2 leaves the Golgi and transfers copper to small sacs (vesicles) for elimination through bile. (medlineplus.gov)
- About half the mutations change one of the protein building blocks (amino acids) used to make copper-transporting ATPase 2. (medlineplus.gov)
- This type of mutation alters the 3-dimensional structure of the protein or its stability, preventing copper-transporting ATPase 2 from functioning properly. (medlineplus.gov)
- Other types of mutations delete or insert small segments of DNA within the ATP7B gene or introduce a stop signal in the gene's instructions for making copper-transporting ATPase 2. (medlineplus.gov)
Nucleocytoplasmic transport2
- Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. (rug.nl)
- nucleocytoplasmic transport and plant defense signaling). (uni-goettingen.de)
Plants1
- As a scientist, I have 30 years of experience conducting research on various molecular problems using a range of organisms, from bacteria to plants. (queensu.ca)
Cargo4
- Overall, our results suggest that poly-PR might cause length-dependent defects in cargo loading, cargo release, Kapβ transport and Ran gradient across the nuclear envelope. (rug.nl)
- Kinesin moves cargo inside cells away from the nucleus along microtubules, in anterograde transport. (wikipedia.org)
- Dynein produces the axonemal beating of cilia and flagella and also transports cargo along microtubules towards the cell nucleus, in retrograde transport. (wikipedia.org)
- Molecular machines are essential dynamic components for fuel production, cargo delivery, information storage and processing in living systems. (nature.com)
Receptors1
- Jafarinia, H , Van der Giessen, E & Onck, PR 2022, ' Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors ', Scientific Reports , vol. 12, nr. 1, 21324. (rug.nl)
Junctions5
- Molecular junctions offer significant potential for enhancing thermoelectric power generation. (lu.se)
- Quantum interference effects and associated sharp features in electron transmission are expected to enable the tuning and enhancement of thermoelectric properties in molecular junctions. (lu.se)
- Our detailed experimental single-molecule break-junction studies of conductance and thermopower, the latter being the first ever performed on porphyrin molecular junctions, revealed that the electrical conductance of the P1 and Zn-P1 junctions is relatively close, and the same holds for P2 and Zn-P2, while there is a 6 times reduction in the electrical conductance between P1 and P2 type junctions. (lu.se)
- We use a many-body theory that properly describes the complementary wave-particle nature of the electron to investigate transport in an ensemble of Pt-benzene-Pt junctions. (beilstein-journals.org)
- 1. In addition, we demonstrate that the isolated resonance approximation is extremely accurate and determine that transport occurs predominantly via the HOMO orbital in Pt-benzene-Pt junctions. (beilstein-journals.org)
Variational2
- M. Chipot, D. Kinderlehrer and M. Kowalczyk, A variational principle for molecular motors. (esaim-m2an.org)
- Momentum-space projection of these solitary waves turned up to be accurate variational ground-state wave functions for the extended Holstein molecular crystal model, lending unambiguous evidence to the absence of formal quantum phase transitions in Holstein systems. (ntu.edu.sg)
Clinically1
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Mammalian1
- Furthermore, urea transport was inhibited by classic inhibitors of mammalian and piscine urea transporters in the order thiourea>N-methylurea>acetamide. (mcmaster.ca)
Controlling1
- By controlling the morphology of the thin film, we show that this transition to subdiffusive transport occurs at earlier times as disorder is increased. (nature.com)
Copper transport3
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Recognition2
- Emerging applications of these dynamic smart materials in the contexts of molecular recognition, optoelectronics, drug delivery, photodynamic therapy and water desalination are highlighted. (nature.com)
- With the increasing molecular definition of several types of collagen and recognition of the concentration of certain types in cartilage tissue, many skeletal dysplasias came to be defined as collagen abnormalities. (medscape.com)
Humans1
- However, molecular detection of natural Ehrlichia infection detected in humans in Costa Rica has not been reported. (cdc.gov)
Equilibrium1
- P. Reimann, Brownian motors: noisy transport far from equilibrium. (esaim-m2an.org)
Potentially1
- Current knowledge suggests that a glutathione S-transferase-like protein (ligandin) protects anthocyanins and potentially proanthocyanidin precursors during the transport to the central vacuole. (preprints.org)
Aspects1
- WIRES Computational Molecular Science reviews and highlights research on computational molecular sciences that utilize techniques of rigorous chemical as well as physical theories and computer-based modelling, relying on specialized hardware and software development, algorithm design, and database management to examine and elucidate all aspects of the molecular sciences. (ntu.edu.sg)
Spatial2
- Here we report a spatial, temporal and spectral visualization of exciton transport in molecular crystals and disordered thin films. (nature.com)
- This energy transfer process is a simultaneous exchange of two electrons between nearest molecular neighbours, the rate of which depends on the spatial and energetic overlap of the two molecular wavefunctions. (nature.com)
Interaction1
- These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. (yeastgenome.org)
Motors5
- for example, many protein-based molecular motors harness the chemical free energy released by the hydrolysis of ATP in order to perform mechanical work. (wikipedia.org)
- One important difference between molecular motors and macroscopic motors is that molecular motors operate in the thermal bath, an environment in which the fluctuations due to thermal noise are significant. (wikipedia.org)
- Synthetic molecular motors have been created by chemists that yield rotation, possibly generating torque. (wikipedia.org)
- There are two major families of molecular motors that transport organelles throughout the cell. (wikipedia.org)
- Astumian, R. D. & Derényi, I. Fluctuation driven transport and models of molecular motors and pumps. (nature.com)
Diffusion4
- Using tetracene as an archetype molecular crystal, the imaging reveals that exciton transport occurs by random walk diffusion, with a transition to subdiffusion as excitons become trapped. (nature.com)
- Such approaches produce only an average 'diffusion length', L D , defined as the mean displacement of an exciton during its lifetime, but no direct evidence exists that exciton transport occurs by hopping-driven diffusion. (nature.com)
- S. Hastings and D. Kinderlehrer, Remarks about diffusion mediated transport: thinking about motion in small systems. (esaim-m2an.org)
- D. Kinderlehrer and M. Kowalczyk, Diffusion-mediated transport and the flashing ratchet. (esaim-m2an.org)
Research3
- Articles published in Journal of Molecular Pharmaceutics & Organic Process Research have been cited by esteemed scholars and scientists all around the world. (omicsonline.org)
- Journal of Molecular Pharmaceutics & Organic Process Research has got h-index 14, which means every article in Journal of Molecular Pharmaceutics & Organic Process Research has got 14 average citations. (omicsonline.org)
- Following are the list of articles that have cited the articles published in Journal of Molecular Pharmaceutics & Organic Process Research . (omicsonline.org)
Basis1
- Understanding the molecular basis of AS is critical for the development of specific therapies. (springer.com)
Chemical2
- PrimeStore MTM transport media contains guanidine thiocyanate, which produces a dangerous chemical reaction that releases cyanide gas when exposed to bleach (sodium hypochlorite). (cdc.gov)
- A chemical gradient was still detected at pH 7.4 in the usual HEPES-based transport buffer in contrast to what was observed in a bicarbonate/CO 2 -buffered medium. (aspetjournals.org)
Metabolism1
- Li M. Drug transport and transport-metabolism interplay in the human and rat intestine. (omicsonline.org)
Cell1
- An HeLa-derived cell line was employed, in which folate-specific transport was mediated exclusively by PCFT. (aspetjournals.org)