• 1, 2, 3] Approximately 20% of the genes expressed in human leukocytes are regulated positively or negatively by glucocorticoids. (medscape.com)
  • At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
  • Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
  • The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
  • The whole mitogenome of O. conispadiceus is 16,027 basepairs (bp) in length with a base composition of 41.4% A, 34.8% T, 16.1% C, 7.7% G and contains 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a major non-coding region (MNR). (tonmo.com)
  • In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
  • Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
  • The protein produced from the EWSR1/FLI1 fusion gene, called EWS/FLI, has functions of the protein products of both genes. (medlineplus.gov)
  • which is the first step in the production of proteins from genes. (medlineplus.gov)
  • The FLI protein controls the growth and development of some cell types by regulating the transcription of certain genes. (medlineplus.gov)
  • It is thought that the EWS/FLI protein turns the transcription of a variety of genes on and off abnormally. (medlineplus.gov)
  • The NF-AT family of transcription factors are regulators of early immune response genes in T cells following their activation by CD40L, FasL and interleukins including IL-2, -3, -4 and -5. (bdbiosciences.com)
  • In vitro , NF-AT cooperates with the mitogenic transcription factor AP-1 to induce multiple cytokine genes. (bdbiosciences.com)
  • These proteins are differentially expressed in tissues, suggesting that each may activate distinct sets of genes. (bdbiosciences.com)
  • We performed a genome-wide microarray analysis of lungs exposed to single dose multi-walled CNT (MWCNT) by pharyngeal aspiration for 7 days and compared to vehicle and carbon black controls, to identify differentially expressed genes and mechanisms that potentially function in the development of CNT-induced lung fibrosis. (cdc.gov)
  • We demonstrated that MWCNT induced the expression of Th2 cytokines interleukin (IL)-4 and IL-13, and a panel of signature downstream target genes including I14i1, Chia, and Cc11 1/Eotaxin, at the protein level in the lungs. (cdc.gov)
  • Activation of Th2-type responses is featured by the activation of Il-4Ra/STAT6 and the up-regulation of GATA-3, which serves as a transcription factor and mediates the transactivation of Th2 target genes, in CD4+cess. (cdc.gov)
  • The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
  • The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related genes. (nature.com)
  • Protein-protein interaction network was further constructed, among which 5 vital genes including TP53, AKT1, TNF, MYC and CCND1 were recognized. (bvsalud.org)
  • We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
  • [ 4 ] The 6 genes involved in WS are PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2), with different frequencies. (medscape.com)
  • Genes to cells : devoted to molecular & cellular mechanisms 2023 0 0. (cdc.gov)
  • Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
  • There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
  • The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. (rochester.edu)
  • The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. (embl.de)
  • We aim to understand the molecular mechanisms that allow plants to integrate beneficial and damaging effects of light and respond to them with striking plasticity. (csic.es)
  • To understand the molecular mechanisms that coordinate these processes we are using genetic, genomic, biochemical and proteomic tools. (csic.es)
  • In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. (caister.com)
  • The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. (caister.com)
  • The Organoid group, previously Clevers group, studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. (hubrecht.eu)
  • However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. (nih.gov)
  • AIM OF THE STUDY: Through the integration of network pharmacology, molecular docking techniques, experimental assays, and bioinformatics analysis, our study aims to forecast the active ingredients, potential targets, and molecular mechanisms underlying the therapeutic efficacy of this herb pair against CRC. (bvsalud.org)
  • 2011). In developing rat lung, 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal) (NNA), a constituent of THS, disrupted signaling mechanisms by decreasing the levels of peroxisome proliferator-activated receptor and up-regulating fibronectin (Rehan et al. (immune-source.com)
  • Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
  • This 'Molecular Perspectives' will highlight several diverse mechanisms of isolated conduction system disease as well as conduction system degeneration associated with other cardiac and non-cardiac disorders. (medscape.com)
  • Understanding of the molecular and ionic mechanisms underlying cardiac conduction is essential for the appreciation of the pathogenesis of conduction abnormalities in structurally normal and altered hearts. (medscape.com)
  • Journal of Molecular Biology 2008, 381 (2), 373-382. (ncl.ac.uk)
  • Nature Structural and Molecular Biology, 23 (7). (sussex.ac.uk)
  • Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
  • PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. (embl.de)
  • Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
  • Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M, Thomas G, Ghysdael J. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. (medlineplus.gov)
  • We aim to understand how plants respond to beneficial and damaging light stimulus by controlling in a coordinated way protein homeostasis, chromatin dynamics and transcriptional networks. (csic.es)
  • We are especially interested in the events that lead to coordinated transcriptional changes during light adaptation as changes in chromatin states, transcription factor stability and protein homeostasis. (csic.es)
  • Activated and released IRE1α acts as an RNase to initiate transcription of XBP1 mRNA and it becomes a transcriptional activator for unfolded protein response (UPR) gene targets, such as BiP and calreticulin ( 10 ). (spandidos-publications.com)
  • In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). (hubrecht.eu)
  • Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)
  • In the last decades, HOX proteins have been extensively studied due to their pivotal role in transcriptional events. (mdpi.com)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)
  • While previous publications have established ESE-1's transcription factor function, we have reported that ESE-1 initiates transformation of MECs via a novel non-nuclear, non-transcriptional mechanism [ 13 ]. (biomedcentral.com)
  • However, the proteins needed for transcriptional control have been reported to be immunogenic and there is often a substantial leakage in the systems (Clackson, 2000). (lu.se)
  • 4] Glucocorticoids are involved in almost every cellular, molecular, and physiologic network of the organism and play a pivotal role in critical biologic processes, such as growth, reproduction, intermediary metabolism, immune and inflammatory reactions, and central nervous system and cardiovascular functions. (medscape.com)
  • STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
  • Central to the self-protective antioxidant system is NF-E2-related aspect (Nrf2), a capncollar basic-region leucine zipper nuclear transcription aspect that mediates the principal cellular protection against the cytotoxic ramifications of oxidative tension, including pathways for xenobiotic cleansing, antioxidants, anti-inflammatory response, DNA fix, molecular chaperones, and proteasome systems. (mingsheng88.org)
  • It is also reported that human PITX2 insufficiency results in cellular and molecular changes leading to atrial electrical and structural remodeling linked to arrhythmogenesis 6 . (nature.com)
  • The use of mouse models, as well as human diseases resulting from deficiencies in the methylation machinery, have been integral parts of understanding the role of these proteins in development and cellular homeostasis. (caister.com)
  • Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. (novusbio.com)
  • Central to the epigenetic control of gene expression is the histone code through which input signals can be translated into a heritable pattern of gene expression defining cellular output states ( Fig. 1 ). (aacrjournals.org)
  • The human ETS (E26 Transformation-Specific) protein family is a diverse group of 27 known transcription factors that regulate such varied cellular processes as differentiation and apoptosis, but also appear to induce oncogenesis when mutated or aberrantly expressed [ 1 - 4 ]. (biomedcentral.com)
  • 2023. Editorial: Role of Transcription Factors and Sigma Factors in Bacterial Stress. (openwetware.org)
  • 2023. Comparative genomics sheds light on transcription factor-mediated regulation in the extreme acidophilic Acidithiobacillia representatives. (openwetware.org)
  • Journal of molecular medicine (Berlin, Germany) 2023 0 0. (cdc.gov)
  • In the present study, we examined the role of protein tyrosine phosphorylation and the mitogen-activated protein kinases, ERK1/2,in mediating BK-induced AP-1 and DNA replication in cultured rat mesangial cells. (nih.gov)
  • BK (10(-9) to 10(-7) M) stimulated a rapid increase in tyrosine phosphorylation of multiple proteins with an estimated molecular mass of 120-130, 90-95, and 44-42 kDa. (nih.gov)
  • 0.05) in phosphorylation of Elk-1, a transcription factor required for growth factor-induced c-fos transcription. (nih.gov)
  • In accord with the stimulation of Elk-1 phosphorylation, BK induced c-fos gene expression and the production of Fos/AP-1 complexes. (nih.gov)
  • AP-1 pathway and that BK mitogenic signaling is critically dependent on protein tyrosine phosphorylation. (nih.gov)
  • Despite rapid expansion of information obtained from researchers, the molecular mechanism of hepatocarcinogenesis and the molecular genetics of HCC remain elusive. (hindawi.com)
  • Knowledge derived from human genetics and from experimental studies in engineered animal models has led to the discovery of multiple molecular defects responsible for progressive conduction system diseases. (medscape.com)
  • Genetic interactions can be used to identify novel components of molecular pathways and can reveal the redundancy that underlies the robustness of genetic networks. (biomedcentral.com)
  • Recently two variants in PARIS were identified in early onset Parkinson's disease in Chinese providing a genetic link of PARIS to PD 7 . (nature.com)
  • Genetic factors might play a substantial role in the incidence of YEL-AVD. (cdc.gov)
  • The major risk factors include chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, environmental carcinogens such as aflatoxin B1 (AFB1), alcoholic cirrhosis, and inherited genetic disorder such as hemochromatosis, Wilson's disease, and tyrosinemia. (hindawi.com)
  • A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
  • Abnormal cardiac development appears to occur through a process that is heterogeneous and complex, with both environmental and genetic risk factors. (cdc.gov)
  • The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
  • The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin. (rochester.edu)
  • The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation. (rochester.edu)
  • Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)
  • Whereas most regions of the genome are constantly methylated these elements are mainly kept free of methylation thereby facilitating the establishment of an open chromatin structure and of initiation of transcription. (caister.com)
  • The epigenetic modification of DNA with 5-methylcytosine is an important regulatory event involved in chromatin structure, genomic imprinting, inactivation of the X chromosome, transcription, and retrotransposon silencing. (caister.com)
  • DNA methyltransferases are not limited to catalyzing DNA methylation, but also take part in the regulation of gene expression through interactions with other proteins that repress transcription and modify chromatin structure. (caister.com)
  • The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
  • Accumulating molecular evidence suggests a general involvement of mitochondrial dysfunction in the underlying molecular mechanism of PD but the mechanistic underpinnings of this link are poorly defined. (nature.com)
  • As its mechanism of action remains unclear, we identified Chtop-interacting proteins using a biotinylation-proteomics approach. (embl.de)
  • Carbon nanotube (CNT)-induced lung fibrosing lesions are delineated by an acute inflammation followed by chronic interstitial fibrosis, for which the molecular mechanism is largely unknown. (cdc.gov)
  • Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
  • ER alerts a self-protective mechanism that is called ER stress during nutrient deprivation, pathogen infection, alterations in redox status, intraluminal Ca 2+ levels and folding defective protein conditions ( 9 ). (spandidos-publications.com)
  • Nevertheless, the potential active ingredients and molecular mechanism remains to be further explored. (bvsalud.org)
  • These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)
  • its molecular mechanism remains unclear. (medscape.com)
  • Surprisingly, chinmo-/- GSCs rely on a new mechanism of competition in which they secrete the extracellular matrix protein Perlecan to selectively evict non-mutant GSCs and then upregulate Perlecan-binding proteins to remain in the altered niche. (lu.se)
  • The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
  • The EWS/FLI protein has the DNA-binding function of the FLI protein as well as the transcription regulation function of the EWS protein. (medlineplus.gov)
  • Regulation of transcription factors via natural decoys in genomic DNA. (utmb.edu)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in order to dissect the molecular regulation of hematopoiesis. (lu.se)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
  • Alternative splicing of the primary transcript gives rise to the 2 mRNA and protein isoforms, hGR-alpha and hGR-beta. (medscape.com)
  • In contrast, protein kinase C inhibition or depletion had no effect on BK-induced c-fos mRNA, AP-1-DNA binding activity, or DNA synthesis. (nih.gov)
  • RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
  • Within the brain, the protein is involved in the development of specialized cells that process smell. (biolegend.com)
  • In comparison, HCV or HCV protein were discovered by another research13,14 to induce ROS creation and activate Nrf2/ARE pathway, which protected hepatic cells from oxidative stress subsequently. (mingsheng88.org)
  • Codanin-1 Mutations Engineered in Human Erythroid Cells Demonstrate Role of CDAN1 in Terminal Erythroid Maturation. (rochester.edu)
  • The ability of E2F-1 to prompt apoptosis in DNA damaged cells coincides with enhanced PRMT1 methylation. (embl.de)
  • This dysregulation of transcription leads to uncontrolled growth and division (proliferation) and abnormal maturation and survival of cells, causing tumor development. (medlineplus.gov)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • Among its diverse biological actions, the vasoactive peptide bradykinin (BK) induces the transcription factor AP-1 and proliferation of mesangial cells (S. S. El-Dahr, S. Dipp, I. V. Yosipiv, and W. H. Baricos. (nih.gov)
  • We have demonstrated that clear visualization of single molecules in cells enables their molecular quantification. (nii.ac.jp)
  • In APC-deficient colon carcinoma cells, we demonstrated that ß-catenin accumulates and is constitutively complexed with the TCF family member TCF4, providing a molecular explanation for the initiation of colon cancer (5). (hubrecht.eu)
  • The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
  • On the other hand, ATF-3 is rapidly induced in cells treated with growth stimulators such as serum and growth factors [ 20 ]. (hindawi.com)
  • The ER81 ETS protein, for example, is activated in human breast cancer cells by the oncoprotein HER-2, resulting in over-expression of the prosurvival telomerase reverse transcriptase (hTERT) gene [ 6 ]. (biomedcentral.com)
  • Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. (lu.se)
  • In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • In contrast to nonpacemaker cells, SA and AV nodal cells predominantly use calcium channels for the initial upstroke in phase 0 (Fig. 1) and lack sodium ion channels for the rapid initial upstroke in phase 1 of their action potentials. (medscape.com)
  • 1 Center for Psychiatric Neuroscience, Prilly-Lausanne, Switzerland. (nih.gov)
  • Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
  • RNA, lipids, and proteins. (who.int)
  • Molecular Microbiology 2014, 92 (3), 440-452. (ncl.ac.uk)
  • Molecular Microbiology 2013, 89 (1), 84-95. (ncl.ac.uk)
  • Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)
  • Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface. (utmb.edu)
  • We examined fluorescent protein-labeled nuclear proteins, such as transcription factors, RNA polymerase II and nucleosome remodeling factors, by simultaneous multi-color single-molecule imaging using HILO microscopy. (nii.ac.jp)
  • First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
  • Residence Times of Molecular Complexes in Solution from NMR Data of Intermolecular Hydrogen-Bond Scalar Coupling. (utmb.edu)
  • The object of this research is to clarify structures and their changes of DNA and protein complexes that are formed transiently and locally. (nii.ac.jp)
  • The well-known function of AUF1 is the destabilization of mRNAs by forming complexes with other proteins. (nature.com)
  • Endoplasmic reticulum (ER) is an essential organelle responsible for protein synthesis, folding, post-translational modification of proteins and protein trafficking in eukaryotes ( 8 ). (spandidos-publications.com)
  • Quantification on molecular dynamics and interactions with multi-dimensional analysis and 10-nm-resolution analysis of the images enabled us to classify states of the proteins and interactions. (nii.ac.jp)
  • Global mapping of protein-metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity. (mpg.de)
  • Finally, using a monoclonal antibody targeting the SAR domain, we demonstrate that the SAR domain contains a region accessible for protein - protein interactions. (biomedcentral.com)
  • In the nucleus, Nrf2 identifies and binds to a conserved antioxidant response component (ARE) and induces transcription of the battery pack of chemoprotective antoxidant genes9,10, including those encoding antioxidant proteins like heme oxygenase (HO-1)11. (mingsheng88.org)
  • Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
  • Methylation by PRMT1 hinders methylation by PRMT5, which augments E2F-1-dependent apoptosis, whereas PRMT5-dependent methylation favors proliferation by antagonizing methylation by PRMT1. (embl.de)
  • Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
  • Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
  • In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
  • Lung cancer is a major cause of cancer-related deaths, and non-small-cell lung cancer (NSCLC) comprises ∼75% of all lung cancers ( 1 ). (aacrjournals.org)
  • High-risk types (e.g., types 16 and 18) can cause low-grade cervical cell abnormalities, high-grade cervical cell abnormalities that are precursors to cancer, and cancers ( 5 - 7 ). (cdc.gov)
  • The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency. (duke.edu)
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
  • We have shown in frogs (4), flies (7) and worms (11) that the TCF proteins constitute the effectors of the canonical Wnt pathway. (hubrecht.eu)
  • The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. (novusbio.com)
  • [ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
  • Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylation and oxidative stress may cause an accumulation of unfolded proteins in the endoplasmic reticulum (ER), leading to the unfolded protein response (UPR) and autophagy. (spandidos-publications.com)
  • We identified 36 new putative partners for PRMT6 and we validated the interaction in vivo for 7 of them. (embl.de)
  • Protein-protein interaction network was established by STRING database. (bvsalud.org)
  • PROMISed: A novel web-based tool to facilitate analysis and visualization of the molecular interaction networks from co-fractionation mass spectrometry (CF-MS) experiments. (mpg.de)
  • Genome-wide measurement of protein-DNA binding dynamics using competition ChIP. (duke.edu)
  • Genome-wide protein-DNA binding dynamics suggest a molecular clutch for transcription factor function. (duke.edu)
  • Changes in conformational dynamics of basic side chains upon protein-DNA association. (utmb.edu)
  • Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein-DNA Affinity. (utmb.edu)
  • In parallel, we carried out single-molecule force measurement and molecular dynamics simulations on the same subjects. (nii.ac.jp)
  • Genomic characterization of SARS-CoV-2 in Egypt: insights into spike protein thermodynamic stability. (cdc.gov)
  • Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
  • mannose receptor (Mister/Compact disc206) as the principal subscriber base path for both regular cable blood-derived AFP (nAFP) and tumor-derived AFP (tAFP) protein. (immune-source.com)
  • Two of them died of hemorrhagic diathesis and renal and respiratory failure, and 17DD-YF vaccine was detected in serum samples from all patients and in the liver in 1 case. (cdc.gov)
  • 2,000 human cases and ≈750 deaths occurred during July 2016-June 2018 ( 1 ). (cdc.gov)
  • The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. (hubrecht.eu)
  • An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. (novusbio.com)
  • The mouse Pitx2 gene encodes three distinct protein isoforms (Pitx2a, b, c), and Pitx2c plays a determinant role in left-right atrium signaling from early somitogenesis onward 5 . (nature.com)
  • This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeodomain. (wikipedia.org)
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
  • Overexpression of one ETS protein in particular, the epithelium-specific ETS factor ESE-1, is implicated in human mammary transformation. (biomedcentral.com)
  • Breast cancer (BC) is the most common cancer in females worldwide, with nearly 25% of all new cancer cases and 15% of all cancer deaths 1 . (nature.com)
  • It will quite effectively cater to the needs of molecular biologists, molecular geneticists, cell and molecular biologists, animal, plant, and crop geneticists, synthetic biologists, biotechnologists, and researchers involved with the fields of stem cell and molecular aspects of cancer research. (caister.com)
  • 2014). In these tests, we discovered significant amounts of nicotine and cigarettes particular nitrosamines (TSNAs), two of which (4-(methylnitrosamino_-1-(3-pyridyl)-1-butanone NNK) and N-nitrosonornicotine (NNN)) are known cancer causing agents and the third, NNA, offers been reported to trigger DNA harm (Suspend, 2010). (immune-source.com)
  • Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
  • The ETS family transcription factor ESE-1 is often overexpressed in human breast cancer. (biomedcentral.com)
  • Longitudinal data on humoral response and neutralizing antibodies against SARS-CoV-2 Omicron BA.1 and subvariants BA.4/5 and BQ.1.1 after COVID-19 vaccination in cancer patients. (cdc.gov)
  • In the same paper we also demonstrated that accumulating PARIS acts on PGC-1α, the master regulator of mitochondrial biogenesis, along the NRF1/2-TFAM axis to intervene in mitochondrial biogenesis, and that the transcriptionally inactive PARIS mutant (C571A) lacks repression capacity to induce the phenotype. (nature.com)
  • To further evaluate the role of CRTC1 in the brain, we generated a knockout mouse line and analyzed its behavioral and molecular phenotype. (nih.gov)
  • Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). (embl.de)
  • This homeobox transcription factor is expressed during early cardiac morphogenesis and serves as a master regulatory protein. (cdc.gov)
  • Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)
  • Purvalanol induced mitochondrial membrane potential loss, caspase-7 and caspase-3 activation and PARP cleavage following a 48 h treatment. (spandidos-publications.com)
  • Journal of Biological Chemistry 2012, 287 (1), 337-346. (ncl.ac.uk)
  • Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. (embl.de)
  • The encoded protein plays an important role in the embryogenesis of pancreatic islets of Langerhans. (wikipedia.org)
  • Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
  • Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. (rochester.edu)
  • however, its role in antioxidant gene transcription remains elusive. (embl.de)
  • The assembly of PRMT6 protein network allowed us to formulate functional hypotheses which led to the discovery of new molecular partners for the architectural transcription factor HMGA1a, a known substrate for PRMT6, and to provide evidences for a modulatory role of HMGA1a on the methyltransferase activity of PRMT6. (embl.de)
  • The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. (novusbio.com)
  • The co-occurrence analysis of core concepts in this stringent response, i.e. the (p)ppGpp nucleotides with gene products was also inspected and suggest that besides the enzymes RelA and SpoT that control the basal levels of (p)ppGpp nucleotides, many other proteins have a key role in this response. (biomedcentral.com)
  • To assess the role of NES2 in regulating ESE-1 subcellular localization and subsequent transformation potency, we site-specifically mutagenized NES2, within full-length GFP-ESE-1 and GFP-NES2-SAR reporter constructs. (biomedcentral.com)
  • Role of the pioneer transcription factor GATA2 in health and disease. (cdc.gov)
  • 1, 4] Furthermore, glucocorticoids represent one of the most widely used therapeutic compounds, often used in the treatment of inflammatory, autoimmune, and lymphoproliferative disorders. (medscape.com)