• Influenza A virus subtype H10N3 is a subtype of viruses that causes influenza (flu). (wikipedia.org)
  • All human infections caused by a new influenza subtype are required to be reported under the International Health Regulations (IHR, 2005).4 This includes any influenza A virus that has demonstrated the capacity to infect a human and its haemagglutinin gene (or protein) is not a mutated form of those, i.e. (who.int)
  • Gene expression analysis has emerged as a powerful tool in molecular subtype classification for colorectal cancer. (mirxes.us)
  • 2015). The consensus molecular subtypes of colorectal cancer. (mirxes.us)
  • 2016). Immune and stromal classification of colorectal cancer is associated with molecular subtypes and relevant for precision immunotherapy. (mirxes.us)
  • 2011). Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair, and epithelial-to-mesenchymal transition. (mirxes.us)
  • Recent studies have found that they have clinical and molecular features of both the BRAF mutant/MSI and the conventional BRAF wild-type cancers and comprise a distinct colorectal cancer subgroup. (hindawi.com)
  • This review highlights the importance of the BRAF mutation occurring in colorectal cancer stratified for molecular background and discusses its prognostic and clinical significance. (hindawi.com)
  • BRAF mutant/MSS cancers form a distinct colorectal cancer entity that shares clinical and molecular features with both BRAF mutant/MSI serrated pathway cancers and the BRAF wild-type cancers of the conventional pathway [ 9 - 11 ]. (hindawi.com)
  • Out of our six consensus molecular subtypes, [inaudible] belong to three luminal tumors. (urotoday.com)
  • Despite a limited number of breast tumors examined, our analysis identified cysteinyl-tRNA synthetase as a biomarker that is highly associated with cell surface NIS protein levels in the ER-positive breast cancer subtype. (umd.edu)
  • We performed RNA-sequencing (RNA-seq) and histological analysis on radiographically guided biopsies taken from different regions of GBM and showed that the tissue contained within the contrast-enhancing (CE) core of tumors have different cellular and molecular compositions compared with tissue from the nonenhancing (NE) margins of tumors. (columbia.edu)
  • Notably, the patterns of cell type-specific alterations varied between the different GBM subtypes: the NE regions of proneural tumors were enriched in oligodendrocyte progenitor genes, whereas the NE regions of mesenchymal GBM were enriched in astrocytic and microglial genes. (columbia.edu)
  • The gene expression analysis broadly sorts the tumors into three subtypes: proliferative, metabolic and mesenchymal. (oncozine.com)
  • Recently, the gene expression profiling of various tumors has provided new subtype-specific options for targeted therapies. (figshare.com)
  • Recently, the 12th St Gallen International Breast Cancer Conference Expert Panel recommends that the subtype classification of breast cancer, namely 'HR positive' (including 'luminal A' and 'luminal B' tumors), 'HER2 amplified' and 'triple negative,' should guide the treatment plan for breast cancer patients. (springer.com)
  • By examining the biological of activity of the nutrients formed from serine in different molecular subsets of tumors, we will define new therapeutic targets for patients with these types of breast cancers. (marathonofhopecancercentres.ca)
  • Epidemiology data is changing ever since we have a better understanding of molecular and genetic behaviors of these tumors and especially after the new World Health Organization (WHO) classification from 2016. (medscape.com)
  • By reviewing biomarkers and breast cancer molecular subtypes, we propose that the divergent outcome observed from patients stratified by hormone status are driven by different cancer hallmarks. (jcancer.org)
  • More evidence indicates that luminal-like subtypes may. (lu.se)
  • More evidence indicates that luminal-like subtypes may have the most improved outcomes after neoadjuvant chemotherapy. (lu.se)
  • The three groups were associated with the luminal A, luminal B and basal-like molecular subtypes of breast cancer, respectively, whereas cancers of the HER2-enriched and normal-like subtypes were distributed among the three groups. (lu.se)
  • The methylation frequencies were significantly different between subtypes, with luminal B and basal-like tumours being most and least frequently methylated, respectively. (lu.se)
  • Conclusions: We have found that breast cancers of the basal-like, luminal A and luminal B molecular subtypes harbour specific methylation profiles. (lu.se)
  • Most previously identified gene expression signatures that differentiate DCIS and invasive breast cancer have been consistently biased for improved performance in the luminal subtypes. (breastcancerresearch.no)
  • Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with distinct molecular subtypes. (aacrjournals.org)
  • Each of these subtypes is associated with a clear therapy recommendation and distinct characteristics of the patient's prognosis. (cercabiotech.com)
  • However, recent advancements in gene expression analysis have revolutionized our understanding of CRC's molecular landscape, leading to the identification of distinct molecular subtypes. (mirxes.us)
  • Gene expression analysis has revealed several molecular subtypes of CRC, each with distinct characteristics and clinical implications. (mirxes.us)
  • In this study, using data sets from TCGA and the GSE19422 cohorts, we identified two distinct PCC subtypes with distinct gene expression patterns. (figshare.com)
  • Identification of Distinct Molecular Subtypes of Endometrioid Adenocarcinoma. (bvsalud.org)
  • In this study, we identified two distinct molecular subtypes of EAC with different gene expression patterns and clinicopathologic characteristics. (bvsalud.org)
  • We aimed to investigate whether the molecular subtypes also display distinct methylation profiles. (lu.se)
  • We show that progression from DCIS to invasive breast cancer occurs in an intrinsic subtype-specific manner, indicating distinct evolutionary disease paths. (breastcancerresearch.no)
  • We hypothesize that each molecular subtype of breast cancer likely undergoes a distinct evolutionary course of disease progression leading to specific molecular patterns of the final tumor. (breastcancerresearch.no)
  • No specific biochemical test exists for the presence of medulloblastoma, although several molecular studies have revealed that histologically identical medulloblastomas are composed of distinct subgroups with different prognosis. (medscape.com)
  • In muscle-invasive bladder cancer, molecular subtypes haven't been thoroughly studied. (urotoday.com)
  • Therefore, we adopted a consensus molecular classification from muscle-invasive bladder cancer. (urotoday.com)
  • We find that there is not sufficient evidence to conclude that the basal subtype of muscle-invasive bladder cancer responds well to chemotherapy, since only a minority of studies support this conclusion. (lu.se)
  • An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer. (cngb.org)
  • The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. (cngb.org)
  • Medical College of Georgia at Augusta University ) While trying to develop a comparatively easy, inexpensive way to give physicians and their patients with bladder cancer a better idea of likely outcome and best treatment options, scientists found that sophisticated new subtyping techniques designed to do this provide no better information than long-standing pathology tests. (steelbuildershs.com)
  • What is a Bladder Cancer Molecular Subtype? (lu.se)
  • Comparisons with the The Cancer Genome Atlas dataset showed that the samples from CE regions resembled the proneural, classical, or mesenchymal subtypes of GBM, whereas the samples from the NE regions predominantly resembled the neural subtype. (columbia.edu)
  • Forty-one percentage of pGBM were designated as Mesenchymal subtype, while only 15% were the Proneural subtype. (oncotarget.com)
  • However, sGBM displayed the opposite ratio of Mesenchymal (15%) and Proneural (44%) subtypes. (oncotarget.com)
  • These subtypespecific patterns provide new insights into molecular and cellular composition of the infiltrative margins of GBM. (columbia.edu)
  • Considering very limited WGS data was available for VGI strains, we developed a novel computational pipeline to predict subtypes based on MLST to generalize our conclusion on subtype prevalence and geographical distribution patterns. (researchsquare.com)
  • Finally, by utilizing gene expression data, we observed that a large fraction of genes reported as having subtype-specific expression patterns might be regulated through methylation. (lu.se)
  • 4. Clinical Impact of Molecular Subtyping of Pancreatic Cancer. (cngb.org)
  • Consensus molecular classification was developed by compiling six different molecular classifiers. (urotoday.com)
  • To apply this consensus molecular classification, we generated the Hopkins BCG cohort. (urotoday.com)
  • 2015) [1] introduced the Consensus Molecular Subtypes (CMS) classification system. (mirxes.us)
  • The Consensus Molecular Subtypes (CMS) system and other studies utilizing RNA sequencing have provided crucial insights into the heterogeneity of CRC. (mirxes.us)
  • We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. (nature.com)
  • Figure 4: Neuropeptide associations to individual hypothalamic neuronal subtypes. (nature.com)
  • The chief inhibitory neurons of the mammalian brain, GABAergic neurons, are comprised of a myriad of diverse neuronal subtypes. (jneurosci.org)
  • GABAergic neurons, the chief inhibitory neurons of the mammalian brain, are comprised of diverse neuronal subtypes distinguishable on the bases of location in given brain regions, microanatomical features, including dendritic arborizations and axonal projections, expression of specific macromolecules, and neurophysiological properties. (jneurosci.org)
  • Thus, stratification of breast cancer by clinically relevant subtypes is urgently required. (jcancer.org)
  • The molecular stratification of glioma patients into subtypes is the most direct way to translate genome-wide high-throughput data into information that can be used in a clinical setting. (biomedcentral.com)
  • We consider the CMS groups the most robust classification system currently available for CRC-with clear biological interpretability-and the basis for future clinical stratification and subtype-based targeted interventions. (szzhongchaoled.com)
  • Different breast tumor subtypes have different risk factors, clinical presentation, histopathological features, outcome, and response to systemic therapies [ 3 - 8 ]. (jcancer.org)
  • In the past, several groups have attempted to identify brain tumor subtypes computationally and stratify glioma patients into subtypes in terms of the gene expression pattern of their classifiers. (biomedcentral.com)
  • These genes identified in the present research may serve as potential subtype-specific therapeutic targets to understand the underlying mechanisms of tumorigenesis. (figshare.com)
  • Additionally, we identified three potential subtype-specific biomarkers , comprising MDM2 (MDM2 proto-oncogene ) for subtype I, and MSH2 ( mutS homolog 2) and MSH6 ( mutS homolog 6) for subtype II. (bvsalud.org)
  • Title : CME ACTIVITY: Clinical Characteristics and Molecular Subtyping of Vibrio vulnificus Illnesses, Israel Published Date : December 2008 Source : Emerg Infect Dis. (cdc.gov)
  • The primary goal of this study is to identify molecular subtypes of breast cancer through gene expression profiles of 327 breast cancer samples and determine molecular and clinical characteristics of different breast cancer subtypes. (refine.bio)
  • Identifying the molecular subtype of CRC helps tailor treatment plans to the patient's specific tumor characteristics. (mirxes.us)
  • A phase 3 trial revealed that the HER2-enriched molecular subtype of breast cancer is more responsive to both dual and single targeting regimens. (cancertherapyadvisor.com)
  • The HER2-enriched molecular subtype is significantly more responsive to both dual and single HER2-targeting regimens than the other subtypes within HER2-positive disease," Dr. Carey told Cancer Therapy Advisor . (cancertherapyadvisor.com)
  • Expression of immune signatures is directly associated with response to HER2-targeting, and is independent of other factors such as dual or single HER2-targeting or molecular subtype. (cancertherapyadvisor.com)
  • More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. (biomedcentral.com)
  • This work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic molecular subtypes of breast cancer. (breastcancerresearch.no)
  • Subtypes indicative of high stromal infiltration responded well in some studies and poorly in others. (lu.se)
  • Our results suggested that differential CAF-related protein expression depended on the molecular subtypes and stromal histologic features of breast cancer, indicating that in the future, this system could potentially use these markers for prognosis prediction and targeted therapy of breast cancer. (elsevierpure.com)
  • Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
  • These findings suggest that subtype-specific molecular markers may have the potential to predict risk of progression. (breastcancerresearch.no)
  • The authors conclude that the use of molecular biomarkers in public health practice is still in its infancy, and several promising markers may soon find their way into the public health arena. (cdc.gov)
  • The precise classification system that best captures such a predictive effect, and the exact subtypes for which other treatment options are more beneficial remains to be established, preferably in prospective studies. (lu.se)
  • 8,12 Therefore, we suspected that some subtypes of C gattii VGI might be more virulent, but no subtype classification system was available for C gattii VGI up to now. (researchsquare.com)
  • Recently, we established a robust and reliable glioma classification system that includes six hierarchically-nested subtypes and six sets of classifiers. (biomedcentral.com)
  • To translate our glioma classification system into a clinically useful application that is readily usable by clinicians and other statistically and computationally naïve users, we implemented GliomaPredict, a computational tool that allows anyone to reliably predict the subtype of a new glioma patient utilizing his/her tumor gene expression profile. (biomedcentral.com)
  • Currently, there is no molecular classification system for EAC, so there are no corresponding targeted treatments . (bvsalud.org)
  • Expression and pharmacological characterization of a canine 5-hydroxytryptamine1D receptor subtype. (aspetjournals.org)
  • However, we found that NanoString offers the most flexibility and fewest limitations in regards to robust clinical tissue subtype characterization. (aacrjournals.org)
  • Comprehensive molecular characterization of human colon and rectal cancer. (mirxes.us)
  • Gene expression analysis is a sophisticated molecular technique that allows scientists to measure the activity levels of thousands of genes within CRC tumor samples. (mirxes.us)
  • Genes enriched in Subtype I PCCs were involved in the dopaminergic synapse, nicotine addiction, and long-term depression pathways, while genes enriched in subtype II PCCs were involved in protein digestion and absorption, vascular smooth muscle contraction, and ECM receptor interaction pathways. (figshare.com)
  • We further identified subtype specific genes such as ALK, IGF1R, RET, and RSPO2 for subtype I and EGFR, ESR1, and SMO for subtype II, the overexpression of which led to cell invasion and tumorigenesis. (figshare.com)
  • The up-regulated genes in subtype I EAC were associated with the immune response , defense response, cell motion , and cell motility pathway, whereas the up-regulated genes in subtype II EAC were associated with the cell cycle , DNA replication , and RNA processing pathways. (bvsalud.org)
  • Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. (escholarship.org)
  • Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil. (oncozine.com)
  • To overcome BCG resistance, we need to understand the mechanisms of a BCG therapeutic effect and identify molecular correlates that can predict the BCG responses. (urotoday.com)
  • Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer. (biomedcentral.com)
  • Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. (refine.bio)
  • Molecular subtypes are associated with varying clinical outcomes. (mirxes.us)
  • Understanding the subtype can aid in predicting patient prognosis and guiding treatment decisions for more effective outcomes [4]. (mirxes.us)
  • Frederick, WAI 2008, ' Molecular Subtypes of Breast Cancer: An Insight into the Disparity in Breast Cancer Outcomes ', Breast Diseases , vol. 19, no. 2, pp. 126-128. (johnshopkins.edu)
  • The basal-like subtype was associated with worse prognosis and a trend towards better response to adjuvant therapy. (amsterdamumc.org)
  • This article provides an overview of all the known molecular subtypes of GIST and provides information about clinical correlates, treatment, and prognosis depending on the subtype. (elsevierpure.com)
  • Subtype I EAC cases, accounting for the majority of cases (56%), were associated with an earlier stage, a more well-differentiated grade, a lower tumor invasion rate, and a more favorable prognosis , and the median tumor necrosis percent (15%) was also significantly higher in subtype I EAC. (bvsalud.org)
  • In addition to multi-omics (WGS and RNA-Seq) experiments, we also performed in vitro and in vivo evaluation to characterize the virulence trait of divergent molecular subtypes of C gattii VGI strains. (researchsquare.com)
  • Molecular subtyping indicated relatedness between the Vibrio cholerae isolates in this and in a 2007 outbreak, uncovering a clonal group of V. cholerae circulating in the Mekong basin. (cdc.gov)
  • The molecular properties that differentiate DCIS and IDC involve cells and processes of the tumor microenvironment, differentially between the subtypes. (breastcancerresearch.no)
  • Encyclopedia of molecular biology and molecular medicine: denaturation of DNA to growth factors, volume 2. (cdc.gov)
  • ME used the enhanced resolving power of molecular biology to assess exposure/disease relationships. (cdc.gov)
  • This information accelerates the development of targeted therapies, and clinical trials can be designed to evaluate the efficacy of these treatments for specific CRC subtypes [7]. (mirxes.us)
  • Our findings may further guide towards the development of targeted therapies and potential molecular biomarkers against PCC. (figshare.com)
  • These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. (nature.com)
  • Epidemiology, molecular. (cdc.gov)
  • The use of molecular biological methods in molecular epidemiology (ME) as a powerful tool for public health researchers was reviewed. (cdc.gov)
  • The information provided by GISN through its participating institutions has identified new influenza threats, substantially helped define the epidemiology of influenza and the molecular evolution of the viruses, and formed the basis for selecting new influenza vaccine strains and for updating diagnostic tests. (who.int)
  • This is accomplished by intricately interconnected interneuronal networks, composed of various GABAergic subtypes, which strictly regulate pyramidal cell activity. (jneurosci.org)
  • Mutations in isocitrate dehydrogenase-1 (IDH1) were found to be highly concentrated in the Proneural subtypes. (oncotarget.com)
  • Here, we summarize and discuss the scientific literature examining transcriptomic or panel-based molecular subtyping applied to neoadjuvant chemotherapy-treated patient cohorts. (lu.se)
  • We developed GliomaPredict as a computational tool that allows the fast and reliable classification of glioma patients into one of six previously published stratified subtypes based on sets of extensively validated classifiers derived from hundreds of glioma transcriptomic profiles. (biomedcentral.com)
  • It represents a group of very heterogeneous clinical, histopathological and molecular diseases. (bvsalud.org)
  • This study aimed to evaluate the expression of CXCR4 in molecular subtypes of adult and pediatric infiltrating gliomas. (umn.edu)
  • Back to 1970s, breast cancer was divided into two subtypes according to the status of estrogen receptor (ER). (jcancer.org)
  • This review aims at identifying these dominant hallmarks driving breast cancer heterogeneity by focusing on identified biomarkers and the associated subtypes. (jcancer.org)
  • Reasons for these discrepancies may include the possibility that the molecular profile of breast cancers evolves over time and that biomarkers are heterogeneously expressed within the tumor [ 4 ] and technical inconsistencies in both tissue processing and sample evaluation. (springer.com)
  • Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. (biomedcentral.com)
  • We systematically analyzed breast cancer patient survival combining information of stage and molecular subtype with a large sample size, which will help us know the influence of related factors on breast cancer patient survival better. (biomedcentral.com)
  • Expression of CAF-related proteins in the stroma differed depending on breast cancer molecular subtypes. (elsevierpure.com)
  • The aim of this work is to study the molecular profile of the breast cancers by immunostaining on Moroccan series to a classification with a prognostic value allowing a treatment tailored to each group of patients. (bvsalud.org)
  • Gene expression analysis can identify potential therapeutic targets specific to each molecular subtype. (mirxes.us)
  • From 2011 to 2017, we collected 32 strains of C gattii from 18 hospitals across China, of which 27 [84·4%] strains molecular traits were profiled by whole-genome sequencing (WGS) and multi-locus sequence typing (MLST) and compared with strains previously described in China from 2006 to 2020. (researchsquare.com)
  • Totally 119 clinical cases caused by C gattii strains (87 in previous reports and 32 in our study) distributed widely in 20 provincial-level administrative regions of China, of which 114 strains molecular types were obtained. (researchsquare.com)
  • The other nine strains could not be assigned to these four subtypes clearly. (researchsquare.com)
  • 5,6 VGII is the main molecular type in clinical strains across the world and the subtype VGIIa is more virulent than others. (researchsquare.com)
  • 10 However, VGI is an emerging and more abundant molecular type in Asia, Australia, and Europe 11 , and some studies showed obvious differences in virulence among individual VGI strains. (researchsquare.com)
  • Rapid molecular genetic subtyping of serotype M1 group A Streptococcus strains. (cdc.gov)
  • ABSTRACT Information on the prevalence of influenza, circulating virus subtypes and seasonality is essential for selecting strains for annual vaccines and for planning immunization programmes. (who.int)
  • Whole transcriptome sequencing data was used to assess the distribution of molecular subtypes and genetic alterations in 88 pGBM and 34 sGBM in a Chinese population-based cohort, and the biological progression and prognostic impact were analyzed by combining clinical information. (oncotarget.com)
  • These surging data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. (escholarship.org)
  • Through further bioinformatics analyses, we identified causes for prognostic differences between subtypes. (figshare.com)
  • These informatics methods are illustrated using our recent published studies on platform-independent Informatics pipeline for molecular sub-typing of glioblastoma and ovarian cancers. (umn.edu)
  • Recent studies have also found that presence of the BRAF mutation has direct implications for clinical management as along with TNM stage, BRAF mutational status was the only molecular variable that independently accounted for poor survival [ 13 ], and studies have found that BRAF mutant cancers are refractory to anti-EGRF therapy [ 14 , 15 ]. (hindawi.com)
  • Molecular heterogeneity has been demonstrated by genomic analysis, even for similar histology cancers. (bvsalud.org)
  • Diagnostic samples showed a typical spread of subtypes with consistent gene expression profiles across matched fresh, frozen, and formalin-fixed paraffin-embedded tissues. (aacrjournals.org)
  • Serotonergic ligands displaced specific [3H]5-HT binding with a rank order of potency expected of a 5-HT1D receptor subtype, 5-carboxyamidotryptamine greater than 5-HT greater than yohimbine greater than 8-hydroxy-2-(di-n-propylamino)tetralin greater than ketanserin = spiperone greater than zacopride. (aspetjournals.org)
  • We used these data (n=45) to construct a phylogenetic tree and identify four VGI subtypes. (researchsquare.com)
  • Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)
  • With incorporation of WGS and other advanced molecular detection methods, PulseNet will continue to improve foodborne disease detection and identify outbreaks faster and with more accuracy. (cdc.gov)
  • Our finding suggests the subtyping methods will affect this relatedness. (cdc.gov)
  • There is a growing understanding of the molecular drivers of GISTs lacking mutations in KIT or PDGFRA, so called wild-type GISTs, further aiding in management decisions. (elsevierpure.com)