• Using noncontact atomic force microscopy researchers at IBM , with the help of folks at the Utrecht University, managed to view the structure of pentacene ( a polycyclic aromatic hydrocarbon molecule) down to the resolution of individual atoms. (medgadget.com)
  • To image the chemical structure of a molecule with an AFM, it is necessary to operate in very close proximity to the molecule. (medgadget.com)
  • A tip terminated with a carbon monoxide (CO) molecule yielded the optimum contrast at a tip height of approximately 0.5 nanometers above the molecule being imaged and-acting like a powerful magnifying glass-resolved the individual atoms within the pentacene molecule, revealing its exact atomic-scale chemical structure. (medgadget.com)
  • Eventually, however, with help from insights gained during the CXCR4 project, Wu, as a new professor, and her young team of students used a novel "fusion partner" molecule that would hold CCR5 proteins together enough to form usable crystals, together with efforts of computational modeling, compound synthesis and cell signaling assays from Drs. Hualiang Jiang, Hong Liu and Xin Xie's groups at SIMM, which led to the structure determination of CCR5. (scripps.edu)
  • So, if DNA-tagged molecular shapes (whether made of DNA with Rothemund staples, or Schafmeister polymers, or whatever) were allowed to self-assemble to a DNA framework, and then zinc or light (or whatever reagent) were added, then the shapes could bond quite strongly into a single large strong precise molecule. (typepad.com)
  • Draw the correct VSEPR predicted structure of a molecule based on steric number and lone pair count. (ionicviper.org)
  • This is a 1080p motion graphics video a large bending strand of a molecule structure. (videohive.net)
  • New York University chemists have developed a computational approach for determining the viability and suitability of complex molecular structures--an advancement that could aid in the development of pharmaceuticals as well as a range of other materials. (eurekalert.org)
  • Journal of Molecular Structure is a scientific journal published by Elsevier ScienceDirect since 1968. (wikipedia.org)
  • Pulay P, Fogarasi G, Pang F, Boggs JE (1979) Systematic ab initio gradient calculations of molecular geometries, force constants, and dipole moment derivatives. (springer.com)
  • But after carrying out some very good calculations on these he revolted against the Hückel method, threw his excellent calculations out the window, and for his thesis developed entirely independently his now well known all-electron LCAO SCF self-consistent-field method for the calculation of atomic and molecular wave functions, now appropriately referred to, I believe, as the Hartree-Fock-Roothaan method. (wikipedia.org)
  • Dendrimer, molecular structure.Dendrimers are artificially created branched polymers and subbranches along a central backbone of carbon atoms, usually extending from a central atom or ring of atoms. (sciencephoto.com)
  • SHANGHAI, CHINA, AND LA JOLLA, CA - September 12, 2013 - In a long-awaited finding, a team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. (scripps.edu)
  • It was a fortunate cioncidence that in 1976 a Workshop on "Unconventional Electron Microscope Methods for the Investigation of Molecular Structures" (sponsored by the European Molecular Biology Organisation, the Deutsche Forschungsgemeinschaft and the Max-Planck-Gesell- schaft) took place, and that most speakers presenting introductory lectures agreed to publish their contributions in an expanded version in this volume. (ebooks.com)
  • In contrast, molecular structure databases such as PubChem ( 6 ) and ChemSpider ( 7 ) contain millions of compounds, with PubChem alone having surpassed 50 million entries. (pnas.org)
  • A common approach to determine a complex plant polymer's structure is to dissolve it in solutions with specific chemical compounds that will break it apart into smaller and smaller pieces from which the complete structure can be deduced. (phys.org)
  • According to IBM's Dan Rugar, three-dimensional imaging would have tremendous medical implications for controlling diseases and understanding DNA and protein structures. (aps.org)
  • Her goal from the beginning was to determine the structures and understand the functions of these two HIV co-receptors and she was very determined which was inspiring," said Stevens. (scripps.edu)
  • Papers describing routine studies of little structural significance (e.g. straightforward X-ray crystal structure determinations) are not encouraged. (elsevier.com)
  • One is a protein structure called a zinc finger, wherein several amino acids (cysteine and/or histidine) bind to a single zinc ion. (typepad.com)
  • Nair S, Hagberg H, Krishnamurthy R, Thornton C, Mallard C. Death Associated Protein Kinases: Molecular Structure and Brain Injury. (mdpi.com)
  • When combined with a heuristic, allowing simultaneous constrained fitting of the high-resolution structures of the major plaque proteins (desmoplakin, plakophilin, and plakoglobin), it reveals their mutual molecular interactions and explains their stoichiometry. (nih.gov)
  • A distinction is made between the determination of relative values with high precision so that trends in structure or vibrational frequencies can be followed and the determination of absolute values to permit intercomparison between different techniques. (springer.com)
  • The most im- pressive analogy, however, concerns the potential of the electron microscope as a tool for structure determination (where the radiation wavelenght is smaller than the atomic distan- ces). (ebooks.com)
  • In a video interview, biochemist Wes Sundquist discusses how the HIV virus uses molecular pathways in host cells to replicate itself and spread infection to nearby cells. (nih.gov)
  • Recently, several computational approaches were presented for searching molecular structure databases using MS/MS data. (pnas.org)
  • However, the number of possible configurations is enormous, and the pathways leading to the most stable ones are complex, which makes these favored structures difficult to nail down in computational searches. (eurekalert.org)
  • Portalone G, Schultz G, Domenicano A, Hargittai I (1984) Molecular structure and ring distortions of fluorobenzene: An electron diffraction study, and a comparison with other experimental and ab initio results. (springer.com)
  • One thing that we've lacked is a high-resolution molecular 'picture' of the CCR5 receptor structure that we can use for precise drug design," Wu said. (scripps.edu)
  • The easy separation of these two classes of human leukocyte interferon makes the purification procedures more rational and will facilitate the preparation of both subspecies to a high degree of molecular homogeneity. (pnas.org)
  • Due to the high degree of molecular customisation during synthesis, they may one day be used for a variety of applications, such as nanotechnology, drug delivery systems, nanoscale batteries, lubricants, catalysts and herbicides. (sciencephoto.com)
  • As in most receptor-structure projects, Wu and her colleagues further stabilized CCR5 with a compound that is known to bind to it, in this case the Pfizer drug maraviroc (sold under the brand name Selzentry® or Celsentri® outside the US). (scripps.edu)
  • 30-40% of the molecular species have the polynucleotide-binding property and 60-70% lack affinity for the polynucleotide ligand. (pnas.org)
  • Boggs JE, Cordell FR (1981) Accurate ab initio gradient calculation of the structures and conformations of some boric and fluoroboric acids. (springer.com)
  • We used cryoelectron tomography of vitreous sections from human epidermis to record 3D images of desmosomes in vivo and in situ at molecular resolution. (nih.gov)
  • In addition to reviewing current knowledge, we present new aspects of the molecular structure of DAPk domains, and relate these findings to interacting partners of DAPk1, DAPk-regulation in NMDA-induced cerebral injury and novel approaches to blocking the injurious effects of DAPk1. (mdpi.com)
  • The nicotinic cholinergic receptor: correlation of molecular structure with functional properties. (nih.gov)
  • The physicochemical properties and molecular structures of waxy rice starches isolated from the newly inbred Korean varieties, Nunbora, Baegseolchal, Baegokchal, and Boseokchal were investigated. (springer.com)
  • Shi M, Gao Q. Physicochemical properties, structure and in vitro digestion of resistant starch from waxy rice starch. (springer.com)
  • A ) Two-dimensional projection image of a straight desmosome shows the periodic structure in extracellular and intracellular regions. (nih.gov)
  • Now that we have both human CXCR4 and CCR5 HIV co-receptor three-dimensional structures, it is likely we will see the next generation of HIV therapeutics. (scripps.edu)