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  • Molecule
  • Using noncontact atomic force microscopy researchers at IBM , with the help of folks at the Utrecht University, managed to view the structure of pentacene ( a polycyclic aromatic hydrocarbon molecule) down to the resolution of individual atoms. (medgadget.com)
  • To image the chemical structure of a molecule with an AFM, it is necessary to operate in very close proximity to the molecule. (medgadget.com)
  • A tip terminated with a carbon monoxide (CO) molecule yielded the optimum contrast at a tip height of approximately 0.5 nanometers above the molecule being imaged and-acting like a powerful magnifying glass-resolved the individual atoms within the pentacene molecule, revealing its exact atomic-scale chemical structure. (medgadget.com)
  • Eventually, however, with help from insights gained during the CXCR4 project, Wu, as a new professor, and her young team of students used a novel "fusion partner" molecule that would hold CCR5 proteins together enough to form usable crystals, together with efforts of computational modeling, compound synthesis and cell signaling assays from Drs. Hualiang Jiang, Hong Liu and Xin Xie's groups at SIMM, which led to the structure determination of CCR5. (scripps.edu)
  • So, if DNA-tagged molecular shapes (whether made of DNA with Rothemund staples, or Schafmeister polymers, or whatever) were allowed to self-assemble to a DNA framework, and then zinc or light (or whatever reagent) were added, then the shapes could bond quite strongly into a single large strong precise molecule. (typepad.com)
  • It is not always the case that the structure of a molecule is easy to relate to its function. (wikipedia.org)
  • atomic structure
  • SHANGHAI, CHINA, AND LA JOLLA, CA - September 12, 2013 - In a long-awaited finding, a team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. (scripps.edu)
  • biology
  • Molecular biology is particularly concerned with the flow and consequences of biological information at the level and proteins. (wikipedia.org)
  • Delbruck's efforts to promote the "Phage Group" (exploring genetics by way of the viruses that infect bacteria) was important in the early development of molecular biology in general and the development of Watson's scientific interests in particular. (wikipedia.org)
  • proteins
  • When combined with a heuristic, allowing simultaneous constrained fitting of the high-resolution structures of the major plaque proteins (desmoplakin, plakophilin, and plakoglobin), it reveals their mutual molecular interactions and explains their stoichiometry. (nih.gov)
  • In 1951, Pauling published the structure of the alpha helix, a fundamentally important structural component of proteins. (wikipedia.org)
  • atom
  • The fluorine atoms are labelled Ftop attached to Stop, and on the hypervalent S atom: Fcis, the closest F atom to Ftop, Ftrans the furthest away F atom from Ftop, and Feq Carlowitz first determined the structure in 1983. (wikipedia.org)
  • Isopropyl cyanide (C3H7CN) contains a carbon atom bounded by a simple link to two methyl (-CH3) structures and to a cyano group (-CN). (wikipedia.org)
  • experimental
  • As for the clustering in neutron-rich Be, we discuss the comparison between the antisymmetrized molecular-dynamics results and the recent experimental data, which shows that the clustering feature manifests itself very clearly in neutron-rich Be isotopes both in the ground and excited states. (springer.com)
  • complex
  • The cytoplasmic surface of intercellular junctions is a complex network of molecular interactions that link the extracellular region of the desmosomal cadherins with the cytoskeletal intermediate filaments. (nih.gov)
  • liquid
  • A unique class of partially crystalline aromatic polyesters based on p-hydroxybenzoic acid and related monomers, liquid-crystal polymers are capable of forming regions of highly ordered structure while in the liquid phase. (wikipedia.org)
  • degree
  • The easy separation of these two classes of human leukocyte interferon makes the purification procedures more rational and will facilitate the preparation of both subspecies to a high degree of molecular homogeneity. (pnas.org)
  • available
  • For more details on how to use this software, an on-line user manual is also available at the Molecular Ventures web site at http://www.molvent.com/manual . (arizona.edu)
  • human
  • Now that we have both human CXCR4 and CCR5 HIV co-receptor three-dimensional structures, it is likely we will see the next generation of HIV therapeutics. (scripps.edu)
  • We used cryoelectron tomography of vitreous sections from human epidermis to record 3D images of desmosomes in vivo and in situ at molecular resolution. (nih.gov)
  • known
  • As in most receptor-structure projects, Wu and her colleagues further stabilized CCR5 with a compound that is known to bind to it, in this case the Pfizer drug maraviroc (sold under the brand name Selzentry® or Celsentri® outside the US). (scripps.edu)
  • Although 3D structures of the major plaque components are known, the overall architecture remains unknown. (nih.gov)