• The results are published in the journal Nature Structural & Molecular Biology . (eurekalert.org)
  • We wanted to study the protein itself because it is unique," says Jeff Perry of the Scripps Research Institute's Department of Molecular Biology and Skaggs Institute for Chemical Biology, formerly of Berkeley Lab, who led the research with Yannone. (news-medical.net)
  • Their findings will soon appear in Nature Structural & Molecular Biology and are now available online. (news-medical.net)
  • Co-principal investigator is Priscilla Cooper, head of the Department of Molecular Biology in Berkeley Lab's Life Sciences Division. (news-medical.net)
  • The findings are reported in a Nature Structural & Molecular Biology advance online publication on March 9, 2015. (bioquicknews.com)
  • The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)
  • Our research focuses on major areas of modern biochemistry and molecular biology. (lu.se)
  • The three-dimensional (3D) structures of proteins form the structural framework of their functions. (frontiersin.org)
  • A vibrational Raman optical activity (ROA) study of a range of different structural types of virus exemplified by filamentous bacteriophage fd, tobacco mosaic virus, satellite tobacco mosaic virus, bacteriophage MS2 and cowpea mosaic virus has revealed that, on account of its sensitivity to chirality, ROA is an incisive probe of their aqueous solution structures at the molecular level. (dtu.dk)
  • A team led by scientists at The Scripps Research Institute (TSRI) in La Jolla, California has determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within cells. (bioquicknews.com)
  • The molecular and chemical details are relatively clear for enveloped viruses, such as influenza, HIV and herpes, but up to now the mechanisms for cell entry of non-enveloped viruses, such as BTV and others, had not been well understood. (eurekalert.org)
  • This represents a key piece in the puzzle and a significant step forward for understanding molecular structures and mechanisms in this family of viruses. (eurekalert.org)
  • A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer. (news-medical.net)
  • Professor Keiichi Namba, who leads the Protonic NanoMachine Group of the Graduate School of Frontier Biosciences in Osaka University is interested in the remarkable mechanisms underlying these functions and is actively seeking to unveil their secrets by studying the three-dimensional (3D) structures of biological molecules. (jeol.com)
  • Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. (medlineplus.gov)
  • We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)
  • combined molecular modelling and MDs to apprehend new mechanistic insights into the exciting CRISPR-Cas9 system in the DNA cleavage state. (frontiersin.org)
  • Molecular Spectra and Molecular Structure IV. (wikipedia.org)
  • Protein ROA bands are especially prominent from which, as we have shown by comparison with the ROA spectra of proteins with known structures and by using a pattern recognition program, the folds of the major coat protein subunits may be deduced. (dtu.dk)
  • Thus, to identify the functions of proteins, it is necessary not only to understand their molecular structures by using analytical equipment and method but also to observe their 3D structures in detail. (jeol.com)
  • He is particularly interested in a group of proteins that are called molecular motors. (jeol.com)
  • The flagellar motor is composed of about 30 different proteins that form substructures, such as rotor, stator and bushing, and the structure closely resembles that of generic electric motors. (jeol.com)
  • The X-ray crystal structures of three of these derivatives were determined and their conformations were compared with those of estradiol and DES. (aspetjournals.org)
  • it is evident that protein structures will be an essential component of a large number of biological research studies. (frontiersin.org)
  • It also highlights the importance of efficient computational tools to process the structures and derive various biological interpretations. (frontiersin.org)
  • Classical approaches such as molecular dynamics (MD) are useful to apprehend new biological systems. (frontiersin.org)
  • Prof. Namba is one of the pioneers in research on the 3D structures of biological molecules. (jeol.com)
  • Molecular structures of metabolites and analogues of diethylstilbestrol and their relationship to receptor binding and biological activity. (aspetjournals.org)
  • While their psychedelic effects are associated with 5-HT2AR, the enclosed study summarizes efforts to shed light on the pharmacodynamic profiles, not yet known at the receptor level, using molecular docking and three-dimensional quantitative structure-activity relationship (3-D QSAR ) studies. (bvsalud.org)
  • Molecular basis of Refsum disease: sequence variations in phytanoyl-CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7). (medlineplus.gov)
  • For over 40 years, prof. Namba has been engaged in research on revealing protein functions from their structures. (jeol.com)
  • The CyHV-3 structure is typical of viruses of the order Herpesvirales. (cdc.gov)
  • With 21 investigators in 15 institutions, SBDR's goal is to gain fundamental insights into the molecular machines that maintain genomic integrity, by applying a range of experimental techniques. (news-medical.net)
  • Click molecule labels to explore molecular sequence information. (nih.gov)
  • Graphical inspection of the results led to the depiction of a 3-D structure analysis -activity relationship (SAR) scheme that could be used as a guideline for molecular determinants by which any untested cathinone molecule can be predicted as a potential 5-HT2AR binder prior to experimental evaluation. (bvsalud.org)
  • Chemical extraction, quantitative characterization, and spectroscopic experiments have been performed to determine the molecular composition and chemical functionality of a pulp and paper mill secondary sludge. (iwaponline.com)
  • These materials development, structure control and improvement of characterization tool are the critical factors in making innovation in nano electronics. (asiaresearchnews.com)
  • these include computational analysis of structures and complexes with developments and applications that integrate docking and molecular dynamics approaches, and complex experimental data such as cryogenic electron microscopy (cryo-EM). (frontiersin.org)
  • Molecular docking is a computational chemistry method which has become essential for the rational drug design process. (mdpi.com)
  • A five-year research partnership between the London School of Hygiene & Tropical Medicine and the University of California, Los Angeles (UCLA) has revealed the atomic-level structure of the bluetongue virus (BTV), a disease that has killed an estimated two million cattle in Europe over the past two decades. (eurekalert.org)
  • To realize such 2D structures, the atomic layer deposition and thin film growth from 2D nano sheet is proposed. (asiaresearchnews.com)
  • In order to discuss these three key issues, NIMS is going to organize the "NIMS Conference 2013" entitled, "Structure Control of Atomic / Molecular Thin Films and Their Applications" from July 1st to 3rd in 2013 in Tsukuba Science City. (asiaresearchnews.com)
  • The course covers theoretical models for the structure and reactions of atomic nuclear, as well as experiments in nuclear physics and their scientific applications. (lu.se)
  • Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target? (mdpi.com)
  • Hazardous drugs have very different molecular structure and formulations, are unsafe, and limited measurement methods are available. (cdc.gov)
  • My Ph.D. work in the group of Malcolm Levitt will focus on the development of NMR techniques for the investigation of molecular structure. (europa.eu)
  • A workflow for HILIC can be based on the design of experiments approach, to account for all major contributors to the retention mechanism, and direct correlation of experimental retention times to the molecular descriptors. (chromatographyonline.com)
  • RNA is similar in structure to DNA but is involved in different cellular functions. (cdc.gov)
  • the structure folds at exactly the same point and at exactly the same angle. (jeol.com)
  • This information is not available from the X-ray crystal structure of cowpea mosaic virus since no nucleic acid is visible. (dtu.dk)
  • The molecular and crystal structures of the compound were clarified by single crystal X-ray diffraction indicated that it crystallizes as the sodium salt in the triclinic space group P -1 , with the 4-azo-pyrazolone and the sulphophenyl groups being nearly coplanar. (researchsquare.com)
  • They use the false discovery rate analysis to segregate molecular signals from the background and show how this approach can properly complement current measures Olek and Joseph . (frontiersin.org)
  • Mukherji M, Chien W, Kershaw NJ, Clifton IJ, Schofield CJ, Wierzbicki AS, Lloyd MD. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. (medlineplus.gov)
  • Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Faculty of Pharmacy and Medicine, Rome Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. (bvsalud.org)
  • Biologists have long wanted to know how this molecular motor-called the "dynein-dynactin complex"-works. (bioquicknews.com)
  • Human phytanoyl-CoA hydroxylase: resolution of the gene structure and the molecular basis of Refsum's disease. (medlineplus.gov)
  • Prof. Namba became obsessed with the mystery and started a series of research studies to reveal the 3D structures of these molecular motors. (jeol.com)
  • Only the last of the 10 crystals we had for phasing - a crucial step in determining structure - worked, so it was a bit of a cliff-hanger. (news-medical.net)
  • RNA contains the same basic elements of DNA but with three major differences in its structure. (cdc.gov)
  • R" denotes a variety of groups that attach to the basic structure. (cdc.gov)
  • The principal aim of this work was to provide a perspective with practical utility in streamlining the chromatographic method development in pharmaceutical industries based upon predicting the chromatographic retention times from molecular structures. (chromatographyonline.com)
  • Cooper says, "Understanding the relationship between the structure of WRN and how it performs its multiple functions to prevent aging and cancer is a perfect example of the kind of problem we designed the SBDR program to solve. (news-medical.net)
  • It is a large glycoprotein with a molecular weight of about 95 kD, and exists as a homodimer composed of two identical subunits. (cdc.gov)
  • Using these experimentally validated and predicted binding targets, we were able to build molecular signaling networks that are potentially reflective of and play a role in MWCNT-induced lung inflammatory and fibrotic pathology. (cdc.gov)
  • Perry and Yannone and their colleagues determined the structure of the WRN exonuclease domain (WRN-exo) and showed how the enzyme may function in a series of specific DNA repair events. (news-medical.net)
  • This enzyme is critical for the normal function of cell structures called peroxisomes. (medlineplus.gov)
  • The bioactive conformations of cathinones were modeled by AutoDock Vina and were used to build structure-based (SB) 3-D QSAR models using the Open3DQSAR engine. (bvsalud.org)
  • Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)
  • In the new research, however, TSRI biologist Dr. Gabriel C. Lander and his laboratory, in collaboration with Dr. Trina A. Schroer and her group at Johns Hopkins University, created a picture of the whole dynein-dynactin structure. (bioquicknews.com)