• Focus will be paid to the integration of machine learning techniques with phenomenological quantum-mechanical Hamiltonians, enhancing transferability and interpretability of electronic structure simulations at a coarse-grained resolution. (aiche.org)
  • Identifying local structure in molecular simulations is of utmost importance. (osti.gov)
  • Using ideas from computer vision, we adapt a specific type of neural network called a PointNet to identify local structural environments in molecular simulations. (osti.gov)
  • Our results suggest the approach will be broadly applicable to many types of local structure in simulations. (osti.gov)
  • article{osti_1542673, title = {A generalized deep learning approach for local structure identification in molecular simulations}, author = {DeFever, Ryan S. and Targonski, Colin and Hall, Steven W. and Smith, Melissa C. and Sarupria, Sapna}, abstractNote = {Identifying local structure in molecular simulations is of utmost importance. (osti.gov)
  • Having a precise description of water s structure is critical to constructing accurate simulations of molecular events, including protein folding, substrate binding, macromolecular recognition, and complex formation. (phys.org)
  • Dr. Gaurav Chopra and Professor Michael Levitt in the Department of Structural Biology used molecular dynamics simulations involving a state-of-the-art Quantum Mechanical Polarizable Force Field (QMPFF3) to study the hydration of buckminsterfullerene, the smallest hydrophobic nanosphere widely referred to as a buckyball or C 60 . (phys.org)
  • There were many challenges to overcome in designing and implementing QMPFF3-based molecular dynamics simulations especially to study the behavior of water molecules next to hydrophobic surfaces at atomic detail and subpicosecond time resolution. (phys.org)
  • In this work, molecular dynamics (MD) simulations were first used to investigate the solvation structure of benzene, thiophene, and n-hexane in monoethanolamine-based DESs. (aiche.org)
  • Molecular dynamics (MD) simulations with INTERFACE and reactive INTERFACE force fields (IFF and IFF-R) were used to predict bulk and Young's moduli of amorphous PA6-CNT/G nanocomposites as a function of CNT/G loading. (dtic.mil)
  • Molecular dynamics simulations and neutron diffraction studies of the structure and melting of long n-alkane monolayers on graphite. (dtu.dk)
  • First, we report pure hydrodynamical simulations from which we infer statistics of the CNM structures. (eas-journal.org)
  • Hypothesis generation in molecular and cellular biology is an empirical process in which knowledge derived from prior experiments is distilled into a comprehensible model. (biomedcentral.com)
  • Ontologies have become an important source of knowledge in molecular biology. (biomedcentral.com)
  • Plant Molecular Biology, 10(4), 303–310. (ncsu.edu)
  • Journal of Molecular Biology, 204, 500–534. (ncsu.edu)
  • The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)
  • Our research focuses on major areas of modern biochemistry and molecular biology. (lu.se)
  • International agreements provide descriptive, unambiguous, unique, systematic "IUPAC" names that are reasonably convenient for most organic molecules of modest molecular weight. (videolectures.net)
  • Particularly, MolCode not only consistently generates valid (99.95% Validity) and diverse (98.75% Uniqueness) molecular graphs/structures with desirable properties, but also generate drug-like molecules with high affinity to target proteins (61.8% high affinity ratio), which demonstrates MolCode's potential applications in material design and drug discovery. (biorxiv.org)
  • Many studies propose to generate 2D/3D molecules and optimize molecular properties with deep generative models 20 - 25 . (biorxiv.org)
  • However, complete information about a molecule cannot be obtained from these methods since the 3D structures of molecules are still unknown, which limits their practical applications. (biorxiv.org)
  • With its high data capacity, its wide range of functions beginning with the generation of molecules reaching up to the construction of rather complicated inorganic structural frameworks, Diamond is a comprehensive tool for both molecular and solid state chemists as well as for surface and material scientists. (crystalimpact.com)
  • Then, molecular models are analyzed to visualize molecules' shapes, and 3-D structures are sketched. (flinnsci.com)
  • Students practice drawing Lewis structures of specific molecules, and use these structures to predict their molecular geometry. (flinnsci.com)
  • Students then examine the constructed 11 molecular models to visualize the shapes of molecules and sketch their three-dimensional structures. (flinnsci.com)
  • A new algorithm has been implemented for generating crystal structures with molecules occupying special Wyckoff positions. (mendeley.com)
  • The Lewis Structure Generator that we put in your hands here is an excellent tool to obtain structures of more than 400 molecules. (centrogye.com)
  • In Chem 101A, we will focus on drawing Lewis structures of molecules and polyatomic ions that have one central atom with several other atoms attached to it. (centrogye.com)
  • Newswise - DALLAS - March 29, 2018 - Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called "anti-aging" protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. (newswise.com)
  • The crystal structure of the ternary complex of NADPH, the potent antifolate [2, 4-diamino-5-¿3-[3-(2-acetyloxyethyl)-3-benzyltriazen-1-yl]-4 -chloroph enyl¿-6-ethylpyrimidine] (TAB, 1) and Pneumocystis carinii dihydrofolate reductase (pcDHFR), refined to 2.1 A resolution, reveals that TAB binds similar to the antifolates trimethoprim and methotrexate. (rcsb.org)
  • It reveals the liquid structures in the adjacent neighbour shells, which is a function of electron-withdrawing sulphur attached to thiophene and the Ï -electron cloud of benzene. (aiche.org)
  • Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems. (broadinstitute.org)
  • The cryo-electron-microscopy structures enable modelling by large-scale molecular dynamics simulation, resulting in all-atom models for the hexamer-of-hexamer and pentamer-of-hexamer elements as well as for the entire capsid. (nature.com)
  • Figure 3: All-atom molecular dynamics simulation of CA tubular assembly. (nature.com)
  • This has enabled molecular property prediction within vast chemical compound spaces and the high-dimensional parametrization of energy landscapes for the efficient molecular simulation of measurable observables. (esi.ac.at)
  • Economou, I, Prediction of Structure and Physical Properties of Complex Fluids Using Molecular Simulation , 2007, Sound/Visual production (digital). (dtu.dk)
  • Using a technique called single particle electron microscopy (a methodology closely related to cryo-EM), Terunaga Nakagawa , M.D., Ph.D., associate professor of Molecular Physiology and Biophysics in the Vanderbilt University School of Medicine, showed that GluD2 functions through a "molecular bridge" that spans the synapse, or space between nerve cells. (vumc.org)
  • In MolCode, 3D geometric information empowers the molecular 2D graph generation, which in turn helps guide the prediction of molecular 3D structure. (biorxiv.org)
  • Genarris is an open source Python package for generating random molecular crystal structures with physical constraints for seeding crystal structure prediction algorithms and training machine learning models. (mendeley.com)
  • A researcher at Vanderbilt University Medical Center, with colleagues from Japan and Oxford University in England, has solved the molecular structure of a mysterious glutamate receptor. (vumc.org)
  • Understanding the structure and function of ABCA4 is important to uncovering the underlying mechanisms and facilitating therapy development. (elifesciences.org)
  • We demonstrated a 'do-it-yourself' approach for structuring and extracting knowledge in the context of experimental research on biomolecular mechanisms. (biomedcentral.com)
  • Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. (medlineplus.gov)
  • We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)
  • This field of genetics emerged from the availability of several studies with classical molecular markers, such as isozymes, RAPD, AFLP, and microsatellites. (intechopen.com)
  • Department of Molecular Genetics AFRC Institute of Plant Science Research (Cambridge Laboratory), Maris Lane, Trumpington Cambridge CB2 2LQ, U.K. (ncsu.edu)
  • Due to intramolecular interactions or rotations of structural motifs, the same molecular graph can correspond to various spatial conformations with different quantum properties 33 - 37 . (biorxiv.org)
  • It offers an extensive set of functions that let you easily model any arbitrary portion of a crystal structure from a basic set of structural parameters (cell, space group, atomic positions). (crystalimpact.com)
  • Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex biological and chemical systems. (mdpi.com)
  • Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
  • However, further refinement of methodology is highly desired as most existing methods lack unified modeling of 2D topology and 3D geometry information and fail to effectively learn the structure-property relationship for molecule design. (biorxiv.org)
  • Extensive experimental results show that MolCode outperforms previous methods on a series of challenging tasks including de novo molecule design, targeted molecule discovery, and structure-based drug design. (biorxiv.org)
  • Furthermore, some methods leverage the chemical priors of molecular fragments/motifs and propose to generate molecular graphs fragment-by-fragment 31 , 32 . (biorxiv.org)
  • Existing methods enabled scientists to study the Arp2/3 complex's structure is one of two ways: either in isolation when the structure was inactive, or once bound to actin filaments. (labroots.com)
  • This thesis discusses the use of computational chemistry methods, such as molecular dynamics (MD) and ab initio calculations, and experimental biochemical techniques, such as site-directed mutagenesis, in vivo bacterial assays, chemical cross-linking, and circular dichroism spectroscopy, in tandem to elucidate ion channel structure-function relationships. (caltech.edu)
  • Single particle EM allows researchers to determine the structure of large, flexible membrane-bound receptors in their natural environments in a way that traditional methods cannot, said Nakagawa, a corresponding author of the paper. (vumc.org)
  • Population genetic studies enabled the detection of population structure with those markers, but a more comprehensive analysis of natural populations was only possible with the development of statistical methods that combined both molecular data and environmental variables. (intechopen.com)
  • Hazardous drugs have very different molecular structure and formulations, are unsafe, and limited measurement methods are available. (cdc.gov)
  • The structures provided insights into a minimal Cas9 scaffold and revealed the remarkable mechanistic diversity of the CRISPR-Cas9 systems. (broadinstitute.org)
  • These structures provide a molecular basis to understand many disease-causing mutations and a rational guide for new experiments to uncover how ABCA4 recruits, flips, and releases retinoids. (elifesciences.org)
  • These studies provide a molecular understanding of how MATH-BTB proteins recruit substrates to Cul3 and how their dimerization and conformational variability may facilitate avid interactions with diverse substrates. (rcsb.org)
  • sf2 molecular geometry lewis structure polarity and bond. (centrogye.com)
  • The number of significant figures in 400000 m is: A. Lewis structures don't tell us everything, but along with molecule geometry and polarity they are hugely informative. (centrogye.com)
  • Intercommunication between functional groups for individual adsorbates often serves as the primary driving force that controls monolayer ordering as well as electronic structure especially in the limit of weak interaction between the adsorbate and substrate. (nyu.edu)
  • Therefore, molecular generative models considering 3D geometry information are desired to better learn structure-property relationships. (biorxiv.org)
  • With the Lewis Structures and Molecular Geometry Guided-Inquiry Chemistry Kit, students draw Lewis structures to predict molecular geometry. (flinnsci.com)
  • Though there are different processes that can introduce characteristic scales, such as geometry, decaying turbulence, the transition scale from supersonic to subsonic turbulence (the sonic scale), line-of-sight effects and energy injection caused by expanding supernova shells, outflows, HII-regions, and although the relative contribution of these effects strongly varies from cloud to cloud, it is remarkable that the resulting turbulent structure of molecular clouds shows similar characteristics. (aanda.org)
  • PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health - Name the molecular geometry of the compound. (centrogye.com)
  • molecular geometry of xef4. (centrogye.com)
  • Name the molecular geometry of the compound. (centrogye.com)
  • The molecular geometry of CBr4 is tetrahedral, because, the carbon (C) central atom has no lone pair and is attached to the four bromine atoms with the help of a single bond. (centrogye.com)
  • Many existing approaches use ML to predict molecular properties from quantum chemical calculations. (esi.ac.at)
  • This sample contains a large variety of different molecular cloud types with different star-forming activity. (aanda.org)
  • However, the size of the chemical space is estimated to be in the order of 10 607 , which precludes an exhaustive computational or experimental search of possible molecular candidates. (biorxiv.org)
  • For that, we study the large-scale spatial distribution of low-density molecular gas and search for characteristic length scales. (aanda.org)
  • Participants will be introduced to the coverage, precision and quality of different search engines and learn how to improve their literature searches through a structured customisation of keywords and the use of different search operators. (lu.se)
  • This research was catalyzed by the solving of atomic resolution crystal structures of the mechanosensitive channels of large and small conductance (MscL and MscS) by the Rees group. (caltech.edu)
  • The course covers theoretical models for the structure and reactions of atomic nuclear, as well as experiments in nuclear physics and their scientific applications. (lu.se)
  • The structure of the tubular assembly shows, at the three-fold interface 11 , a three-helix bundle with critical hydrophobic interactions. (nature.com)
  • The structure defines the interactions that RNA polymerase and δ make with the DNA site for transcription initiation, known as the "promoter. (rutgers.edu)
  • Alteration of cytosine-guanine interactions due to N7 metal cation binding: a structure-activity relationship for cisplatin analogues. (aspetjournals.org)
  • The reduction of molecular complexity in the individual DOM fractions attenuates intermolecular interactions and substantially increases the disposable resolution of any structure selective characterization. (awi.de)
  • Comparative mass analysis showed that fractionation of SR DOM was governed by multiple molecular interactions depending on O/C ratio, molecular weight and aromaticity. (awi.de)
  • Lewis structures and VSEPR theory offer useful models for picturing the structures of covalent compounds. (flinnsci.com)
  • These structures explain the observed SAR for previously described compounds and new compounds, which possess up to 8-fold improved potency against the isolated enzyme. (ub.edu)
  • In this talk I will discuss the arrangement and interfacial electronic properties of ordered molecular domains that form through interadsorbate hydrogen bonding at noble metal surfaces probed with high spatial resolution, low temperature scanning tunneling microscopy (STM) and spectroscopy, as well as supporting density functional theory (DFT) calculations. (nyu.edu)
  • By providing a first look at the structure of the protein complex that includes FGF23 and its co-receptors, the FGF receptor and a-Klotho, the most recent study challenges the long-accepted belief that only the cell-attached form of aKlotho can serve as a receptor for FGF23 and hence that FGF23 action is restricted to tissues having the cell-attached form. (newswise.com)
  • One of the major, paradigm-changing findings revealed by solving the protein complex structure is that the circulating form of soluble a-Klotho can actually serve as a co-receptor for FGF23. (newswise.com)
  • Nicotine is a small molecule ligand that binds to and gates nicotinic acetylcholine receptors, and a thorough understanding of nicotine structure could aid efforts to elucidate receptor structure-function relationships and design new pharmaceuticals. (caltech.edu)
  • His Oxford colleagues used X-ray crystallography to solve another part of the structure, and researchers at Keio University in Japan verified receptor function with electrophysiology data. (vumc.org)
  • While their psychedelic effects are associated with 5-HT2AR, the enclosed study summarizes efforts to shed light on the pharmacodynamic profiles, not yet known at the receptor level, using molecular docking and three-dimensional quantitative structure-activity relationship (3-D QSAR ) studies. (bvsalud.org)
  • Molecular basis of Refsum disease: sequence variations in phytanoyl-CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7). (medlineplus.gov)
  • In a paper published in Science, the Rutgers CCB scientists show how the molecular machine responsible for transcription initiation--a protein complex that consists of the enzyme RNA polymerase and the initiation factor δ- recognizes a specific site on DNA preceding a gene, binds to DNA, unwinds the DNA helix, and pre-organizes the unwound DNA to enable subsequent reactions. (rutgers.edu)
  • Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster. (ncsu.edu)
  • Human phytanoyl-CoA hydroxylase: resolution of the gene structure and the molecular basis of Refsum's disease. (medlineplus.gov)
  • A new method for estimating the unit cell volume based on the single molecule structure has been developed using a machine-learned model trained on experimental structures. (mendeley.com)
  • Genarris finds the experimental structures of the two polymorphs of benzene and the three polymorphs of glycine. (mendeley.com)
  • Graphical inspection of the results led to the depiction of a 3-D structure analysis -activity relationship (SAR) scheme that could be used as a guideline for molecular determinants by which any untested cathinone molecule can be predicted as a potential 5-HT2AR binder prior to experimental evaluation. (bvsalud.org)
  • Multiple co-crystal structures of an adenine-based series of inhibitors bound to the molecular chaperone Hsp90 have been determined. (ub.edu)
  • We determined the 2.1 Å resolution structure of MLE core bound to a U10 RNA and ADP-AlF 4 . (cipsm.de)
  • For the SBr4 structure use the periodic table to find the total number of valence electro Drawing Lewis Dot Diagrams. (centrogye.com)
  • Click molecule labels to explore molecular sequence information. (nih.gov)
  • The final challenge was to find a method to visualize water structure around buckyball. (phys.org)
  • The primary differences in the molecular dynamics (MD) models and those observed in this crystal complex result from small conformational changes in active-site residues on energy minimization. (rcsb.org)
  • Crystal structure of dimeric HIV-1 capsid protein. (nature.com)
  • In simple cases order parameters are physically intuitive and trivial to develop (e.g., ion-pair distance), however in most cases, order parameter development becomes a much more difficult endeavor (e.g., crystal structure identification). (osti.gov)
  • We demonstrate the method on crystal structure identification in Lennard-Jones (four different phases), water (eight different phases), and mesophase (six different phases) systems. (osti.gov)
  • The method achieves as high as 99.5% accuracy in crystal structure identification. (osti.gov)
  • Diamond is our outstanding molecular and crystal structure visualization software. (crystalimpact.com)
  • It integrates a multitude of functions, which overcome the work with crystal structure data - in research and education as well as for publications and presentations. (crystalimpact.com)
  • Diamond does not only draw nice pictures of molecular and crystal structures like most of its competitive programs do. (crystalimpact.com)
  • an orientation never observed in any DHFR crystal structure to date. (rcsb.org)
  • The crystal structures of acridinedione derivatives are expected to provide useful information on the mol-ecular conformation, which has a direct relationship to biological activity. (iucr.org)
  • Here, we report the crystal structures of Campylobacter jejuni Cas9 (CjCas9), one of the smallest Cas9 orthologs, in complex with an sgRNA and its target DNA. (broadinstitute.org)
  • Initial studies of MscL verified the relevance of the crystal structure conformation under physiological conditions and compared different MscL homologues. (caltech.edu)
  • Using example systems from heterogeneous catalysis and organic electronics, I will discuss the challenges associated with encoding physical symmetries and invariance properties into deep learning models of molecular electronic structure. (esi.ac.at)
  • R Ligands: Developing of Predictive Structure-Based Bioactive Conformations and Three-Dimensional Structure-Activity Relationships Models for Future Recognition of Abuse Drugs. (bvsalud.org)
  • The bioactive conformations of cathinones were modeled by AutoDock Vina and were used to build structure-based (SB) 3-D QSAR models using the Open3DQSAR engine. (bvsalud.org)
  • In this talk, I will outline the extension of this methodology to polymers, specifically addressing the problem of the molecular weight transferability of electronic coarse-graining predictions. (aiche.org)
  • 1034 CHAPTER 24 The Chemistry of Life: Organic and Biological Chemistry Aldehyde H Figure 23.14 shows the tertiary structure of myoglobin, a protein with a molecular weight O of about 18,000 amu and containing one heme group. (centrogye.com)
  • The androgen testosterone (17β -hydroxyandrostenone) has a molecular weight of 288 daltons. (cdc.gov)
  • It is a large glycoprotein with a molecular weight of about 95 kD, and exists as a homodimer composed of two identical subunits. (cdc.gov)
  • It is important that chemists agree on notation and nomenclature in order to communicate molecular constitution and configuration. (videolectures.net)
  • Many chemists prefer the second structure because it gives us a couple of zeroes. (centrogye.com)
  • gebr4 molecular geometrypatricia caroline swanson obituary 03/06/2022 / governor's award high school / en ballarat restaurants broadsheet / por / governor's award high school / en ballarat restaurants broadsheet / por CBr4 is in a tetrahedral molecular shape, so all the dipoles of the 4 polar C-Br bonds cancel each other out, resulting in an overall nonpolar molecule. (centrogye.com)
  • We define a SPOP-binding consensus (SBC) and determine structures revealing recognition of SBCs from the phosphatase Puc, the transcriptional regulator Ci, and the chromatin component MacroH2A. (rcsb.org)
  • Molecular structures have interesting properties to model for many applications. (tue.nl)
  • For these applications, one of the properties that are interesting for modeling is the dynamics of molecular structures: in short, how they move over time. (tue.nl)
  • The molecular properties of ABCA4 are unique and intriguing. (elifesciences.org)
  • However, as all properties derive from the QM wave function, an ML model that is able to predict the wave function also has the potential to predict all other molecular properties. (esi.ac.at)
  • The structure and shape of a molecule influence its physical properties and affect its chemical properties as well. (flinnsci.com)
  • Because the transcription machineries in bacteria and higher organisms are structurally and mechanistically related, the structure also provides a framework for understanding transcription and transcriptional regulation in higher organisms, including humans. (rutgers.edu)
  • Here we present MolCode, a roto-translation equivariant generative framework for Mo lecular graph-structure Co-de sign. (biorxiv.org)
  • Atoms, which form the building blocks of molecular structures, consist of a nucleus, containing neutrons and protons, and a shell of electrons. (tue.nl)
  • The most popular method to study the water structure around any solute used a one-dimensional radial distribution function that averages the number of water O and H atoms at a particular distance to increase the signal to noise ratio, Chopra explains. (phys.org)
  • CBr4 is a nonpolar molecule because of the zero net dipole moment caused by its symmetrical structure. (centrogye.com)
  • These results confirm prior molecular modeling investigations of the binding of TAB to pcDHFR that identified four low-energy binding geometries, two involving rotations about the terminal N(2)-N(3) triazenyl linkage and two involving atropisomerism about the pivotal pyrimethamine-phenyl bond. (rcsb.org)
  • The solvation shell structure and characteristics were investigated in tandem with the possibility of benzene and thiophene clustering. (aiche.org)
  • Despite decades of clinical, biochemical, and animal model studies, the molecular mechanism of ABCA4 is unknown. (elifesciences.org)
  • We aim to better understand how the spatial structure of molecular clouds is governed by turbulence. (aanda.org)
  • We employ a 35 square degrees 13 CO 1 → 0 molecular line survey of Cygnus X and visual extinction (A V ) maps of 17 Galactic clouds to analyze the spatial structure with the Δ-variance method. (aanda.org)
  • The Δ-variance spectra obtained from the A V maps show differences between low-mass star-forming (SF) clouds and massive giant molecular clouds (GMC) in terms of shape of the spectrum and its power-law exponent β . (aanda.org)
  • Low-mass SF clouds have a double-peak structure with characteristic size scales around 1 pc (though with a large scatter around this value) and 4 pc. (aanda.org)
  • Understanding star formation in molecular clouds - IV. (aanda.org)
  • Then we present a 3D calculation, which includes magnetic field and self-gravity with the purpose of studying the formation of molecular clouds. (eas-journal.org)
  • Here, we report the structures of human ABCA4 in two conformations. (elifesciences.org)
  • Although its chemical structure was elucidated 1 in 1934, its detailed conformation remains still to be established in spite of numerous physicochemical applications 2 . (nature.com)
  • Draw the best Lewis dot structure for TeBr4. (centrogye.com)
  • And there are a total of 4 bonded pairs(single bonds) present in the CBr4 lewis structure, Vishal Goyal is the founder of Topblogtenz, a comprehensive resource for students seeking guidance and support in their chemistry studies. (centrogye.com)
  • Ethylene, C2H4 has the Lewis Structure: The molecular shape is predicted to be trigonal planar around each carbon atom. (centrogye.com)
  • Steps of drawing lewis structure of H 2 O 2. (centrogye.com)
  • lewis dot structure calculator novoeasysite. (centrogye.com)
  • We identify a dimeric SPOP-Cul3 assembly involving a conserved helical structure C-terminal of BTB domains, which we call "3-box" due to its facilitating Cul3 binding and its resemblance to F-/SOCS-boxes in other cullin-based E3s. (rcsb.org)
  • Here we report the cryo-electron microscopy structure of a tubular HIV-1 capsid-protein assembly at 8 Å resolution and the three-dimensional structure of a native HIV-1 core by cryo-electron tomography. (nature.com)
  • High-resolution transmission electron images and selected area electron diffraction patterns reveal a nanodomain structure. (rsc.org)
  • RNA is similar in structure to DNA but is involved in different cellular functions. (cdc.gov)