Molecular pulmonary surfactant associated protein c. Medical search. Frequent questions

SP-D has a significant roles in immune and inflammatory regulation of the lung as it regulates of the level of surfactant in the lungs by a process named surfactant homeostasis. (wikipedia.org)
Dr. Garcia-Arcos leads a team of scientists focused on lipid metabolism, surfactant lipid homeostasis, and cellular lipid uptake and usage during pulmonary and cardiovascular disease. (downstate.edu)
In the lab, we use cell culture and in vivo models to study the regulation of surfactant homeostasis and its dysregulation during disease. (downstate.edu)
CONCLUSION: In cftrm1HGU/m1HGU mice surfactant homeostasis is perturbed by an increased phospholipid pool in the alveolar compartment. (bmj.com)
Surfactant proteins, SP-A and SP-D, are collagen-containing C-type (calcium dependent) lectins called collectins, which contribute significantly to surfactant homeostasis and pulmonary immunity. (ox.ac.uk)
SFTPB is the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. (avivasysbio.com)
This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. (lsbio.com)

Adsorption of surfactant lipids by single-walled carbon nanotube s in mouse lung upon pharyngeal aspiration. (cdc.gov)
Quantitation of adsorbed lipids by LC-MS along with the structural assessments of phospholipid binding by atomic force microscopy and molecular modeling indicated that the phospholipids (approximately 108 molecules per SWCNT) formed an uninterrupted "coating" whereby the hydrophobic alkyl chains of the phospholipids were adsorbed onto the SWCNT with the polar head groups pointed away from the SWCNT into the aqueous phase. (cdc.gov)
Taken together, this is the first demonstration of the in vivo adsorption of the surfactant lipids and proteins on SWCNTs in a physiologically relevant animal model. (cdc.gov)
Pulmonary surfactant is mainly composed of phospholipids and minor amounts of other lipids and specific proteins. (downstate.edu)
A delicate balance between synthesis, secretion, recycling and degradation of the lipids is required to maintain surfactant function and lung performance. (downstate.edu)
Samaha G., Garcia-Arcos I., (2020) "Alveolar lipids in pulmonary disease. (downstate.edu)
The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. (lsbio.com)
We used stable isotope tracers and high resolution-mass spectrometry techniques to describe lipids and metabolites profile and surfactant specific proteins metabolism and amounts in different disease in children and adults. (irpcds.org)
At this interface, proteins and lipids of the pulmonary surfactant bind to MWCNTs, affecting their surface characteristics. (biomedcentral.com)
Lung surfactant components (90% lipids and 10% proteins), especially lipids, are absolutely essential for normal pulmonary function. (hoanglab.info)
Of the 90% lipids in lung surfactant, 80% is phosphatidylcholine (PC). (hoanglab.info)

Dr. Pryhuber's particular clinical interests are care of infants with pulmonary hypertension, lung injury, growth and developmental failure, often complicated by chronic and inflammatory disease. (rochester.edu)
Targeted AntiBiotics for Chronic pulmonary diseases (TARGET ABC): can targeted antibiotic therapy improve the prognosis of Pseudomonas aeruginosa-infected patients with chronic pulmonary obstructive disease, non-cystic fibrosis bronchiectasis, and asthma? (sdu.dk)
International Journal of Chronic Obstructive Pulmonary Disease. (sdu.dk)
However, the fundamental question of whether surfactant alterations in the CF lung are secondary to the pulmonary damage or are present before initiation of chronic infection and inflammation has yet to be resolved in patients with cystic fibrosis but can now be addressed in CF mice that exhibit the basic defect in the airways. (bmj.com)
Although a large and diverse list of ILDs have been described, the majority seen in clinical practice are idiopathic pulmonary fibrosis (IPF), chronic hypersensitivity pneumonitis (HP), collagen vascular disease (CVD)-associated ILD , and sarcoidosis. (medscape.com)
[ 8 ] Regardless of the underlying disease process, the universal pathophysiology is believed to be acute injury to lung parenchyma leading to chronic interstitial inflammation, tissue destruction, fibroblastic activation and proliferation, pulmonary fibrosis and, eventually, architectural remodeling with honeycomb changes. (medscape.com)
Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. (cdc.gov)
Mannose-binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis. (cdc.gov)
Pulmonary surfactant status in critical diseases, both acute and chronic, is also a key topic of the laboratory. (irpcds.org)
The overarching problems that we try to address are 1) how do we define the molecular signatures of a biological system in response to stress caused by the environment, chronic diseases and aging? (oregonstate.edu)
Aging strongly correlates with the development and incidence of chronic respiratory diseases, including cancer and idiopathic pulmonary fibrosis, but is most strongly linked with development of chronic obstructive pulmonary disease. (karger.com)

Mutations in this gene are associated with idiopathic pulmonary fibrosis. (lsbio.com)
Idiopathic persistent pulmonary hypertension of the newborn can present without signs of acute perinatal distress. (medscape.com)

We found that SWCNTs selectively adsorbed two types of the most abundant surfactant phospholipids: phosphatidylcholines (PC) and phosphatidylglycerols (PG). (cdc.gov)
Molecular speciation of these phospholipids was also consistent with pulmonary surfactant. (cdc.gov)
BACKGROUND: Progressive pulmonary dysfunction is a characteristic symptom of cystic fibrosis (CF) and is associated with functional impairment and biochemical alterations of surfactant phospholipids in the airways. (bmj.com)
Surfactant is composed of phospholipids and other surfactant-associated proteins. (avivasysbio.com)
Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
These include the generation of a variety of lipid mediators, along with membrane remodelling, modification of extracellular non-cellular phospholipid components of pulmonary surfactant, microparticles and lipoproteins, and degradation of microbial membranes and dietary phospholipids. (ijbs.com)

In contrast to adult primary pulmonary hypertension, the newborn syndrome is not defined by a specific pressure of the pulmonary circulation. (medscape.com)

In molecular biology, Pulmonary surfactant protein D (SP-D) is a protein domain predominantly found in lung surfactant. (wikipedia.org)
Dr. Pryhuber trained as a post-doctoral Proctor Research Scholar and participant in the University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung. (rochester.edu)
She serves on NIH study sections and as reviewer for journals in her area of expertise, manages an active laboratory, supervises students in pulmonary biology and epithelial cell research and has received awards recognizing both teaching and original research accomplishments. (rochester.edu)
Our experimental approaches include a wide variety of techniques in the areas of molecular biology, biochemistry, cell biology and physiology. (downstate.edu)
PhD and MD/PhD: Students interested in PhD training should contact Jeffrey Whitsett and apply to the Molecular and Developmental Biology Graduate Program . (cincinnatichildrens.org)

While it has been known for decades that an adequate development of the alveolar surfactant system is essential for neonates, the role of lipid metabolism in adult lung disease is poorly understood despite accumulating evidence showing its relevance. (downstate.edu)
Pulmonary metabolism in smoke-related disease. (downstate.edu)
CONCLUSION: Obesity altered ceramide metabolism leading to pulmonary surfactant dysfunction and impaired resolution of airway inflammation, finally contributing to the phenotypes of obese asthmatics. (ajou.ac.kr)

Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. (cdc.gov)
Direct Molecular Diagnosis of Aspergillosis and CYP51A Profiling from Respiratory Samples of French Patients. (cdc.gov)

Abstract: Abstract: The delicate alveolar structure of the mammalian lungs is stabilized against forces tending to its collapse, thanks to the coating of a complex lipid-protein network assembled by the pulmonary surfactant system. (imdea.org)
The PI has had more than five years of experience working with replacement lung surfactants, understanding and relating the role of lipid-protein interactions on structural and mechanical properties of lung surfactants using experimental and theoretical techniques developed by her, as well as guiding graduate and undergraduate student research projects. (ku.edu)
Pulmonary surfactant, also known as lung surfactant, is a detergent-like, lipid-protein mixture synthesized by alveolar type II epithelial cells. (biophysics.org)

Dr. Ledford's current work in the area of pulmonary surfactant immunobiology combines her knowledge of mouse genetics, pulmonary disease models and immune function regulation and focuses on understanding the role of Surfactant Protein-A (SP-A) and how it regulates signaling pathways within various immune cell populations. (bio5.org)
Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. (nature.com)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)

It is a syndrome characterized by marked pulmonary hypertension that causes hypoxemia secondary to right-to-left shunting of blood at the foramen ovale and ductus arteriosus. (medscape.com)

She leads the neonatal pulmonary hypertension consultation team. (rochester.edu)
Persistent pulmonary hypertension of the newborn (PPHN) is defined as the failure of the normal circulatory transition that occurs after birth. (medscape.com)
In cases of congenital diaphragmatic hernia (CDH) associated with pulmonary hypoplasia, hypertrophy of the contralateral lung has been demonstrated, with associated pulmonary artery hypertension. (medscape.com)

This review is an update on the structural and functional aspects of SP-A and SP-D, with emphasis on their roles in controlling pulmonary infection, allergy and inflammation. (ox.ac.uk)
In the lung, this recognition is aided by surfactant which also serves to maintain the balance between inflammation and pulmonary function, although the underlying mechanisms are unknown. (nih.gov)
Here we have explored pulmonary innate recognition of a variety of fungal particles, including zymosan, Candida albicans and Aspergillus fumigatus, and demonstrate that opsonisation with surfactant components can limit inflammation by reducing host-cell fungal interactions. (nih.gov)
Meconium-stained amniotic fluid (MSAF) can cause mechanical obstruction of airways and pulmonary air leak, pneumonitis, vasoconstriction of pulmonary vessels, and inactivation of surfactant effect which could result in pulmonary inflammation and apoptosis. (hindawi.com)
However, the molecular mechanism under obesity-induced inflammation has not yet been fully understood. (ajou.ac.kr)
OBJECTIVE: Considering the essential role of hydrophobic surfactant protein B (SP-B) in lung function, SP-B was targeted to examine its involvement in the development of obesity-induced airway inflammation in asthmatics. (ajou.ac.kr)

Our research team has 30 years of experience in translational medicine of acute lung diseases (including animal models, newborns, and adults) and in genetic mutations of lung surfactant-specific proteins. (irpcds.org)

Patients with pneumonia and aspiration as risk factors and those with pulmonary sepsis were assigned to the direct ARDS group, whereas those with pancreatitis or non-pulmonary sepsis were assigned to the indirect ARDS group. (biomedcentral.com)
Patients who could not be classified as uniquely direct or indirect ARDS and patients with both pneumonia and non-pulmonary sepsis were excluded. (biomedcentral.com)

I was also co-founder and Technical Development Director of a successful spin-out, Molecular Profiles Ltd (which became Juniper Pharma in 2013 and was acquired by Catalent in 2018). (nottingham.ac.uk)

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. (thermofisher.com)
The volume of liquid in the lung is determined by the net rate at which liquid is secreted across the pulmonary epithelium (4-5 mL/kg/h) and the rate at which it flows from the trachea into the fetal pharynx. (medscape.com)
Proteins secreted by the epididymal epithelium. (bvsalud.org)

However, when the lungs are overwhelmed with exogenous insults, SP-A and SP-D can assume pro-inflammatory roles in order to complement pulmonary innate and adaptive immunity. (ox.ac.uk)
In fractions 1-4 from newborn CF piglets an additional cluster containing acute phase proteins was observed, suggesting an early inflammatory response in CF piglets. (biomedcentral.com)
Moreover, we found that pulmonary inflammatory responses to resting Aspergillus conidia were initiated by these PRRs in acidified phagolysosomes, following the uptake of fungal particles by leukocytes. (nih.gov)
3 days later, we study lung pathological, the levels of inflammatory factors, and cell apoptosis in the pulmonary tissue was detected by Tunel and cell apoptosis rate was calculated accordingly. (researchsquare.com)

Surfactant allows the lungs to inflate by decreasing the alveolar surface tension and the work needed for inspiration in each breathing cycle. (downstate.edu)
METHODS: The amount and composition of phospholipid classes and phosphatidylcholine molecular species were determined in bronchoalveolar lavage (BAL) fluid and lavaged lungs by high performance liquid chromatography (HPLC). (bmj.com)
Its first target will be alpha-1 antitrypsin (AAT) deficiency, a condition caused when a faulty gene fails to produce a protein that protects the lungs from damage when the body's immune system is triggered to fight an infection or by irritants. (imperial.ac.uk)
Attempts have been made to treat AAT deficiency by introducing the missing protein into patients' lungs (an approach called protein replacement therapy), but the results have not been encouraging. (imperial.ac.uk)

In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)
While antenatal glucocorticoids are widely used to enhance lung function in preterm infants, cellular and molecular mechanisms by which glucocorticoid receptor (GR) signaling influences lung maturation remain poorly understood. (stanford.edu)
Deletion of the glucocorticoid receptor gene (Nr3c1) from fetal pulmonary mesenchymal cells phenocopied defects caused by global Nr3c1 deletion, while lung epithelial- or endothelial-specific Nr3c1 deletion did not impair lung function at birth. (stanford.edu)

The distal lung is a honeycomb-like collection of delicate gas exchange sacs called alveoli lined by two interspersed epithelial cell types: the cuboidal, surfactant-producing alveolar type II (AT2) and the flat, gas-exchanging alveolar type I (AT1) cell. (stanford.edu)

SFTPA1 / Surfactant Protein A is a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. (lsbio.com)

Lung surfactant in a cystic fibrosis animal model: increased alveolar phospholipid pool size without altered composition and surface tension function in cftrm1HGU/m1HGU mice. (bmj.com)
The amount of SP-A in BAL fluid and the composition of phospholipid as well as phosphatidylcholine molecular species in BAL fluid and lung tissue was unchanged in cftrm1HGU/m1HGU mice compared with controls. (bmj.com)

Next are patients with genetic mutations in: surfactant protein B (SFTPB), ABCA3, surfactant protein C (SFTPC) and pulmonary alveolar proteinosis (PAP). (cincinnatichildrens.org)

The diagnosis is confirmed regardless of the pulmonary arterial pressure, as long as it is accompanied by a right-to-left shunt and absence of congenital heart disease. (medscape.com)

The present study clearly indicates that the pre-coating of MWCNTs with pulmonary surfactant more than the functionalization of the tubes is a key factor in determining their ability to cause oxidative stress, cytokine/chemokine release and apoptosis. (biomedcentral.com)

Lung cellular and molecular physiology. (sdu.dk)

Julie Ledford's research focuses on respiratory disease, and genetic and molecular mechanisms of allergic airway diseases in children. (bio5.org)
Disentangling the role of pulmonary impairment in lung cancer development is important from an etiological perspective, for refining disease susceptibility mechanisms, and for informing precision prevention and risk stratification strategies. (nature.com)
Our data therefore provides crucial new insights into the mechanisms by which surfactant can maintain pulmonary function in the face of microbial challenge, and defines the phagolysosome as a novel intracellular compartment involved in the innate sensing of extracellular pathogens in the lung. (nih.gov)
We integrated genome-wide gene expression profiling, ATAC-seq, and single cell RNA-seq data in mice in which GR was deleted or activated to identify the cellular and molecular mechanisms by which glucocorticoids control prenatal lung maturation. (stanford.edu)
Here, we review alveolar renewal and repair with a focus on the niches, rather than the stem cells, highlighting what is known about the cellular and molecular mechanisms by which they control stem cell activity in vivo. (stanford.edu)
Martin's expertise and research interests include studying the interaction of nano-sized materials with a variety of different biological systems, and to determine how these interactions affect molecular mechanisms within them, thus establishing structure-activity relationships. (swansea.ac.uk)

More recently, Dr. Ledford's research has focused on understanding how genetic variation within human SP-A2 alters functionality of the protein in relation to eosinophil activities and how this translates to characteristics observed in human asthma. (bio5.org)
We examine the genetic correlation between pulmonary function phenotypes and lung cancer, followed by Mendelian randomization (MR) using novel genetic instruments to formally test the causal relevance of impaired pulmonary function, using the largest available dataset of 29,266 lung cancer cases and 56,450 controls from the OncoArray lung cancer collaboration 16 . (nature.com)
The lab has also pioneered, successfully tested, and published several molecular genetic tools, aiding molecular genetic studies in B. pseudomallei and other Burkholderia species. (hoanglab.info)
The ease of genetic manipulations of B. pseudomallei using these tools will expand research that will contribute to molecular genetics, pathogenesis, and bacteria-host interaction studies - crucial for the discovery of novel vaccines, therapeutics, and diagnostic targets. (hoanglab.info)

We used mass-spectrometry based proteomic analysis of unstimulated and carbachol stimulated newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglet airways to study proteins in the airway surface liquid and mucus, to investigate if levels of MUC5AC and MUC5B were affected by carbachol stimulation and whether the proteins clustered according to function. (biomedcentral.com)
Samples collected from newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglets revealed that distinct proteins were bound to the mucus as opposed to the ones easily washed off and associated with the airway liquid. (biomedcentral.com)

In addition, the presence of surfactant proteins A, B, and D on SWCNTs was determined by LC-MS. Finally, we demonstrated that the presence of this surfactant coating markedly enhanced the in vitro uptake of SWCNTs by macrophages. (cdc.gov)
Aim of the present study was to investigate if the pre-coating of MWCNTs with pulmonary surfactant has an influence on potential adverse effects, upon both (i) human monocyte derived macrophages (MDM) monocultures, and (ii) a sophisticated in vitro model of the human epithelial airway barrier. (biomedcentral.com)
The exaggerated immune response to repeated inhalation of these particles leads to infiltration and proliferation of activated pulmonary macrophages and lymphocytes, resulting in lymphocytic alveolitis and bronchiolitis with noncaseating granulomas. (cdc.gov)

Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)
For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)

SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. (avivasysbio.com)
Both in vitro systems were exposed to MWCNTs either pre-coated with a porcine pulmonary surfactant (Curosurf) or not. (biomedcentral.com)
Thus the coating of nano-objects with pulmonary surfactant should be considered for future lung in vitro risk assessment studies. (biomedcentral.com)

In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)

Lung cancer and obstructive pulmonary disease share multiple etiological factors, such as cigarette smoking, occupational inhalation hazards, and air pollution, and 50-70% of lung cancer patients present with co-existing COPD or airflow obstruction 6 . (nature.com)

CollaboratorPreliminary studies of lung surfactant lipid nanoparticle interactions. (ku.edu)
Status: FundedPreliminary studies of lung surfactant lipid nanoparticle interactions. (ku.edu)
Status: FundedLipid membrane-protein interactions during the early stages of Tau protein aggregation. (ku.edu)
To further comprehend the way in which these nanoformulations interact with lung components at the molecular level, we used fluorescence spectroscopy, turbidity measurements, and dynamic light scattering to evaluate the interactions of the two SPION with surfactant protein A (SP-A), a key protein in setting up the nanoparticle behavior in the alveolar fluid. (ox.ac.uk)
We reveal the potential to exploit interactions of sPLA 2 s with other proteins in medical terms, for the development of original diagnostic and therapeutic procedures. (ijbs.com)
We study protein mobility and interactions by solution-phase hydrogen/deuterium exchange mass spectrometry (HDX-MS). (oregonstate.edu)

We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)

Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), constitute a major global burden of disease [ 1 ]. (biomedcentral.com)

Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)

We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Pulmonary hypoplasia or aplasia is part of the spectrum of malformations characterized by incomplete development of lung tissue. (medscape.com)
These proteins are both tissue- and species-specific. (bvsalud.org)

We retrospectively enrolled adult patients (≥ 18 years old) with ARDS (according to the Berlin definition) [ 8 ] who were admitted to the Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital and the Intensive Care Unit, the First Affiliated Hospital of Shandong First Medical University, from 1 January 2015 to 30 June 2020. (biomedcentral.com)

Neither artificial membrane slabs, nor 'live cells' imaged under conditions in which cells have a shabby life that doesn't last long (how much of this is due to the mistreatment of the membrane proteins? (biophysics.org)
As to the role of the cytoskeleton, what does this tell us about the membrane itself, or the behavior of membrane proteins as individual molecules in their interplay with the membrane? (biophysics.org)

Finally, the further GIX sPLA 2 s are found in venom of marine snails, and GXIA and GXIB sPLA 2 s are plant proteins. (ijbs.com)
These antigens include organic dusts containing bacteria, fungi,4 animal or plant proteins, or low-molecular-weight chemicals. (cdc.gov)

Delivery and Performance of Surfactant Replacement Therapies to Treat Pulmonary Disorders. (ku.edu)

Monitoring Adsorption and Aggregation of an Intrinsically Disordered Protein at Solid Substrates. (ku.edu)

Multiple Linear Regression Modeling To Predict the Stability of Polymer-Drug Solid Dispersions: Comparison of the Effects of Polymers and Manufacturing Methods on Solid Dispersion Stability MOLECULAR PHARMACEUTICS. (nottingham.ac.uk)
It improves protein stability, extends storage time, and reduces shipping costs. (betalifesci.com)

Відкрита артеріальна протока (ВАП) Patent ductus arteriosus (PDA) is a persistence of the fetal connection (ductus arteriosus) between the aorta and pulmonary artery after birth. (msdmanuals.com)

The major biophysical function of this lung surfactant film is to reduce the alveolar surface tension to near-zero value. (biophysics.org)

Proteins in the first four extracted fractions clustered together and the fifth fraction contained the mucus cluster, mucins and other proteins known to associate with mucins, whereas the traditional airway surface liquid proteins clustered to fraction 1-4 and were absent from the mucus fraction. (biomedcentral.com)

To understand the contribution of E proteins to Eα function, mutants lacking one or two of the respective binding sites were generated. (bvsalud.org)
A study was therefore undertaken to investigate the pool sizes, composition, and function of lung surfactant in the non-infected cftrm1HGU/m1HGU mouse. (bmj.com)

Postnatal diagnosis of pulmonary hypoplasia can be made with specific criteria such as clinical and radiologic criteria, or pathologic criteria such as lung weight or lung weight-to-body weight ratio, mean radial alveolar count, and DNA estimation for growth assessment at autopsy. (medscape.com)

Progress in deciphering the molecular and cellular basis of immunity against fungi is guiding preclinical studies into vaccine and immune reconstitution strategies for vulnerable patient groups. (jci.org)

Epithelial differentiation is delayed, and surfactant deficiency is associated. (medscape.com)

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