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  • vitro
  • Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem cells may be the most promising route toward the therapy of muscle diseases such as muscular dystrophies. (frontiersin.org)
  • muscle stem
  • To which extent head muscle stem cells retain properties of the early head mesoderm and might even be able to switch between a skeletal muscle and cardiac fate is not known. (frontiersin.org)
  • This is due to the fact that the timing and mechanisms underlying head muscle stem cell development are still obscure. (frontiersin.org)
  • Consequently, it is not clear at which time point one should compare the properties of head mesodermal cells and head muscle stem cells. (frontiersin.org)
  • Our study reveals a common theme of head muscle stem cell development that is quite different from the trunk. (frontiersin.org)
  • We propose that this unique mechanism of muscle stem cell development is a legacy of the evolutionary history of the chordate head mesoderm. (frontiersin.org)
  • However, in a number of diseases including muscular dystrophies, cancer and HIV/Aids, the ability of muscle stem cells to repair muscle is compromised. (frontiersin.org)
  • myoblast
  • Here we describe the engineering of a muscle construct, in this case from mouse myoblast progenitor cells, and the stimulation by electrical pulses. (jove.com)
  • Using molecular, cellular and physiological techniques, we are attempting to define the regulation of this cell population in health and disease.Techniques used in the lab include: histology, immunohistochemistry, protein and RNA expression assays, isolated single fibre and primary myoblast cultures, in situ muscle stimulation to assess contractile function, adenoviral mediated overexpression and/or silencing and metabolic enzyme assays. (mcmaster.ca)
  • vascular
  • Their myogenic cells and surrounding vascular endothelial cells were Cxcr4- and its ligand Cxcl12-positive, respectively. (nii.ac.jp)
  • Molecules that can be used to therapeutically target these key cells, and their communication with neighboring vascular, inflammatory and fibrotic cell types, will lead to more effective approaches to muscle regenerative medicine and to novel cures for degenerative diseases, including atherosclerosis, vascular damage in diabetes and in peripheral ischemic vascular disease. (europa.eu)
  • The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch signaling in vascular smooth muscle cells. (semanticscholar.org)
  • Activation of Notch signaling by Jagged-1 (Jag-1) in vascular smooth muscle cells (VSMC) promotes a differentiated phenotype characterized by increased expression of contractile proteins. (semanticscholar.org)
  • quiescent state
  • Here, we found that functional overload, which is widely used to model resistance exercise, causes skeletal muscle hypertrophy and converts satellite cells from quiescent state to activated state. (hindawi.com)
  • These cells are located between the basal lamina and plasma membrane of skeletal muscle fibers in which they represent 2.5%-6% of all nuclei and remain in a quiescent state under normal physiological conditions [ 2 ]. (hindawi.com)
  • Presently, it is largely accepted that cells, particularly stem cells, enter a quiescent state to preserve their self-renewing capacity and avoid genetic perturbations caused by frequent division. (frontiersin.org)
  • morphology
  • Once synthesised, the various enzymatic and other proteinaceous components of saliva are secreted through a series of ductal cells bearing epithelial-type morphology, until the eventual expulsion of the saliva through one major duct into the cavity of the mouth. (jove.com)
  • population
  • These cells are maintained as a proliferating population in embryonic and fetal muscles of the trunk and limbs throughout development. (nih.gov)
  • In the present study, we utilize transgenic technology and demonstrate that the 4.6 kb upstream fragment of the Foxk1 gene directs β‐galactosidase expression to the myogenic progenitor cell population. (embopress.org)
  • We further establish that Sox15 directs Foxk1 expression to the myogenic progenitor cell population, as it binds to an evolutionarily conserved site and recruits Fhl3 to transcriptionally coactivate Foxk1 gene expression. (embopress.org)
  • Mammalian skeletal muscle can remodel, repair, and regenerate itself by mobilizing satellite cells, a resident population of myogenic progenitor cells. (pnas.org)
  • These cells have many characteristics of stem cells, including the capacity divide numerous times, self-renew their population and enter a state of quiescence when they are not needed. (mcmaster.ca)
  • In CML patients, ADAM8+ cells showed TKI resistance and residual CML cells after TKIs-treatment were concentrated in ADAM8+ population, suggesting that ADAM8 is a marker of TKI-resistant CML cells. (utahcordbank.com)