BiologySpecimensMoleculesBiologistPathwaysVertebrateCellularSciencesAgriculturalProteinsSkeletalResearchersTissuesLipidPathologyPharmacologyMicrobialSoft tissueGenomicGeneticClinicalResearchProcessesExperimentalMicroscopySamplesSituOrganicProgrammeMethodsMechanismsScientificSystemsHumanSuitableScientistsCellsSurfaceApplicationPotentialTechnologies
Biology13
- This Funding Opportunity Announcement (FOA) invites grant applications proposing exploratory research projects focused on further development and validation of emerging technologies offering novel capabilities for targeting, probing, or assessing molecular and cellular features of cancer biology for basic, clinical, or epidemiological cancer research. (nih.gov)
- L. Andrew Staehelin, a longstanding member of the University of Colorado Boulder Department of Molecular, Cellular, and Developmental Biology (MCDB) passed away on Sept. 28, 2022. (colorado.edu)
- Andrew was known as a stimulating and inspiring teacher who particularly enjoyed the challenges of teaching large courses, such as "Introduction to Molecular and Cellular Biology" and "Cell Biology. (colorado.edu)
- Kee-Hong Kim, associate professor of food science and an international award-winning nutritional biologist focusing on lipid biochemistry, enzymology and nutritional molecular biology. (purdue.edu)
- Professor Vogel is a biochemist and the director of the Institute for Molecular Infection Biology (IMIB) at the Medical Faculty of the University of Würzburg and spokesman of the Research Center for Infectious Diseases (ZINF). (uni-wuerzburg.de)
- He is an elected member of the European Molecular Biology Organization EMBO and of the National Academy of Sciences (Leopoldina). (uni-wuerzburg.de)
- QIAcard FTA Elute Formats are intended for molecular biology applications. (qiagen.com)
- By combining the power of structural biology, biochemistry and multiscale molecular simulations, researchers from Germany and Finland found a key role of an accessory subunit in energy production by respiratory complex I, a central bioenergetic enzyme. (csc.fi)
- With stem cell biology and molecular understanding of reproductive failure, new therapies for previously untreatable infertility are currently on the near horizon. (infertile.com)
- The focus of the division is firstly, to facilitate the application of molecular biology techniques/tools in research, analysis, and product development. (gov.ng)
- 2. To provide training and facilities for molecular biology research, analyses, and other relevant scientific endeavours. (gov.ng)
- The use of DNA profile in forensic dentistry testing offers a new perspective on human identification, is considered one of the major developments in the molecular biology of the XXI century. (bvsalud.org)
- The aim of this study was to investigate the applicability of DNA in forensic identification process in forensic dentistry since molecular biology is playing a role of great importance in the identification in more complex cases where biological traces are virtually nonexistent. (bvsalud.org)
Specimens8
- These situations are common in the case of complex data from biological specimens. (nature.com)
- The collection, featuring over 3,500 natural history specimens, provides a fantastic resource for biological scientists and the wider community. (reading.ac.uk)
- K. Richter: Cutting artefacts on ultrathin cryosections of biological bulk specimens. (laboratoryresource.com.au)
- In the world of life sciences, one of the most critical aspects of research is the ability to observe and understand the intricacies of biological specimens at the cellular and molecular levels. (bioimagingtech.com)
- Fixatives: Formaldehyde, glutaraldehyde, and osmium tetroxide are common fixatives used to preserve the structure and integrity of biological specimens. (bioimagingtech.com)
- Human biological specimens have been used for of a number of molecular parameters and will require many decades for translational purposes in cancer systematic preservation of frozen biospecimens or research, in particular for testing hypotheses and derived biomaterial. (who.int)
- Access to human biological specimens is often a prerequisite for such R&D advances. (who.int)
- Thus, Firstly, the rights of the individuals whose tissues development of high-quality BRCs has the potential or biological specimens are to be included in the to accelerate and facilitate this translational process. (who.int)
Molecules3
- The field of metabolomics (Section 6) generally revolves around these molecules with a molecular weight between 50 - 1500 daltons (Da). (wikipedia.org)
- Trees survive Minnesota winters using combinations of molecules expressed naturally to stabilize critical biological structures. (umn.edu)
- This work will involve looking at molecular pathways and other molecules to help stabilize these more complicated structures. (umn.edu)
Biologist1
- L. Andrew Staehelin, CU Boulder Molecular Biologist, Dies at 83. (colorado.edu)
Pathways3
- The focus will be on organic residues at the biomolecular level, especially lipids and metabolites due to their preservation pathways and archaeological significance. (wikipedia.org)
- Genetics has substantially advanced understanding of AD heritable risk, yet how genetic risk factors affect biological pathways that influence AD pathophysiology is not always clear 1 . (emtherapro.com)
- However, the ultimate biological effectors of AD genetic and environmental risk are often the proteins and the metabolic pathways they modulate. (emtherapro.com)
Vertebrate2
- Here we report evidence of protein preservation in a terrestrial vertebrate found inside the vascular canals of a rib of a 195-million-year-old sauropodomorph dinosaur, where blood vessels and nerves would normally have been present in the living organism. (nature.com)
- Preserved dinosaur egg color not only pushes the current limits of the vertebrate molecular and associated soft tissue fossil record, but also provides a perspective on the potential application of this unexplored paleontological resource. (peerj.com)
Cellular3
- Technologies proposed for development may be intended to have widespread applicability but must be focused on improving molecular and/or cellular characterizations of cancer. (nih.gov)
- We therefore suggest that energy loss (e.g., through impaired mitochondria) or disturbance of information (e.g., through mutations or aneuploidy) or changes in the composition or distribution of matter (e.g., through micro-environmental changes or toxic agents) can irreversibly disturb molecular mechanisms, leading to increased local entropy of cellular functions and structures. (frontiersin.org)
- This ensures that the cellular structures and molecular components are not compromised during preparation. (bioimagingtech.com)
Sciences7
- Proceedings of the Royal Society B: Biological Sciences. (icr.org)
- Alexander Chubykin, assistant professor of biological sciences, "Theta Oscillations in Visual Cortex of Alzheimer's Disease Mice. (purdue.edu)
- 98% of students in the School of Biological Sciences said our teaching staff were good or very good at explaining things (National Student Survey, 2023). (reading.ac.uk)
- Our £60m Health and Life Sciences building is the home of the School of Biological Sciences. (reading.ac.uk)
- For more information, please visit the School of Biological Sciences website . (reading.ac.uk)
- International journal of molecular sciences, 22(7), p. 3772. (unibe.ch)
- Therefore it is recommended that comprehensive of biomedical sciences: molecular and genetic cancer centres and academic medical centres have epidemiology (aimed at assessing the genetic and wel -organized BRCs that actively cooperate in environmental basis of cancer causation in the general national and international networks of tissue banks. (who.int)
Agricultural1
- He conducted ground-breaking studies of agricultural systems on the pollination of crops, biological pest control and the preservation of biodiversity. (uni-wuerzburg.de)
Proteins3
- Translated into biological terms, this means the construction manual is DNA, which contains the information to produce proteins. (mpg.de)
- Proteins are often referred to as 'molecular machines' because they often act as catalysts, which accelerate biochemical reactions in organisms. (mpg.de)
- We propose that these particles likely had a crucial role in the preservation of the proteins, and may be remnants partially contributed from haemoglobin and other iron-rich proteins from the original blood. (nature.com)
Skeletal2
- This includes sedimentological and biological reconstructions of palaeo-environments, theoretical or experimental studies of trace element partitioning and isotope fractionation in carbonate (bio)minerals, and studies targeting original skeletal carbonate preservation and diagenetic alteration. (copernicus.org)
- Recently, it has been proposed that dental calculus may provide a more robust environment for DNA preservation than other skeletal remains, but this has not been systematically tested. (altmetric.com)
Researchers5
- In order to start this process, the researchers needed a construction manual as well as various molecular 'machines' and nutrients. (mpg.de)
- According to the researchers, this is an important step towards a continuously self-replicating system that mimics biological processes. (mpg.de)
- These researchers have employed these strategies to improve preservation of single cells. (umn.edu)
- The researchers are attempting to expand their project to include bio-inspired strategies to improve preservation of tissues. (umn.edu)
- Researchers must balance the preservation of delicate structures with the need to enhance contrast for visualization. (bioimagingtech.com)
Tissues2
- Various organizations have set up guidelines for handling and processing biological tissues. (digitaljournal.com)
- Due to the irreplaceable property of biological tissues, the preservation becomes necessary as it provides information and data for molecular epidemiological studies used for cancer research. (digitaljournal.com)
Lipid1
- The ceramic matrix serves as a protective environment which favours significant lipid preservation. (wikipedia.org)
Pathology1
- population as well as in families), molecular pathology (aimed at developing molecular-based classification and diagnosis procedures for cancer diseases), and pharmacogenomics/pharmacoproteomics (understanding the correlation between an individual patient's genotype/phenotype and response to drug treatment). (who.int)
Pharmacology1
- Darci J. Trader, assistant professor of medicinal chemistry and molecular pharmacology, "Discovery of Proteasome Stimulators to Treat Diseases Associated with Protein Accumulation. (purdue.edu)
Microbial1
- Secondly, the division was envisaged to be a resource centre for the scientific community and the industries in the area of microbial culture collection, preservation, and distribution. (gov.ng)
Soft tissue2
- In some exceptionally preserved fossils, in which the degradation process may have been arrested sufficiently early in the fossilization process, some soft tissue preservation can occur because they are isolated, cemented and protected by inorganic environment and have not been completely permineralized (for example, feathers and claw sheaths). (nature.com)
- An evidence-based guideline on the application of molecular testing in the diagnosis, prediction of prognosis, and selection of therapy in non-GIST soft tissue sarcomas. (cdc.gov)
Genomic2
- Fossilized organic remains are important sources of information because they provide a unique form of biological and evolutionary information, and have the long-term potential for genomic explorations. (nature.com)
- As part of a national effort to develop therapeutics and biomarkers for AD, the Accelerated Medicines Partnership for Alzheimer's Disease (AMP-AD) Consortium has been leveraging unbiased molecular profiling data at the genomic, transcriptomic, proteomic and metabolomic levels to further understanding of AD pathogenesis. (emtherapro.com)
Genetic1
- In cases where the bodies are in an advanced state of decomposition, charred or rotting, or even when identification can not be performed by traditional dental methods, teeth are the only elements that can be used to identify, for better resist than any human tissue for post mortem degradation, variations in pressure and temperature enabling the preservation of individual genetic identity. (bvsalud.org)
Clinical4
- Tissue blocks have been collected and stored over the years for use in molecular epidemiology, clinical trials and other basic research purpose. (digitaljournal.com)
- Projects proposing the application of existing technologies where the novelty resides in the biological or clinical target/question being pursued are not responsive to this solicitation and will not be reviewed. (nih.gov)
- Aside from providing useful information to guide clinical decision-making, cancer biomarkers are increasingly linked to specific molecular pathway deregulations and/or cancer pathogenesis to justify application of certain therapeutic/interventional strategies (2). (ddw-online.com)
- The characteristics of B+ promote enhanced clinical performance and better preservation of bone levels around the implant as observed in a study with sheep. (mis-implants.com)
Research7
- His passion for improving "cryo" techniques culminated with the introduction of high-pressure freezing to the cell biological research community. (colorado.edu)
- Dive into the research topics of 'Liquid nitrogen preservation of red blood cells for transfusion. (psu.edu)
- Ultimately, my research aims at exploring to which extent we can meaningfully integrate molecular data for life, past and present. (jasminawiemann.com)
- Journal of Ultrastructure and Molecular Structure Research, pp. 210-217, 1986. (laboratoryresource.com.au)
- Digital Preservation Service (DPS) for research data is available for all bodies under the Ministry of Education and Culture. (csc.fi)
- BRCs are important for developing personalised of biological research. (who.int)
- 2004). This paragraph addresses the importance, and is also a mechanism for al owing patients to justification and sustainability of developing BRCs for benefit from the applications of molecular cancer cancer research. (who.int)
Processes3
- Both processes are fundamental for the self-preservation and reproduction of biological systems. (mpg.de)
- The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain incompletely understood. (emtherapro.com)
- In recent years, glycans have been increasingly recognised as mediators of important biological processes, and studies are improving our understanding of a range of human diseases, and how to treat them (4). (ddw-online.com)
Experimental2
- During his 36 years with CU Boulder, Andrew took advantage of the sabbatical leave system to work at other universities, learning new experimental techniques and exploring new biological systems. (colorado.edu)
- With the continuing improvement assessing biomarkers identified in experimental of survival after therapy, performing such molecular- studies. (who.int)
Microscopy2
- His initial method of choice was freeze-fracture electron microscopy, which introduced him to the concept of rapid freezing for the preservation of cells in a good approximation to their native structure. (colorado.edu)
- Microtomes: Microtomes are indispensable tools for preparing thin slices of biological samples for microscopy. (bioimagingtech.com)
Samples1
- Extreme biomimetics: Preservation of molecular detail in centimeter-scale samples of biological meshes laid down by sponges. (mpg.de)
Situ1
- To do so, I rely on the power of large and diverse fossil and modern sample sets that are analyzed via an array of non-destructive in situ methods for patterns in their molecular composition. (jasminawiemann.com)
Organic1
- LCMD is a computational/theoretical laboratory, focusing on electronic structure theory in the area of method development and conceptual work applied to the field of homogeneous catalysis and organic molecular material s . (epfl.ch)
Programme1
- At its twelfth meeting, the Advisory Committee also discussed access to, and preservation of, WHO archives of the Smallpox Eradication Programme. (who.int)
Methods3
- We use a combination of electrophysiology, live cell imaging and molecular methods to unravel the complexities of amacrine cell synapses. (lsu.edu)
- Some of the common methods available for determining cyanide in biological media are reported in Table 7-1. (cdc.gov)
- Second-tier imaging with molecular methods, preferably with fluorodeoxyglucose positron emission tomography (FDG-PET) (or single-photon emission CT [SPECT] if PET is unavailable), can provide greater diagnostic specificity. (medscape.com)
Mechanisms1
- Recent projects have included the molecular engineering of viruses, and the mechanisms of bacterial pathogenicity and host colonisation. (reading.ac.uk)
Scientific1
- These have always drawn a lot of attention from both the scientific community and the general public not only because of their rarity, but also because of the potential for retrieval of valuable biological and evolutionary information that is generally not available from the permineralized hard skeletons that make up the bulk of fossilized vertebrates 1 . (nature.com)
Systems1
- In biological systems, most fatty acids have an even number of carbon atoms, mainly between C14 and C24, maximising at C16 and C18. (wikipedia.org)
Human4
- Museum programs address current topics, such as biological diversity, global climate change, molecular systematics for enhancing the understanding of the relationship between living things, ecosystem modeling and the documentation and preservation of human cultural heritages. (si.edu)
- Understanding the biological effects of AD risk factor polymorphisms in human brain often requires additional levels of analysis using other -omics approaches. (emtherapro.com)
- This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure. (infertile.com)
- These two major areas of activity are aimed at enhancing biotechnology through increased utilization of beneficial microorganisms and other biological resources for human benefits while driving industrial growth. (gov.ng)
Suitable2
- QIAcard FTA Elute formats are suitable for room temperature (15-25°C) shipment and preservation. (qiagen.com)
- Sample preparation involves a series of steps designed to render the biological material suitable for microscopic analysis. (bioimagingtech.com)
Scientists2
- Scientists built a biological machine in vitro , which is capable of replicating itself. (mpg.de)
- Smith stated that during the convention three scientists presented posters on topics including: the application of phage display to develop a molecular probe for snake venom identification, improving envenomation outcomes by inhibiting systemic distribution factors, and physical, chemical, and biological comparison of clinically available products for their use in alveolar ridge preservation. (health.mil)
Cells1
- Liquid nitrogen preservation of red blood cells for transfusion. (psu.edu)
Surface1
- Surface plasmon resonance showed the binding affinity of AELP-B6 to galectin-3 (6.488 × 10-5 M) was about 10 times stronger than that of AELP-B5 (4.588 × 10-4 M). The above findings provide a molecular structure and bioactivity basis for future potential applications of AELP in the food and medical industries. (bvsalud.org)
Application1
- Recently, the application of metabolomics in ancient residue analysis has been established where it was successfully used to determine distinct molecular residue markers in archaeological pottery. (wikipedia.org)
Potential1
- Thus, remains of echinoids and crustaceans - two groups with multi-elemental skeletons assumed to have low preservation potential - can still undergo extensive age mixing comparable to that of the co-occurring mollusk shells. (copernicus.org)
Technologies1
- This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program . (nih.gov)