Molecular perspective nanoparticles. Medical search. Frequent questions

Herein we demonstrate this approach using a model community of environmental microbes (that is, wastewater-activated sludge) dosed with gold nanoparticles of varying surface coatings and morphologies. (nature.com)

French researchers studied how and where E171 nanoparticles enter the bloodstream, first studying the route through pigs and then in vitro with human buccal cells, for a 2023 study published in the journal Nanotoxicology . (childrenshealthdefense.org)
International Journal of Molecular Sciences, 2023. (nanomedicine-rj.com)

Molecular modeling in structural nano-toxicology: interactions of nano-particles with nano-machinery of cells. (cdc.gov)
Combustion-derived nanoparticles: A review of their Toxicology following Inhalation Exposure. (mcgill.ca)
Correspondence to: Linda M. Sargent, Toxicology and Molecular Biol- have not been investigated fully. (cdc.gov)

As pharmaceutical excipients, mesoporous silica nanoparticles (MSNs) have attracted considerable concern based on potential risks to the public. (frontiersin.org)
Herein, we report the fabrication of core (silica)-shell (mesoporous silica nanoparticles, MSNs) architectures to deliver methylene blue and cupric doxorubicin as model drugs for synergistic photodynamic therapy, chemotherapy, and chemodynamic therapy. (mdpi.com)

The combination of monolayer protected gold nanoparticles (AuNPs) and DCC might add a new dimension for the development of protein-like receptors or sensors for carbohydrates due to several attractive features i) multivalency, ii) high stability of the nanosystems in physiologically relevant conditions, iii) intrinsic photochemical properties originating from the gold core. (europa.eu)
The thiol terminal of CB[7]SH synthesised in Chapter 4 is subsequently used in Chapter 5 to tether CB[7] to the surface of gold nanoparticles (AuNPs) creating a delivery system whose surface chemistry can be readily modified with therapeutic and targeting agents. (cam.ac.uk)
Antidiabetic properties of phytosynthesized gold nanoparticles (AuNPs) from Datura stramonium seed. (nanomedicine-rj.com)

We observed that the gold-nanoparticle morphology imposes a stronger force in shaping the microbial community structure than does the surface coating. (nature.com)
In this context, the NANOCARB project has the objective to build up an original method for the development of an innovative class of carbohydrate receptors using dynamic combinatorial chemistry (DCC) on the surface of a gold nanoparticle. (europa.eu)
Gold nanoparticle-functionalized reverse thermal gel for tissue engineering applications. (nanomedicine-rj.com)

Post his doctoral training, he worked in the lab of Zhenpeng Qin at the UT-Dallas and UT-Southwestern Medical Center, where he extended his doctoral work on hyperthermia to molecular hyperthermia, a term coined for specific photoinactivation of biological molecules using plasmonic gold nanoparticles. (msu.edu)

Liu Y, Chen Z, Liu C, Yu D, Lu Z, Zhang N. Gadolinium-loaded polymeric nanoparticles modified with anti-VEGF as multifunctional MRI contrast agents for the diagnosis of liver cancer. (springer.com)
Moreover, CREBZF mRNA delivered by polymeric nanoparticles (CREBZF-mRNA-NPs) was used to examine application value of our findings. (biomedcentral.com)
Drugs containing polymeric nanoparticles (PN) have better pharmacological and therapeutic properties. (pdfplayer.org)

Overall, systematic biological data suggested that intravenous injection of nanoparticles of pharmaceutical excipients substantially affected hepatic metabolism function and induced oxidative stress and inflammation, whereas oral administration exhibited milder effects compared with intravenous injection. (frontiersin.org)
Martin's expertise and research interests include studying the interaction of nano-sized materials with a variety of different biological systems, and to determine how these interactions affect molecular mechanisms within them, thus establishing structure-activity relationships. (swansea.ac.uk)
A detailed understanding of the molecular details of interactions between nanoparticle s and biological nano-machinery - macromolecules, membranes, and intracellular organelles - is crucial for obtaining adequate information on mechanisms of action of nanomaterial s as well as a perspective on the long term effects of these materials and their possible toxicological outcomes. (cdc.gov)
Because of their size, which can be engineered and manipulated at the atomic or molecular level, nanoparticles exhibit unique physical, chemical and biological properties. (childrenshealthdefense.org)
9. Nguyen, N.H.A. and P. Falagan-Lotsch, Mechanistic Insights into the Biological Effects of Engineered Nanomaterials: A Focus on Gold Nanoparticles. (nanomedicine-rj.com)
Green nanoparticle synthesis" refers to the process of creating nanoparticles using renewable resources The purpose of this research is to evaluate green nanoparticles' (AgNPs) biological activity as a potential broadly available, cost-effective antibacterial and anticancer treatment. (ac.ir)
Recent advances in our biological understanding of gliomas have led to important and substantive changes in their classification, in the identification of prognostic and predictive molecular markers, and in the therapeutic management of newly diagnosed glioma. (cancernetwork.com)
As such, secondary glioblastomas are to be classified as a distinct biological and molecular entity for which different treatment strategies will ultimately be proposed. (cancernetwork.com)

We use molecular biology, microscopy (light, fluorescence, ultrastructural), analytical chemistry and immunocytochemistry techniques to investigate the mechanisms underlying the pathologic and functional responses to these environmental exposures. (gulfbase.org)
American Journal of Respiratory Cell and Molecular Biology, 39: 198-207 (2008). (gulfbase.org)
American Journal of Respiratory Cell and Molecular Biology,38: 532-540 (2008). (gulfbase.org)

Recently, green synthesis of nanoparticles has been a target of research due to its simplicity, safety, eco-friendliness and cost-effectiveness. (nanomedicine-rj.com)
This study describes the green synthesis of gold nanoparticles via aqueous extract of Melissa officinalis L. (Mel). (nanomedicine-rj.com)
The various parameters affecting the synthesis of gold nanoparticles (pH, gold salt concentration, extract volume, temperature, and reaction time) were investigated and optimized. (nanomedicine-rj.com)
Green synthesis of gold nanoparticles using Sargassum carpophyllum extract and its application in visual detection of melamine. (nanomedicine-rj.com)
Green synthesis of gold nanoparticles using Centaurea behen leaf aqueous extract and investigating their antioxidant and cytotoxic effects on acute leukemia cancer cell line (THP-1). (nanomedicine-rj.com)

By the end of the course, the students will have gained knowledge in the following areas: What nanotechnology is, The size and shape dependent properties at the nanometer scale, Enhanced physical properties of nanomaterials, What nanoparticles are and how to synthesize them and Applications of nanotechnology in engineering, biomedical, energy, and environmental fields. (kfs.edu.eg)

Fig. 1: Characterization of gold nanoparticles before and after addition to SBRs. (nature.com)
Molecular characterization has allowed for further refinement of the condition's classification and is now an integral part of the diagnosis of malignant glioma. (cancernetwork.com)

Nanoparticles are ultrafine particles between 1 to 100 nanometers in diameter. (childrenshealthdefense.org)

2015 ) reported that intravenous injection (IV) of silica nanoparticles showed significant capture of the particles in the liver and induced hepatic injury. (frontiersin.org)
Taking inspiration from the structure of diatom algae frustules and motivated by the need for new detecting strategies for emerging nanopollutants in water, we analyze the potential of nanoporous silica tablets as metering devices for the concentration of biomolecules or nanoparticles in water. (springer.com)
Using molecular dynamics and previous results from the literature, we demonstrate the correlation between the self-diffusion coefficient of water in silica nanopores and the concentration of proteins or nanoparticles contained therein. (springer.com)

Martin's research is focused on the nanoparticle-(mammalian)cell interaction, with a view to determining the mechanistic toxicological, immunological and genotoxic effects that nanoparticles, with varying physico-chemical characteristics, may cause at the cellular level by using advanced, next-level in vitro systems combined with state-of-the-art microscopy and bioanalytical approaches. (swansea.ac.uk)

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, is awarding $65 million to renew its Programs for Nanotechnology Research to help researchers develop tools based on materials designed at the molecular level to detect and deliver treatments for heart, lung, and blood diseases. (nanowerk.com)
With the rise of nanotechnology, research in recent years has also shown the dangers of titanium dioxide nanoparticles and their genotoxicity, which refers to a chemical agent's ability to harm or damage DNA in cells, thus potentially causing cancer. (childrenshealthdefense.org)
Nanotechnology involves making nanoparticles (NPs) with different shapes, sizes, and controlled distributions so that they can be used in a variety of ways [1-3]. (ac.ir)
Because of their passive and ligand- based targeting mechanisms, nanoparticles (NPs) accumulate preferentially at tumor sites.The recent utilization of nanotechnology in CC diagnosis and therapy and the development of HPV vaccinations. (pdfplayer.org)

From these findings, 'the present study concluded that TiO2NPs [nanoparticles] is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer's disease incidence. (childrenshealthdefense.org)

Nanoparticles, classified as anthropogenic and natural particles, and fibers of diameters less than 100 nm, have unrestricted access to most areas of the lung due to their size. (mcgill.ca)
The deposition of nanoparticles in the lung can lead to chronic inflammation, epithelial injury, and further to pulmonary fibrosis. (mcgill.ca)

This thesis highlights the complexity of core-hole dynamics in molecular and cluster chemistry and emphasizes the need for meticulous experimental and theoretical investigations of the underlying mechanisms. (lu.se)
Specific molecular mechanisms concerning sperm structures and functions were also examined relative to their association to cryotolerance, and spermiogram or seminogram modifications following cryopreservation procedures. (tci-thaijo.org)
However, the underlying molecular mechanisms of circRNAs remain unclear. (biomedcentral.com)
Therefore, the molecular mechanisms underlying BC progression must be further investigated for novel effective therapies development. (biomedcentral.com)

Antibacterial properties of nanoparticles. (nature.com)

The work performed in this project has covered several aspects related to the main scope, which is the development of dynamic combinatorial chemistry on multivalent nanoparticles as tool to develop carbohydrate recognition. (europa.eu)
Gold nanoparticles in combinatorial cancer therapy strategies. (nanomedicine-rj.com)

To celebrate the 50th anniversary of MIT and to facilitate the development of MIPs for biomedical applications, the Society of Molecular Imprinting, the Royal Society of Chemistry, and Nanjing University are going to jointly organize an on-line symposium, International Symposium on Molecular Imprinting Technology for Biomedical Applications 2022 (Biomed MIT 2022), September 26-28, 2022. (rsc.org)

The use of metal nanoparticles (NPs) for trace explosive detection has drawn considerable interest in recent years. (dundee.ac.uk)
A label-free electrochemical biosensor based on screen-printed electrodes modified with gold nanoparticles for quick detection of bacterial pathogens. (nanomedicine-rj.com)
Potential perspectives of molecular recognition imaging at the single molecule level for detection. (araid.es)

Here, we summarize the imaging modalities used for image-guided therapies and discuss recent advances on nanoparticle-based image-guided therapies. (springer.com)

Molecular imprinting technology (MIT) has emerged as an important biomimetic molecular recognition methodology that allows for the rational development of antibody and enzyme alternatives for many applications. (rsc.org)
The concept of DCC on gold nanoparticles was validated using metal ions as analytes, rather than carbohydrates, because of the higher strength of interaction with the recognition modules. (europa.eu)
Recently, there has been a surge of interest in the use of charged cyclodextrins for biomedical applications, owing to their enhanced properties, such as superior solubility and improved molecular recognition compared to neutral CDs. (bvsalud.org)

Studies that connect molecular-level understanding to macroscopic electrochemical technologies are of particular interest. (electrochem.org)

Surface coating governed the nanoparticle partitioning between the bioparticulate and aqueous phases. (nature.com)

Bioanalytical characterisation of nanoparticles in food (Nanofood) (INTERREG 4A). (sdu.dk)

This review focuses on the use of structure-based computational molecular modeling as a tool to understand and to predict the interactions between nanomaterial s and nano-biosystems. (cdc.gov)

Overall, the findings show that the green synthesized gold nanoparticles are appropriate candidates for biomedical applications. (nanomedicine-rj.com)
Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application. (nanomedicine-rj.com)
Silver nanoparticles (Ag NPs) synthesized by the green method have shown several applications such as biomedical, anticancer, etc. (ac.ir)

It contains a cationic polyacrylate copolymer of moderately high molecular weight pH buffer, along with a crosslinking agent. (worldoil.com)

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles. (springer.com)

Zhu D, Liu F, Ma L, Liu D, Wang Z. Nanoparticle-based systems for T1-weighted magnetic resonance imaging contrast agents. (springer.com)
Gleich and Weizenecker proposed the magnetic particle imaging (MPI) approach ( Gleich & Weizenecker, 2005 ), whereby the positions of these magnetic nanoparticles (MNPs) accumulated in cancerous tissue can be detected by applying a local alternating magnetic field from a source positioned outside the body. (intechopen.com)

In this review, we will introduce two sensing methods (cavity optomechanical sensing and surface-enhanced Raman scattering sensing) which can be used to detect the nanoparticles. (hep.com.cn)
At Purdue, he developed computational methods using physics-based methods such as molecular dynamics to flexibly refine protein structures obtained from Cryo-electron microscopy (cryo-EM), X-ray crystallography and NMR. (msu.edu)

These species are often molecular or supramolecular structures that behave as molecular-level sensory devices, which are usually referred to as chemosensors. (rsc.org)
Chih-Hao Hsu, Xue-Hui Dong, Zhiwei Lin, Bo Ni, Pengtao Lu, Zhang Jiang, Ding Tian, An-Chang Shi, Edwin L. Thomas and Stephen Z. D. Cheng, Tunable Affinity and Molecular Architecture Lead to Diverse Self-Assembled Supramolecular Structures in Thin Films. (uakron.edu)

Because of the aforementioned special properties of nanoparticles, nanofertilizers can be tuned to have specialized delivery to plants. (wikipedia.org)
Special interests include the ability for nanoparticle geometry and surface properties to interfere with the human immune system and bloodstream. (swansea.ac.uk)
A rationale on how nanoparticle s of different sizes, shape, structure and chemical properties can affect the organization and functions of nano-machinery of cells is also presented. (cdc.gov)
In this latter situation, the self-diffusion coefficient of water reduces according to the geometry and surface properties of the pore and to the concentration of suspended biomolecules or nanoparticles in the pore, as extensively demonstrated in a previous study. (springer.com)
Gold nanoparticles possess attractive properties that make them valuable in medicine. (nanomedicine-rj.com)

In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. (childrenshealthdefense.org)

Xue-Hui Dong, Bo Ni, Mingjun Huang, Chih-Hao Hsu, Ruobing Bai, Wen-Bin Zhang, An-Chang Shi, and Stephen Z. D. Cheng, Molecular-Curvature-Induced Spontaneous Formation of Curved and Concentric Lamellae through Nucleation. (uakron.edu)

It has been shown, using gold nanoparticles and other surfactant-based multivalent systems, that multivalency can be exploited to create structures for sensing and catalysis under physiologically relevant conditions. (europa.eu)
Preliminary in vitro investigations into the delivery of a pro-apoptotic peptide, (KLAKLAK)₂, are presented as well as a perspective as to where the use of such AuNP-CB[7] structures could be utilised in biomedicine. (cam.ac.uk)

Next-generation DNA sequencing and metagenomic analysis provide powerful tools for the environmentally friendly design of nanoparticles. (nature.com)
Environmentally safe biosynthesis of gold nanoparticles using plant water extracts. (nanomedicine-rj.com)

Starting from this first and fundamental step our aims and future perspectives will be presented. (rsc.org)

In the last decades, the advent of nanotechnologies enabled the design of tailored molecular sensors to detect different pollutants in water, such as pathogens, organic, and inorganic chemicals [ 6 ]. (springer.com)

Environmental Health Perspectives, 115: 1757-1766 (2007). (gulfbase.org)
Environmental Health Perspectives, 115: 548-555 (2007). (gulfbase.org)
Environmental Health Perspectives, 113: 956-963 (2005). (gulfbase.org)

Image-guided therapy using nanoparticles have been used for various therapeutic applications such as drug and gene delivery, hyperthermia, and photodynamic therapy. (springer.com)
Our findings firstly illustrated that circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1 positive feedback loop mediated BC progression, and delivering CREBZF mRNA nanoparticles suppressed BC progression in vitro and in vivo, which might provide novel insights into therapeutic strategies for breast cancer. (biomedcentral.com)
Nanoparticles (NPs) are tailored drug delivery vectors that can selectively target huge dosages of chemotherapeutic drugs or therapeutic genes into cancer cells while leaving healthy cells alone. (pdfplayer.org)

Two systems were studied: monolayer protected gold nanoparticles and surfactant-based aggregates. (europa.eu)
Aggregates are shown to disassemble in the presence of common biomolecules found in intracellular and extracellular fluid with timescales that can be tuned depending on the molecular weight of the selected PEG chains. (cam.ac.uk)

The enhanced permeation and retention (EPR) effect ( Matsumura & Maeda, 1986 ) caused by the leakage of internally administered nanoparticles from blood vessels and their accumulation in cancerous tissues can be used to diagnose cancer. (intechopen.com)

Nanoparticles are promising candidates for implementation in agriculture. (wikipedia.org)

The severity of toxicological consequences warrants further examination of the effects of nanoparticles in humans, possible treatments and increased regulatory measures. (mcgill.ca)

100 publications within the field of nanotoxicology and the nanoparticle-cell interaction in vitro . (swansea.ac.uk)

The word "nanoparticle" (NP) refers to the very small particles that are made in a wide range of industrial physicochemical processes. (ac.ir)

The last Section of the paper discussed potential details and expansions of the different notions conferred in the paper, in the perspective of monitoring the disturbances due to EMF noise of medical devices working near living tissues. (bvsalud.org)

When these environments collaborate, perspectives are expanded, and new insights emerge. (sdu.dk)

PN has been touted as a promising carrier for anticancer drugs among targeted drug delivery systems.We reviewed numerous ways for directing nanoparticles to a specific site and preparation processes, patent inventions, and prospects in this study. (pdfplayer.org)

Extracellular vesicles (EVs) are cell-derived membranous nanoparticles present in most biologic fluids. (cdc.gov)

The present study aimed at the biosynthesis of silver nanoparticles by using aloe Vera leaves extract. (ac.ir)

Gwinn MR, Vallyathan V. Nanoparticles: Health Effects - Pros and Cons. (mcgill.ca)
Over the last several years, nanoparticles have come under scrutiny for adverse health effects. (childrenshealthdefense.org)
Effects of aliskiren-loaded nanoparticles on (pro-)renin and renin receptor gene expression in the heart and kidney of spontaneously hypertensive rats. (sav.sk)

Using nature's laws material scientists develop new materials that don't exist in nature - especially functional materials at a low molecular level. (rwth-aachen.de)
DOI: https://doi.org/10.5888/ from microdata -- the molecular, nanoparticle level -- to mac- pcd19.220067. (cdc.gov)
At the molecular level, diverse categories of starch degradation products, such as dextrin and highly branched starch, serve as versatile amphiphilic carriers for encapsulating active ingredients. (bvsalud.org)

Research has shown nanoparticles to be a groundbreaking tool for tackling many arising global issues, the agricultural industry being no exception. (wikipedia.org)

Szpak A, Fiejdasz S, Prendota W, Strączek T, Kapusta C, Szmyd J, Nowakowska M, Zapotoczny S. T1-T2 dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes. (springer.com)

Anatomy3

Organisms5

Diseases1

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes26

Disciplines and Occupations5

Technology, Industry, Agriculture39

Humanities2

Health Care3

Dosed with gold nanoparticles1

20232

Toxicology3

Mesoporous silica nanoparticles2

AuNPs3

Gold-nanoparticle3

Molecules1

Polymeric3

Biological8

Biology3

Synthesis5

Nanomaterials1

Characterization2

Ultrafine Particles1

Silica3

Physico-chemical1

Nanotechnology4

Genotoxic1

Lung2

Mechanisms4

Antibacterial1

Combinatorial2

Chemistry1

Detection3

Advances1

Recognition3

Electrochemical1

Aqueous1

Bioanalytical1

Interactions1

Biomedical3

Cationic1

Toxicity1

Magnetic2

Methods2

Supramolecular structures2

Properties5

Orally1

Zhang1

Structures2

Environmentally2

Future perspectives1

Detect1

Environmental Health Persp3

Therapeutic3

Aggregates2

Internally1

Candidates1

Toxicological1

Nanotoxicology1

Refers1

Tissues1

Insights1

Processes1

Fluids1

Extract1

Effects3

Level3

Agricultural1

Complexes1