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  • amino acids
  • The latter represent an assortment of fairly unrelated sequences essentially characterised by a high content of basic amino acids and a length of 10-30 residues. (mdpi.com)
  • Houghten, R.A. (1984) General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigenantibody interaction at the level of individual amino acids. (springer.com)
  • Almost all discussions of prebiotic chemistry assume that amino acids and nucleotides condensed non-enzymatically to form oligomeric products. (scripps.edu)
  • Our lab showed that carbonyl sulfide (COS), a simple gas that is present in the emissions from present-day volcanoes, is a condensing agent that brings about the formation of peptides from amino acids under mild conditions in aqueous solution. (scripps.edu)
  • synthesis
  • Geysen, H.M., Melven, R.H., and Barteling, S.J. (1984) Use of peptide synthesis to probe viral antigen54s for epitopes to a resolution of a single amino acid. (springer.com)
  • We designed, synthesized, and characterized alpha-helical peptides that act autocatalytically in templating their own synthesis by accelerating the thioester-promoted amide-bond condensation of shorter fragments in neutral aqueous solution. (scripps.edu)
  • We have established the viability of reversible covalent reactions in water as a basis for template-directed synthesis of sequence-adaptive peptide nucleic acids. (scripps.edu)
  • Pipkorn R, Wiessler M, Waldeck W, Hennrich U, Nokihara K, Beining M, Braun K. Improved Synthesis Strategy for Peptide Nucleic Acids (PNA) appropriate for Cell-specific Fluorescence Imaging. (medsci.org)
  • In this context our modified solid phase peptide chemistry using temperature shifts during synthesis is considered as an appropriate technology. (medsci.org)
  • Contributions were made by the introduction of the Merriefield's solide phase peptide synthesis [ 8 ] and Carpino's protecting group methodologies [ 9 ]. (medsci.org)
  • specificity
  • The system will enable testing direct from a tube of blood using peptide nucleic acids-based methods to improve specificity. (genomeweb.com)
  • In developing the model of the DNA double helix, Watson and Crick[*]opened up a new dimension in the understanding of specificity.131 Concomitant with the increasing interest in large systems more and more detailed problems are being encountered, and there is a growing tendency to transfer molecular models from the chemist's desk to the computer. (docme.ru)
  • chemistry
  • The combined use of computer graphics and theoretical chemistry is opening u p new perspectives in molecular research. (docme.ru)
  • 2. Interactive Modeling Computer-assisted molecular design (CAMD) was introduced into chemistry only a relatively short time ago, whereas computer-assisted design in engineering (CAD) has been well established for several years. (docme.ru)
  • AMPLIFICATION
  • An isothermal process for amplifying a nucleic acid target molecule that relies on an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide, wherein the upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, wherein the oligonucleotide is a substrate for the strand invasion system. (freepatentsonline.com)
  • synthetic
  • Among these synthetic vectors are cationic polymers, branched dendrimers, cationic liposomes and cellpenetrating peptides (CPPs). (mdpi.com)
  • Several classes of nucleic acid analogs have been reported, but no synthetic informational polymer had previously proven responsive to selection pressures under enzyme free conditions. (scripps.edu)
  • Novel
  • 3) some of the challenges faced when projecting development and use of novel instruments that will utilize molecular techniques onboard autonomous platforms;and future directions. (springer.com)
  • The invention further relates to a novel pharmaceutical compositions comprising condensed DNA incorporated into matrices (gene-activated matrices) that may be utilized for delivery of nucleic acids into targeted cells. (google.com)
  • Technology
  • Near patient molecular solution, also called point-of-care diagnosis, is a technology that helps diagnose and monitor health at the convenience of the patient. (mynewsdesk.com)
  • Increasing incidence of diseases such as cardiac disorders and diabetes in developing countries, growing preference for home-based point-of-care devices, advancements in technology, and wide availability of easy to use devices are spurring growth of the near patient molecular solution market. (mynewsdesk.com)
  • 3) Then there is Leopol's Nucleic-acid-peptide molecular technology. (biology-online.org)
  • diagnostic
  • PCR based: Idylla is a real-time PCR-based molecular diagnostic system designed in such a way that physicians have fast access to highly reliable clinical molecular diagnostic information. (mynewsdesk.com)
  • End users of near patient molecular solution or POC devices include hospitals, homecare, research laboratories and diagnostic laboratories. (mynewsdesk.com)
  • This is due to technological advancements in molecular diagnostic tools, high prevalence of infectious diseases, high patient awareness, and faster adoption of these devices in the region. (mynewsdesk.com)
  • The near patient molecular solution market in Asia is projected to witness rapid growth due to rampant research and development activities and growing awareness among the populace about infectious diseases and their diagnostic procedures. (mynewsdesk.com)
  • and as a molecular diagnostic assay. (thefreedictionary.com)
  • pathways
  • Starting with an array of 81 sequence similar 32-residue coiled-coil peptides, we estimated the relative stability difference between all plausible A2B-type coiled-coil ensembles and used this information to predict the auto- and cross-catalysis pathways and the resulting plausible network motif and connectivities. (scripps.edu)
  • development
  • Advanced Viral Research is a biotechnology company specializing in the development of peptide nucleic acids for pharmaceutical use. (thefreedictionary.com)
  • Our studies have ranged from defining simple condensation reagents that could have acted on the early Earth, to the development of replicating peptides that participate in chemical systems displaying behavior reminiscent of biology, such as symbiosis or parasitism. (scripps.edu)
  • distinct
  • We have sought to converge the two distinct fields of DNA and peptide self-assembly by using an artificially synthesised polymer that has attributes of both chemical families. (esrf.eu)
  • specific
  • This study demonstrates how artificial activation of Escherichia coli mazEF and hipBA toxin-antitoxin systems using sequence-specific antisense peptide nucleic acid oligomers is an innovative antibacterial strategy. (frontiersin.org)
  • bacterial
  • However, simple molecular variants of commonly used antibiotics are becoming less effective in overcoming bacterial resistance mechanisms ( Ventola, 2015a ). (frontiersin.org)
  • systems
  • Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest in recent years due to their superior safety profile compared to their viral counterpart. (mdpi.com)
  • One of the reasons for this is that interactive work with three-dimensional structures-a typical operation in molecular design-requires highly developed computer graphics systems, which have become available only in the last few years. (docme.ru)
  • functional
  • Our approach made use of the sequence-dependant auto- and cross-catalytic functional characteristics of template-directed peptide fragment condensation reactions. (scripps.edu)
  • After ligation to the modular peptide-based BioShuttle carrier, which was utilized to facilitate the delivery of the functional modules into the cells' cytoplasm, the modules were scrutinized. (medsci.org)
  • Application
  • On the basis of application, the global near patient molecular solution market is segmented as infectious diseases testing kits, pregnancy and fertility kits, hematology testing kits, urinalysis testing kits, and glucose monitoring kits. (mynewsdesk.com)
  • research
  • Computer-Assisted Molecular Design (CAMD)- An Overview By Horst Friihbeis," Robert Klein, and Holger Wallmeier Dedicated to Professor Heinz Harnisch on the occasion ofhis 60th birthday A new instrument, long established as C A D in engineering, is beginning to make its presence felt in chemical research laboratories: Computer-Assisted Molecular Design (CAMD). (docme.ru)
  • The interest of industrial research in computer-assisted molecular design stems from the desire to make the search for new drugs and plant protection agents more efficient. (docme.ru)
  • We regard computer-assisted molecular design as a new additional tool for research-combination with experiment still remains an essential precondition for successful molecular design. (docme.ru)
  • chronic
  • Broniarek I, Koziel A, Jarmuszkiewicz W. The effect of chronic exposure to high palmitic acid concentrations on the aerobic metabolism of human endothelial EA.hy926 cells. (edu.pl)