• Instead, condensates can form and maintain organization through a range of different processes, the most well-known of which is phase separation of proteins, RNA and other biopolymers into either colloidal emulsions, gels, liquid crystals, solid crystals or aggregates within cells. (wikipedia.org)
  • Coacervate / condensate phase of polyelectrolytes and proteins. (aalto.fi)
  • For protein systems, we focus on block proteins that undergo liquid-liquid phase separation (LLPS) as a preassembly step for structural protein materials. (aalto.fi)
  • However, constructing such molecular systems is a challenge because of the difficulties in working with membrane proteins, very hydrophobic molecules that are prone to aggregate. (uni-muenchen.de)
  • In this way, a hydrophobic environment was supplied to the membrane proteins to fold and function to interact with the extravesicular environment. (uni-muenchen.de)
  • By assessing the functions of membrane proteins with a fluorescence-activated cell sorter, the artificial cell could evolve based on the function of the membrane proteins. (uni-muenchen.de)
  • The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. (cshlpress.com)
  • Studying the architecture, conformational dynamics and interactions of proteins that undergo liquid-liquid phase separation. (leeds.ac.uk)
  • Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. (frontiersin.org)
  • Our simulation experiments indicate, that for receptor/raft ratios smaller than 1, i.e., when the number of raft compartments clearly exceeds the number of pathway specific membrane proteins, we observe significant decrease in LRP6 phosphorylation and downstream pathway activity. (frontiersin.org)
  • Video microscopy technology resolving single molecule movement was employed to monitor the dynamic interaction of membrane-associated signalling proteins with TCR signalling clusters in plasma membrane domains. (biomedcentral.com)
  • These studies tracked the movement of Lck and LAT in the T cell plasma membrane and showed retention of these proteins in the submicron TCR signalling domains and their subsequent release. (biomedcentral.com)
  • Numerous intracellular signalling proteins interact with plasma membrane lipids of the cytoplasmic leaflet via specific lipid headgroup-binding domains. (biomedcentral.com)
  • Infection by envelope viruses is mediated by fusion proteins on the virus surface and requires exposure of a fusion peptide (FP), which inserts into the target membrane. (cnr.it)
  • GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. (mpg.de)
  • Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains. (mpg.de)
  • MitoNEET belongs to the CDGSH Iron-Sulfur Domain (cisd)-gene family of proteins and is a [2Fe-2S] cluster-containing protein found on the outer membrane of mitochondria. (researchgate.net)
  • While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
  • Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
  • Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)
  • We are aiming at characterizing the signaling mechanisms that regulate the liquid-liquid phase transitions in the synaptic vesicle cycle, mitochondrial functions, and degradation pathways at nerve terminals to clarify how do they become affected at the early stages of neurodegenerative diseases and which molecular steps lead to protein aggregate formation. (ki.se)
  • We encapsulated a reconstituted in vitro transcription-translation system inside a cell-sized phospholipid vesicle together with the DNA encoding membrane protein of interest. (uni-muenchen.de)
  • In our research we use a mass spectrometry-based integrative structural biology toolkit, and a combination of other biochemical and biophysical techniques, to elucidate the functional mechanisms of protein complexes, and characterise dynamic and transient assemblies involved in essential cellular functions, cellular organisation and disease. (leeds.ac.uk)
  • Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane. (biomedcentral.com)
  • We will here discuss recent data which provide a detailed picture of the membrane raft characteristics of the plasma membrane domains supporting active TCR signalling protein complexes. (biomedcentral.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder. (the-scientist.com)
  • Elegant studies have demonstrated Dvl-mediated formation of a membrane proximal "signalosome," which enables critical protein interactions at the PM ( 5 ). (rupress.org)
  • S100B is a calcium/zinc-binding protein secreted by mature astrocytes, associated, at high levels, with nervous tissue injury in a variety of neuropathological processes, including Multiple Sclerosis in the acute phase. (cnr.it)
  • Multi-protein assemblies underlie the mesoscale organization of the plasma membrane. (mpg.de)
  • Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
  • Liquid-liquid phase separation in cells has emerged as a common principle for the organization of membrane-less compartments. (ki.se)
  • In nerve terminals in the central nervous system, liquid-liquid phase separation has been implicated in the organization or assembly of several functional compartments. (ki.se)
  • Many cellular compartments are enclosed by membranes, with channels, pores and transporters regulating their composition. (leeds.ac.uk)
  • The 19th Annual Wiley Prize in Biomedical Sciences celebrated a breakthrough in cell biology: how membrane-less cellular compartments are formed. (hymanlab.org)
  • Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane. (ki.se)
  • Research topics include improved molecular dynamics and Monte Carlo simulations, efficient quantum dynamics techniques, electronic structure methods that yield a deeper understanding of intermolecular forces, and the incorporation of machine learning in theoretical chemistry. (gatech.edu)
  • By integrating data principally from state-of-the-art structural-MS and combining it with other functional, biochemical and biophysical methods we aim to establish the molecular principles of LLPS in neurodegeneration, unravelling how structural dynamics and RNA interactions mediate LLPS. (leeds.ac.uk)
  • STED-FLCS: An advanced tool to reveal spatiotemporal heterogeneity of molecular membrane dynamics. (mpg.de)
  • Molecular plasma membrane dynamics dissected by STED nanoscopy and Fluorescence Correlation Spectroscopy (STED-FCS). (mpg.de)
  • Molecular dynamics (MD) simulations showed a preferred interacting crystallographic plane for both crystalline allomorphs that exposes the CH groups (100 and 010) and is therefore considered hydrophobic. (cea.fr)
  • With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)
  • At the interface between two regions, for example the air-liquid interface of a lipid solution, there can arise non-equilibrium situations. (lu.se)
  • Similar conditions also exist in living system, with obvious examples found in the lipid tear film formed on our eyes, which prevent evaporation and dry eyes, and the membrane system in the alveoli of the lung. (lu.se)
  • Even though LRP6 is homogenously distributed in the membrane and only a minor fraction is raft-associated, its localization to lipid rafts is vital for the activation of the LRP6 signalosome, hence wnt/β-catenin signaling. (frontiersin.org)
  • Lipid rafts are local assemblies of highly concentrated sphingolipids and cholesterol in the cell membrane. (frontiersin.org)
  • Early T cell signalling reactions are embedded in the complex and dynamic lipid bilayer matrix of the T cell plasma membrane and are critically defined by their lateral compartmentalisation in plasma membrane domains [ 1 , 2 ]. (biomedcentral.com)
  • However specific lipid-mediated interactions at the T cell plasma membrane bilayer are also a central functional element in early TCR signalling. (biomedcentral.com)
  • Not much is known about the lipid biosynthesis of tetraether membranes which confer extremophilic characteristics to archaea. (basyc.nl)
  • Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells. (mpg.de)
  • A lipid bound actin meshwork organizes liquid phase separation in model membranes. (mpg.de)
  • STED microscopy detects and quantifies liquid phase separation in lipid membranes using a new far-red emitting fluorescent phosphoglycerolipid analogue. (mpg.de)
  • Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. (mpg.de)
  • STED nanoscopy reveals molecular details of cholesterol- and cytoskeleton-modulated lipid interactions in living cells. (mpg.de)
  • Specific recent and current research topics that contribute to the synthetic biology toolbox for development of artificial cells include membrane texturing through phase separation, artificial DNA adhesion receptors, hybrid lipid-polymer membrane systems for enhanced stability and lifetime, encapsulation of feedback-responsive systems and controlled generation of eukaryote-like membrane architectures. (royalsociety.org)
  • Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)
  • We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)
  • The analysis of detergent-resistant T cell membranes had initiated the concept that early TCR signalling steps take place in cholesterol/sphingolipid-rich raft domains of T cell plasma membranes [ 10 ] (see Box for an overview of the current perception of raft domains in cell membranes). (biomedcentral.com)
  • Unfortunately, de Gennes wrote in Nature that polymers should be distinguished from other types of colloids, even though they can display similar clustering and phase separation behaviour, a stance that has been reflected in the reduced usage of the term colloid to describe the higher-order association behaviour of biopolymers in modern cell biology and molecular self-assembly. (wikipedia.org)
  • To address our goals we use several model systems such as giant reticular spinal axon in lamprey, Drosophila neuromuscular junction, and mammalian neurons, in combination with molecular biology, genetics, cellular imaging techniques, and intracellular recordings. (ki.se)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent advances in our understanding of nuclear organization and function. (cshlpress.com)
  • Phase separation, so well-known in salad dressings, was unheard of in cellular biology. (princeton.edu)
  • Then he headed to Max Planck Institute of Molecular Cell Biology and Genetics to work with Tony Hyman, a leader in the study of cellular structures. (princeton.edu)
  • Molecular Biology of the Cell. (quantabiodesign.com)
  • Unlike many organelles, biomolecular condensate composition is not controlled by a bounding membrane. (wikipedia.org)
  • https://doi.org/10.1083/jcb.202205069 ) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane. (rupress.org)
  • The two independent discoveries leading to the principle that multivalent low-affinity interactions between selected sets of macromolecules, some containing intrinsically disordered regions, formed a molecular condensate with unique dynamic properties, gave birth to the large, blossoming field of biomolecular condensates. (hymanlab.org)
  • The NEXUS project will develop an easily customizable integrated platform to enable Extracellular Vesicles (EVs) separation, purification, and multivariate characterization from complex biofluids. (cnr.it)
  • These complexes assemble into submicron TCR signalling domains in the T cell plasma membrane which were first studied by confocal fluorescence microscopy at the contact zone of a T cell with TCR-activating glass coverslips. (biomedcentral.com)
  • Confocal fluorescence microscopy was employed to monitor the distribution of TCR signalling plasma membrane sites and to relate their distribution to that of clustered raft markers which show resistance to Triton X 100 detergent solubilisation. (biomedcentral.com)
  • Swi6 - an HP1 orthologue in Schizosaccharomyces pombe (S. pombe) - can both undergo liquid-liquid phase separation (LLPS) and compact nucleosomes in vitro [Sanulli, 2018]. (emerging-researchers.org)
  • We hypothesize that swi6-sm1, an allele of Swi6, may be such a separation-of-function allele, as the mutations that comprise the swi6-sm1 allele are in the N-terminal extension, a region of Swi6 implicated in its LLPS activity [Larson, 2017]. (emerging-researchers.org)
  • Ultimately, we hope to understand the role of LLPS in chromatin organization and its potential contribution to the integrity of the nuclear envelope. (emerging-researchers.org)
  • However, in the cytoplasm and nucleus, membrane-less organelles (MLOs) form by liquid-liquid phase separation (LLPS). (leeds.ac.uk)
  • Recent studies found Axin ( 6 ) and the DC ( 7 ) undergo liquid-liquid phase separation (LLPS) and drive DC assembly. (rupress.org)
  • we tend to get especially excited about assembly phenomena, the influence of interfaces (surfaces), and external driving of the material self-organization via molecular and energy flows. (aalto.fi)
  • As a result of this self-organization, cells drive fluid flows that circulate around the colony at a constant peak speed of ~30 µm s −1 , providing a stable and high-speed avenue for directed material transport at the macroscopic scale. (nature.com)
  • In biochemistry, biomolecular condensates are a class of membrane-less organelles and organelle subdomains, which carry out specialized functions within the cell. (wikipedia.org)
  • A total of 1187 participants from 14 hospitals completed the survey in two phases: September 2013-April 2014 and May 2015-April 2017. (pubfacts.com)
  • In most cases, the condensed phase is not in equilibrium with the vapor phase, and as a consequence there will be evaporation of water and possible also other volatile components. (lu.se)
  • Dr. Benny D. Freeman, chemical engineering professor, has been selected to receive the 2009 American Chemical Society Award in Applied Polymer Science for his pioneering research that has defined the state of the art in polymer-based gas, liquid and vapor separation membranes. (utexas.edu)
  • Fertilization in mammals is accompanied by an intense period of chromatin remodeling and major changes in nuclear organization. (bvsalud.org)
  • We report that LADs reorganize gradually in two-cell embryos and that blocking ZGA leads to major changes in nuclear organization, including altered chromatin and genomic features of LADs and redistribution of H3K4me3 toward the nuclear lamina. (bvsalud.org)
  • The existence of membrane-less organelles, often called bodies or puncta, has been known for a long time, but what exactly they represented and how they were formed was not known. (hymanlab.org)
  • Each, synergistically, made groundbreaking contributions to the discovery that membrane-less organelles are liquid-liquid phase-separated entities. (hymanlab.org)
  • For most individual signaling pathway, this quantitative point of view would imply, that rafts clearly outnumber the membrane-associated pathway components, such as receptor and kinases. (frontiersin.org)
  • Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. (biomedcentral.com)
  • This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. (biomedcentral.com)
  • The results led to a refined perception of membrane rafts which resolves the controversies. (biomedcentral.com)
  • Our current interest is in the molecular mechanisms, which link the synaptic vesicle cycle with the onset of neurodegenerative diseases and primerily under conditions that lead to α-synuclein-related pathologies observed in Parkinson's disease, as well as in several diseases referred to as synucleinopathies. (ki.se)
  • The swelling of starch grains and their growth was described by a molecular-aggregate model, which he also applied to the cellulose of the plant cell wall. (wikipedia.org)
  • When cell biologists largely abandoned colloidal phase separation, it was left to relative outsiders - agricultural scientists and physicists - to make further progress in the study of phase separating biomolecules in cells. (wikipedia.org)
  • From the molecular analysis inside the artificial cells, we have found that the properties and phase transitions of polymers confined to the artificial cell often differ from those in bulk systems. (uni-muenchen.de)
  • In the case of molecular diffusion in one-component polymer solutions, polymer diffusion is slower than diffusion within larger cells when the artificial cell size is smaller than ~100 μm. (uni-muenchen.de)
  • In the case of two-component polymer solutions, phase separation is induced within the cell size space even under conditions that maintain a uniform phase in bulk. (uni-muenchen.de)
  • Based on these results, we will discuss the role of cell size space in regulating molecular behavior. (uni-muenchen.de)
  • This volume is therefore essential reading for all cell and molecular biologists, as well as pathologists interested in the role of nuclear architecture in disease. (cshlpress.com)
  • If phase separation could happen in a bottle at dinner, why not within a cell? (princeton.edu)
  • Recently, structural MS methods have been shown to be promising tools to achieve this endeavour, including XL-MS and in-cell FPOP, yielding unprecedented insights into the structure and organisation of cellular macromolecular assemblies. (leeds.ac.uk)
  • However, according to various experimental measurements, approximately 25 to 35 % of the cell plasma membrane is covered by nanoscopic raft domains with diameters ranging between 10 to 200 nm. (frontiersin.org)
  • Extrapolating/Translating these values to the membrane of a "normal sized" cell yields a raft abundance, that, by far, outnumbers the membrane-associated pathway components of most individual signaling pathway, such as receptor and kinases. (frontiersin.org)
  • The TCR signalling cascade is initiated by phosphorylation of critical tyrosines of the TCR/CD3 complex by the Src-family kinases Lck or Fyn which are anchored in the cytoplasmic leaflet of the T cell plasma membrane. (biomedcentral.com)
  • The cytosolic ZAP-70 tyrosine kinase is recruited to the T cell plasma membrane via binding to the tyrosine phosphorylated TCR-complex [ 3 ]. (biomedcentral.com)
  • They share a common vision that the ability to build a synthetic cell from its basic constituents will result in a deep molecular understanding of life. (basyc.nl)
  • Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. (rupress.org)
  • This philosophy from early in my scientific career stuck with me, and I believe was instrumental in my lab's contribution to the discovery of multivalency-driven liquid-liquid phase separation as a general principle in cell organization. (hymanlab.org)
  • As cell membranes are both dynamic and compositionally complex, replicating these aspects in a model membrane are essential. (lu.se)
  • Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. (biomedcentral.com)
  • We study the molecular and biophysical mechanisms underlying and regulating vesicle trafficking in neurons and in particular in their axons and presynaptic nerve terminals. (ki.se)
  • In this study, we explore the underlying mechanisms of transport-generated interfacial phase separation using a combination of surface together with theoretical modelling solving diffusion equations. (lu.se)
  • The molecular mechanisms continue to remain unclear. (aps.org)
  • Chemistry is the central science, and the School of Chemistry and Biochemistry is at the heart of wide-ranging molecular research at Georgia Tech and elsewhere. (gatech.edu)
  • We love understanding soft materials at molecular level, work in tight collaboration with experimentalists and do our molecular modelling at atomistic to mesoscale. (aalto.fi)
  • Around the same time, Thomas Harrison Montgomery Jr. described the morphology of the nucleolus, an organelle within the nucleus, which has subsequently been shown to form through intracellular phase separation. (wikipedia.org)
  • Once such a system can be constructed, we will be able to observe the evolutionary processes in the laboratory at a molecular level. (uni-muenchen.de)
  • This non-equilibrium situation implies several simultaneous transport processes across the interfacial layer separating the condensed and the gas phases, which in turn can have consequences on the molecular organization in the interfacial layer. (lu.se)
  • Helicates and Molecular Switches : Magic Self-Assembly Processes and Cations Translocation? (unige.ch)
  • The article nicely explains how the team used neutron reflectometry to study surfactant self-organisation in the context of laundry detergent pods, with some surprising results. (durham.ac.uk)
  • Operando characterization of heterogeneously catalyzed gas-and multi-phase reactions using nuclear magnetic resonance imaging. (uni-bremen.de)
  • Longitudinal Relaxation (T 1) of Methane/Hydrogen Mixtures for Operando Characterization of Gas-Phase Reactions. (uni-bremen.de)
  • In the 1980s and 1990s, Athene Donald's polymer physics lab in Cambridge extensively characterised phase transitions / phase separation of starch granules from the cytoplasm of plant cells, which behave as liquid crystals. (wikipedia.org)
  • We have qualitatively explained these phenomena by considering the length-dependent membrane wettability of polymers. (uni-muenchen.de)
  • Despite its prominence and importance, our understanding of how the nucleus and its DNA are organized in space and time-and the implications of that organization for proper function-has lagged behind that of other cellular structures. (cshlpress.com)
  • This "proof of principle" could potentially be exploited in chiral recognition, in chiral synthesis (forming a chiral product from non-chiral reactants), and in chiral separations. (nanowerk.com)
  • it includes the study of electrolytic and colloidal solutions, and of the molecular forces brought into play by solution, osmosis, diffusion, cohesion, and crystallization. (wikipedia.org)
  • Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure. (mpg.de)
  • Coaligned dual-channel STED nanoscopy and molecular diffusion analysis at 20 nm resolution. (mpg.de)
  • Typically, flow electrification occurs via diffusion of electric-charge carriers (ions) from the electrical double layer, which is inevitably formed between a liquid-solid interface, to the bulk of the flow. (aps.org)
  • Recently, a model for heterochromatin organization based on distinct liquid-like phase has been proposed. (emerging-researchers.org)
  • α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander? (ki.se)
  • Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation. (ki.se)
  • Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. (mpg.de)
  • We examine assembly and adsorption in reverse micellar systems but also driven self-organization of colloidal assemblies in apolar media. (aalto.fi)
  • Within this pathway, Dishevelled interprets and propagates signals from 19 Wnts engaging 10 Frizzled (Fzd) receptors/co-receptors embedded in the plasma membrane (PM). For years, interest in how Dishevelled receives, interprets, and relays this information has been immense. (rupress.org)
  • In 1991, Pierre-Gilles de Gennes received the Nobel Prize in Physics for developing a generalized theory of phase transitions with particular applications to describing ordering and phase transitions in polymers. (wikipedia.org)
  • Colloidal phase separation as a driving force in cellular organisation appealed strongly to Stephane Leduc, who wrote in his influential 1911 book The Mechanism of Life: "Hence the study of life may be best begun by the study of those physico-chemical phenomena which result from the contact of two different liquids. (wikipedia.org)
  • Beginning in the early 1970s, Harold M Farrell Jr. at the US Department of Agriculture developed a colloidal phase separation model for milk casein micelles that form within mammary gland cells before secretion as milk. (wikipedia.org)
  • In system containing of self-assembling amphiphilic molecules or colloidal suspensions, there is then a possibility of transport-generated interfacial phase separation. (lu.se)
  • Debackere and Rappa (1994) have suggested that technological paradigms typically emerge in two phases: bootlegging and bandwagon. (hyle.org)
  • Multifunctional Separation Mechanism on Poly(oxyethylene) Stationary Phases in Capillary Liquid Chromatography. (quantabiodesign.com)
  • I am basically a Liquid chromatography and mass spectrometry specialist for the Bionanosience department. (basyc.nl)
  • A method of analysis of eight flavones using high-performance liquid chromatography (HPLC)-diode array detection mass spectrometry in root and aerial tissues of the medicinal plant Scutellaria baicalensis was developed by Christopher RH et al (2005).2 The identity of the analytes was confirmed using retention time UV-visible and mass spectral comparisons to commercial standards. (webmedcentral.com)
  • A high-speed counter-current chromatography (HSCCC) method was developed by Li H B et al (2005)3 for the preparative separation and purification of three bioactive flavonoids, namely, baicalein, wogonin and oroxylin A, from Scutellaria baicalensis Georgi. (webmedcentral.com)
  • The methodology presented allows the amount of native membrane material in the nSLB to be precisely controlled and display a uniform lateral distribution. (lu.se)
  • HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)
  • In one of these, the self-organisation is driven by hydrogen bonding between the molecules, while the chiral centre has no discernable impact on the regular array. (nanowerk.com)
  • WB Hardy linked formation of biological colloids with phase separation in his study of globulins, stating that: "The globulin is dispersed in the solvent as particles which are the colloid particles and which are so large as to form an internal phase", and further contributed to the basic physical description of oil-water phase separation. (wikipedia.org)
  • With a background in soft matter and biological physics, his current research interests are encompassed by the physical properties and applications of biomimetic membranes. (royalsociety.org)
  • In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. (lu.se)
  • However, the molecular mechanism of viral factory assembly, and their precise role in virus replication remain unexplained. (leeds.ac.uk)
  • Self-Assembly of Solid-Supported Membranes Using a Triggered Fusion of Phospholipid-Enriched Proteoliposomes Prepared from the Inner Mitochondrial Membrane. (quantabiodesign.com)
  • Our data indicate that the rearrangement of LADs is an integral component of the maternal-to-zygotic transition and that transcription contributes to shaping nuclear organization at the beginning of mammalian development. (bvsalud.org)