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  • Regrow Limbs
  • The short synopsis of my reading of this article is simply that by activating a gene that goes back to early evolution, we may be able to regrow limbs like Sponges, worms, or Starfish. (thinkatheist.com)
  • But maybe 20 years from now, we'll be able to have people born with the ability to regrow limbs, and that's a win for science. (thinkatheist.com)
  • species
  • We call this cell mass a "multipotential cell cluster" and it is similar, but not identical, to the true blastema of regenerating species such as the newt. (pitt.edu)
  • Similar genes exist in axolotl and another newt species, but not in any other species. (phys.org)
  • The contribution of EryCs to the limb blastema, at least in this species, is specific to the terrestrial adult life-stage," concludes co-author Chikafumi Chiba, a professor at the University of Tsukuba. (phys.org)
  • positional
  • Retinoic acid (RA) is able to respecify the positional identity of the blastema to a more proximal value, thus raising the possibility that the RA response system is activated during limb regeneration. (ucl.ac.uk)
  • embryonic
  • These findings delineate in detail the molecular changes that take place in the RPE during the process of transdifferentiation in the embryonic chick, and specifically identify Lin-28 as an important factor in this process. (biomedcentral.com)
  • unclear
  • Because of the restricted expression of Shh to the posterior margin, it remains unclear, however, whether Shh induces the limb polarity directly or through a secondary signal. (biomedcentral.com)
  • hindlimb
  • The results of a series of skin grafting experiments performed on the hindlimb of the newt Triturus cristatus are described. (cloudfront.net)
  • crucial
  • However, very few molecular tools exist for studying crucial cell lineage relationships over regeneration or for robust and sustained misexpression of genetic elements to test their function. (biologists.org)
  • genes
  • Molecular studies of appendage regeneration have been hindered by the lack of a stable and efficient means of transferring exogenous genes. (biomedcentral.com)
  • FV vectors are efficient mean of transferring genes into axolotl limb/tail and infection persists throughout regeneration and reamputation. (biomedcentral.com)
  • Can this remarkable ability be explained by genes shared by vertebrates, including humans, or by unique genes that the newt may have evolved? (phys.org)
  • In the study, the researchers constructed a database of all the protein-coding genes from the Japanese fire-bellied newt that had been reported in the Japan newt research community. (phys.org)
  • Thus, it is of interest to understand the molecular role of ems genes at the cellular level in different phyla. (biologists.org)
  • digits
  • Such injuries - the partial or complete loss of digits or limbs and deforming facial injuries - have profoundly affected the quality of life of the wounded as well as presented a new set of challenges for the medical community faced with treating them. (medgadget.com)
  • The proposed studies address one of the most pressing needs of the wounded soldier population: the replacement of lost digits and limbs. (pitt.edu)
  • Overexpression of BMP-2 in regenerating limbs caused a loss of digits. (biomedcentral.com)
  • Overexpression of Noggin ( BMP inhibitor) in regenerating limbs also resulted in a loss of digits. (biomedcentral.com)
  • mammals
  • Anoop Kumar and colleagues from University College London (UCL), writing in the journal Science, said the finding 'may hold promise for future efforts to promote limb regeneration in mammals. (yahoo.com)
  • Unlike typical mammals, which heal wounds by forming a scar, these mice begin by forming a blastema, a structure associated with rapid cell growth and de-differentiation as seen in amphibians. (thinkatheist.com)
  • But unlike mammals which form a scar, the newt forms a blastema . (viewzone.com)