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  • genes
  • Hypothesizing that the Amazonian water system differences would affect the expression of muscle growth-related genes in juvenile tambaqui Colossoma macropomum (Cuvier 1818), this study aimed to analyze the morphometric data and expression of myogenic regulatory factors (MRFs) in the white and red muscle from tambaqui obtained from clear and black Amazonian water systems. (hindawi.com)
  • Ticho, B.S., Stainier, D.Y.R., Fishman, M.C., and Breitbart, R.E. (1996) Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos. (zfin.org)
  • Transcription factors, such as the MEF2s, regulate skeletal and cardiac muscle-specific genes during development. (zfin.org)
  • We report the identification of three zebrafish MEF2 genes which, like their mammalian counterparts, encode factors that function as DNA-binding transcriptional activators of muscle specific promoters. (zfin.org)
  • The pattern of MEF2 expression in zebrafish defines discrete cell populations in the developing somites and heart and has mechanistic implications for developmental regulation of the MEF2 genes, when compared with other species. (zfin.org)
  • It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. (biomedcentral.com)
  • The inductive signals entering the mesoderm are related to the subsequent activation of genes encoding protein transcription factors of bHLH gene family and analogs. (deepdyve.com)
  • Given the pleiotropic manifestation of CACNA1C mutations in TS and the recent implication of common variation in CACNA1C across multiple neuropsychiatric disorders [ 14 ], we reasoned that characterization of the Ca v 1.2-dependent signaling network in TS would help elucidate its molecular basis and prioritize genes for therapeutic development. (biomedcentral.com)
  • The expression of muscle-specific genes associated with myogenesis is controlled by several myogenic transcription factors, including myogenin and MEF2D. (ahajournals.org)
  • TGF-β elicits cellular effects by activating receptor-regulated Smad2 and Smad3 that form complexes with common partner Smad4, which accumulate in the nucleus and regulate transcription of target genes. (ahajournals.org)
  • Disruption of the MT network by chemical agents, such as nocodazole and colchicine, leads to ligand-independent Smad nuclear accumulation and transcription of TGF-β-responsive genes and increases TGF-β-induced Smad activity. (ahajournals.org)
  • Key features of primary networks implicated by methylation differences included cell metabolism, cell cycle and transcription and, more specifically, genes involved in cell-cell interaction and Wnt signaling. (frontiersin.org)
  • Members of the MEF2 family of DNA binding proteins interact with a set of AT-rich sequences commonly found in the promoters and enhancers of muscle-specific genes. (nih.gov)
  • mechanisms
  • Understanding the molecular mechanisms that regulate this process remains the focus of investigations by many laboratories. (jneurosci.org)
  • CRC has to be considered a complex disease resulting from a combination of environmental factors, genetic/epigenetic predisposing variants and specific molecular mechanisms. (biomedcentral.com)
  • Comparative Properties of Myogenesis in Invertebrates and in Lower and Higher Vertebrates Ozernyuk, N. 2004-12-27 00:00:00 Development of the muscle system in invertebrates (on the example of nematode Caenorhabditis elegans and Drosophila) and vertebrates (fish, birds, and mammals) demonstrates a number of common patterns at the level of molecular and genetic control mechanisms but also a number of distinctive features. (deepdyve.com)
  • Development of the muscle system in invertebrates (on the example of nematode Caenorhabditis elegans and Drosophila) and vertebrates (fish, birds, and mammals) demonstrates a number of common patterns at the level of molecular and genetic control mechanisms but also a number of distinctive features. (deepdyve.com)
  • These analyses illustrate how a systems biology approach based on gene networks can yield insights into the molecular mechanisms of neural development and function, and provide clues as to the functional impact of the downstream effects of Ca 2+ signaling dysregulation on transcription. (biomedcentral.com)
  • The present review outlines the molecular and biochemical mechanisms which play a role in muscular atrophy, hypertrophy, and remodeling. (carleton.ca)
  • Transforming growth factor-β (TGF-β) has been shown to inhibit myogenesis, yet the molecular mechanisms underlying such inhibition are not known. (ahajournals.org)
  • 3 The molecular mechanisms/signaling pathways that mediate the TGF-β-induced antimyogenic effects, however, remain unknown. (ahajournals.org)
  • Concomitant with the vastly different functional outcomes induced by these diverse exercise modes, the genetic and molecular mechanisms of adaptation are distinct. (springer.com)
  • This article highlights the effects of exercise on molecular and genetic mechanisms of training adaptation in skeletal muscle. (springer.com)
  • These results suggest that the XMyoDa promoter can be activated by binding of MEF2 to the XMyoDa TATA motif and indicate that MEF2-dependent transcriptional activation occurs by different mechanisms depending on the location of the MEF2 binding site. (nih.gov)
  • isoforms
  • These findings demonstrate Cdk5 phosphorylation-dependent destabilization of specific MEF2 isoforms as an important regulatory mechanism in mediating neurotoxin-induced death. (jneurosci.org)
  • genetic
  • indeed, since CRC development may take years, its early detection and the use of biochemical and molecular/genetic diagnostic tools is a keystone for improving survival rates. (biomedcentral.com)
  • mammalian
  • Studies with mammalian hibernators have identified a variety of molecular pathways which are strategically regulated and allow animals to endure multiple stresses associated with the hibernating season. (carleton.ca)
  • 31.8
  • ATF1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 295 amino acids (1-271 and having a molecular mass of 31.8kDa. (prospecbio.com)
  • skeletal muscle
  • Skeletal muscle displays a great deal of plasticity and may have different morphofunctional characteristics as a result of the influences of various intrinsic and extrinsic factors including temperature, nutrition, fasting, and photoperiod. (hindawi.com)
  • Circadian rhythmicity and photic plasticity of myosin gene transcription in fast skeletal muscle of Atlantic cod (Gadus morhua). (semanticscholar.org)
  • Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise. (springer.com)
  • homolog
  • gene regulatory network that controls the activity of a positive feedback circuit on BMP signaling, involving the tumor necrosis factor alpha homolog eiger . (sdbonline.org)