AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Cell PolarityFrizzled ReceptorsWingStereociliaDrosophila ProteinsPupaBody PatterningDrosophilaPhotoreceptor Cells, InvertebrateReceptors, G-Protein-CoupledCadherinsLIM Domain ProteinsEyeGene Expression Regulation, DevelopmentalDrosophila melanogasterAnimals, Genetically ModifiedSignal TransductionMembrane ProteinsEmbryo, NonmammalianGenes, InsectMorphogenesisSaccule and UtricleHair Cells, AuditoryMutationAdaptor Proteins, Signal TransducingMyosin Type IIModels, BiologicalPhenotypeCiliaPhosphoproteinsWnt1 ProteinEye AbnormalitiesAbdomenInsect ProteinsActinsCell Adhesion MoleculesEpitheliumCochleaWnt Signaling PathwayIntracellular Signaling Peptides and ProteinsWnt ProteinsAmino Acid SequenceCell MovementTranscription FactorsCell DifferentiationMutagenesisReceptors, Cell SurfaceMolecular Sequence DataDNA-Binding ProteinsJNK Mitogen-Activated Protein KinasesMembrane GlycoproteinsProtein BindingCells, CulturedCell LineEpithelial CellsGene Expression RegulationBase SequenceProtein TransportMicrotubulesProtein Structure, TertiaryRNA, MessengerCytoskeletonPhosphorylationTranscription, GeneticCell Line, TumorRNA InterferenceCarrier ProteinsApoptosisTight JunctionsCaenorhabditis elegansCell Membranecdc42 GTP-Binding ProteinBlotting, WesternCaenorhabditis elegans ProteinsBinding SitesNeuronsProtein-Serine-Threonine KinasesCell ProliferationPromoter Regions, GeneticReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingNerve Tissue ProteinsModels, MolecularTransfectionGene ExpressionMice, KnockoutRecombinant Fusion ProteinsMice, Inbred C57BLRNA, Small InterferingTime FactorsIntercellular JunctionsGreen Fluorescent ProteinsMicroscopy, FluorescenceHomeodomain ProteinsCell DivisionDown-RegulationAdherens JunctionsEnzyme ActivationSequence Homology, Amino AcidZebrafish
DrosophilaElucidatePathwaysPlasticitySpindleCellular and molecular mechanismsCiliaBiologyEmbryonicDynamicsAsymmetricFindingsOrganismsMechanosensoryOverexpressionInsightsFundamentalEpithelialSignaling cascadeGeneQuantitativeEstablishmentPathwayMesodermRegenerationProteinsMorphogenesisProcessesFunctionalUnderstandingSignalsRemarkablyTissueRegulatesVisualizationCuesDeterminationTherapeuticDevelopmentCellsMesenchymalControlFunctionMedicineTechniquesDynamic
Drosophila3
  • Because of the availability of remarkably powerful genetic, molecular and cell biological tools, we use the fruitfly, Drosophila melanogaster, as our primary model for investigating the fundamental mechanisms of PCP signaling. (stanford.edu)
  • Here, we identify Pins-mediated planar cell polarized divisions in several of the mitotic domains of the early Drosophila embryo. (elifesciences.org)
  • The Drosophila polarity protein Crumbs is essential for the establishment and growth of the apical domain in epithelial cells. (elifesciences.org)
Elucidate3
  • The primary goal of my work on PCP has been to elucidate, at molecular and cell biological levels, the nature of the signals that induce subcellular asymmetry, and how cells then respond to this molecular asymmetry to orient their cytoskeletons. (stanford.edu)
  • Altogether, our findings elucidate conserved cellular and molecular mechanisms through which miR-34/449 regulate motile ciliogenesis. (nature.com)
  • The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
Pathways2
  • To date, three Wnt signaling pathways have been characterized including the canonical Wnt/β-catenin signaling, the noncanonical planar cell polarity pathway (Wnt/PCP) and the Wnt/Ca 2+ pathway [ 7 , 8 ]. (oncotarget.com)
  • It may also provide new insights into the molecular pathways that go awry in common forms of conditions such as obesity and diabetes, which represent major public health concerns [ 8 , 9 ]. (springer.com)
Plasticity3
  • Disentangling the mechanisms that control this functional plasticity of biological processes at the molecular and supramolecular levels is at the heart of fundamental biological research and understanding of diseases. (uni-osnabrueck.de)
  • We seek to define the mechanisms underlying such functional plasticity at membranes in various physiological and pathophysiological processes. (uni-osnabrueck.de)
  • We will follow a multiscale approach to study how functional plasticity is encoded by cellular membrane networks from the molecular and sub-cellular up to the organismic level. (uni-osnabrueck.de)
Spindle1
  • We found that disrupting forces through chemical inhibitors, depletion of an adherens junction protein, or blocking mesoderm invagination disrupted Pins planar polarity and spindle orientation. (elifesciences.org)
Cellular and molecular mechanisms1
  • Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. (biologists.com)
Cilia2
  • Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. (xenbase.org)
  • Recent experimental findings revealed considerable complexity to the underlying mechanosensory mechanisms that transmit extracellular stimuli to intracellular signaling many of which include primary cilia. (aimspress.com)
Biology3
  • Our new research article "The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling" has been published in Frontiers in Cell and Developmental Biology. (lungdevelopmentandrepair.org)
  • I obtained my bachelor's degree from the Molecular Biology and Genetics Department at Bilkent University, in Turkey. (mskcc.org)
  • At the molecular level, most of biology happens at interfaces where water makes contact with macromolecules or molecular aggregates. (lu.se)
Embryonic1
  • To investigate the underlying mechanisms of increased cancer development, the Zhang group established immortalized lines of embryonic fibroblasts from Smurf2-deficient embryos and found that these cells have altered patterns of histone modifications and loosely compacted chromatin. (biomedcentral.com)
Dynamics1
  • This has been established by experiments on simple model interfaces1,2 and by molecular dynamics simulations.8-10 Given an estimate of the number (nH) of water molecules in the hydration layer, e.g. from a simulation, we can obtain, in an essentially model-free way, the rotational correlation time htHi averaged over all sites in the hydration layer. (lu.se)
Asymmetric1
  • Including discussions of the molecular basis of polarization mechanisms, asymmetric division of stem cells during development, the generation of left-right asymmetry of the body axis in mammals, and theoretical approaches to symmetry breaking, the volume is a vital reference for molecular, cell, and developmental biologists, as well as physical scientists interested in how and why symmetry breaking occurs in living systems. (cshlpress.com)
Findings3
  • instead, our findings strongly suggest that Pins planar polarity and force generated from mesoderm invagination are important. (elifesciences.org)
  • Onishi et al published new findings on signaling mechanisms that mediates growth cone turning. (ucsd.edu)
  • Together, these novel findings reveal a molecular cascade that controls cellular properties required for branching morphogenesis. (myspaceastronomy.com)
Organisms2
  • Although mammalian models provide vital insights into the underlying pathology of these diseases, aquatic organisms such as Xenopus and zebrafish provide valuable tools to help screen and dissect out the underlying causes of these diseases. (xenbase.org)
  • To meet this demand, organisms are equipped with sophisticated mechanisms to regulate protein function in time and space. (uni-osnabrueck.de)
Mechanosensory1
  • Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch. (harvard.edu)
Overexpression2
  • The use of molecular techniques, including gene and protein knock downs, knock outs and overexpression allows investigation into the mechanisms of fate determination. (wikipedia.org)
  • Disrupting Pins polarity via overexpression of a myristoylated version of Pins caused randomized division angles. (elifesciences.org)
Insights2
  • In this review, we highlight new molecular insights aiding our understanding of the initiation and progression of DN, including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication, and inhibition of tubular sodium coupled glucose reabsorption. (scite.ai)
  • Understanding molecular mechanisms underlying normal growth plate function has provided valuable insights into the genetic defects that impact growth and foundation for the development of effective therapeutic strategies for individuals with growth disorders. (pfmjournal.org)
Fundamental2
  • The Zou lab studies the fundamental molecular signaling and cellular mechanisms of axon guidance and synapse formation and how disruption of these normal processes may lead to developmental disorders, such as autism. (ucsd.edu)
  • However, fundamental understanding of underlying mechanisms related to light- and bias-induced effects at the nanoscale is still required. (nature.com)
Epithelial3
  • Our major project is to investige a pathway that controls the polarity of epithelial cells within the plane of the epithelium. (stanford.edu)
  • This is said to alterations throughout the kind and orientation of the epithelial sheet and the underlying mesenchymal layer in areas of defective branching throughout the mutant lungs. (myspaceastronomy.com)
  • However, the molecular and cellular events downstream of epithelial and mesenchymal Wnt5a signaling are unclear. (myspaceastronomy.com)
Signaling cascade1
  • Similar results with Xenopus strabismus implicate the planar cell polarity (PCP) signaling cascade in neural convergent extension and tube closure. (silverchair.com)
Gene1
Quantitative2
  • At the Living Systems Institute, we collaborate with biophysicists using super-resolution microscopy to describe these signalling processes in a quantitative way on a molecular level. (exeter.ac.uk)
  • A download between 9 fluid point hadrons applied to a web of 499 molecular quantitative directions. (mariacocchiarelli.com)
Establishment1
  • At the cellular level, several processes are highly controlled, including the establishment and maintenance of apico-basal polarity, the control of the cell cycle and cell cycle exit, and the acquisition of cell subtype identities. (biologists.com)
Pathway1
  • Remarkably, the molecular programs regulating striatal pathway development remain poorly characterized. (jneurosci.org)
Mesoderm1
  • However, the subsequent defect is the maldevelopment of the mesoderm, which, in turn, forms the skeletal and muscular structures that cover the underlying neural structures. (medscape.com)
Regeneration4
  • By understanding Wnt dissemination mechanisms, we will be able to control Wnt signalling in development, and regeneration. (exeter.ac.uk)
  • The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration. (biologists.com)
  • This study provides a new method for investigating the underlying mechanisms of the conditioning response and suggests that loss of the peripheral myelin maybe a major signal to change the intrinsic growth state of adult sensory neurons and promote regeneration. (ucsd.edu)
  • Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
Proteins1
  • Each cell in an embryo receives molecular signals from neighboring cells in the form of proteins, RNAs and even surface interactions. (wikipedia.org)
Morphogenesis1
  • We illustrate where such mechanisms of pattern formation arise in biological systems from cellular to tissue scales, with an emphasis on morphogenesis. (mpi-cbg.de)
Processes1
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
Functional1
  • probes, molecular reporters and fluorescent indicators for structural or functional imaging or microscopy/nanoscopy. (nih.gov)
Understanding2
  • Understanding the molecular basis of AS is critical for the development of specific therapies. (springer.com)
  • A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
Signals1
  • The formation of longitudinal axon tracts in the CNS is complex and requires a myriad of molecular signals and specialized cell types, such as intermediate target and guidepost cells. (jneurosci.org)
Remarkably1
  • Importantly, flies have proven to be a remarkably well-conserved model for the molecular mechanisms of signaling events that direct vertebrate development. (stanford.edu)
Tissue1
  • The mildest form is spina bifida aperta, in which osseous fusion of one or more vertebral arches is lacking, without involvement of the underlying meninges or neural tissue. (medscape.com)
Regulates1
  • Moreover, whether or not or not Wnt5a in numerous cell kinds, much like endothelial cells and pericytes, moreover regulates lung branching requires additional analysis using genetic and molecular approaches. (myspaceastronomy.com)
Visualization1
  • Improvements in imaging tools including live confocal microscopy and super resolution microscopy allow visualization of molecular changes in experimentally manipulated cells as compared to controls. (wikipedia.org)
Cues1
  • It is, in part, directed by external cues that promote front-to-rear polarity in individual cells. (bvsalud.org)
Determination1
  • Cells' fate determination mechanisms were categorized into three different types, autonomously specified cells, conditionally specified cells, or syncytial specified cells. (wikipedia.org)
Therapeutic2
  • We believe that these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for DN over the next decade. (scite.ai)
  • Downregulation of the cancer-progression factor CD147 may be a novel mechanism that underlies the therapeutic effects of Ad-REIC treatment. (bms-911543.com)
Development2
Cells1
  • This process revealed that the Vangl2 Lp mutation caused disruption of the actomyosin network (a kind of scaffold present in cells that is analogous to the musculoskeletal system in the human body), as well as focal adhesions, which function as molecular clutches, enabling cells to attach to their surrounding matrix. (lungdevelopmentandrepair.org)
Mesenchymal1
  • Osteosarcomas and chondrosarcomas are recognized as the most common primary bone sarcomas [ 1 ], which involve mesenchymal tissues and exhibit highly heterogeneous histologic and molecular profiles [ 2 ]. (oncotarget.com)
Control2
  • He received his Ph.D. at the Massachusetts Institute of Technology, studying the neural mechanisms of early motor control in the juvenile songbird model system. (nih.gov)
  • A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis. (harvard.edu)
Function1
  • He discovered an unexpected antagonism between Dishevelleds, which may function as a signal amplification mechanism in filopodia. (ucsd.edu)
Medicine1
  • 12/95-5/2000 Associate Professor, Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa. (vdocuments.net)
Techniques1
  • The modified ZnO surfaces are characterized using a number of complementary techniques, demonstrating that the preparation protocol yields dense, well-defined molecular monolayers. (uni-potsdam.de)
Dynamic2
  • The generic dynamic perturbation factor is less than 2 at room temperature and exhibits a maximum near 260 K. The dynamic perturbation is induced by H-bond constraints that interfere with the cooperative mechanism that facilitates rotation in bulk water. (lu.se)
  • H-bonds were broken simultaneously.4-6 An interface interferes with this cooperative mechanism, leading to a dynamic perturbation that is usually much larger and more amenable to experimental characterization than the structural perturbation. (lu.se)