Molecular mechanisms underlying bacterial. Medical search. Frequent questions

Bacterial pathogens are also responsible for many of the infections acquired in hospitals and for some 'old' diseases, including tuberculosis, which is now on the increase in many parts of the world. (imperial.ac.uk)
Phagocytosis has been considered as an essential defense mechanism of immune response to pathogens among eukaryotes, which are also implicated in diverse physiological processes, including development, apoptotic, tissue repair, and host defense ( 4 ). (frontiersin.org)
Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens. (frontiersin.org)
Here, we review the many functions of autophagy in bacterial infections with a focus on macrophages, the first line of host defenses, and the replicative niche of numerous pathogens. (frontiersin.org)
We study the molecular mechanisms underlying the interaction between pathogens and their mammalian host. (virginia.edu)
To survive in humans and cause infections, bacterial pathogens have developed sophisticated mechanisms to subvert the complement-mediated bactericidal activity. (bvsalud.org)
Similar to other bacterial pathogens, multi-drug resistant (MDR) and even extensively drug-resistant (XDR) S. Typhi strains are spreading globally, which are anticipated to worsen the morbidity and mortality of typhoid fever if new interventions are not implemented. (google.com)
We use a multidisciplinary approach integrating data & computational science, cell biology, molecular biology, microbiology, biochemistry, glycobiology, immunology, structural biology (cryo-EM and X-ray crystallography), and murine models to decipher the interactions between the host and (drug-resistant) bacterial pathogens. (google.com)
Similarly, this kind of close-up on bacterial interactions is essential for infection biology, to help researchers map what molecular mechanisms help pathogens find, invade host cells, and then survive and proliferate within them. (embl-em.de)
Major killers are viruses causing small pox, influenza or AIDS, bacterial pathogens causing plague, tuberculosis or typhoid fever, and parasitic protozoa causing malaria or leishmaniasis. (sgv.org)
While the etiology and manifestation of infectious diseases are vastly different, unifying principles are that viral, bacterial, and parasitic pathogens interact with, infect and destroy eukaryotic cells. (sgv.org)
Further, we study how intracellular C3 contributes to recognition and clearance of intracellular bacterial pathogens. (lu.se)

Dekker aims to understand the molecular mechanisms that underlie drug-resistant phenotypes of bacteria and their evolution, and to apply this knowledge to develop novel clinical diagnostic tools as the head of the institute's Bacterial Pathogenesis and Antimicrobial Resistance Unit. (nih.gov)
The unifying themes of our ongoing research program are seeking to understand the underlying mechanisms that control the pathogenesis and disease associated with Salmonella Typhi , as well as develop intervention strategies against the bacteria and/or its associated disease. (google.com)
Glycan-Mediated Molecular Interactions in Bacterial Pathogenesis. (google.com)
The molecular mechanisms underlying the pathogenesis, particularly the inflammatory response, remain largely unknown. (colorado.edu)
An in-depth molecular understanding of processes underlying pathogenesis not only provides insights into the mechanisms of diseases, but also offers intriguing glimpses into the cell biology of eukaryotic cells. (sgv.org)

Bacterial infections cause a huge burden of disease throughout the world and kill millions of people and animals each year through diseases such as pneumonia, diarrhoea and meningitis, as well as genito-urinary and blood infections. (imperial.ac.uk)
Several of us are part of the "MRC Centre for Molecular Bacteriology and Infection," a College cross-faculty initiative that uses multidisciplinary approaches and cutting edge techniques to study bacterial infections at atomic, cellular and organism levels. (imperial.ac.uk)
During the past few decades, hemocyte-mediated phagocytosis, as one of the most important innate cellular immune function, has also received great attention in crustacean, and a good progress in elucidating the involvement of hemocyte-mediated phagocytosis, as well as its protective roles and mechanisms, against bacterial and viral infections has been achieved. (frontiersin.org)
Regulation of mucus overproduction in bacterial infections. (gra.org)
PROVIDENCE, R.I. [Brown University] -With a new five-year, $11.5 million grant from the National Institutes of Health, Brown University will expand its research in computational biology and launch a new Center of Biomedical Research Excellence (COBRE), which will support five early career faculty members as they tackle the genomics underlying diseases such as cancer, preeclampsia and severe lung infections. (brown.edu)
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. (frontiersin.org)
The treatment of pathogenic E. coli infections is becoming complicated because of the rapid emergence and dissemination of antibiotic-resistant strains, which may consequently result in an increasing number of clinical treatment failures in bacterial-mediated diseases and further threaten public health with the possibility of transmission to humans through aerosols, environmental contact or other methods [ 2 , 6 ]. (hindawi.com)
There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs. (biomedcentral.com)
Nowadays, about 300 forms of well-characterized PIDs have been identified underlying complex phenotypes which encompass a wide spectrum of clinical features ranging from recurrent bacterial infections to other unusual manifestations, such as autoimmune disorders, cancer susceptibility, allergy and auto inflammation (8, 142). (unina.it)
Berberine is an isoquinoline derivative alkaloid isolated from Rhizoma Coptidis, which has been widely used as a drug to treat gastrointestinal infections (e.g., bacterial diarrhea). (hindawi.com)
This adaptive response mechanism provides unique insights into the sophisticated strategies employed by hybrid tilapia against bacterial infections. (aquahoy.com)
Morbidity results from patients succumbing to frequent bacterial infections or to an accelerated-phase lymphoproliferation into the major organs of the body. (medscape.com)
Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. (nature.com)
His research aims to elucidate molecular mechanisms underlying bacterial interactions with human cells and to use that information to identify targets for treatment and diagnostics of bacterial infections. (lu.se)
Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)
Therefore, alternative ways to treat bacterial infections is needed. (lu.se)
If it is severe, the risk and severity of bacterial and fungal infections increase. (msdmanuals.com)
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)
the most common bacterial causes are coagulase-negative staphylococci and Staphylococcus aureus , but other gram-positive and gram-negative infections also occur. (msdmanuals.com)

Through our fundamental research activities, we aim to gain better understanding of the mechanisms of bacterial infection, which would aid the identification of new targets for antimicrobial compounds and vaccine candidates. (imperial.ac.uk)
Moira Whyte's research interests have focused on molecular mechanisms of innate immune cell apoptosis in the context both of chronic inflammatory lung disease and of host defence against bacterial infection. (ed.ac.uk)
Her research interests have focused on molecular mechanisms underlying acute inflammation in the context both of chronic inflammatory lung diseases such as COPD and of host defence against bacterial infection. (ed.ac.uk)
We study Salmonella Typhi pathogenic mechanisms using various infection models. (google.com)
OBJECTIVE: To investigate the correlation of gastric pepsin A with inflammatory cytokines, bacterial infection, and clinical outcomes. (colorado.edu)
The presence of pepsin A in the middle ear was not associated with increased bacterial infection. (colorado.edu)
His research focus is to develop and apply proteomics based techniques to characterize the molecular mechanisms behind invasive bacterial infection. (lu.se)
Periodontal disease is a chronic bacterial infection that affects the gingiva and bone that supports the teeth. (bvsalud.org)
Otitis Media (Acute) Acute otitis media is a bacterial or viral infection of the middle ear, usually accompanying an upper respiratory infection. (msdmanuals.com)

This chemotactic signaling pathway is relatively conserved across bacteria, whereas chemoeffectors and chemoreceptors vary among bacterial species/strains. (nature.com)
In crustacean, phagocytosis by hemocyte has also been well-recognized as a crucial defense mechanism for the host against infectious agents such as bacteria and viruses. (frontiersin.org)
We attempted to gain a deeper understanding of the phagocytic mechanism of different hemocytes and their contribution to the host defense immunity in crustaceans, which will be beneficial for the establishment of potential effective strategies to control diseases caused by viruses and bacteria in crustacean industries. (frontiersin.org)
Her pioneering studies on the molecular mechanisms underlying cell shape and cell polarity in Caulobacter crescentus , says Errington, "have helped change the way people think about bacteria. (the-scientist.com)
Bacteria induce autophagy mainly via their pathogen-associated molecular patterns (PAMPs) and pathogen-induced damage-associated molecular patterns (DAMPs) ( 4 , 5 ). (frontiersin.org)
In particular, we investigate how the obligate intracellular bacteria Chlamydia trachomatis manipulates the host and establishes an intracellular niche favorable for bacterial survival and replication, resulting in disease. (virginia.edu)
We are interested in uncovering fundamental, molecular mechanisms underlying central survival mechanisms in both bacteria and archaea with the aim of understanding how microorganisms respond to nutritional stress, antibiotics, and other changes in their environment. (au.dk)
Fibrillar adhesins are proteins located on the bacterial cell surface, which mediate interactions with the environment, e.g. with host cells or other bacteria. (embl-em.de)
Monzon's project is just one of the many EMBL initiatives looking into the molecular mechanisms of bacteria. (embl-em.de)
The studies use both in vitro cellular models of bacterial communities (biofilms) to characterise the phenotype of disease-causing bacteria. (lu.se)
Most bacterial nosocomial pneumonias occur by aspiration of bacteria colonizing the oropharynx or upper gastrointestinal tract of the patient. (cdc.gov)
The realization of the vastness of bacterial diversity and the development of novel experimental techniques have propelled molecular microbiology into a new era of investigation This course provides insights into how genes are organized and regulated in bacteria and in their viruses. (lu.se)
To provide students with the opportunity to be exposed to the current state of understanding of the molecular biology of bacteria. (lu.se)
established an understanding of the principles underlying the genetics of bacteria. (lu.se)
be able to describe molecular genetic processes in bacteria. (lu.se)

In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
Two of these genes code for proteins that form curli, one type of bacterial amyloid fibers. (hku.hk)
To dissect the basis underlying exosporium assembly we use molecular biology, bacterial genetics, biochemical and structural analysis, omics and single cell imaging techniques to understand the mechanisms through which key morphogenetic proteins drive exosporium assembly and interplay with other spore-coat and exosporium constituents. (tamu.edu)
This report provides both functional and structural evidence that bacterial sialidases can disarm the complement system via desialylating key complement proteins and regulators. (bvsalud.org)
essential oil (LVEO) on the bacterial diversity and myofibrillar proteins (MPs) of large yellow croaker during refrigerated storage at 4 °C for 18 days. (awljournal.org)
These proteins usually have a stalk, which helps them cross the bacterial cell surface and be projected closer to their targets - regardless of what they are trying to bind to. (embl-em.de)
The course comprises molecular biology of genes, proteins, multicomponent protein complexes, and other biomolecules that provide structure and perform the organism's functions. (lu.se)

To accomplish this aim, we blend expertise from bacterial genetics, cellular microbiology, cellular biology and advance imaging techniques. (tamu.edu)
We use bioinformatics analysis of bacterial (meta) genomes, classical biochemistry as well as hybrid methods in structural biology (x-ray crystallography, electron microscopy, and small-angle x-ray scattering) and microbiology (physiology and growth) in our work. (au.dk)
Molecular Microbiology. (au.dk)
The workshop was organized by Hubert Hilbi (SSM section Molecular Microbiology), Urs Greber (LS2, SSM section Virology) and Claudia Rutte (Swiss Academies of Sciences, SCNAT). (sgv.org)
to acquire intellectual ability and practical skills to work productively in a commercial setting, institute, or university laboratory on different aspects concerning molecular microbiology. (lu.se)

The results shown in this report provide new insights into understanding the role of sialidases in bacterial virulence and open a new avenue to investigate the molecular mechanisms of bacterial complement resistance. (bvsalud.org)
Viral titers in ferret nasal wash specimens and nasal turbinate tissue correlated positively with peak titer in Calu-3 cells, whereas additional phenotypic and molecular determinants of influenza virus virulence and transmissibility in ferrets varied in their association with in vitro viral titer measurements. (cdc.gov)

in laboratory medicine and pathobiology at the SickKids Research Institute, followed by a Ph.D. in molecular genetics at the Donnelly Centre, University of Toronto. (gairdner.org)
Artem Babaian, PhD is a University of Toronto Assistant Professor in Molecular Genetics and in the Donnelly Centre for Cellular where he leads The Laboratory for RNA-Based Lifeforms. (gairdner.org)
BSc in Molecular Biology and Genetics at McMaster University, and his doctorate thesis in Medical Genetics with Dr. Dixie Mager was on the role of Endogenous Retrovirus transcription in human cancers for which we was awarded two Alexander Graham Bell graduate scholarship, a Roman M. Babicki scholarship, and the Patricia Baird Award for Excellence in Medical Genetics. (gairdner.org)
Our approach combines bacterial and host genetics, cell biology, biochemistry, microscopy and in vivo techniques. (virginia.edu)
be familiar with the techniques of molecular genetics and their uses and limitations. (lu.se)
The creation and isolation of specific mutants is a cornerstone of bacterial genetics. (lu.se)
The students will gain an understanding of genetics concepts and molecular biology techniques by using them in the context of a research project. (lu.se)

She aims to elucidate the processes underlying photoreceptor degeneration, towards the goal of the development of new therapies. (nih.gov)

The ParB protein forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation. (elifesciences.org)
Mechanisms of C. difficile spore-host interactions. (tamu.edu)
Such drug interactions are crucial for treatment efficacy, but their underlying mechanisms remain largely unknown. (embopress.org)
In particular, we found that polysaccharide and ATP synthesis control multiple drug interactions with previously unexplained mechanisms, and small molecule adjuvants targeting these functions synthetically reshape drug interactions in predictable ways. (embopress.org)
These results provide a new conceptual framework for the design of multidrug combinations and suggest that there are universal mechanisms at the heart of most drug interactions. (embopress.org)
Song J. (2022) Bacterial AB toxins and host-microbe interactions. (google.com)
By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas , the main oyster species exploited worldwide. (nature.com)

Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
You will gain hands-on experience in planning and conducting laboratory experiments that address fundamental cellular mechanisms underlying physiological and disease processes. (lu.se)

We perform drug treatment, bacterial culturing, and live/dead staining in series by using transcriptional reporter strains and novel adaptations to the mother machine technology . (exeter.ac.uk)
The first area involves the identification and evaluation of a new generation of probiotic bacterial strains that can be used to promote metabolic health. (lu.se)
Bacterial strains with potentially beneficial properties are screened in different cell lines and primary cells, after which the most promising strains are evaluated further in animal models and eventually in clinical trials. (lu.se)

In this thesis, during the three years of my PhD program, I have contributed to elucidate "Congenital Immunodeficiencies: novel diagnostic and therapeutic approach", through the clinical, cellular, functional and molecular study of some Immunological disorders. (unina.it)
Meanwhile, many studies have been devoted to elucidate the molecular mechanisms underlying the hypoglycaemic effect of berberine. (hindawi.com)

In this study, by feeding Caenorhabditis elegans expressing human α-syn with Escherichia coli knockout mutants, we conducted a genome-wide screen to identify bacterial genes that promote host neurodegeneration. (nih.gov)
To address this problem, the research team screened for bacterial E. coli genes whose deletion alleviates the PD symptoms in an animal model of PD. (hku.hk)
From a genome-wide screen, Dr Zheng's team identified 38 bacterial genes that can promote neurodegeneration in the animal host. (hku.hk)
The acquisition of resistance genes through a mechanism involving mobile genetic elements, such as plasmids and transposons, is considered a major contributor to antimicrobial resistance [ 9 , 10 ]. (hindawi.com)
Metabolic activity of the bacterial biofilm communities have altered as compared to the planktonic one such as increased rates of EPS production, activation or inhibition of particular genes associated with biofilm formation and decreased growth rate [ 39 ]. (biomedcentral.com)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

There are many resistance mechanisms underlying the emergence and prevalence of antimicrobial resistance. (hindawi.com)
Knowledge of these mechanisms can be used to develop new antimicrobial drugs. (au.dk)

We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae . (cdc.gov)
β-lactamase amino acid substitutions are the dominant mechanisms that lead to CAZ/AVI resistance ( 5 ). (cdc.gov)
We report a novel CAZ/AVI resistance mechanism in epidemic sequence type (ST) 11 KPC-KP. (cdc.gov)
Many studies link changes in available metal nutrients to alterations in bacterial colonization, pathogen resistance, and gut microbiota community composition but the underlying mechanisms remain unclear. (duke.edu)
SEpsis and Bacterial Resistance Alliance (SEBRA) is an awarded cross-professional interdisciplinary group of researchers and clinicians who represent the county hospital SUS Lund, and the Faculties of Medicine and Engineering (LTH) at Lund University. (lu.se)
To shed light on this challenge, a study led by scientists from the Chinese Academy of Fishery Sciences and Nanjing Agricultural University has delved into the molecular complexities of disease resistance, focusing on hybrid tilapia ( Oreochromis niloticus ♀ × O. aureus ♂), which exhibits greater resistance to Streptococcus agalactiae , a common culprit in streptococcosis outbreaks, than Nile tilapia ( O. niloticus ) and blue tilapia ( O. aureus ). (aquahoy.com)
Climate change and widespread travel augment zoonotic transmissions of infectious agents to humans, and bacterial antibiotic resistance emerges with increased use of antibiotics in humans and animals. (sgv.org)
The second area involves the elucidation of mechanisms underlying the development of brain insulin resistance and cognitive dysfunction, with special focus on the enzyme hormone-sensitive lipase. (lu.se)

Now there's a whole new field of people who are working on bacterial cell biology using the same sorts of approaches used to study eukaryotes. (the-scientist.com)
We aim to investigate the molecular mechanisms responsible for these novel functions of COMP, particularly those related to basic cell biology and tumor immunology. (lu.se)

In an effort to understand the molecular basis of adaptation in vertebrates, BBSRC-funded researchers have sequenced the genomes and transcriptomes of five species of the African cichlid fish and uncovered a variety of features that enable the fish to thrive in new habitats and ecological niches. (thefishsite.com)
In addition to helping explain the complex genomic mechanisms that give rise to incredible diversity among cichlid fishes, the findings from these 'natural mutants' shed new light on the molecular process of evolution in all vertebrate species. (thefishsite.com)
Christine Jacobs-Wagner's studies of a bacterial species have changed how scientists think about cell shape and polarity. (the-scientist.com)
No difference was found in the microbial profiles of individuals taking antidepressants or anxiolytics, but a small number of bacterial species belonging to the Firmicutes phylum were associated with antibiotic use - but not with PHQ-9 scores. (news-medical.net)
To address this shortcoming, three bacterial species ( Pediococcus pentosaceus, Lactobacillus plantarum, and Enterococcus faecium ) were isolated from seaweed biomass and evolved to increasing concentrations of NaCl. (dtu.dk)
Current estimates of the number of bacterial species range from 1 to 1000 million. (lu.se)

Research foci includes disease mechanisms (inflammation and metabolic dysfunction in obesity and diabetes), interprofessional healthcare teams (education, technology, and healthcare delivery systems to train and support the healthcare team), and Patient and Population Health (clinical and behavioral outcomes for the prevention and treatment of obesity and diabetes in underserved populations). (ohio.edu)

The researchers then showed that bacterial curli enters the neurons to cross-seed the human amyloid α-synuclein and promote its aggregation, which leads to proteotoxicity, mitochondrial dysfunction, and neuronal death. (hku.hk)

Over the past 10 years that success has played out in a handful of papers in Cell, Science, and other high-impact journals, where Jacobs-Wagner, now at Yale University, has showcased her award-winning work on bacterial physiology and development. (the-scientist.com)
By participating in our research projects, you will gain valuable experience in cutting-edge research techniques, broaden your understanding of cellular mechanisms in physiology and disease, and contribute to our mission to advance knowledge in the field of immunology. (lu.se)

Evolved lineages were analyzed for the molecular mechanisms underlying the observed phenotypes. (dtu.dk)

Future studies will focus on identifying the novel molecular targets of CYLD and the underlying signaling mechanisms involved in inflammatory and infectious diseases, as well as investigating the mechanisms by which CYLD is induced. (gra.org)
Growing evidence indicates that gut microbiota plays a critical role in regulating the progression of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD), but the molecular mechanism underlying such microbe-host interaction is still unclear. (hku.hk)
This research opens a new direction to develop preventative measures for neurodegenerative diseases by targeting bacterial curli production in the human gut. (hku.hk)
Her goal is to advance our molecular understanding of these devastating diseases and to use this knowledge for the development of new diagnostic tools and treatments. (nih.gov)

Objective - Nod1 is an intracellular pattern recognition receptor for bacterial peptidoglycan fragments. (elsevierpure.com)

As part of its i nfection biology transversal theme , EMBL aims to use cutting-edge technologies to systematically map and model host-pathogen interfaces at the atomic, molecular, and tissue levels. (embl-em.de)

To reveal the molecular mechanisms underlying the relationship between the gut microbiome and the brain during depression, the researchers applied an integrative longitudinal multi-cohort and multi-omics approach, beginning by assessing the relationships of bacterial composition and functionality with depression. (news-medical.net)
Dr Zheng pointed out the importance of the study and said: "This study established a new paradigm for understanding how bacterial components from the gut microbiome can influence neuronal health in animals. (hku.hk)

Compared with monomeric sialic acid, molecular interaction studies showed that the synthetic pseudo-glycoprotein bound tightly not only to hemagglutinin (HA)/neuraminidase (NA) but also to mutated drug-resistant NA on the surface of the influenza virus with a dissociation constant (KD) in the 1 µM range, attributed to the cluster effect. (bvsalud.org)
The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients. (google.com)

During sepsis, these host defence systems become pathologically augmented and deregulated and we develop experimental models to delineate cellular and molecular mechanisms involved. (lu.se)

Despite decades of study, the mechanisms of pathogen adhesion remain elusive. (embl-em.de)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

Throughout history, viral, bacterial and parasitic epidemics have plagued humans and livestock. (sgv.org)

Despite the emerging idea of "microbiota-gut-brain" link, little is known about the bacterial molecules that modulate the progression of neurodegeneration. (hku.hk)
Our research program revolves around elucidating fundamental molecular mechanisms by which metals affect the microbiota. (duke.edu)

The molecular mechanism underlying such microbe-host interaction is unclear. (nih.gov)

however, its underlying molecular mechanism remains elusive. (bvsalud.org)
However, the molecular mechanisms underlying this characteristic inflammation have remained elusive. (elsevierpure.com)

2023. Comparative transcriptomes reveal different tolerance mechanisms to Streptococcus agalactiae in hybrid tilapia, nile tilapia, and blue tilapia , Fish & Shellfish Immunology, Volume 142, 2023, 109121, ISSN 1050-4648, https://doi.org/10.1016/j.fsi.2023.109121. (aquahoy.com)

This study demonstrates that bacterial isolates from saline niches are promising microbial factories for the fermentation of saline substrates, without the requirement of previous desalination steps, while preserving high final product yields. (dtu.dk)

In particular, the relationship between these dynamic nucleoprotein complexes and the molecular architecture of the ParB protein is unclear and is the subject of the work presented here. (elifesciences.org)
Taken together, our findings provide new insights into the molecular mechanisms underlying the ability of NA to function as a binding protein. (bvsalud.org)
Moreover, I contributed in the characterization of the potential oncogenic role of the common gamma chain (γc) in primary human hematopoietic malignant cell lines, by evaluating the molecular mechanisms by which this protein promotes tumor growth. (unina.it)
The use of immunoassays has facilitated the measurement of Introduction high molecular weight sensitizers, usually protein molecules, in Asthma is one of the most common causes of chronic ill the picogram and nanogram per cubic meter range. (cdc.gov)

The molecular mechanism underlying the formation of these ParB networks is unclear. (elifesciences.org)
However, the mechanisms that underline C. difficile spore-persistence remain unclear. (tamu.edu)

Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. (mdpi.com)

These findings may give a new insight into the molecular mechanism underlying the aberrant activation of the Gln61 mutants. (awljournal.org)

Bacterial curli promotes the aggregation of α-synuclein through cross-seeding, which leads to mitochondrial stress and neurodegeneration. (hku.hk)

Research focuses on investigating the molecular targets and the underlying signaling mechanisms by which CYLD regulates S. pneumoniae -induced lethality. (gra.org)

Our study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments," said senior author Kerstin Lindblad-Toh, Scientific Director of Vertebrate Genome Biology at the Broad Institute: "These mechanisms are likely to be at work in humans and other vertebrates, and by focusing on the remarkably diverse cichlid fishes we were able to study this process on a broad scale for the first time. (thefishsite.com)

Exposure to grain dusts or purified bacterial endotoxin/LPS resulted in a dose-dependent inhibition of cell growth in both AM and epithelial cell lines. (cdc.gov)

He plans to move on to study other bacterial molecules identified from the screen and investigate how they affect host neurodegeneration. (hku.hk)

A interação de padrões moleculares associados à patógenos (PAMPs) de microrganismos com seus receptores de superfície, em células imunológicas, induz a produção de várias citocinas e quimiocinas que apresentam função pró- e/ou anti-inflamatória estimulando a secreção de uma grande variedade de subtipos de anticorpos e a ativação de mecanismos de controle da doença, como as células T reguladoras. (bvsalud.org)

We attempted to gain a deeper understanding of the phagocytic mechanism of different hemocytes and their contribution to the host defense immunity in crustaceans. (frontiersin.org)
However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. (frontiersin.org)

Persister and viable but non-culturable (VBNC) cells are two important clonal bacterial subpopulations that can survive antibiotic treatment. (exeter.ac.uk)
When we used a high dose of ampicillin (25 × Minimum inhibitory concentration MIC), a β-lactam antibiotic targeting the bacterial wall, we measured that the fraction of VBNC cells (f VBNC = 0.01) was larger than the fraction of persister cells (f P = 0.003). (exeter.ac.uk)
This further strengthen the link between these two antibiotic tolerant subpopulations and opens the way for a better understanding of the molecular mechanisms underlying their functioning. (exeter.ac.uk)

Molecular determinants of organic dust exposures in respiratory cells. (cdc.gov)

Shern works in the Pediatric Oncology Branch of the Center for Cancer Research where his research uses genomic and molecular approaches to understand the causes of childhood malignancies, with the goal of defining and developing precision therapies that target the underlying genetic mutations that cause tumorigenesis. (nih.gov)

Rich history - The Center for Computational Molecular Biology has helped to lay the groundwork for the newly awarded Center for Biomedical Research Excellence in Computational Biology of Human Disease. (brown.edu)
In the early 1990s, the advent of genome sequencing turned molecular biology into a "big data" science where computation became a crucial tool for life sciences research, Rand said. (brown.edu)

Microorganisms have the extraordinary ability to live in almost all environments and to protect themselves from external agents through sophisticated survival mechanisms. (intechopen.com)

In the present study we investigated the molecular mechanisms underlying the biogenesis of functionally heterogenic EVs. (stanford.edu)
The study, through a comprehensive transcriptome analysis, reveals the intricate molecular mechanisms that empower hybrid tilapia with increased tolerance to Streptococcus agalactiae . (aquahoy.com)

Although several studies have tried to clarify some of the immune mechanisms involved in periodontal disease, more studies must be conducted to understand its development and progression and consequently to discover new alternatives for the prevention and treatment of this severe inflammatory disease. (bvsalud.org)
Therefore, this review summarizes some immune mechanisms involved in periodontal disease. (bvsalud.org)

This would be an example of altruism and how bacterial colonies could resemble multicellular organisms. (wikipedia.org)

The possible roles of molecular hydrogen, a common by-product of bacterial fermentation, are also addressed. (techscience.com)

Anatomy30

Organisms19

Diseases6

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes84

Disciplines and Occupations2

Information Science4

Pathogens12

Pathogenesis5

Infections19

Infection9

Bacteria15

Proteins7

Microbiology5

Virulence2

Genetics7

Aims to elucidate1

Interactions7

Processes2

Strains3

Elucidate2

Genes7

Antimicrobial2

Resistance8

Cell biology2

Species6

Metabolic1

Amyloid1

Physiology2

Phenotypes1

Diseases4

Intracellular1

Host-pathogen1

Microbiome2

Drug-resistant2

Cellular1

Pathogen2

Viral1

Microbiota2

Interaction1

Elusive2

Immunology1

Isolates1

Protein4

Unclear2

Genomes1

Mutants1

Curli1

Focuses on investigating1

Humans1

Inhibition1

Molecules1

PAMPs1

Defense2

Antibiotic3

Determinants1

Approaches1

Research2

Survival mechanisms1

Study2

Immune2

Colonies1

Fermentation1