Molecular interactions biological function of genes. Medical search. Frequent questions

Over the years, many statistical methods for the identification of differentially expressed genes have been developed, and most of them focused on the expression analysis of individual genes [ 9 - 15 ]. (hindawi.com)
However, the simple list of individual differentially expressed genes can only tell us which genes are altered by biological differences between different cell types and/or states. (hindawi.com)
To better understand the roles of these differentially expressed genes and their interactions in a complex biological system, a comprehensive pathway analysis is needed. (hindawi.com)
Since the identification of biological pathways is significantly influenced by those differentially expressed genes from different datasets or different statistical methods [ 16 , 17 ], we reason here that an integration of multiple cancer microarray datasets and identification of the most common pathways from these data would reveal key relationships between crucial genes in carcinogenesis. (hindawi.com)
By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
Differential expression analysis was performed on the genes expressed between THCA and paraneoplastic tissues in TCGA, and Wayne analysis was performed on the ERGs obtained from the Gene Set Enrichment Analysis MsigDB and differentially expressed genes (DEGs). (biomedcentral.com)
Univariate Cox and least absolute shrinkage and selection operator (LASSO) analyses were used to identify the set of estrogen-related differentially expressed genes (ERDEGs) associated with progression-free intervals (PFI) and to establish a prediction model. (biomedcentral.com)
Correlation analysis was used to identify estrogen-related differentially expressed genes (ERDEGs). (biomedcentral.com)
We identified 96 differentially expressed genes (DEGs), including 13 upregulated and 83 downregulated genes, in CCA tissues as regulatory T cells were significantly higher and the proportions of activated natural killer cells and monocytes were significantly lower in CCA tissues than the precancerous tissues. (aging-us.com)
Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on differentially expressed genes (DEGs). (spandidos-publications.com)
Liu C, Pan Y, Li Q, Zhang Y. Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer. (medsci.org)
Bioinformatics approaches can identify differentially expressed genes (DEGs) and analyze DEG functions in diseases. (medsci.org)

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. (wikipedia.org)
Zinc finger and BTB domain-containing protein 16 and BAG family molecular chaperone regulator function as co-chaperone proteins in processes involving HB-EGF. (wikipedia.org)
Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. (nih.gov)
Characterization of the structure and dynamics of protein-RNA complexes is essential for understanding how they function at the molecular level: how these proteins specifically recognize their target RNAs, what are the structure-function relationships, and assess their biological role in regulating gene expression. (umassmed.edu)
Characterization of the structure and dynamics of protein-RNA complexes is essential for understanding how they function at the molecular level: how these proteins specifically recognize their target RNAs, what are the structure-function relationships, and to assess their biological role in regulating gene expression. (umassmed.edu)
Have you ever wondered how DNA and proteins work together to carry out the functions of life? (freescience.info)
It unravels the secrets of genes, which are segments of genetic material, such as DNA, containing instructions for building proteins and controlling various cellular processes. (freescience.info)
By investigating nucleic acids like DNA and RNA, as well as proteins and other biomolecules, scientists gain insights into gene expression, protein synthesis, gene transfer, and more. (freescience.info)
By studying genes, proteins, and other molecules within cells, biologists can identify genetic mutations responsible for inherited disorders. (freescience.info)
By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
Genome annotation disclosed 29 SARS-CoV-2 gene products - including 16 non-structural proteins, 4 structural proteins and 9 accessory factors. (news-medical.net)
In short, from a total of 437 high-confidence interacting proteins that bind to one or more SARS-CoV-2 genes, the researchers have identified several gene products, M protein, NSP6, ORF3a, ORF6 and ORF7b that interacted with host cell membrane proteins and complexes. (news-medical.net)
When the interactomes of NSP1 and N protein (i.e., two key SARS-CoV-2 proteins) were compared with other human coronaviruses , host pathways manipulations and divergent protein-protein interactions responsible for differences in disease pathology were uncovered. (news-medical.net)
a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
Gene ontology functional enrichment analysis was performed using search tool for the retrieval of interacting genes/proteins. (ijpsonline.com)
Like unique Lego bricks, these shapes allow the proteins to combine into larger structures, which in turn conduct the biological processes that propel life. (singularityhub.com)
Another is experimental: using both biological lab prowess and physics ingenuity, scientists can isolate protein complexes from cells-like sugar precipitating from lemonade when there's too much of it-and use specialized equipment to analyze the proteins. (singularityhub.com)
To gain insight into the value of the provided data, we used our new similarity measure based on the Gene Ontology to evaluate the molecular functions and biological processes of interacting proteins or domains. (mpg.de)
These proteins display interactions and are involved in the regulation of the cellular cytoskeleton. (biomedcentral.com)
Many molecular pathways in eukaryotic cells are modulated by specific signaling proteins that are controlled, by phosphorylation and dephosphorylation, through the activity of kinase and phosphatase enzymes. (biomedcentral.com)
This occurs through specific modulation of regulatory proteins during the host-pathogen interaction, especially proteins with roles in pathogenesis [ 27 ]. (biomedcentral.com)
The interactome is significantly enriched with genes differentially expressed in MPM tumors compared with normal pleura and with other thoracic tumors, genes whose high expression has been correlated with un-favorable prognosis in lung cancer, genes differentially expressed on crocidolite exposure, and ex-osomederived proteins identified from malignant mesothelioma cell lines. (cdc.gov)
Although a number of important interactions by proteins such as selectins, galectins, and sialic acid-binding immunoglobulin-like lectins are thought to mainly rely on sulfated O-glycans, our insight into the sulfotransferases that modify these glycoproteins, and in particular GalNAc-type O-glycoproteins, is limited. (lu.se)

These interacting partners play important roles in various biological processes such as transcriptional regulation, vesicular transport and apoptosis as well as in signaling pathways such as MAPK, mTOR signaling and NOD-like receptor signaling 22 , 23 . (nature.com)
We evaluate our method using three key pathways related to cancer and demonstrate that it is capable of finding meaningful alterations in gene relations. (hindawi.com)
It is well known that in a biological system genes interact with each other forming various biological pathways in order to carry out a multitude of biological processes. (hindawi.com)
Our focus on the interactions and pathways of cancer-related genes is important since changes in gene relations and key pathways are more relevant to carcinogenesis than individual genes alone. (hindawi.com)
Our long-term goal is to delineate the molecular bases and order of genetic, epigenetic and cellular processes that link altered expression of long ncRNAs and pathways driven by these molecules to cancer. (duke.edu)
Diverse signal recognition receptors and signal transduction pathways were defined which regulate cellular functions, metabolism and development. (mdpi.com)
By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
Identifying ligand-dependent AHR interactions and signaling pathways is essential for understanding toxicity of this class of environmentally relevant compounds. (oregonstate.edu)
For triterpene saponin biosynthesis, we found the genes in MVA and non-MVA pathways were differentially expressed among three examined tissues, indicating the parallel but compartmentally separated biosynthesis pathways of IPP and DMAPP in A. mongolicus . (biomedcentral.com)
The pathways that are probably regulated by the identified plant phytoconstituents were analyzed using Kyoto encyclopedia of genes and genomes. (ijpsonline.com)
Kyoto encyclopedia of genes and genomes pathway identified eight pathways that are directly related to cognitive impairment. (ijpsonline.com)
The phosphoproteome strategy is alternative proteomic method that allows investigation into the molecular mechanisms of signal transduction pathways [ 23 ]. (biomedcentral.com)
A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)
The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. (medscape.com)

HB-EGF biological activities with these genes influence cell cycle progression, molecular chaperone regulation, cell survival, cellular functions, adhesion, and mediation of cell migration. (wikipedia.org)
Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. (nature.com)
Li [ 18 ] observed differences of gene coexpression patterns in different cellular states and attributed these changes in gene coexpression patterns to some third set of influential genes. (hindawi.com)
Our aim is to define the molecular bases of the interactions that are established between chromatin and the components of the nuclear envelope, and determine how they 1) regulate epigenetic state of genes and their transcription, 2) participate in spatial organization of the genome, and 3) contribute to cellular functions during mammalian development. (duke.edu)
However, the underlying mechanisms and cellular functions triggered by internalized sGAG-derivatives are still not well understood. (degruyter.com)
Journal of Molecular Evolution covers experimental, computational, and theoretical work aimed at deciphering features of molecular evolution and the processes bearing on these features, from the initial formation of macromolecular systems through their evolution at the molecular level, the co-evolution of their functions in cellular and organismal systems, and their influence on organismal adaptation, speciation, and ecology. (springer.com)
Novel PPIs were predicted by applying the HiPPIP algorithm, which computes features of protein pairs such as cellular localization, molecular func-tion, biological process membership, genomic location of the gene, and gene expression in microar-ray experiments, and classifies the pairwise features as interacting or noninteracting based on a random forest model. (cdc.gov)
if immediate recombination does not occur, these can manifest as some type of molecular, cellular, or organic system alteration. (cdc.gov)
In recent years there have been significant advances in our understanding of the cellular and molecular mechanisms through which allergic sensitization to chemicals is induced and regulated. (cdc.gov)

A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
DEGs in GO analysis were enriched in biological processes about inflammation and in KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signaling pathway and NF-κB signaling pathway. (researchsquare.com)
R software was used in this study to identify DEGs in HT and PTC using data in Gene Expression Omnibus (GEO). (medsci.org)
According to the PPI network, PTPN6 , HLA-A , C3AR1 , LCK and ITGB2 are hub genes among HT-DEGs, whereas FN1 , CDH2 , SERPINA1 , and CYR61 are PTC-DEG hub genes. (medsci.org)
DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
The DEGs were also typed into protein-protein interaction (PPI) networks to get the interaction data. (medscimonit.com)
Ten DEGs, including 7 hub genes from PPI analysis, were confirmed by real-time PCR. (medscimonit.com)

Network-based methods can provide valuable tools to consolidate newly generated data with existing knowledge, and to decipher the interwoven molecular mechanisms underlying HD. (nature.com)
Therefore, it is critical to understand the relationship (e.g., interactions) between genes across different types of cancer in order to gain insights into the molecular mechanisms of cancer. (hindawi.com)
We explored the potential role of host-microorganism interactions between scale worms and deep sea mussels, and revealed the mechanisms through which scale worm parasitism affects hosts in deep sea chemosynthetic ecosystem. (frontiersin.org)
Welcome to the fascinating world of molecular biology , where biologists study the intricate molecular mechanisms of biological molecules that determine our traits through genomics and mendelian genetics. (freescience.info)
Molecular biology, a branch of science, has revolutionized the field of medicine by providing insights into the intricate mechanisms underlying diseases at a molecular level. (freescience.info)
In the Yildirim lab, we study how epigenetic mechanisms, particularly those that are mediated by long noncoding RNAs (ncRNAs), complement gene expression, impact genome stability and define cell fate decisions. (duke.edu)
Noncoding RNAs (ncRNAs) are noncoding transcripts that take part in epigenetic mechanisms by providing RNA-directed silencing, aiding recruitment of chromatin modifying complexes and in some instances, presenting enhancer-like functions to boost transcription. (duke.edu)
Yet, the molecular mechanisms of these processes are poorly understood for mammalian systems. (duke.edu)
Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. (oregonstate.edu)
Currently, an increasing number of studies are being carried out to deepen our understanding of miRNA regulatory mechanisms and functions. (hindawi.com)
Therefore, the introduction of a systematic approach, which can unravel the underlying mechanisms by which miRNAs exert their functions, becomes increasingly appealing. (hindawi.com)
Thus, further investigations into the specific molecular mechanisms underlying circRNA/miRNA/mRNA regulation are required to aid discovery of effective therapeutic targets. (spandidos-publications.com)
This information, along with an increased understanding of the molecular mechanisms used by tick-borne spirochetes to adapt for transmission by their tick vectors, may lead to unique disease prevention strategies. (cdc.gov)
The molecular mechanisms underlying the suppression of erythropoiesis by P. vivax are remarkably complex and remain unclear. (biomedcentral.com)
When combined with the right virological experiments, human genomic studies have the potential to show us the precise mechanisms involved in such interactions. (cdc.gov)
For this reason, attention here will focus on this now since a more sophisticated appreciation of the opportunities that may exist for the development of relevant molecular mechanisms facilitates, in principle alternative approaches to skin sensitization testing. (cdc.gov)

The large number of genes and the diversity of processes involved in the progression of neurological diseases in general, and HD in specific, emphasizes the need for comprehensive approaches in additional to studies of individual genes 14 . (nature.com)
In a biological system, genes perform different molecular functions and regulate various biological processes via interactions with other genes thus forming a variety of complex networks. (hindawi.com)
Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
Respecting the preferentially intracellular localization of sGAG in vesicle-like structures, also the interaction data indicate sGAG-specific modulation of vesicle-based transport processes. (degruyter.com)
Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. (oregonstate.edu)
Gene ontology functional enrichment analysis revealed twenty eight biological processes and 10 molecular functions associated with cognitive impairment. (ijpsonline.com)
Increasingly, long non-coding RNA (lncRNA) functions are being attributed to many critical biological processes in cancer. (aacrjournals.org)
The identification of gene regulatory networks (GRNs) facilitates the understanding of the underlying molecular mechanism of various biological processes and complex diseases. (biomedcentral.com)
Both behaviors are instrumental in biological function and enzymatic processes in general. (purdue.edu)
For decades, scientists have relied on painfully slow processes to parse out those interactions. (singularityhub.com)
Topics addressed include the evolution of informational macromolecules and their relation to more complex levels of biological organization, including populations and taxa, as well as the molecular basis for the evolution of ecological interactions of species and the use of molecular data to infer fundamental processes in evolutionary ecology. (springer.com)

Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. (nih.gov)
By unraveling the complex interactions between genes and their regulatory elements, researchers can identify disease-causing mutations more accurately. (freescience.info)
With the development of next-generation sequencing (NGS), research has focused on comprehensive genomic analysis based on tumor molecular features, such as somatic mutations and copy number variation. (spandidos-publications.com)
Germline mutations in other genes such as TNFRSF11A, ZNF687 and PFN1, have also been associated with the development of the disease. (bvsalud.org)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
In the first case study, we observed that the real biological networks were most sensitive to overexpression/state-flip and edge-addition/-reverse mutations among node-based and edgetic mutations, respectively. (researchgate.net)

To explore the concepts of genomics, molecular biologists employ cutting-edge techniques such as PCR (polymerase chain reaction), cloning, sequencing, and genetic engineering. (freescience.info)
In this article series on molecular biology, we will dive deeper into the captivating realm of genomics, where biologists study the genome and explore the fascinating world of Mendelian genetics. (freescience.info)
For instance, in cancer treatment, molecular biology techniques have led to breakthroughs in genomics and genetics such as personalized medicine. (freescience.info)
Thanks to molecular biology techniques like DNA sequencing and gene expression analysis, biologists have made significant strides in understanding genetics and genomics. (freescience.info)
We approach these two main areas of research by utilizing a variety of genetic, cell biological and genomics tools using mouse stem cells and mouse models. (duke.edu)
This coverage accommodates such subfields as new genome sequences, comparative structural and functional genomics, population genetics, the molecular evolution of development, the evolution of gene regulation and gene interaction networks, and in vitro evolution of DNA and RNA, molecular evolutionary ecology, and the development of methods and theory that enable molecular evolutionary inference, including but not limited to, phylogenetic methods. (springer.com)
Date Palm Molecular Markers Database will be a useful tool for both basic and applied sciences, such as genomics, genetics, and molecular breeding in date palm. (easyomics.org)
Through the new CDC Human Genomics and Public Health Initiative's support, we will expand from sequencing small viral genomes to sequencing sections of the much larger human genome, the genes involved in this mechanism. (cdc.gov)
In the new era of genomics, the ticks and mammals, which in turn suggests biological func- complete DNA sequence of two spirochetes, Borrelia burg- tions for a few surface-exposed lipoproteins. (cdc.gov)

To facilitate research on HD in a network-oriented manner, we have developed HDNetDB, a database that integrates molecular interactions with many HD-relevant datasets. (nature.com)
22 ] introduced a model to find differential gene coexpression patterns related to cancer by combining independent datasets for different cancers. (hindawi.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Known PPIs of the 62 MPM associated genes were derived from Biological General Repository for Interaction Datasets (BioGRID) and Human Protein Reference Database (HPRD). (cdc.gov)
We provide courses in cutting-edge techniques and approaches for generating and working with large and complex biological datasets. (lu.se)

It is a multidisciplinary conference that brings together scientists from molecular biology, medicine, computer science, mathematics and statistics. (iscb.org)
Molecular biology , a field studied by biologists, focuses on the study of biological molecules and their interactions at the molecular level. (freescience.info)
Their research in evolutionary biology and cell biology contributes to advancements in medicine, agriculture, and biotechnology by unlocking the mysteries of biological molecules and developing new therapies. (freescience.info)
Molecular biology, a branch of science that combines biology and chemistry, is crucial for advancements in medicine, biotechnology, agriculture, and our understanding of evolution and biodiversity. (freescience.info)
Let's delve into the significance of molecular biology in each of these areas. (freescience.info)
Molecular biology aids in drug discovery by identifying potential therapeutic targets and evaluating their efficacy in DNA. (freescience.info)
Molecular biology techniques, such as DNA sequencing and genotyping, have facilitated the identification of genetic variations that impact drug metabolism and efficacy. (freescience.info)
Molecular biology techniques are instrumental in designing safe and effective gene delivery systems for the manipulation of DNA and genome. (freescience.info)
For a better understanding of the regulatory role of miRNAs in coordinating gene expression, we here present a systems biology approach combining data-driven modeling and model-driven experiments. (hindawi.com)
The systems biology approach, combining data-driven modeling and model-driven experiments, provides a systematic and comprehensive perspective on the regulatory roles of miRNAs in gene regulatory networks [ 3 - 5 ]. (hindawi.com)
The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
For synthetic biology, Professor Huang has created novel genetic circuits for the control of gene expression and hence biological behaviour. (hku.hk)
We find applications both in the biophysical/molecular biology field and in the industrial area. (lu.se)
It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB). (lu.se)

A growing body of literature demonstrates that genetic and epigenetic factors condition biological responses to occupational and environmental hazards or serve as targets of them. (cdc.gov)
The framework is a 4×4 matrix involving the risk assessment functions (hazard identification, dose-response modeling, exposure assessment, and risk characterization) on one axis and inherited and acquired genetic and epigenetic data on the other axis. (cdc.gov)
The cells in the matrix identify how genetic and epigenetic data can be used for each risk assessment function. (cdc.gov)
Our laboratory uses primarily XCI as a model to understand how long ncRNAs 1) regulate gene dosage and maintain epigenetic state, 2) impact genome stability, and 3) participate in cell fate decisions. (duke.edu)
Epigenetic modifications of genes involved in bone remodelling and regulation, including RANKL, OPG, HDAC2, DNMT1, and SQSTM1, have been implicated in the development and progression of Paget's disease of bone, providing insight into the molecular basis of the disease and potential targets for therapeutic intervention. (bvsalud.org)

The molecular adaptations required by pathogenic spirochetes for efficient transmission by obligate, blood-feeding ticks are largely unknown. (cdc.gov)
he molecular adaptations required by pathogenic spiro- attention. (cdc.gov)

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
Finally, the calibrated model is used to study the effect of different miRNA expression profiles and cooperative target regulation on p21 expression levels in different biological contexts. (hindawi.com)
Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
However, experimental approaches have limitations when dealing with complex biological systems composed of multiple layers of regulation such as the transcriptional and post-transcriptional regulation by transcription factors (TFs) and miRNAs [ 2 ]. (hindawi.com)
The network combining putative targets of TF and miRNA regulation with experimentally proven molecular interactions was constructed and visualized. (hindawi.com)
Circular RNAs (circRNAs) are molecular sponges that are involved in regulation of multiple types of cancer. (spandidos-publications.com)
MicroRNAs (miRNAs or miRs) are involved in the post-transcriptional regulation of gene expression via complete or partial base pairing with the 3′untranslated region of target genes ( 3 ). (spandidos-publications.com)
Regulation of insulin receptor function. (genscript.com)
In this study, a phosphoproteomic approach was performed to dissect the molecular mechanism of phosphoprotein regulation, which is involved in the inhibitory effect of parasites on erythroid cell development. (biomedcentral.com)

Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)

The database includes protein-protein , TF-gene , miRNA-gene , and genetic interaction s. (droidb.org)
PDB has a complex genetic basis involving multiple genes, with SQSTM1 being the gene most frequently associated with its development. (bvsalud.org)
Genetic association studies have also uncovered several PDB predisposing risk genes contributing to the disease pathology and severity. (bvsalud.org)
Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
Simple sequence repeats (SSRs) have become widely used as molecular markers in plant genetic studies due to their abundance, co-dominant inheritance, extensive genomic coverage, high allelic variation at each locus and simplicity to analyze using conventional PCR amplification. (easyomics.org)
The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)

Cox regression analysis identifies independent prognostic factors for these patients, and enrichment analysis of prognosis-related genes was also performed. (biomedcentral.com)

For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. (scienceopen.com)
Using our similarity measure, we compare predicted domain-domain and human protein-protein interactions with experimentally derived interactions. (mpg.de)

Clinicopathological and transcriptome data of patients with THCA from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were cleaned before consensus clustering. (biomedcentral.com)

When applied to cancer research, microarray technology typically measures gene expressions of cancer and normal tissues or different types of cancer. (hindawi.com)
Therefore, a global transcriptome analysis on A. mongolicus tissues was performed to identify the genes essential for the metabolism and to profile their expression patterns in greater details. (biomedcentral.com)

However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. (medsci.org)

These data can be useful for assessing variability and reducing uncertainty in extrapolations, and they may serve as the foundation upon which identification of biological perturbations would lead to a new paradigm of toxicity pathway-based risk assessments. (cdc.gov)
The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database is a useful tool for understanding genes biological functions and their molecular interactions. (easyomics.org)
The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. (lu.se)

ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. (scienceopen.com)

In lung cancer patients, TP53 gene mutation status is associated with prognosis and therapeutic outcomes [ 10 ]. (aging-us.com)

DroID is a comprehensive gene and protein interactions (interactome) database designed specifically for the model organism Drosophila. (droidb.org)
As these may unveil promising drug targets, the analysis of host-virus interactome (i.e., a complete set of molecular interactions in a particular cell) is direly needed and have actually been reported recently. (news-medical.net)
We constructed an MPM interactome with over 300 computationally predicted proteinprotein interactions (PPIs) and over 2400 known PPIs of 62 literaturecurated genes whose activity affects MPM. (cdc.gov)
Interactome analysis of diseaseassociated genes is a powerful approach with high translational impact. (cdc.gov)

MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)

Large amounts of protein and domain interaction data are being produced by experimental high-throughput techniques and computational approaches. (mpg.de)

In addition, STARD12/14 could regulate the ferroptosis related genes. (medsci.org)
In various organisms, components of the nuclear envelope interact with chromatin that is spatially organized within the nucleus (Fig 2) and subsequently regulate gene expression. (duke.edu)
Using AI, the team predicted hundreds of complexes-many of which are entirely new-that regulate DNA repair, govern the cell's digestive system, and perform other critical biological functions. (singularityhub.com)

HB-EGF is recognized as an important component for the modulation of cell activity in various biological interactions. (wikipedia.org)

GeneMANIA, GO, KEGG and GSEA were applied for exploring the potential biological functions. (medsci.org)

Several statistical methods have been proposed for the analysis of differential gene coexpression patterns. (hindawi.com)
In an integrated analysis of the interactions between changes in the microbiota and host gene dysregulation, we found an agreement between the microbiota and transcriptomic responses to B. pettiboneaei parasitism. (frontiersin.org)
Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmental toxicity in an AHR-dependent manner. (oregonstate.edu)
Professor Earl Prohofsky spent the first decade of his professional career as a theoretical physicist doing analysis on second sound in super fluid helium and crystalline solids, thermal conductivity, ultrasonic attenuation and electron-vibration wave interaction. (purdue.edu)
In 1973 he became interested in the question of whether vibrational waves could be important in the description and analysis of biological phenomena. (purdue.edu)

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. (scienceopen.com)
Here, we have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and MDSCs determines the suppressive activity of the MDSCs via activation of Stat3. (scienceopen.com)
We also demonstrated that this mechanism is relevant in cancer patients, as TDEs from a human tumor cell line activated human MDSCs and triggered their suppressive function in an Hsp72/TLR2-dependent manner. (scienceopen.com)
Collectively, our findings show in both mice and humans that Hsp72 expressed at the surface of TDEs restrains tumor immune surveillance by promoting MDSC suppressive functions. (scienceopen.com)
The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
FUT6 and CGNL1 were downregulated in HNSCC compared with adjacent healthy tissue and the expression levels of these genes were associated with tumor stage. (spandidos-publications.com)

In addition to courses, we arrange several scientific meetings each year, providing valuable opportunities to network with a diverse community of ecologists, evolutionary biologists, molecular and structural biologists, bioinformaticians, and statisticians. (lu.se)

In order to identify genes that may modify disease onset and progression, genome-wide association and gene expression studies have been performed 12 , 13 . (nature.com)
One important area in microarray-based cancer research is to identify genes that are differentially expressed between cancerous and normal cells and to discover diagnostic and prognostic signatures in order to predict therapeutic responses. (hindawi.com)

Kaempferol exhibited the highest binding affinity with acetylcholinesterase, monoamino oxidase A and monoamino oxidase B. Molecular dynamics simulation demonstrated stable intermolecular interactions between kaempferol and acetylcholinesterase. (ijpsonline.com)
The research program is focused on intermolecular interactions and their manifestations in a liquid environment. (lu.se)
The theoretical basis for the description of intermolecular interactions and their consequences are treated using both quantum chemical calculations and statistical mechanical simulations. (lu.se)

Other research in the lab focuses on understanding how spatial organization of the genome is achieved through interactions between chromatin and components of the nuclear envelope. (duke.edu)
We are interested in defining the molecular bases of these interactions and delineating their significance in driving gene expression and genome functions. (duke.edu)
A) SARS-CoV-2 genome annotation, predicting 29 virus gene products. (news-medical.net)
As additional genome sequences become available for other pathogenic and free-living spirochetes, comparisons of their genomes may elucidate genes that are unique to those species of spirochetes associated with ticks. (cdc.gov)

Here we propose an integrative method based on the bootstrapping Kolmogorov-Smirnov test and a large set of microarray data produced with various types of cancer to discover common molecular changes in cells from normal state to cancerous state. (hindawi.com)

For intracellular transportation, Professor Huang has been working on illustrating the functions of a microtubule-based motor molecular, Kinesin-1, in different cell types, which is aimed at understanding its roles in different cell types in development and disease. (hku.hk)

19 ] proposed a similar method to identify differential gene-gene coexpression patterns in cells from normal state to cancerous state. (hindawi.com)
Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. (oregonstate.edu)
Here, we performed comprehensive differential molecular profiling between TMJ fibrous and bony ankylosis. (medscimonit.com)
This study provides a differential gene expression profile between TMJ fibrous and bony ankylosis. (medscimonit.com)

It allows users to obtain, visualize and prioritize molecular interaction networks using HD-relevant gene expression, phenotypic and other types of data obtained from human samples or model organisms. (nature.com)

However, the molecular mechanism is not completely clear. (frontiersin.org)
This female specific dosage compensation mechanism depends on expression of Xist long ncRNA, which coats and transcriptionally silences future inactive X (Xi) balancing X-linked gene expression between XX females and XY males (Fig 1). (duke.edu)
This indicates that estrogen and related genes play an important role in thyroid cancer, but the specific mechanism needs further exploration. (biomedcentral.com)

ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)
The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)

Within VSPB, the Molecular Pathogenesis and Therapeutics Team conducts basic and applied research to understand how these viruses interact with our bodies to cause disease, and how this knowledge can be used to develop and evaluate new antiviral drugs and vaccines. (cdc.gov)

The present study aimed to screen and explore the key circRNA/microRNA (miRNA or miR)/mRNA interactions in head and neck squamous cell carcinoma (HNSCC) using bioinformatics. (spandidos-publications.com)

We carried out a series of bioinformatics studies with the phytoconstituents of Amaranthus tricolor to elicit their possible molecular functions in cognitive disorders including Alzheimer's disease. (ijpsonline.com)

HB-EGF binding and activation of EGF receptors plays a critical role during cardiac valve tissue development and the maintenance of normal heart function in adults. (wikipedia.org)
During valve tissue development the interaction of HB-EGF with EGF receptors and heparan sulfate proteoglycans is essential for the prevention of malformation of valves due to enlargement. (wikipedia.org)
Therefore, this study aimed to compare the fidelity of blood to substantia nigra (SN) tissue gene expression from PD patients to provide a systematic approach to predict role of the key genes of PD pathobiology. (bvsalud.org)

genomes may elucidate genes that are unique to those species of spirochetes associated with ticks. (cdc.gov)

HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions. (wikipedia.org)
Recent studies indicate significant HB-EGF gene expression elevation in a number of human cancers as well as cancer-derived cell lines. (wikipedia.org)
Microarray technology, monitoring mRNA abundance of tens of thousands of genes simultaneously, provides an efficient tool to characterize a cell at the molecular level. (hindawi.com)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
We present SRGS, SPLS (sparse partial least squares)-based recursive gene selection, to infer GRNs from bulk or single-cell expression data. (biomedcentral.com)
It has been shown that SRGS is competitive with the existing GRN methods and effective in the gene regulatory network inference from bulk or single-cell gene expression data. (biomedcentral.com)
Genes interact and work as gene modules to perform cell functions. (biomedcentral.com)
The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
Radiation can disrupt the structure of the DNA (and other macromolecules), thereby disrupting normal cell and organ functions. (cdc.gov)
The MHC genes are codominantly expressed, which means that each individual expresses these genes from both the alleles on the cell surface. (medscape.com)
and some antibodies perform housekeeping functions without any real adaptation by clearing out ordinary cell debris. (cdc.gov)

The transmembrane domain prediction also indicated that these viral gene products contain at least one transmembrane domain in their protein sequences - with the exception of ORF6, which is actually a short protein with only 61 amino acids. (news-medical.net)

The biological molecules of interest which showed infrared and Raman activity were DNA and RNA helices with thousands to many hundred thousand atoms. (purdue.edu)

A molecular regulatory network consisting of three circRNAs, seven miRNAs and seven mRNAs was constructed, resulting in identification of two signaling axes, hsa_circ_0035431/hsa‑miR‑940/fucosyltransferase 6 (FUT6) and hsa_circ_0035431/hsa‑miR‑940/cingulin‑like 1 (CGNL1). (spandidos-publications.com)

Previous applications of microarray technology for cancer research have mostly focused on identifying genes that are differentially expressed between a particular cancer and normal cells. (hindawi.com)

The protein encoded by this gene is a subunit of the augmin complex. (nih.gov)
Reconstitution of the augmin complex provides insights into its architecture and function. (nih.gov)
In addition to their canonical functions in maintaining nuclear architecture and nucleocytoplasmic trafficking, components of the nuclear envelope (i.e. nuclear pore complex (NPC), nuclear lamina) are also involved in intracellular signaling, DNA repair, and gene expression. (duke.edu)
The researchers have also built an interaction network by utilizing the 437 identified virus-host protein-protein interactions, which enabled all the complex analyses that they have pursued. (news-medical.net)
Cognitive impairment is a complex disorder of old age people characterized by changes in cognitive functions like trouble in remembering, concentrating, learning and decision making. (ijpsonline.com)
This study demonstrates a complex pattern of interactions between lncRNA ANRIL (Antisense Non-coding RNA in the INK4 Locus),several miRs, PRC2/PRC1 subunits and p15/CDKN2Bp16/CDKN2A-p14/ARF locus in a large cohort of invasive breast carcinomas. (aacrjournals.org)

Anatomy13

Organisms16

Diseases1

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes92

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Information Science22

Health Care5

Differentially expressed genes12

Proteins25

Pathways16

Cellular9

DEGs7

Mechanisms16

Processes11

Mutations10

Genomics9

Datasets5

Biology14

Epigenetic5

Adaptations required by pathogenic2

Regulation9

RNAs1

Genetic7

Enrichment1

Experimentally2

Expression Omnibus1

Tissues2

Underlying func1

Pathway3

Physiological1

Prognosis1

Interactome4

Regulatory networks1

Computational1

Regulate3

Various biological1

KEGG1

Analysis5

Tumor6

Evolutionary1

Identify genes2

Intermolecular interactions3

Genome4

Integrative1

Roles1

Differential4

Phenotypic1

Mechanism3

Polymorphisms2

Pathogenesis1

Squamous Cell Carc1

Bioinformatics1

Tissue3

Elucidate1

Cell11

Prediction1

Molecules1

Identification1

Cancer Research1

Complex6