Molecular interactions between tryptophan interactions protein residues. Medical search. Frequent questions

Specifically phenylalanine, tryptophan and tyrosine residues highly populate the paratope of the antibody but not the epitope of the antigen. (iucc.ac.il)
The ligand-bound TM configuration promotes asymmetric dimerization of the intracellular juxta-membrane (JM) and kinase domains, which causes autophosphorylation of intracellular tyrosine residues ( 6 , 7 ). (biorxiv.org)
The three dimensional structure of CBM08 has also been solved, and its binding site is composed of tryptophan, phenylalanine and tyrosine residues, different from the other CBMs that usually have only tryptophan residues interacting with the ligand. (fapesp.br)

Furthermore, we showed, through alanine substitution of ALK1, the highly conserved phenylalanine (F), tryptophan (W), and C-terminal amidation were each essential for receptor activation. (unl.edu)
The digestive enzyme chymotrypsin, for example, cuts peptide bonds formed from the carbonyl groups of tryptophan, phenylalanine, and tyrosine. (customuniversitypapers.com)

DnaK contains a single tryptophan localized at residue 102 in the N-terminal domain of the protein. (protabank.org)

The hydrophobic core residues of helices 2, 3, and 4 are well conserved among TFIIS domains, although helix 1 is less conserved. (wikipedia.org)
Recombinant native alphaB-crystallin (wild type [WT]) and the three mutated alphaB species were expressed, and each species was purified to homogeneity by ion-exchange chromatography followed by hydrophobic interaction chromatography. (nih.gov)
Further, during binding experiments with 1-anilino-8-naphthalenesulfonate (ANS), the WT and N78D mutant showed relatively more solvent-exposed hydrophobic residues than the N146D and N78D/N146D mutants. (nih.gov)
The results as a whole suggest that both hydrophobic effects and electrostatic interactions play a significant role in the formation and stabilisation of ordered secondary structures in PrP [Ac-106-126-NH2]. (cnr.it)
Our model predicted several interactions ( i.e ., hydrophobic interactions, hydrogen bonds, and amide-pi stacking) between ALK peptides and ALKR, and several of our substitution and mutagenesis experiments were consistent with the predicted model. (unl.edu)
Molecular simulation studies pointed out that RPG was bound to BSA in the hydrophobic pocket of site II. (omicsdi.org)
Tertiary structure is formed by interactions among amino acid side chains and involves weak interactions including hydrophobic / hydrophilic interactions and hydrogen bonds, ionic bonds, and covalent bonds such as disulfide bridges formed between two cysteine residues. (customuniversitypapers.com)

PslG formed a complex with two mannose monosaccharides in this groove, consistent with binding data obtained from intrinsic tryptophan fluorescence. (rcsb.org)
PSII core complex is formed by two reaction center proteins D1 (PsbA) and D2 (PsbD), along with intrinsic antenna CP43 (PsbC) and CP47 (PsbB). (elifesciences.org)
The intrinsic activity of TrpA can be significantly increased through the exchange of several active-site loop residues, which mimic the corresponding loop in zmBX1. (uni-regensburg.de)

The structural and functional properties compared with WT protein were investigated, respectively, by static light scattering (SLS), circular dichroism (CD), and fluorescence spectroscopy and by determining chaperone activity with the use of three substrates. (nih.gov)
On determining far-UV circular dichroism and tryptophan (Trp) fluorescence spectra, significant secondary and tertiary structural changes were observed in the N146D and N78D/N146D mutants compared with WT and the N78D mutant. (nih.gov)
Insights from the work on formamide and other small amides have been applied to studies of proteins and have led to significant improvements in the calculation of the circular dichroism of proteins from first principles. (nottingham.ac.uk)
His calculations on protein circular dichroism spectroscopy, a key technique in structural biology, are the most accurate to be published. (nottingham.ac.uk)
The microenvironment of the protein-binding site was studied by synchronous fluorescence and circular dichroism (CD) techniques and data indicated that the conformation of BSA changed in the presence of PHs. (omicsdi.org)
Absorption and circular dichroism studies indicated the changes in the secondary structure of BSA upon its interaction with RPG. (omicsdi.org)
This study investigated the interaction between eupatorin and bovine serum albumin (BSA) using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence, circular dichroism (CD) spectroscopies, and molecular modeling at pH 7.4. (omicsdi.org)

Further, biophysical experiments suggested that HomA and HomB are dimeric and most likely the cysteine residues present on surface-exposed loops participate in protein-protein interactions. (nature.com)

Membrane proteins data analysis by cryoEM shows some specificities, as can be found in other typical investigations such as biochemistry, biophysics, or X-ray crystallography. (bvsalud.org)
However with the rapid advances in biochemistry/molecular biology the colloid aspect of the fi eld was largely forgotten and colloid science was for a long period primarily a discipline for technical applications. (lu.se)
Basic concepts of colloid science like the surface force issue has wide applications in biochemistry and molecular biology. (lu.se)

Further characterization of Trp-14 using chloroplast transformation in Chlamydomonas indicated that substitution of D1 Trp-14 to Phe, mimicking Trp oxidation enhanced FtsH-mediated D1 degradation under high light, although the substitution did not affect protein stability and PSII activity. (elifesciences.org)
Characterization of the interaction between eupatorin and bovine serum albumin by spectroscopic and molecular modeling methods. (omicsdi.org)
The functional characterization of all these CBMs, with structure solved or not, is of importance to understanding which carbohydrate they bind preferably and how their interactions impact the catalytic modules linked to these families of CBMs. (fapesp.br)
Systems that previously were considered too complex for a molecular characterization now successively become available to fundamental studies. (lu.se)

Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins. (bvsalud.org)
Thus, inhibiting HOX-PBX interaction represents a potential strategy to prevent these malignancies, as demonstrated by the patented peptide HTL001 that is being studied in clinical trials. (mdpi.com)
Intrigued by the fact that a non-peptide natural product was having the same effect as that of a natural peptide effector, Farmer hypothesized that other compounds might be discovered which will be non-Peptidic in nature but will "copy" or "mimic" naturally occurring proteins. (ijpsr.com)
defined Peptidomimetics as "compounds whose essential elements (pharmacophore) mimic a natural peptide or protein in 3D space and which retain the ability to interact with the biological target and produce the same biological effect" 14 . (ijpsr.com)
Two peptide fragments, corresponding to the amino acid residues 106-126 (PrP[Ac-106-126-NH2]) and 106-114 (PrP[Ac-106-114-NH2]) of the human prion protein have been synthesised in the acetylated and amide form at their N- and C-termini, respectively. (cnr.it)
The obtained benzo[a]pyrene immunomimetic peptide could only simulate chemical carcinogens in the frame of the pIII protein. (actanaturae.ru)
As a result, we prepared a recombinant protein composed of the benzo[a]pyrene immunomimetic peptide and pIII-encoding sequences. (actanaturae.ru)
Using molecular modeling, we predicted the 3-D structure of the mAB B2 active center and analyzed the characteristics of its interaction with different polycyclic aromatic hydrocarbons, as well as with the benzo[a]pyrene immunomimetic peptide. (actanaturae.ru)
Despite the progress, molecular mechanisms governing LK peptide-receptor interactions remain to be elucidated. (unl.edu)
We observed that PET1 behaves as a pH-responsive peptide that modulates the configuration of the EGFR TM through a direct interaction. (biorxiv.org)
describes the use of a phage-displayed combinatorial random peptide library to identify a 27-residue peptide that binds to C3 and inhibits complement activation. (justia.com)
This peptide was truncated to a 13-residue cyclic segment that maintained complete activity, which is referred to in the art as Compstatin. (justia.com)

The peptidomimetic based drugs are designed with the aim of overcoming the shortcomings of natural peptides and proteins. (ijpsr.com)
Therefore, from a past few decades there have been extensive research in designing synthetic peptides and proteins for health care 4- 5 . (ijpsr.com)
Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation CHEMISTRY-A EUROPEAN JOURNAL. (nottingham.ac.uk)

Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)
Effector proteins are then recruited to activate various cellular signaling pathways, including RAS/RAF/MEK, PI3K/AKT/mTOR, and JAK/STAT ( 1 ). (biorxiv.org)

Disulfide bond formation is a common mechanism for regulating conformational changes in proteins during oxidative folding. (bvsalud.org)
To maintain photosynthetic activity, the PSII reaction center protein D1, which is the primary target of unavoidable photo-oxidative damage, is efficiently degraded by FtsH protease. (elifesciences.org)
Here, we show that an oxidative post-translational modification of Trp residue at the N-terminal tail of D1 is correlated with D1 degradation by FtsH during high-light stress. (elifesciences.org)
We revealed that Arabidopsis mutant lacking FtsH2 had increased levels of oxidative Trp residues in D1, among which an N-terminal Trp-14 was distinctively localized in the stromal side. (elifesciences.org)
In photosynthetic organisms, maintenance of photosynthetic light reaction is manifested by so called Photosystem II (PSII) repair system, where the reaction center protein D1 is targeted to photo-oxidative damage and rapidly degraded by the processive protease FtsH. (elifesciences.org)
Here, we characterized oxidative modification of tryptophan (Trp) residues in the PSII core, and hypothesize that the oxidation of N-terminal Trp is one of the key oxidations in the PSII repair, likely enhancing D1's accessibility to FtsH. (elifesciences.org)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

Such proteins include sphingolipid transfer proteins that function as transporters to shuttle sphingolipids between intracellular membranes as well as lipid-binding domains (e.g. (umn.edu)
Among various PRXs, PRX derivatives with a longer molecular length (35 kDa polyethylene glycol as the axile molecule) and a low total degree of substitution (1.5 amino groups/α-cyclodextrins), as well as the modified ratio of two modified amines (cystamine and diethylenetriamine) = ≈1:1, exhibited the highest genome-editing efficacy and intracellular dynamics control. (bvsalud.org)
Using chimeric proteins in which CD4 is fused to the large intracellular loop of each of the AChR subunits we found that agrin induced clustering of only chimeras containing the β subunit loop. (jneurosci.org)
Each subunit has a large intracellular loop between the third and fourth transmembrane domains that is the likely site for regulated interactions with postsynaptic scaffolding proteins. (jneurosci.org)

Although PPL is present in the bloodstream, no information is found on the interaction between PPL and rat serum albumin (RSA), the most abundant protein with the function of transporting endo/exogenous molecules. (nature.com)
The molecular origin of the molecules in the protein hydration layer.1 The current picture, longest decay time, which may be anywhere from 10 ps to founded largely on 17O NMR relaxation2-5 and MD simulation6-11 several nanoseconds, is not fully understood. (lu.se)
The few relatively long-lived hydration water molecules slowed down by several orders of magnitude.12-22 In this Letter, undergo restricted motions on a similar (picosecond) time scale, we argue that the long decay times seen by this technique reflect and their much slower exchange with bulk water does not, for protein conformational fluctuations rather than hydration dy- symmetry reasons, affect the DSS (see below). (lu.se)
The resemblance in the Morphine Phenol system and N-Terminal tyrosine residue in the opioid receptors implied that these molecules also interacted with the opioid receptors in a similar manner and cause similar responses 8-9 . (ijpsr.com)
Upon interaction with the host immune cells, OMPs stimulate the production of pro-inflammatory molecules that may result in an uncontrolled inflammation leading to the transformation of a normal cell to a cancerous cell. (nature.com)
His research spans a wide range, from the quantum chemistry of small molecules and the spectroscopic properties of proteins, to the application of state-of-the-art statistical and computer science methodology to problems in bioinformatics, drug design and sustainable chemistry. (nottingham.ac.uk)

The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. (wikipedia.org)
Specific examples are listed below: MED26 (also known as CRSP70 and ARC70), a subunit of the Mediator complex, which is required for the activity of the enhancer-binding protein Sp1. (wikipedia.org)
PPP1R10, a nuclear regulatory subunit of protein phosphatase 1 that was previously known as p99, FB19 or PNUTS. (wikipedia.org)
The work supports a role for chemical modification in the recognition and subsequent degradation of a key protein subunit of PSII by a bacterial-type protease, suggesting that tryptophan oxidation of components of the photosynthetic apparatus after high light stress plays a critical role in initiating the PSII repair system. (elifesciences.org)
In particular, the intrinsically low catalytic activity of the alpha-subunit TrpA is stimulated several hundredfold through the interaction with the beta-subunit TrpB1. (uni-regensburg.de)
These proteins inhibit the C3 and C5 convertases (multi-subunit proteases), by promoting dissociation of the multisubunit complexes and/or by inactivating the complexes through proteolysis (catalyzed by factor I). Several pharmacological agents that regulate or modulate complement activity have been identified by in vitro assay, but most have been shown in vivo to be of low activity or toxic. (justia.com)

Despite a domain architecture and positioning of catalytic residues similar to those of other family 39 glycoside hydrolases, PslG(31-442) exhibits a unique 32-Å-long active site groove that is distinct from other structurally characterized family members. (rcsb.org)
Classification of microbial transglutaminases by evaluation of evolution trees, sequence motifs, secondary structure topology and conservation of potential catalytic residues. (cnr.it)
CBMs are protein modules involved in guiding catalytic modules in polysaccharidases (enzymes that breakdown polysaccharides) to the substrate. (fapesp.br)

These proteins share the same number of disulfide bridges (17) and a Cys34 thiol group 11 . (nature.com)

In this sense, the present study elucidated the mechanism of interaction between PPL and RSA, using in conjunction spectroscopic and computational techniques. (nature.com)
We argue here that the slow decay in the fluorescence shift can be explained by a ubiquitous solvent polarization mechanism, with no need to invoke slow water motions or a dynamic coupling with protein motions. (lu.se)
However, it is not clear how HomB contributes to ulcer or gastric cancer, and the exact molecular mechanism is not been explored yet. (nature.com)
The mechanism by which MuSK signaling regulates the interaction of the AChR with scaffolding proteins that localize it in the postsynaptic membrane, however, remain unknown. (jneurosci.org)
Finally, we investigated the mechanism of inhibition through molecular dynamics simulations, which showed that PET1 sits between the EGFR TM dimer. (biorxiv.org)

The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme complexes. (uni-regensburg.de)
Over the last 15 years I have developed a research pathway in auxin biosynthesis going back to my degree and PhD work at the Technical University of Munich where I studied the nitrilase pathway in maize auxin biosynthesis and maize tryptophan synthase complex. (brookes.ac.uk)

Interaction between bovine serum albumin (BSA) and phosphorus heterocycles (PHs) was studied using multi-spectroscopic techniques. (omicsdi.org)
Multi-spectroscopic investigation of the binding interaction of fosfomycin with bovine serum albumin. (omicsdi.org)
The interaction between fosfomycin (FOS) and bovine serum albumin (BSA) has been investigated effectively by multi-spectroscopic techniques under physiological pH 7.4. (omicsdi.org)
Interaction of repaglinide with bovine serum albumin: Spectroscopic and molecular docking approaches. (omicsdi.org)
In view of its biological importance, we have examined the interaction between RPG and a model protein, bovine serum albumin (BSA) employing various spectroscopic, electrochemical and molecular docking methods. (omicsdi.org)

Dr. Jennifer Geddes-McAlister joined the Department of Molecular and Cellular Biology at the University of Guelph in July 2018 and she was recently awarded tenure and promotion to Associate Professor. (hupo.org)
Small-angle scattering is becoming a mainstream technique for structural molecular biology. (iucr.org)

Molecular simulation revealed that intermolecular interaction between two tryptophan residues was indispensable for hydrogelation. (bvsalud.org)
In recent years we have seen a revival of the science aspects of the area driven by advances in the understanding of intermolecular interactions, cooperative phenomena and condensed phases. (lu.se)

We have since focused our efforts on specific proteins that can bind and transfer sphingolipids between membrane surfaces and that may help formation and maintain 'raft' microdomains in cells. (umn.edu)
A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences. (cnr.it)
However, it remains unclear where these proteins bind on the AChR and how the interactions are regulated. (jneurosci.org)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl-heidelberg.de)
The bromodomain has been shown to bind acetylated lysine residues on histone tails. (embl-heidelberg.de)

Our research elucidated sphingolipid structural features that regulate their interactions with other membrane lipids and provided insights into the unique physical features at the heart of the lateral organizing functionality of sphingolipid-enriched microdomains. (umn.edu)
Notably, our work revealed that human GLTP forms a novel structural fold among known proteins leading the Protein Data Bank to designate the human GLTP-fold as the founding prototype of the GLTP superfamily. (umn.edu)
Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK. (protabank.org)
In the present study, we explored the structural aspect of HomA and HomB proteins using various computational, biophysical and small-angle X-ray scattering (SAXS) techniques. (nature.com)
Our study provides essential structural information of unexplored proteins of the Hom family that can help in a better understanding of H. pylori pathogenesis. (nature.com)
Structural analysis suggests that a set of histidines surrounding the terminal tryptophan may act as proton acceptor and thereby stabilize the radical pair on a 100 ps timescale. (uni-bielefeld.de)
Giordano D, De Masi L, Argenio MA, Facchiano A. (2021)Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor. (cnr.it)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Alternatively, the interactions could be intra-molecular and be important in maintaining the structural integrity of the protein. (embl-heidelberg.de)
Explain how this method may be used to determine structural relatedness of a protein in different species, and perhaps evolutionary relationships among species. (customuniversitypapers.com)

A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

In our present view, these areas are found for systems where several types of macromolecules (proteins, polysaccharides or polyelectrolytes) and/or amphiphiles interact to form a functional or destructive unit. (lu.se)

The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)

Computer molecular dynamics simulations showed the de novo missense mutation is likely to affect TBX1-DNA interaction. (biomedcentral.com)
Another aspect of Hirst's research focuses on the study of protein-ligand interactions, using techniques including QSAR, machine learning, neural networks, docking, molecular dynamics (MD) simulations and quantum chemistry. (nottingham.ac.uk)
Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding. (cnr.it)

The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. (embl.de)

Although the N-terminal domain is not needed for transcriptional activity, a similar sequence has been identified in other transcription factors and proteins that are predominantly nuclear localized. (wikipedia.org)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
Although PIPER was the best performer in the latest rounds of the CAPRI protein docking experiment, it is much less accurate for docking antibody-protein antigen pairs than other types of complexes, in spite of incorporating sequence-based information on the location of the paratope. (iucc.ac.il)
The use of the new potential significantly improves the performance of docking for antibody-protein antigen complexes, even without any sequence information on the location of the paratope.We note that the asymmetric potential captures the effects of the multi-body interactions inherent to the complex environment in the antibody-protein antigen interface. (iucc.ac.il)
The function of a protein depends on its three-dimensional shape, which in turn depends on the protein's primary structure = its amino acid sequence. (customuniversitypapers.com)
If polypeptides from closely related species have the same amino acid sequence with the same amino acid residues at the same location, then treatment with the same enzyme should lead to synthesis of similar length fragments. (customuniversitypapers.com)

Finally, we used an artificial intelligence- based protein structure prediction server (Robetta) and Autodock Vina to predict the ligand-bound conformation of ALKR. (unl.edu)
The workflow utilized here may be useful for studying other ligand-receptor interactions for a neuropeptide signaling system, particularly in protostomes. (unl.edu)
To mediate these processes, the extracellular ligand binding region of EGFR senses environmental cues via interactions with one of its 7 known ligands, of which epidermal growth factor (EGF) is the most well characterized ( 2 , 3 ). (biorxiv.org)

Major research interests are cancer proteomics, focusing on the secretome, tumoral dynamics, quantitative proteomics, protein phosphorylation, and the stoichiometry of ubiquitination and acetylation. (hupo.org)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

The stability of the RSA-PPL complex was checked by molecular dynamics. (nature.com)
Performance of Web tools for predicting changes in protein stability caused by mutations. (cnr.it)
Predicting the stability of mutant proteins by computational approaches: an overview. (cnr.it)

The thermodynamic of the interaction between RSA and PPL is disclosed based on fluorescence spectroscopy analyses. (nature.com)
We therefore conclude that the long decay times measured with time-dependent fluorescence spectroscopy contain no information about protein hydration dynamics. (lu.se)

The relative contribution of molecular and cellular components to E/I balance of each brain region may vary. (frontiersin.org)

We propose that the resulting disruption of native TM interactions disrupts the conformation of the kinase domain, inhibiting EGFR's ability to send migratory cell signals. (biorxiv.org)

The overall objective of EuroNeut-41 was to design a vaccine that raises antibodies able to prevent HIV cell fusion by blocking the virus fusion protein gp41 in its pre-fusogenic conformation. (europa.eu)

I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)

abstract = "Motivation: An effective docking algorithm for antibody-protein antigen complex prediction is an important first step toward design of biologics and vaccines. (iucc.ac.il)

What is now clear is that certain membrane lipids can function as messenger signals that regulate cell growth, proliferation, inflammation, and programmed cell death processes, while other membrane lipids appear to cluster together in bilayers to form microdomains that regulate the spatial distribution and lateral interactions of membrane proteins. (umn.edu)
The findings have proven to be important for current understanding how the spatial organization of lipids in membranes can regulate proteins that translocate onto membranes to function. (umn.edu)
In this review we will highlight mechanisms that control targeting of PSD-95 at the synapse, and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic structure and strength. (frontiersin.org)

In the last decades, HOX proteins have been extensively studied due to their pivotal role in transcriptional events. (mdpi.com)
The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)

Her lab applies mass spectrometry-based proteomics to investigate host-pathogen interactions with a focus on One Health approaches to overcoming fungal disease. (hupo.org)
Outer membrane proteins (OMPs) of H. pylori play a crucial role in the host-pathogen interaction, virulence and pathogenesis. (nature.com)

Two approach lines of the molecular biophysical field were applied, one experimental another computational. (nature.com)

In this chapter, we review our experience with the ABC transporter BmrA, as well as our statistical analysis of amphipathic belts around membrane proteins, to bring awareness on some particular features of membrane protein investigations by cryoEM. (bvsalud.org)

The molecular docking described the microenvironment of the interaction sites, rich in apolar residues. (nature.com)

hydrogen bonds and van der Waals interaction were the main force to stabilize the complex. (omicsdi.org)
The folding of the polypeptide into the secondary structure of the protein backbone such as an -helix or a -pleated sheet involves the formation of weak hydrogen bonds. (customuniversitypapers.com)

Although inhibitory postsynaptic sites lack PSDs, they also consist of complex protein matrices. (frontiersin.org)
At the neuromuscular junction, the acetylcholine receptor (AChR) is specifically clustered in the postsynaptic membrane via interactions with rapsyn and other scaffolding proteins. (jneurosci.org)

Molecular dynamics simulation of PSII implies that both Trp-14 oxidation and Phe substitution cause fluctuation of D1 N-terminal tail. (elifesciences.org)

Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)

It also acts synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator. (wikipedia.org)
HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)

He received his PhD from the University of Mexico, and post-doctoral training in the Department of Molecular Genetics at Harvard Medical School. (hupo.org)

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (embl.de)

The goal of present investigation is to elucidate the molecular biophysical mechanisms of the interaction between RSA and PPL. (nature.com)
A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer. (cnr.it)

The BX1 protein from Zea mays (zmBX1), which is part of secondary metabolism, catalyzes the same reaction as that of its homologue TrpA, but with high activity in the absence of an interaction partner. (uni-regensburg.de)
Moreover, findings suggest an evolutionary trajectory that describes the transition from a primary metabolic enzyme regulated by an interaction partner to a self-reliant, stand-alone, secondary metabolic enzyme. (uni-regensburg.de)

All of these alterations have deep effects on muscle proteins and also on proteolytic enzyme systems (Huff Lonergan et al. (earthwormexpress.com)

Using a proline-rich domain derived from formin (a product of the murine limb deformity locus), we have identified a family of murine formin binding proteins (FBP's), each of which contains one or more of a special class of tyrosine-rich WW domains. (embl.de)

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. (unl.edu)
In conclusion, our results provide important information defining possible interactions between ALK peptides and their receptors. (unl.edu)
The plasma protein inhibitors are factor H and C4-binding protein, and the regulatory membrane proteins located on cell surfaces are complement receptors 1 (CR1), decay-accelerating factor (DAF), and membrane cofactor protein (MCP). (justia.com)

The 80 or so N-terminal residues form a protein interaction domain containing a conserved motif, which has been called the LW motif because of the invariant leucine and tryptophan residues it contains. (wikipedia.org)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)

As muscle is converted to meat, the muscle fibers modify their metabolism in order to adapt to the new conditions (absence of oxygen and nutrient supply, lack of residues removing), and as a consequence, many changes occur. (earthwormexpress.com)

In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
Two of these WW domains, in the proteins FBP11 and FBP21, are strikingly similar to those found in the yeast splicing factor PRP40. (embl.de)

Analysis of antibody-protein antigen complexes has revealed an inherent asymmetry within these interfaces. (iucc.ac.il)
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)

The larger eukaryotic and archaeal proteins possess N- and C-terminal hydrophilic extensions. (tcdb.org)

Using ELISA, we demonstrated that the recombinant protein specifically interacts with the anti-benzo[a]pyrene monoclonal antibody (mAB B2). (actanaturae.ru)

Anatomy10

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Stability3

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20211

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