Molecular interaction. Medical search. Frequent questions

Mol Biol Cell (1999) Kohn KW, Aladjem MI, Weinstein JN, Pommier Y. Molecular interaction maps of bioregulatory networks: a general rubric for systems biology. (wikipedia.org)
A Ph.D. degree in Plant Pathology, Plant Biology, Biochemistry or a closely related field, A solid publication record, strong oral and written communications skills, excellent molecular biology skills, and knowledge in molecular plant-pathogen interactions. (greeninnovationhub.com)
The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)
Our research focuses on major areas of modern biochemistry and molecular biology. (lu.se)

Network-based methods can provide valuable tools to consolidate newly generated data with existing knowledge, and to decipher the interwoven molecular mechanisms underlying HD. (nature.com)
Such drug interactions are crucial for treatment efficacy, but their underlying mechanisms remain largely unknown. (embopress.org)
In particular, we found that polysaccharide and ATP synthesis control multiple drug interactions with previously unexplained mechanisms, and small molecule adjuvants targeting these functions synthetically reshape drug interactions in predictable ways. (embopress.org)
These results provide a new conceptual framework for the design of multidrug combinations and suggest that there are universal mechanisms at the heart of most drug interactions. (embopress.org)
Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
The study highlights how combining multiple methods helps to systematically dissect the molecular mechanisms driving oligomer formation and to design ultimately efficient strategies for preventing detrimental protein aggregation. (lu.se)
We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)

Another type of interface, known as helix-helix, or coiled-coil interaction, forms when helices of two proteins wrap around each other. (jove.com)
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. (jove.com)
Computer programs can predict PPIs based on similar interactions found in other proteins by comparing protein sequences and three-dimensional structures. (jove.com)
This new edition introduces new, emerging proteins involved in host-virus interactions and provides in-depth coverage of plant virus genes' interactions with host, localization and expression. (researchandmarkets.com)
These tend to fall roughly into two categories: validation of putative or suspected interactions and identification of unknown associated proteins. (aacrjournals.org)
Unlike immunofluorescence microscopy approaches, which provide correlative information about proteins sharing cellular space, co-IP can confirm direct often high-affinity physical interactions between two proteins or protein complexes of equal or better affinity. (aacrjournals.org)
The validity of co-IP approaches can quickly deteriorate when forced expression of tagged proteins are used to investigate possible interactions, yet this approach, particularly when endogenous factors are assessed, can provide useful information about potential protein associations. (aacrjournals.org)
Objective: The present study aimed to evaluate the molecular analysis of possible interactions between UBE2Q1 with B4GALT1 and P53 proteins. (eurekaselect.com)
The Molecular Operating Environment (MOE) software was also used to perform the molecular docking of the UBC domain of UBE2Q1 (2QGX) with B4GALT1 (2AGD), and P53 (tetramerization (1AIE) and DNA binding domains (1GZH)) proteins. (eurekaselect.com)
The aim of the project is to investigate protein-protein interactions between the molecular chaperone DNAJB6 and aggregation-prone peptides and proteins which cause severe neurodegenerative protein aggregation diseases. (lu.se)
However, not much is known about the general characteristic features of the human proteins interacting with viral proteins (referred to as hVIPs) as well as the motifs and domains utilized by human - virus protein - protein interactions (referred to as Hu-Vir PPIs). (bvsalud.org)
In any given viral- human PPI pair, at least one of the two proteins is structurally disordered suggesting that disorder associated conformational flexibility as one of the characteristic features of virus -host interaction. (bvsalud.org)
Hu-Vir PPIs are mostly mediated via domain-motif interactions (DMIs) where viral proteins employ motifs that mimic host ELMs to bind to domains in human proteins . (bvsalud.org)
In this project we investigate and model interactions between nanoparticles and proteins in serum and cellular environments. (lu.se)
We study the interactions of these particles with a set of model proteins covering a representative array of protein sizes and charges. (lu.se)
We investigate the fate of the particles in a crowded mixture of proteins, thus mimicking the interaction of nanoparticles with the cell cytoplasm. (lu.se)

An intra-molecular C-Hcdots, three dots, centeredO inter-action occurs. (who.int)

Gaerdes, A. , Passow, U. and Ulrich, M. (2007): On the way to molecular investigations of marine algae-bacteria interactions , International Max Plank Research School of marine Microbiology: Evaluation Report. (awi.de)
However, this contact information is not typically linked with the molecular information in outbreak investigations, which could provide a more complete picture of HIV transmission. (cdc.gov)

We discuss the use of high-end rendering techniques to greatly increase the level of detail and interactivity of molecular visualisation, and describe the requirements placed upon that visualisation by the relationship between the abstract and physical models. (eg.org)

To explore this potential and advance our knowledge of the role of sPLA 2 in related diseases, it is necessary to systematically investigate the molecular interaction of the enzyme with lipids. (rsc.org)
By combining quantitative transcriptomics and immunohistochemistry, we systematically identify the cellular origin, molecular identity and tissue distribution of extracellular matrix molecules in mouse hair follicles, and reveal that BM composition and architecture are exquisitely specialized for distinct inter-tissue interactions, including epidermal-fibroblast, epidermal-muscle and epidermal-nerve interactions. (biorxiv.org)

2016) International Journal of Molecular Sciences , 17 (9), art. (edu.au)

Dr. Michael Coughtrie, Department of Molecular & Cellular Pathology. (aspetjournals.org)

It is important to understand the molecular characteristics of individual cells and the effects of intercellular interactions in the tumor microenvironment (cells within and surrounding tumors) to gain insight into the factors contributing to tumor progression. (scienceblog.com)

The Molecular Interactions and Dynamics (MID) Gordon Research Conference has long served the physical chemistry and chemical physics communities, as topics touch on the interactions and dynamics in isolated molecules, clusters, solution, surfaces, interfaces, and biological systems. (grc.org)
This GRC will be held in conjunction with the "Molecular Interactions and Dynamics" Gordon Research Seminar (GRS). (grc.org)
We used all-atom molecular dynamics (MD) simulations to investigate the interactions between dendrimers and hydrocarbons. (confex.com)

In: XIII International Congress on Molecular Plant-Microbe Interactions, 14th-19th July 2007, Sorrento, Italy. (worc.ac.uk)

Intermolecular interactions. (vu.nl)
Metropolis Monte Carlo simulations are used to gain insight into the underlying intermolecular interactions. (lu.se)

The findings demonstrate that the physical-chemical properties of the interfacial layers reflect a subtle balance between molecular and electrostatic competitive interactions, providing new experimental quantitative insights for testing the suitability of extended new theories on charged interfaces and ion specific interactions. (kth.se)
The analyses herein reveal that the intramolecular interactions have a strong covalent component and are certainly not dominantly electrostatic in nature, as it is incorrectly suggested by the sigma-hole model whose weaknesses are consistently exposed. (vu.nl)
Rheology of dense suspensions, electrostatic interactions in suspensions, Poisson-Boltzmann equation, molecular and particle simulations. (lu.se)

Based on the above outlined molecular data on the interaction between EmIR and mammalian insulin, the parasite's insulin receptor orthologue most probably mediates the insulin effects on parasite growth and is, therefore, a potential candidate factor for host-parasite communication via evolutionary conserved pathways. (uni-wuerzburg.de)

In many cases, highly expressed genes are associated with specific cell types that are overly abundant, dominant biological processes, or significant interactions among cell types not commonly found in healthy tissue. (scienceblog.com)
It can also identify the specific cell-to-cell interactions associated with genes of interest. (scienceblog.com)
The first is a simple differential expression mode that identifies genes exhibiting significantly higher expression at sites of cell-to-cell interaction, suggesting that these interactions lead to increased gene expression rates. (scienceblog.com)
The software's validation was conducted by identifying genes known to influence interactions between tumor and immune cells. (scienceblog.com)
Dr. Deshpande mentioned that many of the identified genes were consistent with the current understanding of tumor-immune interactions in these cancer types. (scienceblog.com)
Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)
Molecular genetic testing for sequence variants in the GJB3 , GJB4 , and GJA1 genes is available (also as next-generation sequencing panel) and expected to yield a positive result in at least two thirds of patients. (medscape.com)
Molecular diagnostic testing for mutations in the connexin genes GJB3, GJB4 , and GJA1 is available. (medscape.com)

Three fluorinated metformin derivatives (MTF1, MTF2 and MTF3) were synthesized and investigated for their human bloodstream - human serum albumin (HSA) interaction studies by multi-spectroscopic techniques (circular dichroism, steady state, time-resolved and synchronous fluorescence), combined with molecular docking and quantum chemical calculation. (amrita.edu)

Molecular Interaction Maps, also known as MIMs, is a graphic notation to depict cellular and molecular interactions. (wikipedia.org)
Ritchlin is co-leading a new research team dedicated to psoriatic spectrum diseases as part of the $64.5 million Autoimmune and Immune-Mediated Diseases Program (AIM) of the Accelerating Medicine Partnership (AMP), a huge public-private partnership involving the National Institutes of Health that is collecting and analyzing troves of biological data in order to better understand the cellular and molecular compositions and interactions that lead to disease. (medscape.com)

Experiments were conducted to examine the molecular basis for the high affinity and potency of a new class of 5-HT(2A) receptor agonists, N-benzyl phenethylamines. (erowid.org)
Protein- Protein interaction (PPI) analysis also depicted a high affinity of the UBC domain of UBE2Q1 to the B4GALT1 and P53 (tetramerization and DNA binding domains). (eurekaselect.com)

For these reasons, a search for the molecular structural characteristics that determine the effects of these and related substances has attracted attention (Johnson et al. (erowid.org)
Although the basement membrane (BM) is located at tissue interfaces, its mode of action in inter-tissue interactions remains poorly understood, mainly because the molecular and structural details of the BM at distinct inter-tissue interfaces remain unclear. (biorxiv.org)

2021 Science Advances 7: eabl7173, Qi et al, 2021 Molecular Plant 14:1-16). (greeninnovationhub.com)

We found that drug interactions between antibiotics representing the main modes of action are highly robust to genetic perturbation. (embopress.org)
Drug interactions between antibiotics are highly robust to genetic perturbations. (embopress.org)
Thus, genetic-environmental interactions may play an important role in modulating sulfotransferase activity and in determining individual response to chemicals metabolized by these important enzymes. (aspetjournals.org)
A Varying Coefficient Model to Jointly Test Genetic and Gene-Environment Interaction Effects. (nih.gov)
Epidemiologists and laboratory scientists at CDC recommended using molecular data to identify genetic similarity among the infections," said Bill Switzer, who leads the Molecular Epidemiology and Bioinformatics Team at the CDC's Division of HIV/AIDS Prevention. (cdc.gov)

Vi har nyligen publicerat dessa resultat i Molecular Cell 2016. (lu.se)

2019 Molecular Plant 12:678-688, Chen et al. (greeninnovationhub.com)

Molecular interaction map of the mammalian cell cycle control and DNA repair systems. (wikipedia.org)
In the present work, the effects of host insulin on Echinococcus metacestode vesicles and the proposed interaction between EmIR and mammalian insulin have been studied using biochemical and cell-biological approaches. (uni-wuerzburg.de)

By employing a Langmuir trough integrated with X-ray reflectivity and grazing incidence X-ray diffraction techniques, this study examined the molecular packing structure of 1,2-palmitoyl- sn-glycero -3-phosphocholine (DPPC) films before and after enzyme adsorption and enzyme-catalyzed degradation. (rsc.org)

Many biological processes depend on protein-protein interactions. (jove.com)

It deserved note that it was feasible to study the interaction between protein and polypeptide by molecular docking, and the method created great possibilities for the study of polypeptide-protein interaction at the molecular level. (magtech.com.cn)

In this research, molecular imprinted polymers (MIPs) for luteolin were prepared using acrylamide, 4-vinylpyridine and 1-allyl-piperazine as functional monomers and ethylene glycol dimethacrylate as cross-linker by non-covalent imprinting method. (scirp.org)

MOTIVATION Viruses , from the human protein-protein interaction network perspective, target hubs, bottlenecks and interconnected nodes enriched in certain biological pathways. (bvsalud.org)
namely, metabolic pathways, regulatory pathways, and molecular assemblies, and maintains gene catalogs for all the organisms that have be. (bvsalud.org)

Rare violations of this principle expose cellular functions that control drug interactions and can be targeted by small molecules to alter drug interactions in predictable ways. (embopress.org)
Some proposed applications involve dendrimer interactions with aromatic and hydrophobic hydrocarbons, or molecules containing moieties with these properties. (confex.com)
SPR, surface plasmon resonance, reveals the interaction between protein and other biomolecules through physical optical effects, and helps clients understand molecular function and to screen effective molecules. (medicilon.com)

A detailed description of the interactions between dendrimers and aromatic hydrocarbons can assist researchers in selecting and tuning dendrimer properties for specific applications. (confex.com)
We performed extensive simulations of aromatic hydrocarbon-dendrimer interactions, totaling several microseconds of simulation time for 70,000+ atom systems. (confex.com)

A quantitative understanding of the lipid packing and lipid-enzyme interaction provides an intuitive means of designing and optimizing lipid-related drug delivery systems. (rsc.org)
A- complexes, mediated via atoms Z of groups 15-17 in the periodic table, based on quantitative Kohn-Sham molecular orbital theory. (vu.nl)

Together, these genomes and associated functional data elucidate key aspects of the molecular host-parasite interactions that define chronic whipworm infection. (nature.com)
As part of its work, this eight-center project - coined ELLIPSS, for Elucidating the Landscape of Immunoendotypes in Psoriatic Skin and Synovium - hopes to define at a molecular and single-cell level how the transition to PsA unfolds in the setting of psoriasis. (medscape.com)

Hence, a user-defined query was used to conduct analysis on the provided bacterial strains whose molecular data available in the STITCH database. (bioinformation.net)

Molecular docking was introduced to study the molecular mechanism of the interaction between amanitin and RNA polymerase II. (magtech.com.cn)

Tentative identification of 2-quinolones in asphalt and their interaction with carboxylic acids present. (cdc.gov)

To uncover the causes of drug interactions, we developed a systematic approach based on precise quantification of the individual and joint effects of antibiotics on growth of genome-wide Escherichia coli gene deletion strains. (embopress.org)

The number of studies that have used protein interaction discovery approaches for identification of associated factors is overwhelming. (aacrjournals.org)
Students understand the concepts and methodological background of molecular trophic ecology, of molecular identification, and of DNA-barcoding. (uibk.ac.at)

Laboratory methods, such as affinity purification, mass spectrometry, and protein microarrays, can be used to identify new interactions. (jove.com)
Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, People's Republic of China. (who.int)

Furthermore, molecular nanoprobes monitoring changes in pH and reactive oxygen species activity are developed and used to further understand SOM modifications by ECM fungi. (lu.se)

Molecular Approaches and Viral Evolution. (researchandmarkets.com)
Plant Virus-Host Interaction: Molecular Approaches and Viral Evolution, Second Edition, provides comprehensive coverage of molecular approaches for virus-host interaction. (researchandmarkets.com)
In this study, we have analyzed the interactions of the lead compound SS-31 (Elamipretide) with model and mitochondrial membranes using biophysical and computational approaches. (biorxiv.org)
The lecture series provides an overview of the state-of-the-art in molecular trophic ecology and deals with the concepts and the methodological approaches used in this research field including diagnostic PCR and NGS. (uibk.ac.at)
The purpose of an Interaction Profile is to evaluate data on the toxicology of the "whole" priority mixture (if available) and on the joint toxic action of the chemicals in the mixture in order to recommend approaches for the exposure-based assessment of the potential hazard to public health. (cdc.gov)

It allows users to obtain, visualize and prioritize molecular interaction networks using HD-relevant gene expression, phenotypic and other types of data obtained from human samples or model organisms. (nature.com)

Subsequently, the software algorithm detects molecular changes resulting from the interaction between these two cell types. (scienceblog.com)

To facilitate research on HD in a network-oriented manner, we have developed HDNetDB, a database that integrates molecular interactions with many HD-relevant datasets. (nature.com)
The book contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, synergism with pivotal coverage of RNA silencing, and the counter-defensive strategies used by viruses to overcome the silencing response in plants. (researchandmarkets.com)
His research interests focus on light-matter interaction, nanostructures synthesis and electrodynamic si1mulations. (icmab.es)

Our data provide a molecular explanation for Lin28 specificity and a model for how it regulates let-7. (cornell.edu)

UV-visible spectra were used to evaluate the interaction strength between the template and the monomers. (scirp.org)
A weight-of-evidence (WOE) approach is commonly used in these documents to evaluate the influence of interactions in the overall toxicity of the mixture. (cdc.gov)

JOZWIAK, K. Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. (bvsalud.org)

A previous molecular modeling study, based on the structure of the homologous molluscan acetylcholine-binding protein, predicted that RgIA interacts with three residues on the α9(+) face and two residues on the α10(-) face of the α9α10 nAChR. (aspetjournals.org)
Our study highlights the significance of BM heterogeneity in distinct inter-tissue interactions. (biorxiv.org)
This study will employ a multi-level approach to study clinical, psychosocial, neuroendocrine, genotypic, gene-environment interaction, and molecular factors associated with PTSD risk and resilience in a sample of 500 WTC responders. (cdc.gov)

Our data support the interaction of α-CTx RgIA at the α10/α9 rather than the α9/α10 nAChR subunit interface, and may facilitate the development of selective ligands with therapeutic potential. (aspetjournals.org)

The classic method for analysis of protein-protein interactions is the co-immunoprecipitation (co-IP), also known as a "pull down" ( 1, 2 ), which constitutes the gold standard in the field. (aacrjournals.org)
CDC and health departments use molecular analysis to identify transmission clusters that might not be recognized with traditional public health tools and to better understand networks experiencing rapid transmission. (cdc.gov)

However, which mutations are most important, which events must occur, and if a specific order is involved in molecular tumorigenesis is unclear. (medscape.com)

Two regions, between amino acid residues 48-74 and 233-239 of pVI, were required for the interaction with hexon. (microbiologyresearch.org)

We will discuss several examples such as the case of molecular detection based on colloidal aggregates, and the use of photonic crystals to enhance light absorption in the near infrared spectral range in silicon based nanostructures. (icmab.es)
Created with support from CDC's Advanced Molecular Detection (AMD) program, MicrobeTrace is a secure, browser-based platform that among the cases. (cdc.gov)

It is currently believed that specific molecular interactions between ions and the various chemical functional groups, including the disruption of the interfacial water structure, are the key underlying steps. (kth.se)
One component of these BMs, laminin α5, is required for the topological and functional integrity of hair germ-dermal papilla interactions. (biorxiv.org)

Mol Biol Cell (2006) doi:10.1091/mbc.E05-09-0824 Kohn KW, Aladjem MI, Kim S, Weinstein JN, Pommier Y. Depicting combinatorial complexity with the molecular interaction map notation. (wikipedia.org)
Dr. Fertig stated that SpaceMarkers can assist cancer researchers in determining whether a gene is overexpressed due to cell-to-cell interactions. (scienceblog.com)
Regions exhibiting high activity from two cell types are recognized as sites of cell-to-cell interaction. (scienceblog.com)

Anatomy15

Organisms13

Diseases1

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Phenomena and Processes82

Disciplines and Occupations12

Technology, Industry, Agriculture7

Information Science22

Health Care6

Biology4

Mechanisms7

Proteins16

Intra-molecular1

Investigations2

Abstract1

Systematically2

International Journal1

Department of Molecular1

Intercellular interactions1

Dynamics3

Plant-microbe1

Intermolecular interactions2

Electrostatic3

Outlined molecular data1

Genes8

Fluorescence1

Cellular and molecular2

High affinity2

Structural2

20211

Genetic5

20161

20191

Mammalian2

Degradation1

Biological processes1

Polypeptide1

Polymers1

Pathways2

Molecules3

Aromatic2

Quantitative2

Define2

Bacterial1

Mechanism1

Carboxylic1

Strains1

Identification2

Laboratory2

Reactive1

Approaches5

Gene expression1

Algorithm1

Research3

Specificity1

Evaluate2

Receptor1

Study3

Data1

Analysis2

Mutations1

Residues1

Detection2

Functional2

Cell3